The network for 'ear development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ear development

The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax2paired box gene 21.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Chd7chromodomain helicase DNA binding protein 71.000
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Ush1gUsher syndrome 1G homolog (human)0.999
Fgfr1fibroblast growth factor receptor 10.998
Cdh23cadherin 23 (otocadherin)0.998
Jag1jagged 10.998
Hand1heart and neural crest derivatives expressed transcript 10.998
Foxc1forkhead box C10.998
Gbx2gastrulation brain homeobox 20.998
Sox2SRY-box containing gene 20.998
Prrx1paired related homeobox 10.997
Fgf10fibroblast growth factor 100.996
Ptenphosphatase and tensin homolog0.996
Foxg1forkhead box G10.996
Foxc2forkhead box C20.996
Otx2orthodenticle homolog 2 (Drosophila)0.995
Pou4f3POU domain, class 4, transcription factor 30.995
Pax3paired box gene 30.994
Efnb2ephrin B20.994
Hoxa1homeobox A10.994
Msx1homeobox, msh-like 10.993
Dlx5distal-less homeobox 50.992
Pitx2paired-like homeodomain transcription factor 20.992
Zeb1zinc finger E-box binding homeobox 10.991
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.988
Nognoggin0.987
Dlx6distal-less homeobox 60.983
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.983
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.981
Gata3GATA binding protein 30.979
Ascl1achaete-scute complex homolog 1 (Drosophila)0.977
Pax8paired box gene 80.976
Thrbthyroid hormone receptor beta0.975
Lmx1aLIM homeobox transcription factor 1 alpha0.975
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.975
Espnespin0.975
Tgfb2transforming growth factor, beta 20.971
Egfrepidermal growth factor receptor0.968
Hoxd13homeobox D130.965
Smosmoothened homolog (Drosophila)0.962
Gli2GLI-Kruppel family member GLI20.962
Retret proto-oncogene0.960
Prrx2paired related homeobox 20.955
Hoxd11homeobox D110.954
Neurog3neurogenin 30.952
Chrdchordin0.952
Pax9paired box gene 90.947
Sox9SRY-box containing gene 90.947
Wnt5awingless-related MMTV integration site 5A0.945
Msx2homeobox, msh-like 20.942
Gscgoosecoid homeobox0.942
Fgf8fibroblast growth factor 80.938
Dccdeleted in colorectal carcinoma0.938
Grid1glutamate receptor, ionotropic, delta 10.937
Myo7amyosin VIIA0.936
Alx4aristaless-like homeobox 40.933
Trp63transformation related protein 630.933
Bcl2B-cell leukemia/lymphoma 20.933
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.932
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.924
Neurod1neurogenic differentiation 10.923
Meox2mesenchyme homeobox 20.923
Srrm4serine/arginine repetitive matrix 40.921
Hes1hairy and enhancer of split 1 (Drosophila)0.920
Bmp4bone morphogenetic protein 40.916
Tbx15T-box 150.915
Ptk7PTK7 protein tyrosine kinase 70.909
Lef1lymphoid enhancer binding factor 10.901
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.901
Nodalnodal0.900
Notch1Notch gene homolog 1 (Drosophila)0.896
Dlx1distal-less homeobox 10.895
Sall4sal-like 4 (Drosophila)0.891
Neurog1neurogenin 10.885
Ctnnb1catenin (cadherin associated protein), beta 10.885
Pou3f3POU domain, class 3, transcription factor 30.884
Pitx1paired-like homeodomain transcription factor 10.884
Hoxa13homeobox A130.880
Foxf1aforkhead box F1a0.876
Ntf3neurotrophin 30.876
Atoh1atonal homolog 1 (Drosophila)0.872
Hoxa11homeobox A110.870
Isl1ISL1 transcription factor, LIM/homeodomain0.863
Dll1delta-like 1 (Drosophila)0.856
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.856
Pax6paired box gene 60.856
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.852
Fgfr3fibroblast growth factor receptor 30.850
Nr2f1nuclear receptor subfamily 2, group F, member 10.848
Ror2receptor tyrosine kinase-like orphan receptor 20.846
Pcdh15protocadherin 150.838
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.835
Whrnwhirlin0.835
Tbx1T-box 10.833
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
eya1eyes absent homolog 10.999
fgf3fibroblast growth factor 30.998
sox10SRY-box containing gene 100.990
atoh1aatonal homolog 1a0.990
sparcsecreted acidic cysteine rich glycoprotein0.987
dladeltaA0.981
atoh1batonal homolog 1b0.976
fgf17fibroblast growth factor 170.974
aldh1a3aldehyde dehydrogenase 1 family, member A30.970
gpr126G protein-coupled receptor 1260.968
igfbp3insulin-like growth factor binding protein 30.968
bmp2bbone morphogenetic protein 2b0.968
hmx2H6 family homeobox 20.964
gata3GATA-binding protein 30.963
hnf1baHNF1 homeobox Ba0.962
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.962
gbx2gastrulation brain homeo box 20.960
neurog1neurogenin 10.958
tbx1T-box 10.954
hmx3homeo box (H6 family) 30.954
jag1bjagged 1b0.942
fgfr4fibroblast growth factor receptor 40.940
dlx4adistal-less homeobox gene 4a0.924
crabp2acellular retinoic acid binding protein 2, a0.905
pitx3paired-like homeodomain transcription factor 30.903
lmx1b.1LIM homeobox transcription factor 1, beta 10.900
dlx5adistal-less homeobox gene 5a0.899
foxa2forkhead box A20.895
myo7aamyosin VIIAa0.888
sox2SRY-box containing gene 20.884
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.883
fgf8afibroblast growth factor 8 a0.865
ugdhUDP-glucose dehydrogenase0.844
foxi1forkhead box I10.837
sox9aSRY-box containing gene 9a0.834
ush1cUsher syndrome 1C (autosomal recessive, severe)0.832
bmp2abone morphogenetic protein 2a0.825
gli2aGLI-Kruppel family member GLI2a0.818
wnt1wingless-type MMTV integration site family, member 10.817
flhfloating head0.817
gli1GLI-Kruppel family member 10.802
sulf1sulfatase 10.792
runx2brunt-related transcription factor 2b0.787
igf1rbinsulin-like growth factor 1b receptor0.779
hmx4H6 family homeobox 40.773
fgf10afibroblast growth factor 10a0.770
aldh1a2aldehyde dehydrogenase 1 family, member A20.761
fgf20afibroblast growth factor 20a0.758
ncs1aneuronal calcium sensor 1a0.757
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.754
dlx2adistal-less homeobox gene 2a0.741
dmrt2adoublesex and mab-3 related transcription factor 2a0.731
dachadachshund a0.726
notch1bnotch homolog 1b0.723
shhbsonic hedgehog b0.704
wnt11rwingless-type MMTV integration site family, member 11, related0.703
tal1T-cell acute lymphocytic leukemia 10.699
dlx3bdistal-less homeobox gene 3b0.687
edn1endothelin 10.685
twist3twist30.681
pax8paired box gene 80.680
pcdh10bprotocadherin 10b0.676
pcdh8protocadherin 80.670
notch1anotch homolog 1a0.665
bmp4bone morphogenetic protein 40.658
tgfb3transforming growth factor, beta 30.657
robo3roundabout homolog 30.649
fzd7afrizzled homolog 7a0.646
six4bsine oculis homeobox homolog 4b0.644
wnt5bwingless-type MMTV integration site family, member 5b0.636
grhl2bgrainyhead-like 2b (Drosophila)0.636
tp63tumor protein p630.627
wnt3wingless-type MMTV integration site family, member 30.621
barhl2BarH-like 20.615
otpborthopedia homolog b0.610
gja3gap junction protein, alpha 30.604
rx2retinal homeobox gene 20.604
wnt10awingless-type MMTV integration site family, member 10a0.603
foxc1aforkhead box C1a0.602
wnt4awingless-type MMTV integration site family, member 4a0.595
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.592
ndr2nodal-related 20.590
hhiphedgehog interacting protein0.588
neurod4neurogenic differentiation 40.585
cdh23cadherin-like 230.583
tfap2atranscription factor AP-2 alpha0.581
kif17kinesin family member 170.580
spry4sprouty (Drosophila) homolog 40.579
foxa3forkhead box A30.577
fn1fibronectin 10.572
osr2odd-skipped related 2 (Drosophila)0.565
nbl1neuroblastoma, suppression of tumorigenicity 10.561
dlcdeltaC0.560
vcanaversican a0.557
epb41l5erythrocyte membrane protein band 4.1 like 50.556
smosmoothened homolog (Drosophila)0.552
msxemuscle segment homeobox E0.546
msxcmuscle segment homeobox C0.546
sox21bSRY-box containing gene 21 b0.541
mmp2matrix metalloproteinase 20.533
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BBS10Bardet-Biedl syndrome 100.618
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.408
NOTCH1notch 10.402
TAL1T-cell acute lymphocytic leukemia 10.333
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.292
ZFYVE9zinc finger, FYVE domain containing 90.231
PAX3paired box 30.208
CSNK1Ecasein kinase 1, epsilon0.200
FSTL1follistatin-like 10.181
NOTCH3notch 30.164
FGF1fibroblast growth factor 1 (acidic)0.163
POU3F2POU class 3 homeobox 20.160
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.114
NR4A1nuclear receptor subfamily 4, group A, member 10.090
BMPR1Abone morphogenetic protein receptor, type IA0.081
DVL3dishevelled, dsh homolog 3 (Drosophila)0.073
JAG1jagged 10.061
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.059
COL3A1collagen, type III, alpha 10.057
PTPN11protein tyrosine phosphatase, non-receptor type 110.056
DVL1dishevelled, dsh homolog 1 (Drosophila)0.055
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.052
COL2A1collagen, type II, alpha 10.050
BMP7bone morphogenetic protein 70.046
COL1A1collagen, type I, alpha 10.046
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.046
SMAD3SMAD family member 30.044
HNF4Ahepatocyte nuclear factor 4, alpha0.043
SOX2SRY (sex determining region Y)-box 20.042
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.042
FZD1frizzled homolog 1 (Drosophila)0.042
CAV1caveolin 1, caveolae protein, 22kDa0.042
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.041
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.039
NKX2-1NK2 homeobox 10.038
NR0B2nuclear receptor subfamily 0, group B, member 20.037
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.037
FOXA2forkhead box A20.037
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.036
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.035
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.031
PTCH1patched 10.031
BCL2L1BCL2-like 10.030
IRS1insulin receptor substrate 10.030
TM4SF1transmembrane 4 L six family member 10.029
VEGFAvascular endothelial growth factor A0.029
MEOX2mesenchyme homeobox 20.029
MEOX1mesenchyme homeobox 10.029
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.028
PLCG1phospholipase C, gamma 10.028
RB1retinoblastoma 10.027
PPARAperoxisome proliferator-activated receptor alpha0.027
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.026
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.026
SHC1SHC (Src homology 2 domain containing) transforming protein 10.025
APCadenomatous polyposis coli0.025
PLXNB1plexin B10.025
WT1Wilms tumor 10.024
SMAD7SMAD family member 70.024
TBX5T-box 50.024
GFI1Bgrowth factor independent 1B transcription repressor0.024
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.022
HSPB1heat shock 27kDa protein 10.022
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.022
TCF4transcription factor 40.022
PDZK1PDZ domain containing 10.020
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.020
SIX3SIX homeobox 30.020
COL5A1collagen, type V, alpha 10.019
EGFRepidermal growth factor receptor0.019
SOX1SRY (sex determining region Y)-box 10.019
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.018
MSX2msh homeobox 20.018
FRS2fibroblast growth factor receptor substrate 20.018
AXIN1axin 10.018
KRT8keratin 80.018
IGF1Rinsulin-like growth factor 1 receptor0.018
FOXD3forkhead box D30.017
NR5A1nuclear receptor subfamily 5, group A, member 10.017
MSX1msh homeobox 10.017
HSF1heat shock transcription factor 10.017
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.017
USHBP1Usher syndrome 1C binding protein 10.017
PTMAprothymosin, alpha0.017
SOX11SRY (sex determining region Y)-box 110.017
PAX6paired box 60.016
TGFB3transforming growth factor, beta 30.016
PAX2paired box 20.016
HOXA10homeobox A100.016
HMGA2high mobility group AT-hook 20.016
TBX2T-box 20.016
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.016
SIM2single-minded homolog 2 (Drosophila)0.016
EIF2C2eukaryotic translation initiation factor 2C, 20.016
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.016
BCRbreakpoint cluster region0.015
FBN1fibrillin 10.015
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.015
LRRK2leucine-rich repeat kinase 20.015
SOX9SRY (sex determining region Y)-box 90.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sod3superoxide dismutase 3, extracellular0.129
Bcl2B-cell CLL/lymphoma 20.069
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.039
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.033
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.032
RGD1305627hypothetical LOC3144670.029
F2rl3coagulation factor II (thrombin) receptor-like 30.023
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.022
RT1-DaRT1 class II, locus Da0.022
Nr4a2nuclear receptor subfamily 4, group A, member 20.022
Mapk3mitogen activated protein kinase 30.021
Lamc1laminin, gamma 10.021
DffbDNA fragmentation factor, beta polypeptide (caspase-activated DNase)0.020
C1qccomplement component 1, q subcomponent, C chain0.020
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.020
Olr1278olfactory receptor 12780.020
Trhr2thyrotropin releasing hormone receptor 20.019
Unc5bunc-5 homolog B (C. elegans)0.019
Nos3nitric oxide synthase 3, endothelial cell0.018
Pdia3protein disulfide isomerase family A, member 30.018
Prl8a9prolactin family 8, subfamily a, member 90.017
Tgfb2transforming growth factor, beta 20.017
Sox17SRY (sex determining region Y)-box 170.017
Il3interleukin 30.017
Eef2eukaryotic translation elongation factor 20.017
Clec11aC-type lectin domain family 11, member a0.017
Gdf9growth differentiation factor 90.016
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.016
Ddr1discoidin domain receptor tyrosine kinase 10.016
Atp2c2ATPase, Ca++ transporting, type 2C, member 20.016
Bmp1bone morphogenetic protein 10.015
Shox2short stature homeobox 20.015
Actn4actinin alpha 40.015
Jag2jagged 20.015
Crygccrystallin, gamma C0.015
Dmddystrophin0.015
Nrxn3neurexin 30.015
Mfhas1malignant fibrous histiocytoma amplified sequence 10.014
Ccnd3cyclin D30.014
Acacbacetyl-Coenzyme A carboxylase beta0.014
KlKlotho0.014
Tgfbr2transforming growth factor, beta receptor II0.013
Chrna9cholinergic receptor, nicotinic, alpha 90.013
Fn1fibronectin 10.013
Ppap2bphosphatidic acid phosphatase type 2B0.013
Ptpn14protein tyrosine phosphatase, non-receptor type 140.013
Nficnuclear factor I/C0.013
Ugt8UDP glycosyltransferase 80.013
Calrcalreticulin0.013
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.013
Sdc3syndecan 30.013
Prkchprotein kinase C, eta0.013
RT1-EC2RT1 class Ib, locus EC20.013
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.013
Hoxa2homeo box A20.013
Fstl1follistatin-like 10.013
Acanaggrecan0.013
Fgf22fibroblast growth factor 220.012
Arf6ADP-ribosylation factor 60.012
Hyal2hyaluronoglucosaminidase 20.012
Egfl7EGF-like-domain, multiple 70.012
Hcn2hyperpolarization activated cyclic nucleotide-gated potassium channel 20.012
Slc22a1solute carrier family 22 (organic cation transporter), member 10.012
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.012
Grm5glutamate receptor, metabotropic 50.012
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.012
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.011
Dll3delta-like 3 (Drosophila)0.011
Smad7SMAD family member 70.011
Gucy2gguanylate cyclase 2G0.011
HhipHedgehog-interacting protein0.011
Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.011
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.011
Igfbp3insulin-like growth factor binding protein 30.011
Myo1cmyosin IC0.011
Podxlpodocalyxin-like0.011
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.011
Slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.011
Plxdc2plexin domain containing 20.011
Notch1Notch homolog 1, translocation-associated (Drosophila)0.011
Trim9tripartite motif-containing 90.011
Epas1endothelial PAS domain protein 10.011
Dlx5distal-less homeobox 50.011
Gabbr2gamma-aminobutyric acid (GABA) B receptor 20.011
Pcsk2proprotein convertase subtilisin/kexin type 20.011
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.011
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.011
Apoeapolipoprotein E0.011
Igf1insulin-like growth factor 10.011
Acvr1activin A receptor, type I0.011
Nfibnuclear factor I/B0.011
Foxd3forkhead box D30.011
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.011
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.011
Dchs1dachsous 1 (Drosophila)0.011
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.010
Trim29tripartite motif-containing 290.010
Wipf1WAS/WASL interacting protein family, member 10.010
Dab2disabled homolog 2 (Drosophila)0.010
Vax1ventral anterior homeobox 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism