The network for 'regulation of interferon alpha production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interferon alpha production

Any process that modulates the frequency, rate, or extent of interferon-alpha production.

NameDescriptionProbabilityFunc Analog Organism
Gbp7guanylate binding protein 70.972
Gbp2guanylate binding protein 20.968
Irgm1immunity-related GTPase family M member 10.952
Gbp3guanylate binding protein 30.930
Iigp1interferon inducible GTPase 10.920
Igtpinterferon gamma induced GTPase0.891
Casp4caspase 4, apoptosis-related cysteine peptidase0.881
Irgm2immunity-related GTPase family M member 20.851
Ifih1interferon induced with helicase C domain 10.840
Casp1caspase 10.817
Stat1signal transducer and activator of transcription 10.779
Ifit1interferon-induced protein with tetratricopeptide repeats 10.624
Tgtp2T-cell specific GTPase 20.616
Ifi47interferon gamma inducible protein 470.444
Trim21tripartite motif-containing 210.435
Ifit2interferon-induced protein with tetratricopeptide repeats 20.305
Aim2absent in melanoma 20.295
Usp18ubiquitin specific peptidase 180.287
Irf9interferon regulatory factor 90.282
Trim30atripartite motif-containing 30A0.267
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.215
Ifit3interferon-induced protein with tetratricopeptide repeats 30.200
Parp14poly (ADP-ribose) polymerase family, member 140.193
Myd88myeloid differentiation primary response gene 880.180
Rtp4receptor transporter protein 40.171
Tlr4toll-like receptor 40.165
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.123
Gbp6guanylate binding protein 60.123
Ccr2chemokine (C-C motif) receptor 20.117
PycardPYD and CARD domain containing0.095
Ticam1toll-like receptor adaptor molecule 10.085
Oasl22'-5' oligoadenylate synthetase-like 20.083
Cxcl10chemokine (C-X-C motif) ligand 100.081
Rsad2radical S-adenosyl methionine domain containing 20.072
Serpinb9serine (or cysteine) peptidase inhibitor, clade B, member 90.070
Parp9poly (ADP-ribose) polymerase family, member 90.056
NmiN-myc (and STAT) interactor0.055
Irf8interferon regulatory factor 80.048
Ifi44interferon-induced protein 440.047
Gbp10guanylate-binding protein 100.047
Samd9lsterile alpha motif domain containing 9-like0.045
Uba7ubiquitin-like modifier activating enzyme 70.045
H2-Q7histocompatibility 2, Q region locus 70.040
Unc93b1unc-93 homolog B1 (C. elegans)0.036
Sfpi1SFFV proviral integration 10.036
Casp12caspase 120.036
Cd180CD180 antigen0.032
AW112010expressed sequence AW1120100.029
Trim25tripartite motif-containing 250.028
Map3k8mitogen-activated protein kinase kinase kinase 80.028
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.027
Irf7interferon regulatory factor 70.025
Il10interleukin 100.025
Erap1endoplasmic reticulum aminopeptidase 10.024
Parp12poly (ADP-ribose) polymerase family, member 120.023
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.023
Trim30dtripartite motif-containing 30D0.022
Nlrp3NLR family, pyrin domain containing 30.022
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.021
Irf1interferon regulatory factor 10.021
Birc3baculoviral IAP repeat-containing 30.020
Samhd1SAM domain and HD domain, 10.020
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.020
BC006779cDNA sequence BC0067790.019
Herc6hect domain and RLD 60.019
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.017
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.015
Ifi203interferon activated gene 2030.015
Lyz2lysozyme 20.015
Csf1colony stimulating factor 1 (macrophage)0.015
Dtx3ldeltex 3-like (Drosophila)0.014
Cd274CD274 antigen0.014
Cd14CD14 antigen0.014
Ikzf1IKAROS family zinc finger 10.013
Ifi35interferon-induced protein 350.013
Hspa9heat shock protein 90.013
1810019J16RikRIKEN cDNA 1810019J16 gene0.012
Ccl2chemokine (C-C motif) ligand 20.012
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.012
Isg15ISG15 ubiquitin-like modifier0.012
Cxcl9chemokine (C-X-C motif) ligand 90.011
TankTRAF family member-associated Nf-kappa B activator0.010
Tnftumor necrosis factor0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.948
STAT1signal transducer and activator of transcription 1, 91kDa0.905
CYLDcylindromatosis (turban tumor syndrome)0.884
MYD88myeloid differentiation primary response gene (88)0.868
STAT2signal transducer and activator of transcription 2, 113kDa0.823
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.626
TBK1TANK-binding kinase 10.558
IRF7interferon regulatory factor 70.518
IRF3interferon regulatory factor 30.470
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.300
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.218
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.210
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.191
IRF1interferon regulatory factor 10.171
IRAK1interleukin-1 receptor-associated kinase 10.164
TRIM21tripartite motif containing 210.161
PARP12poly (ADP-ribose) polymerase family, member 120.138
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.133
ZC3HAV1zinc finger CCCH-type, antiviral 10.099
NLRC5NLR family, CARD domain containing 50.096
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.087
TRIM25tripartite motif containing 250.069
IRF9interferon regulatory factor 90.067
MAP3K14mitogen-activated protein kinase kinase kinase 140.057
CALCOCO2calcium binding and coiled-coil domain 20.043
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.041
AZI25-azacytidine induced 20.040
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.038
ADARadenosine deaminase, RNA-specific0.038
SP110SP110 nuclear body protein0.037
IFNAR2interferon (alpha, beta and omega) receptor 20.036
CREBBPCREB binding protein0.035
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.030
MAVSmitochondrial antiviral signaling protein0.029
PPP2R2Bprotein phosphatase 2, regulatory subunit B, beta0.028
EIF2C2eukaryotic translation initiation factor 2C, 20.028
TANKTRAF family member-associated NFKB activator0.027
PIAS4protein inhibitor of activated STAT, 40.026
C19orf66chromosome 19 open reading frame 660.026
IFIH1interferon induced with helicase C domain 10.024
TLR2toll-like receptor 20.024
IFI35interferon-induced protein 350.021
IRF2interferon regulatory factor 20.020
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.020
IFNAR1interferon (alpha, beta and omega) receptor 10.018
ZNFX1zinc finger, NFX1-type containing 10.018
TRANK1tetratricopeptide repeat and ankyrin repeat containing 10.018
ISG20interferon stimulated exonuclease gene 20kDa0.017
IRF2BP2interferon regulatory factor 2 binding protein 20.017
KIAA1274KIAA12740.016
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.016
TLR4toll-like receptor 40.015
TICAM2toll-like receptor adaptor molecule 20.015
KAT2BK(lysine) acetyltransferase 2B0.014
NMIN-myc (and STAT) interactor0.014
PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme0.014
OPTNoptineurin0.014
IRF8interferon regulatory factor 80.013
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.012
TMEM140transmembrane protein 1400.012
PRKD2protein kinase D20.012
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.011
CLTCclathrin, heavy chain (Hc)0.011
DTX3Ldeltex 3-like (Drosophila)0.011
TRAF2TNF receptor-associated factor 20.011
MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.011
JAK2Janus kinase 20.011
FKBP5FK506 binding protein 50.011
TLR1toll-like receptor 10.010
EIF2C1eukaryotic translation initiation factor 2C, 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism