The network for 'establishment or maintenance of bipolar cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of bipolar cell polarity

Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns.

NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)0.994
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.992
Dvl2dishevelled 2, dsh homolog (Drosophila)0.990
Pax6paired box gene 60.949
Rac1RAS-related C3 botulinum substrate 10.945
Emx1empty spiracles homolog 1 (Drosophila)0.915
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.833
Shhsonic hedgehog0.801
MecomMDS1 and EVI1 complex locus0.769
Pitx2paired-like homeodomain transcription factor 20.696
Sox2SRY-box containing gene 20.688
Neurod1neurogenic differentiation 10.680
Vangl1vang-like 1 (van gogh, Drosophila)0.675
Otx2orthodenticle homolog 2 (Drosophila)0.626
Dvl3dishevelled 3, dsh homolog (Drosophila)0.609
Pax2paired box gene 20.565
Phox2bpaired-like homeobox 2b0.542
Ptk7PTK7 protein tyrosine kinase 70.494
Vegfavascular endothelial growth factor A0.464
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.456
Prph2peripherin 20.431
Lhx9LIM homeobox protein 90.418
Emx2empty spiracles homolog 2 (Drosophila)0.415
Fgf8fibroblast growth factor 80.408
Ascl1achaete-scute complex homolog 1 (Drosophila)0.407
Cd151CD151 antigen0.398
Gata4GATA binding protein 40.362
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.355
Rargretinoic acid receptor, gamma0.355
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.333
Itgb1integrin beta 1 (fibronectin receptor beta)0.319
Itga3integrin alpha 30.315
Dlx1distal-less homeobox 10.307
Crb2crumbs homolog 2 (Drosophila)0.299
Lhx1LIM homeobox protein 10.295
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.292
Hoxa1homeobox A10.270
Neurog2neurogenin 20.270
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.268
Atoh7atonal homolog 7 (Drosophila)0.267
Retret proto-oncogene0.250
Neurod4neurogenic differentiation 40.243
Gdnfglial cell line derived neurotrophic factor0.242
Bmp4bone morphogenetic protein 40.233
Fgfr1fibroblast growth factor receptor 10.228
Nhlh1nescient helix loop helix 10.227
Arhgap1Rho GTPase activating protein 10.226
Isl1ISL1 transcription factor, LIM/homeodomain0.223
Nr5a1nuclear receptor subfamily 5, group A, member 10.198
Sox11SRY-box containing gene 110.195
Foxc2forkhead box C20.188
Gbx2gastrulation brain homeobox 20.165
Ush1gUsher syndrome 1G homolog (human)0.164
Tcfap2atranscription factor AP-2, alpha0.164
Tlx3T-cell leukemia, homeobox 30.163
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.162
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.161
Smad4MAD homolog 4 (Drosophila)0.150
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.149
Ptenphosphatase and tensin homolog0.148
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.143
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.143
Zic3zinc finger protein of the cerebellum 30.141
Wdr1WD repeat domain 10.138
Ptf1apancreas specific transcription factor, 1a0.138
Prkczprotein kinase C, zeta0.136
Kiss1KiSS-1 metastasis-suppressor0.129
Crb1crumbs homolog 1 (Drosophila)0.123
Tbx3T-box 30.114
Ldb3LIM domain binding 30.113
Col4a1collagen, type IV, alpha 10.111
Arpc4actin related protein 2/3 complex, subunit 40.110
Notch2Notch gene homolog 2 (Drosophila)0.106
Gata1GATA binding protein 10.102
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.101
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.095
Foxc1forkhead box C10.095
Otx1orthodenticle homolog 1 (Drosophila)0.091
Sp3trans-acting transcription factor 30.091
Ctnnb1catenin (cadherin associated protein), beta 10.089
Vaspvasodilator-stimulated phosphoprotein0.087
Fzd2frizzled homolog 2 (Drosophila)0.083
Tagln2transgelin 20.082
Hoxd13homeobox D130.079
Pou3f4POU domain, class 3, transcription factor 40.078
Atoh1atonal homolog 1 (Drosophila)0.077
Pou4f3POU domain, class 4, transcription factor 30.076
Map2k2mitogen-activated protein kinase kinase 20.076
Eya1eyes absent 1 homolog (Drosophila)0.075
Lamc1laminin, gamma 10.074
Onecut1one cut domain, family member 10.074
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.072
Fgf17fibroblast growth factor 170.072
Lrp2low density lipoprotein receptor-related protein 20.071
Insm1insulinoma-associated 10.071
Srrm4serine/arginine repetitive matrix 40.070
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.069
Osr1odd-skipped related 1 (Drosophila)0.069
Pou4f2POU domain, class 4, transcription factor 20.069
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
nid-1Protein NID-10.082
art-1Protein ART-10.074
dnj-16Protein DNJ-160.052
lag-1Protein LAG-10.049
gei-4Protein GEI-40.043
elo-2Protein ELO-20.040
ina-1Protein INA-10.030
mpk-1Protein MPK-10.029
sur-5Protein SUR-50.024
sem-5Protein SEM-50.024
C43H6.4Protein C43H6.40.022
pes-9Protein PES-90.022
lat-1Protein LAT-10.020
C06G3.6Protein C06G3.60.017
par-6Protein PAR-60.017
spl-1Protein SPL-10.016
ajm-1Protein AJM-10.015
T25B9.9Protein T25B9.90.015
T03G11.6Protein T03G11.60.014
B0395.3Protein B0395.30.012
sli-1Protein SLI-10.012
aagr-2Protein AAGR-20.011
F22F7.1Protein F22F7.10.011
CELE_T04H1.2Protein T04H1.20.011
CELE_Y57G11C.3Protein Y57G11C.30.011
F25G6.8Protein F25G6.80.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a0.905
guca1cguanylate cyclase activator 1C0.799
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.767
prkciprotein kinase C, iota0.461
pitpnbphosphotidylinositol transfer protein, beta0.460
mibmind bomb0.446
epb41l5erythrocyte membrane protein band 4.1 like 50.376
crb3bcrumbs homolog 3b0.310
lrp2low density lipoprotein-related protein 20.212
cdh2cadherin 2, neuronal0.140
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.111
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.110
ahcyl1S-adenosylhomocysteine hydrolase-like 10.105
prickle1aprickle-like 1 (Drosophila) a0.102
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.098
ythdf1YTH domain family, member 10.092
mstnamyostatin a0.089
shdbSrc homology 2 domain containing transforming protein D, b0.088
acvr1bactivin A receptor, type IB0.088
nrg1neuregulin 10.077
ilkintegrin linked kinase0.075
osr2odd-skipped related 2 (Drosophila)0.075
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.071
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.069
synj1synaptojanin 10.065
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.058
skianuclear oncoprotein skia0.057
srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.057
axin1axin 10.055
ift88intraflagellar transport 88 homolog0.053
casz1castor zinc finger 10.051
dag1dystroglycan 10.050
ehd1EH-domain containing 10.049
homezhomeodomain leucine zipper gene0.048
cyt1type I cytokeratin, enveloping layer0.047
pacsin3protein kinase C and casein kinase substrate in neurons 30.047
sp2sp2 transcription factor0.045
notch1anotch homolog 1a0.043
anxa5bannexin A5b0.042
krt8keratin 80.042
cplx4acomplexin 4a0.041
ephb4beph receptor B4b0.040
grmaglutamate receptor, metabotropic a0.039
dlg1discs, large (Drosophila) homolog 10.036
kitbkit receptor b0.036
lama1laminin, alpha 10.036
dynlt3dynein, light chain, Tctex-type 30.035
pvrl1apoliovirus receptor-related 1a0.035
laptm4alysosomal-associated protein transmembrane 4 alpha0.035
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.034
acsl4aacyl-CoA synthetase long-chain family member 4a0.033
cntn1bcontactin 1b0.033
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.033
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.033
rcn1reticulocalbin 1, EF-hand calcium binding domain0.032
olfm1bolfactomedin 1b0.031
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.031
rhpn2rhophilin, Rho GTPase binding protein 20.030
gro2groucho 20.030
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.029
kif7kinesin family member 70.028
kif17kinesin family member 170.028
ctbp2lC-terminal binding protein 2, like0.027
lbx2ladybird homeobox homolog 2 (Drosophila)0.027
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.026
csadcysteine sulfinic acid decarboxylase0.026
atp1a3bATPase, Na+/K+ transporting, alpha 3b polypeptide0.026
cldncclaudin c0.026
foxa3forkhead box A30.026
prkcbbprotein kinase C, beta b0.025
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.025
bcl2l10BCL2-like 10 (apoptosis facilitator)0.025
inhbaainhibin, beta Aa0.025
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.025
mxi1max interacting protein0.024
tm9sf2transmembrane 9 superfamily member 20.024
pfn2profilin 20.023
her1hairy-related 10.023
tpp1tripeptidyl peptidase I0.023
psen1presenilin 10.023
csrp1acysteine and glycine-rich protein 1a0.022
sarsseryl-tRNA synthetase0.022
tpm1tropomyosin 1 (alpha)0.021
smad2MAD homolog 2 (Drosophila)0.021
ptp4a1protein tyrosine phosphatase type IVA, member 10.021
mvpmajor vault protein0.021
selt2selenoprotein T, 20.021
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
l(2)gllethal (2) giant larvae0.986
Rac1CG2248 gene product from transcript CG2248-RA0.932
ChcClathrin heavy chain0.891
Rab11Rab-protein 110.810
VangVan Gogh0.752
Ras85DRas oncogene at 85D0.742
Cdc42CG12530 gene product from transcript CG12530-RA0.555
Syx7Syntaxin 70.476
cpacapping protein alpha0.465
KhcKinesin heavy chain0.443
JIL-1CG6297 gene product from transcript CG6297-RA0.437
Arp87CActin-related protein 87C0.431
frcfringe connection0.390
aPKCatypical protein kinase C0.370
par-6CG5884 gene product from transcript CG5884-RA0.277
bowlbrother of odd with entrails limited0.244
schlankCG3576 gene product from transcript CG3576-RB0.212
Dhc64CDynein heavy chain 64C0.193
DlicDynein light intermediate chain0.188
trptransient receptor potential0.157
ric8aCG15797 gene product from transcript CG15797-RA0.142
sqhspaghetti squash0.139
Vps28Vacuolar protein sorting 280.138
par-1CG8201 gene product from transcript CG8201-RA0.132
Rab5Rab-protein 50.124
Eb1CG3265 gene product from transcript CG3265-RF0.119
sec8CG2095 gene product from transcript CG2095-RA0.114
Vhlvon Hippel-Lindau0.110
cpbcapping protein beta0.100
JraJun-related antigen0.095
Wnt4Wnt oncogene analog 40.089
rawCG12437 gene product from transcript CG12437-RB0.088
SaraSmad anchor for receptor activation0.087
lkb1CG9374 gene product from transcript CG9374-RJ0.084
gammaCopgamma-coatomer protein0.083
sec6CG5341 gene product from transcript CG5341-RA0.074
Sgt1CG9617 gene product from transcript CG9617-RA0.070
bibbig brain0.069
sinahsina homologue0.067
CG31740CG31740 gene product from transcript CG31740-RA0.062
CG10103CG10103 gene product from transcript CG10103-RA0.061
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.061
Syx5Syntaxin 50.060
sds22CG5851 gene product from transcript CG5851-RA0.059
Tak1TGF-beta activated kinase 10.055
RalaRas-related protein0.052
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.051
CG34449CG34449 gene product from transcript CG34449-RB0.051
CG32556CG32556 gene product from transcript CG32556-RB0.048
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.047
Rab7Rab-protein 70.046
stanstarry night0.045
Gbeta76CG protein beta-subunit 76C0.044
bab2CG9102 gene product from transcript CG9102-RA0.044
Arr2Arrestin 20.043
CG3529CG3529 gene product from transcript CG3529-RB0.043
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.988
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.985
MAPTmicrotubule-associated protein tau0.979
GDAguanine deaminase0.952
EGFRepidermal growth factor receptor0.929
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.901
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.888
DVL1dishevelled, dsh homolog 1 (Drosophila)0.855
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.854
LRRK2leucine-rich repeat kinase 20.841
RHOAras homolog gene family, member A0.827
PKP2plakophilin 20.813
CNKSR2connector enhancer of kinase suppressor of Ras 20.812
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.797
DVL3dishevelled, dsh homolog 3 (Drosophila)0.797
CD44CD44 molecule (Indian blood group)0.763
INADLInaD-like (Drosophila)0.735
SORBS3sorbin and SH3 domain containing 30.728
APCadenomatous polyposis coli0.711
CD247CD247 molecule0.699
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.699
GMFBglia maturation factor, beta0.698
JUPjunction plakoglobin0.619
CSNK1Ecasein kinase 1, epsilon0.609
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.608
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.584
MCCmutated in colorectal cancers0.572
IQGAP1IQ motif containing GTPase activating protein 10.559
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.533
PSEN1presenilin 10.513
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.513
LATlinker for activation of T cells0.503
CHMP1Achromatin modifying protein 1A0.471
LCKlymphocyte-specific protein tyrosine kinase0.402
EXOC5exocyst complex component 50.399
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.364
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.334
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.329
DLG1discs, large homolog 1 (Drosophila)0.319
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.317
ABI1abl-interactor 10.314
PFN1profilin 10.295
FMR1fragile X mental retardation 10.290
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.286
SHC1SHC (Src homology 2 domain containing) transforming protein 10.272
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.264
ARHGEF2Rho/Rac guanine nucleotide exchange factor (GEF) 20.249
AXIN1axin 10.242
KIF5Bkinesin family member 5B0.230
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.227
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.224
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.215
JUBjub, ajuba homolog (Xenopus laevis)0.205
CDH5cadherin 5, type 2 (vascular endothelium)0.198
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.197
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.194
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.191
SOS1son of sevenless homolog 1 (Drosophila)0.190
SMAD2SMAD family member 20.188
MYH9myosin, heavy chain 9, non-muscle0.184
CALM1calmodulin 1 (phosphorylase kinase, delta)0.178
RIN1Ras and Rab interactor 10.176
PRKCZprotein kinase C, zeta0.175
ACTBactin, beta0.170
UBE2R2ubiquitin-conjugating enzyme E2R 20.169
CD81CD81 molecule0.167
TRIP6thyroid hormone receptor interactor 60.164
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.164
KRT18keratin 180.158
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.155
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.155
MYST2MYST histone acetyltransferase 20.153
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.149
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.148
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.143
TNS4tensin 40.138
GSK3Bglycogen synthase kinase 3 beta0.138
PDCD6IPprogrammed cell death 6 interacting protein0.134
FAM110Cfamily with sequence similarity 110, member C0.132
RHOCras homolog gene family, member C0.131
ATF1activating transcription factor 10.128
ELLelongation factor RNA polymerase II0.127
RASSF5Ras association (RalGDS/AF-6) domain family member 50.119
TMOD3tropomodulin 3 (ubiquitous)0.119
SYKspleen tyrosine kinase0.116
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.115
MARK2MAP/microtubule affinity-regulating kinase 20.108
STRN3striatin, calmodulin binding protein 30.104
INSRinsulin receptor0.104
RANBP9RAN binding protein 90.102
CSNK1Dcasein kinase 1, delta0.101
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.100
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.100
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism