The network for 'apoptotic nuclear changes' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

apoptotic nuclear changes

Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.

NameDescriptionProbabilityFunc Analog Organism
Aim2absent in melanoma 20.600
DffbDNA fragmentation factor, beta subunit0.466
Gbp5guanylate binding protein 50.432
PycardPYD and CARD domain containing0.308
Il18interleukin 180.203
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.123
Rnf31ring finger protein 310.121
Gja5gap junction protein, alpha 50.121
Cideccell death-inducing DFFA-like effector c0.114
Plin1perilipin 10.062
Safbscaffold attachment factor B0.054
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.051
Ndufaf4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.049
Gbp7guanylate binding protein 70.049
Atrataxia telangiectasia and Rad3 related0.046
Rbl1retinoblastoma-like 1 (p107)0.044
Bak1BCL2-antagonist/killer 10.043
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.042
Adam10a disintegrin and metallopeptidase domain 100.037
Tlr4toll-like receptor 40.036
Apaf1apoptotic peptidase activating factor 10.033
Rb1retinoblastoma 10.033
Cfdcomplement factor D (adipsin)0.032
BidBH3 interacting domain death agonist0.031
SharpinSHANK-associated RH domain interacting protein0.031
Eya2eyes absent 2 homolog (Drosophila)0.029
Uqcrbubiquinol-cytochrome c reductase binding protein0.028
Cycscytochrome c, somatic0.028
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.027
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.027
Sod2superoxide dismutase 2, mitochondrial0.026
Casp8caspase 80.025
Gcshglycine cleavage system protein H (aminomethyl carrier)0.024
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.023
Nfyanuclear transcription factor-Y alpha0.023
Casp7caspase 70.022
Cox5acytochrome c oxidase, subunit Va0.018
Ldb1LIM domain binding 10.018
Casp3caspase 30.018
Lystlysosomal trafficking regulator0.018
Nlrp6NLR family, pyrin domain containing 60.017
Ripk3receptor-interacting serine-threonine kinase 30.017
Mdh1malate dehydrogenase 1, NAD (soluble)0.017
Uqcrc2ubiquinol cytochrome c reductase core protein 20.017
Ctslcathepsin L0.017
Gja1gap junction protein, alpha 10.017
Bmpr1abone morphogenetic protein receptor, type 1A0.017
Traf2TNF receptor-associated factor 20.016
Thrspthyroid hormone responsive SPOT14 homolog (Rattus)0.016
Fam60afamily with sequence similarity 60, member A0.016
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.016
Fam96afamily with sequence similarity 96, member A0.015
Ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.015
FaddFas (TNFRSF6)-associated via death domain0.015
Ndufa5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 50.014
Mta2metastasis-associated gene family, member 20.013
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.013
Plin4perilipin 40.013
Pabpn1poly(A) binding protein, nuclear 10.013
Tfamtranscription factor A, mitochondrial0.013
Adrb3adrenergic receptor, beta 30.013
Pola1polymerase (DNA directed), alpha 10.012
Bcl2B-cell leukemia/lymphoma 20.012
Rbm10RNA binding motif protein 100.012
Coro1bcoronin, actin binding protein 1B0.012
Fabp4fatty acid binding protein 4, adipocyte0.012
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.012
Ikbkbinhibitor of kappaB kinase beta0.011
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.011
Hmgb1high mobility group box 10.011
Nlrp3NLR family, pyrin domain containing 30.011
Ifi203interferon activated gene 2030.011
Ncoa5nuclear receptor coactivator 50.011
Fh1fumarate hydratase 10.011
Cyc1cytochrome c-10.011
Cbfbcore binding factor beta0.011
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.011
Alx1ALX homeobox 10.011
Ppp4cprotein phosphatase 4, catalytic subunit0.011
Hhathedgehog acyltransferase0.011
Dna2DNA replication helicase 2 homolog (yeast)0.011
Cdk4cyclin-dependent kinase 40.010
Asxl1additional sex combs like 1 (Drosophila)0.010
Pparaperoxisome proliferator activated receptor alpha0.010
Zfp740zinc finger protein 7400.010
Adprhl2ADP-ribosylhydrolase like 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 10.889
BCL2B-cell CLL/lymphoma 20.778
CASP9caspase 9, apoptosis-related cysteine peptidase0.767
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.695
CASP3caspase 3, apoptosis-related cysteine peptidase0.438
BAK1BCL2-antagonist/killer 10.399
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.321
XIAPX-linked inhibitor of apoptosis0.318
BMP2bone morphogenetic protein 20.310
POU5F1POU class 5 homeobox 10.272
SYVN1synovial apoptosis inhibitor 1, synoviolin0.196
BCL2L11BCL2-like 11 (apoptosis facilitator)0.160
APAF1apoptotic peptidase activating factor 10.141
BAXBCL2-associated X protein0.121
ZMYND11zinc finger, MYND-type containing 110.108
GATA4GATA binding protein 40.082
GDF5growth differentiation factor 50.054
TGFB1transforming growth factor, beta 10.053
FKBP1AFK506 binding protein 1A, 12kDa0.048
PARP1poly (ADP-ribose) polymerase 10.041
BMPR1Abone morphogenetic protein receptor, type IA0.040
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.039
TGFB3transforming growth factor, beta 30.038
VDAC1voltage-dependent anion channel 10.038
ACVR1activin A receptor, type I0.038
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.037
C4orf14chromosome 4 open reading frame 140.033
TP53tumor protein p530.030
TNRC6Ctrinucleotide repeat containing 6C0.029
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.026
PRKG1protein kinase, cGMP-dependent, type I0.025
EXOSC3exosome component 30.024
SMURF2SMAD specific E3 ubiquitin protein ligase 20.023
FSTL1follistatin-like 10.021
MDH2malate dehydrogenase 2, NAD (mitochondrial)0.018
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.018
BIDBH3 interacting domain death agonist0.017
TXN2thioredoxin 20.017
EIF2C1eukaryotic translation initiation factor 2C, 10.017
MAPK8mitogen-activated protein kinase 80.016
RNF31ring finger protein 310.016
RNF144Bring finger protein 144B0.015
STOML2stomatin (EPB72)-like 20.015
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.015
ARandrogen receptor0.014
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.014
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.013
MRPS7mitochondrial ribosomal protein S70.012
BBC3BCL2 binding component 30.012
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.012
NCAPD2non-SMC condensin I complex, subunit D20.012
BADBCL2-associated agonist of cell death0.012
FOXRED1FAD-dependent oxidoreductase domain containing 10.011
NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)0.011
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.011
EIF2C2eukaryotic translation initiation factor 2C, 20.011
BIKBCL2-interacting killer (apoptosis-inducing)0.011
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.010
RANBP3RAN binding protein 30.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism