The network for 'negative regulation of interleukin 8 secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of interleukin 8 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.

NameDescriptionProbabilityFunc Analog Organism
Lgals3lectin, galactose binding, soluble 30.262
5830411N06RikRIKEN cDNA 5830411N06 gene0.184
Cd3eCD3 antigen, epsilon polypeptide0.162
Anxa3annexin A30.137
S100a6S100 calcium binding protein A6 (calcyclin)0.127
Anxa2annexin A20.123
Dysfdysferlin0.117
Cd247CD247 antigen0.104
Anxa5annexin A50.073
Ms4a15membrane-spanning 4-domains, subfamily A, member 150.053
Rnh1ribonuclease/angiogenin inhibitor 10.053
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.048
Lce3blate cornified envelope 3B0.045
S100a11S100 calcium binding protein A11 (calgizzarin)0.045
Stx7syntaxin 70.040
Il2rbinterleukin 2 receptor, beta chain0.039
Tmem89transmembrane protein 890.038
Cd8aCD8 antigen, alpha chain0.035
Oxtoxytocin0.033
Asah1N-acylsphingosine amidohydrolase 10.032
Lamp2lysosomal-associated membrane protein 20.032
2310007L24RikRIKEN cDNA 2310007L24 gene0.032
Hcsthematopoietic cell signal transducer0.030
Sdcbpsyndecan binding protein0.030
Sat1spermidine/spermine N1-acetyl transferase 10.029
Lypd5Ly6/Plaur domain containing 50.028
Degs1degenerative spermatocyte homolog 1 (Drosophila)0.026
Cstbcystatin B0.026
Ccl6chemokine (C-C motif) ligand 60.026
Wdr95WD40 repeat domain 950.023
LitafLPS-induced TN factor0.022
Slc1a7solute carrier family 1 (glutamate transporter), member 70.022
Nupr1nuclear protein 10.021
Cd163l1CD163 molecule-like 10.021
Folr4folate receptor 4 (delta)0.020
Aqp12aquaporin 120.020
Prss27protease, serine, 270.020
S100a10S100 calcium binding protein A10 (calpactin)0.019
D630042P16RikRIKEN cDNA D630042P16 gene0.019
MdficMyoD family inhibitor domain containing0.018
Ggngametogenetin0.018
Tssk1testis-specific serine kinase 10.018
Sit1suppression inducing transmembrane adaptor 10.018
E230025N22RikRiken cDNA E230025N22 gene0.018
Slc36a3solute carrier family 36 (proton/amino acid symporter), member 30.017
Pdcd1programmed cell death 10.017
Sptlc2serine palmitoyltransferase, long chain base subunit 20.017
RltprRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing0.017
Prss2protease, serine, 20.017
9130404H23RikRIKEN cDNA 9130404H23 gene0.017
Chatcholine acetyltransferase0.016
Foxs1forkhead box S10.016
Wbscr28Williams-Beuren syndrome chromosome region 28 (human)0.016
Zap70zeta-chain (TCR) associated protein kinase0.016
Sohlh1spermatogenesis and oogenesis specific basic helix-loop-helix 10.016
Rya3antimicrobial peptide RYA30.016
Acot9acyl-CoA thioesterase 90.016
Tbc1d10cTBC1 domain family, member 10c0.015
Cyfip1cytoplasmic FMR1 interacting protein 10.015
Fam19a3family with sequence similarity 19, member A30.015
Gm1123predicted gene 11230.015
1700066B19RikRIKEN cDNA 1700066B19 gene0.015
Crip1cysteine-rich protein 1 (intestinal)0.015
Lim2lens intrinsic membrane protein 20.015
Spns3spinster homolog 3 (Drosophila)0.014
Ctla4cytotoxic T-lymphocyte-associated protein 40.014
Nat2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.014
Astlastacin-like metalloendopeptidase (M12 family)0.014
Tmem176btransmembrane protein 176B0.014
2310061N02RikRIKEN cDNA 2310061N02 gene0.014
2410004A20RikRIKEN cDNA 2410004A20 gene0.014
2310021H06RikRIKEN cDNA 2310021H06 gene0.013
Gpr114G protein-coupled receptor 1140.012
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.012
Fbll1fibrillarin-like 10.012
4931429L15RikRIKEN cDNA 4931429L15 gene0.012
UgdhUDP-glucose dehydrogenase0.012
Otporthopedia homolog (Drosophila)0.012
Slc35f5solute carrier family 35, member F50.012
Patl2protein associated with topoisomerase II homolog 2 (yeast)0.012
Fbxo24F-box protein 240.012
Fcnbficolin B0.012
Wdr64WD repeat domain 640.012
Hs3st6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.011
Rnase4ribonuclease, RNase A family 40.011
Unc5clunc-5 homolog C (C. elegans)-like0.011
Krt42keratin 420.011
Kcpkielin/chordin-like protein0.011
Tmbim1transmembrane BAX inhibitor motif containing 10.011
Ip6k3inositol hexaphosphate kinase 30.011
Ggt6gamma-glutamyltransferase 60.011
Nyxnyctalopin0.011
Abhd16babhydrolase domain containing 16B0.010
Cpne3copine III0.010
Sctrsecretin receptor0.010
Pabpc1lpoly(A) binding protein, cytoplasmic 1-like0.010
4930527J03RikRIKEN cDNA 4930527J03 gene0.010
Lrrc66leucine rich repeat containing 660.010
Vsig10lZV-set and immunoglobulin domain containing 10 like0.010
Ly6dlymphocyte antigen 6 complex, locus D0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMN1survival of motor neuron 1, telomeric1.000
S100A10S100 calcium binding protein A100.958
ANXA1annexin A10.948
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.842
TK1thymidine kinase 1, soluble0.841
ANXA5annexin A50.679
ANXA2annexin A20.513
S100A11S100 calcium binding protein A110.383
LGALS1lectin, galactoside-binding, soluble, 10.342
FN1fibronectin 10.210
VIMvimentin0.141
S100A6S100 calcium binding protein A60.100
ANXA4annexin A40.071
TMSB10thymosin beta 100.063
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.047
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.033
LGALS3lectin, galactoside-binding, soluble, 30.033
NMT2N-myristoyltransferase 20.029
IQGAP1IQ motif containing GTPase activating protein 10.023
CTSBcathepsin B0.021
TSC22D1TSC22 domain family, member 10.021
EMP3epithelial membrane protein 30.020
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.020
CD63CD63 molecule0.019
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.017
ACTG1actin, gamma 10.017
NPC2Niemann-Pick disease, type C20.014
EMP1epithelial membrane protein 10.014
MYOFmyoferlin0.014
CASTcalpastatin0.013
CLIC1chloride intracellular channel 10.013
S100A4S100 calcium binding protein A40.013
PAFAH1B3platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)0.011
TIMP1TIMP metallopeptidase inhibitor 10.011
ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)0.010
ITGB5integrin, beta 50.010
HEXBhexosaminidase B (beta polypeptide)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism