The network for 'morphogenesis of a polarized epithelium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of a polarized epithelium

The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.

NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Dvl2dishevelled 2, dsh homolog (Drosophila)0.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Ptk7PTK7 protein tyrosine kinase 70.999
Fgfr2fibroblast growth factor receptor 20.998
Shhsonic hedgehog0.998
Dvl3dishevelled 3, dsh homolog (Drosophila)0.997
Pax6paired box gene 60.995
Dlg4discs, large homolog 4 (Drosophila)0.994
Gli3GLI-Kruppel family member GLI30.994
Pitx2paired-like homeodomain transcription factor 20.985
Appamyloid beta (A4) precursor protein0.981
Sox11SRY-box containing gene 110.977
Wnt3awingless-related MMTV integration site 3A0.975
Foxc1forkhead box C10.967
Itga3integrin alpha 30.961
Bmp4bone morphogenetic protein 40.959
Fzd1frizzled homolog 1 (Drosophila)0.954
Gli2GLI-Kruppel family member GLI20.950
Dlg1discs, large homolog 1 (Drosophila)0.950
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.948
Vangl1vang-like 1 (van gogh, Drosophila)0.939
Egfrepidermal growth factor receptor0.939
Sfrp2secreted frizzled-related protein 20.931
Otx2orthodenticle homolog 2 (Drosophila)0.929
Fgf8fibroblast growth factor 80.929
Sox2SRY-box containing gene 20.929
Lrp6low density lipoprotein receptor-related protein 60.909
Ptk2PTK2 protein tyrosine kinase 20.908
Vegfavascular endothelial growth factor A0.883
Emx1empty spiracles homolog 1 (Drosophila)0.878
Dkk1dickkopf homolog 1 (Xenopus laevis)0.878
Gpc3glypican 30.847
Lama5laminin, alpha 50.844
Lmx1bLIM homeobox transcription factor 1 beta0.828
Tbx2T-box 20.818
Wnt4wingless-related MMTV integration site 40.817
Itgb1integrin beta 1 (fibronectin receptor beta)0.813
Axin1axin 10.794
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.788
Wnt5awingless-related MMTV integration site 5A0.776
Tbrachyury0.773
Ptenphosphatase and tensin homolog0.747
MecomMDS1 and EVI1 complex locus0.746
Mks1Meckel syndrome, type 10.744
Gdnfglial cell line derived neurotrophic factor0.743
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.726
Fgfr1fibroblast growth factor receptor 10.722
Sall4sal-like 4 (Drosophila)0.706
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.699
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.680
En1engrailed 10.678
Pou4f3POU domain, class 4, transcription factor 30.663
Pax3paired box gene 30.646
Grb2growth factor receptor bound protein 20.646
Pax2paired box gene 20.643
Foxc2forkhead box C20.622
Hoxd11homeobox D110.605
Neurod1neurogenic differentiation 10.600
Tbx3T-box 30.574
Foxf1aforkhead box F1a0.572
Bmp7bone morphogenetic protein 70.554
Hoxa1homeobox A10.551
Lef1lymphoid enhancer binding factor 10.549
Sfrp1secreted frizzled-related protein 10.548
Ntf3neurotrophin 30.544
Smurf2SMAD specific E3 ubiquitin protein ligase 20.530
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.529
Meox2mesenchyme homeobox 20.521
Apcadenomatosis polyposis coli0.501
Psen1presenilin 10.499
Msx2homeobox, msh-like 20.495
Neurog2neurogenin 20.495
Zfp185zinc finger protein 1850.488
Twist2twist homolog 2 (Drosophila)0.486
Wnt6wingless-related MMTV integration site 60.484
Fjx1four jointed box 1 (Drosophila)0.476
Tgfb2transforming growth factor, beta 20.473
Foxg1forkhead box G10.473
Trp63transformation related protein 630.465
Ascl1achaete-scute complex homolog 1 (Drosophila)0.457
Tcfap2atranscription factor AP-2, alpha0.452
Hoxd9homeobox D90.452
Msx1homeobox, msh-like 10.428
Bcl2B-cell leukemia/lymphoma 20.427
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.424
Fzd7frizzled homolog 7 (Drosophila)0.419
Fgfr3fibroblast growth factor receptor 30.418
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.416
Ptpn11protein tyrosine phosphatase, non-receptor type 110.396
Tcfap2ctranscription factor AP-2, gamma0.393
Efsembryonal Fyn-associated substrate0.391
Lrp2low density lipoprotein receptor-related protein 20.384
Pou3f3POU domain, class 3, transcription factor 30.377
Zic3zinc finger protein of the cerebellum 30.372
Notch2Notch gene homolog 2 (Drosophila)0.371
Tcfcp2l1transcription factor CP2-like 10.369
Bdnfbrain derived neurotrophic factor0.367
Lhx1LIM homeobox protein 10.364
Trp73transformation related protein 730.364
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
fzfrizzled1.000
dshdishevelled0.999
pkprickle0.998
edechinoid0.997
NNotch0.997
rokRho-kinase0.996
rinrasputin0.990
hbshibris0.980
ininturned0.978
VangVan Gogh0.977
ttktramtrack0.976
msnmisshapen0.974
sanoserrano0.961
stanstarry night0.957
cindrCIN85 and CD2AP orthologue0.954
gishgilgamesh0.944
Cdc42CG12530 gene product from transcript CG12530-RA0.940
fwfurrowed0.938
wdbwiderborst0.935
mwhmultiple wing hairs0.933
Wnt4Wnt oncogene analog 40.928
wgwingless0.917
frtzfritz0.906
Rho1CG8416 gene product from transcript CG8416-RB0.904
CG32556CG32556 gene product from transcript CG32556-RB0.898
scribscribbled0.894
Rac1CG2248 gene product from transcript CG2248-RA0.883
ftfat0.880
CG42251CG42251 gene product from transcript CG42251-RC0.857
crbcrumbs0.855
argosCG4531 gene product from transcript CG4531-RA0.847
scascabrous0.822
frcfringe connection0.819
TomTwin of m40.814
PebProtein ejaculatory bulb0.810
POSHPlenty of SH3s0.807
par-1CG8201 gene product from transcript CG8201-RA0.781
PknProtein kinase related to protein kinase N0.771
SoxNSoxNeuro0.757
ruroughoid0.741
neurneuralized0.697
fz2frizzled 20.688
G-oalpha47AG protein oalpha 47A0.684
rstroughest0.679
fngfringe0.672
armarmadillo0.651
Mob2CG11711 gene product from transcript CG11711-RC0.651
mirrmirror0.651
Akt1CG4006 gene product from transcript CG4006-RA0.619
nmonemo0.600
rapsrapsynoid0.542
aopanterior open0.535
dgodiego0.526
cswcorkscrew0.489
bdgbedraggled0.468
fjfour-jointed0.466
JraJun-related antigen0.447
bazbazooka0.446
rdgAretinal degeneration A0.442
MtlMig-2-like0.438
sinaseven in absentia0.431
hephemipterous0.426
pydpolychaetoid0.400
CG15730CG15730 gene product from transcript CG15730-RA0.394
edlETS-domain lacking0.393
norpAno receptor potential A0.390
ParpPoly-(ADP-ribose) polymerase0.375
CG31687CG31687 gene product from transcript CG31687-RA0.375
slouslouch0.372
nejnejire0.369
NrtNeurotactin0.352
RRoughened0.335
Traf4TNF-receptor-associated factor 40.323
eygeyegone0.322
stysprouty0.320
RalaRas-related protein0.317
kaykayak0.300
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.295
Ten-mTenascin major0.288
dsdachsous0.287
aseasense0.285
stumpsCG31317 gene product from transcript CG31317-RC0.285
sdksidekick0.281
sevsevenless0.280
spensplit ends0.280
S6kRPS6-p70-protein kinase0.276
hipkhomeodomain interacting protein kinase0.270
sktlskittles0.268
tinctincar0.268
ovoCG6824 gene product from transcript CG6824-RE0.268
kermitCG11546 gene product from transcript CG11546-RB0.258
gbbglass bottom boat0.257
svpseven up0.256
GugGrunge0.254
CG11347CG11347 gene product from transcript CG11347-RE0.248
E(spl)Enhancer of split0.246
TolloCG6890 gene product from transcript CG6890-RA0.244
CG34449CG34449 gene product from transcript CG34449-RB0.243
shgshotgun0.241
mblmuscleblind0.235
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PRKCZprotein kinase C, zeta0.970
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.963
ARHGAP1Rho GTPase activating protein 10.951
APCadenomatous polyposis coli0.918
DVL3dishevelled, dsh homolog 3 (Drosophila)0.918
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.876
AFF4AF4/FMR2 family, member 40.806
GDAguanine deaminase0.788
SORBS3sorbin and SH3 domain containing 30.774
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.768
DVL1dishevelled, dsh homolog 1 (Drosophila)0.731
LRRK2leucine-rich repeat kinase 20.716
CFL1cofilin 1 (non-muscle)0.648
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.614
TPBGtrophoblast glycoprotein0.598
SEC23ASec23 homolog A (S. cerevisiae)0.514
EGFRepidermal growth factor receptor0.422
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.416
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.363
AMPHamphiphysin0.361
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.358
CABLES1Cdk5 and Abl enzyme substrate 10.342
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.331
DNM2dynamin 20.303
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.298
PTNpleiotrophin0.298
F11RF11 receptor0.279
AP2A1adaptor-related protein complex 2, alpha 1 subunit0.277
WNT3Awingless-type MMTV integration site family, member 3A0.265
MED24mediator complex subunit 240.259
TTC30Btetratricopeptide repeat domain 30B0.232
LRP6low density lipoprotein receptor-related protein 60.230
TNS4tensin 40.228
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.228
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.221
PTPRJprotein tyrosine phosphatase, receptor type, J0.215
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.213
ACTA2actin, alpha 2, smooth muscle, aorta0.207
DNM1dynamin 10.207
RTKNrhotekin0.202
JUPjunction plakoglobin0.199
AXIN1axin 10.194
RIN1Ras and Rab interactor 10.193
FZD1frizzled homolog 1 (Drosophila)0.184
WNT5Awingless-type MMTV integration site family, member 5A0.182
JAM2junctional adhesion molecule 20.175
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.169
JAM3junctional adhesion molecule 30.158
FRMD5FERM domain containing 50.154
GRB7growth factor receptor-bound protein 70.154
SATB2SATB homeobox 20.152
SIAH1seven in absentia homolog 1 (Drosophila)0.143
CSNK1Ecasein kinase 1, epsilon0.135
SMAD2SMAD family member 20.134
SOX4SRY (sex determining region Y)-box 40.131
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.128
DKK1dickkopf homolog 1 (Xenopus laevis)0.128
CEP164centrosomal protein 164kDa0.128
SDC2syndecan 20.128
YAP1Yes-associated protein 10.127
AFF1AF4/FMR2 family, member 10.127
EZRezrin0.127
PRKCIprotein kinase C, iota0.124
RHOAras homolog gene family, member A0.122
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.122
FASLGFas ligand (TNF superfamily, member 6)0.119
MAPTmicrotubule-associated protein tau0.113
TYRP1tyrosinase-related protein 10.112
COL7A1collagen, type VII, alpha 10.110
INVSinversin0.109
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.106
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.098
PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)0.097
SYNJ1synaptojanin 10.097
FBLN2fibulin 20.097
MCCmutated in colorectal cancers0.096
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.095
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.095
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.094
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.090
LLGL2lethal giant larvae homolog 2 (Drosophila)0.089
SMAD3SMAD family member 30.088
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.088
SFNstratifin0.084
GSK3Bglycogen synthase kinase 3 beta0.083
PACSIN2protein kinase C and casein kinase substrate in neurons 20.083
BCRbreakpoint cluster region0.080
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.080
PTPRFprotein tyrosine phosphatase, receptor type, F0.080
JUBjub, ajuba homolog (Xenopus laevis)0.079
VCLvinculin0.078
FGFR1fibroblast growth factor receptor 10.078
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.076
SHC1SHC (Src homology 2 domain containing) transforming protein 10.076
HIPK3homeodomain interacting protein kinase 30.075
TNS3tensin 30.075
STON2stonin 20.075
ZEB2zinc finger E-box binding homeobox 20.073
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.072
FERMT2fermitin family member 20.071
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C1rcomplement component 1, r subcomponent0.167
Ap2a1adaptor-related protein complex 2, alpha 1 subunit0.051
Spon1spondin 1, extracellular matrix protein0.045
Cd82Cd82 molecule0.039
Ifitm3interferon induced transmembrane protein 30.038
Baiap2BAI1-associated protein 20.036
Cdc2l5cell division cycle 2-like 5 (cholinesterase-related cell division controller)0.036
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.036
C1scomplement component 1, s subcomponent0.031
Ednrbendothelin receptor type B0.030
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.030
Col5a2collagen, type V, alpha 20.029
Loxlysyl oxidase0.028
Fgfr1Fibroblast growth factor receptor 10.025
Col12a1collagen, type XII, alpha 10.025
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.024
Igfbp5insulin-like growth factor binding protein 50.024
Nfianuclear factor I/A0.024
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.023
Dbn1drebrin 10.023
Fzd2frizzled homolog 2 (Drosophila)0.023
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.023
Paqr5progestin and adipoQ receptor family member V0.023
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.023
Myoz2myozenin 20.023
Ranbp1RAN binding protein 10.022
Aebp1AE binding protein 10.022
Taglntransgelin0.022
Sorbs2sorbin and SH3 domain containing 20.021
Ptbp1polypyrimidine tract binding protein 10.021
Sostdc1sclerostin domain containing 10.020
Hbzhemoglobin, zeta0.020
Fam129bfamily with sequence similarity 129, member B0.020
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.019
Anxa2annexin A20.019
Cald1caldesmon 10.019
Il6stinterleukin 6 signal transducer0.019
Acvr1activin A receptor, type I0.018
Plagl1pleiomorphic adenoma gene-like 10.018
Ece1endothelin converting enzyme 10.018
Fzd1frizzled homolog 1 (Drosophila)0.018
Slc39a14solute carrier family 39 (zinc transporter), member 140.018
Bnc1basonuclin 10.018
Plac1placenta-specific 10.018
Stard8StAR-related lipid transfer (START) domain containing 80.017
Acta2smooth muscle alpha-actin0.017
LOC313672kazrin0.017
Lphn2latrophilin 20.017
Ppapdc1aphosphatidic acid phosphatase type 2 domain containing 1A0.017
Fam189a2family with sequence similarity 189, member A20.017
Prxperiaxin0.017
Bmp4bone morphogenetic protein 40.017
Cxxc4CXXC finger 40.016
Vcam1vascular cell adhesion molecule 10.016
Glud1glutamate dehydrogenase 10.016
Ptk7PTK7 protein tyrosine kinase 70.016
Gja1gap junction protein, alpha 10.016
Prphperipherin0.016
Loxl1lysyl oxidase-like 10.016
Arvcfarmadillo repeat gene deleted in velo-cardio-facial syndrome0.016
Anxa9annexin A90.016
Ptpn12protein tyrosine phosphatase, non-receptor type 120.016
Nrp1neuropilin 10.016
Tcfe2atranscription factor E2a0.016
Lgals7lectin, galactoside-binding, soluble, 70.016
Actg2actin, gamma 2, smooth muscle, enteric0.016
Zfp278zinc finger protein 2780.016
Id3inhibitor of DNA binding 30.016
Wizwidely-interspaced zinc finger motifs0.015
Fmodfibromodulin0.015
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.015
Sorbs1sorbin and SH3 domain containing 10.015
Maptmicrotubule-associated protein tau0.015
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.015
Irx4iroquois homeobox 40.015
Litaflipopolysaccharide-induced TNF factor0.015
Tead2TEA domain family member 20.015
Sorcs2sortilin-related VPS10 domain containing receptor 20.015
Ddah1dimethylarginine dimethylaminohydrolase 10.015
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.015
Nraddneurotrophin receptor associated death domain0.015
Ppp1r10protein phosphatase 1, regulatory subunit 100.015
Fam46bfamily with sequence similarity 46, member B0.015
Col2a1collagen, type II, alpha 10.015
Gakcyclin G associated kinase0.015
Bdkrb2bradykinin receptor B20.015
Lce1flate cornified envelope 1F0.015
A2malpha-2-macroglobulin0.015
Cpceruloplasmin0.014
Aifm3apoptosis-inducing factor, mitochondrion-associated 30.014
SpegSPEG complex locus0.014
Krt7keratin 70.014
RGD1560271similar to inhibitor of MyoD family-a0.014
Hdac6histone deacetylase 60.014
Ccdc8coiled-coil domain containing 80.014
Aardalanine and arginine rich domain containing protein0.014
Tgfatransforming growth factor alpha0.014
Pax9paired box 90.014
Dcdc2doublecortin domain containing 20.014
Rdh10retinol dehydrogenase 10 (all-trans)0.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism