The network for 'circadian regulation of gene expression' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circadian regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.

NameDescriptionProbabilityFunc Analog Organism
Per2period homolog 2 (Drosophila)1.000
Arntlaryl hydrocarbon receptor nuclear translocator-like1.000
Cry2cryptochrome 2 (photolyase-like)1.000
Clockcircadian locomotor output cycles kaput1.000
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.985
Hdac1histone deacetylase 10.944
Per1period homolog 1 (Drosophila)0.937
Id3inhibitor of DNA binding 30.933
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.928
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.901
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.900
Leprleptin receptor0.895
Cry1cryptochrome 1 (photolyase-like)0.890
Id1inhibitor of DNA binding 10.886
Sin3atranscriptional regulator, SIN3A (yeast)0.867
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.864
Rargretinoic acid receptor, gamma0.849
Cav1caveolin 1, caveolae protein0.794
Per3period homolog 3 (Drosophila)0.781
Tefthyrotroph embryonic factor0.751
Insrinsulin receptor0.743
Cdk4cyclin-dependent kinase 40.695
Trib3tribbles homolog 3 (Drosophila)0.659
Mta1metastasis associated 10.632
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.597
Pou5f1POU domain, class 5, transcription factor 10.597
Ghrgrowth hormone receptor0.590
Cdkn1bcyclin-dependent kinase inhibitor 1B0.543
Arandrogen receptor0.518
Tcf3transcription factor 30.498
Rxraretinoid X receptor alpha0.478
Atxn1ataxin 10.469
Nos1nitric oxide synthase 1, neuronal0.444
DbpD site albumin promoter binding protein0.444
Traf6TNF receptor-associated factor 60.402
Ccnd1cyclin D10.383
Sp1trans-acting transcription factor 10.374
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.374
Eif4g2eukaryotic translation initiation factor 4, gamma 20.370
Sall4sal-like 4 (Drosophila)0.356
Smad1MAD homolog 1 (Drosophila)0.352
Nr1d2nuclear receptor subfamily 1, group D, member 20.311
Esr1estrogen receptor 1 (alpha)0.292
Usp2ubiquitin specific peptidase 20.276
Chd4chromodomain helicase DNA binding protein 40.271
Ier3immediate early response 30.255
Mta2metastasis-associated gene family, member 20.250
Irs2insulin receptor substrate 20.249
Rararetinoic acid receptor, alpha0.245
Ece1endothelin converting enzyme 10.234
Rarbretinoic acid receptor, beta0.228
Csf1colony stimulating factor 1 (macrophage)0.225
Ncor1nuclear receptor co-repressor 10.221
Arid1aAT rich interactive domain 1A (SWI-like)0.212
Sh3gl3SH3-domain GRB2-like 30.210
Fbxl3F-box and leucine-rich repeat protein 30.206
Map3k14mitogen-activated protein kinase kinase kinase 140.199
Eya1eyes absent 1 homolog (Drosophila)0.196
Rbbp7retinoblastoma binding protein 70.187
Tcfcp2l1transcription factor CP2-like 10.187
Hlfhepatic leukemia factor0.184
Sox9SRY-box containing gene 90.178
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.177
RoraRAR-related orphan receptor alpha0.175
Btrcbeta-transducin repeat containing protein0.167
Nficnuclear factor I/C0.167
Csnk1ecasein kinase 1, epsilon0.157
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.157
Pknox1Pbx/knotted 1 homeobox0.153
Tenc1tensin like C1 domain-containing phosphatase0.149
Sox2SRY-box containing gene 20.147
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.141
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.141
Lhx3LIM homeobox protein 30.139
Pax8paired box gene 80.137
Mybbp1aMYB binding protein (P160) 1a0.135
NanogNanog homeobox0.134
Ncoa1nuclear receptor coactivator 10.133
Spry4sprouty homolog 4 (Drosophila)0.130
Mylkmyosin, light polypeptide kinase0.127
Suz12suppressor of zeste 12 homolog (Drosophila)0.125
Ctnnb1catenin (cadherin associated protein), beta 10.123
Bcl3B-cell leukemia/lymphoma 30.116
DaxxFas death domain-associated protein0.114
Sall1sal-like 1 (Drosophila)0.114
Pja1praja1, RING-H2 motif containing0.113
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.111
Esrrbestrogen related receptor, beta0.108
Vegfavascular endothelial growth factor A0.106
Nr1d1nuclear receptor subfamily 1, group D, member 10.106
Lamc1laminin, gamma 10.105
Nr0b2nuclear receptor subfamily 0, group B, member 20.104
Lbrlamin B receptor0.104
Pbx1pre B-cell leukemia transcription factor 10.103
Smad3MAD homolog 3 (Drosophila)0.100
Pax2paired box gene 20.099
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nr1d2bnuclear receptor subfamily 1, group D, member 2b1.000
cry3cryptochrome 30.993
per2period homolog 2 (Drosophila)0.978
cry1acryptochrome 1a0.978
otx5orthodenticle homolog 50.794
tefthyrotroph embryonic factor0.734
aanat2arylalkylamine N-acetyltransferase0.608
ntf7neurotrophin 70.485
csnk1dbcasein kinase 1, delta b0.474
rorabRAR-related orphan receptor A, paralog b0.419
tshbthyroid stimulating hormone, beta subunit0.405
cry2bcryptochrome 2b0.365
drd2adopamine receptor D2a0.356
per3period homolog 3 (Drosophila)0.318
tfap2atranscription factor AP-2 alpha0.317
siah2lseven in absentia homolog 2 (Drosophila)-like0.275
arntl1baryl hydrocarbon receptor nuclear translocator-like 1b0.256
thraathyroid hormone receptor alpha a0.250
hsf2heat shock factor 20.233
ncoa2nuclear receptor coactivator 20.213
bhlhe40basic helix-loop-helix family, member e400.200
rorcbRAR-related orphan receptor C b0.197
rxraaretinoid X receptor, alpha a0.170
nr1d2anuclear receptor subfamily 1, group D, member 2a0.165
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 20.146
dlg1discs, large (Drosophila) homolog 10.146
crxcone-rod homeobox0.142
otx1borthodenticle homolog 1b0.108
cry2acryptochrome 2a0.101
irf2bp2ainterferon regulatory factor 2 binding protein 2a0.100
ddb2damage-specific DNA binding protein 20.095
nr1d1nuclear receptor subfamily 1, group d, member 10.085
dmbx1adiencephalon/mesencephalon homeobox 1a0.084
auts2autism susceptibility candidate 20.084
cox4i2cytochrome c oxidase subunit IV isoform 20.083
cry5cryptochrome 50.080
znf395bzinc finger protein 395b0.075
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.072
foxo3bforkhead box O3b0.071
clock3clock homolog 3 (mouse)0.070
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.070
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.069
glra4bglycine receptor, alpha 4b0.066
grk7aG-protein-coupled receptor kinase 7a0.066
nadl1.2neural adhesion molecule L1.20.065
slmapbsarcolemma associated protein b0.065
ctbp1C-terminal binding protein 10.065
prom1bprominin 1 b0.063
thtyrosine hydroxylase0.061
cx55.5connexin 55.50.059
tp53inp1tumor protein p53 inducible nuclear protein 10.058
lrrtm1leucine rich repeat transmembrane neuronal 10.056
nfianuclear factor I/A0.053
dync1h1dynein, cytoplasmic 1, heavy chain 10.051
mdkbmidkine-related growth factor b0.050
csnk1dacasein kinase 1, delta a0.050
cnihcornichon homolog (Drosophila)0.049
eif1beukaryotic translation initiation factor 1B0.044
rxrbbretinoid x receptor, beta b0.044
srsf6bserine/arginine-rich splicing factor 6b0.044
ncor2nuclear receptor co-repressor 20.043
acvr1bactivin A receptor, type IB0.043
eif4e1ceukaryotic translation initiation factor 4E family member 1c0.043
cltcaclathrin, heavy polypeptide a (Hc)0.042
camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.042
vephventricular zone expressed PH domain protein0.041
drd2bdopamine receptor D2b0.041
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.040
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.040
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.039
egr1early growth response 10.038
znf148zinc finger protein 1480.038
crb2bcrumbs homolog 2b0.037
cry-dashcryptochrome DASH0.036
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.036
nr2e3nuclear receptor subfamily 2, group E, member 30.035
ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.035
dpf2lD4, zinc and double PHD fingers family 2, like0.035
otx2orthodenticle homolog 20.035
elnaelastin a0.034
ctbp2C-terminal binding protein 20.033
wwp2WW domain containing E3 ubiquitin protein ligase 20.033
phf20bPHD finger protein 20, b0.033
cry1bcryptochrome 1b0.033
mpp6bmembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)0.031
pnrc2proline-rich nuclear receptor coactivator 20.031
wnt8bwingless-type MMTV integration site family, member 8b0.031
irx7iroquois homeobox protein 70.030
syce2synaptonemal complex central element protein 20.030
cpeb4cytoplasmic polyadenylation element binding protein 40.028
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dcodiscs overgrown0.389
larkCG8597 gene product from transcript CG8597-RD0.069
prodproliferation disrupter0.046
CG4857CG4857 gene product from transcript CG4857-RD0.039
mubmushroom-body expressed0.024
pashapartner of drosha0.024
norpAno receptor potential A0.023
Kr-h1Kruppel homolog 10.018
CrebB-17ACyclic-AMP response element binding protein B at 17A0.017
CkIIalphaCasein kinase II alpha subunit0.015
rapretina aberrant in pattern0.015
SAKSak kinase0.014
MAN1CG3167 gene product from transcript CG3167-RA0.014
Su(z)2Suppressor of zeste 20.014
Su(var)2-10Suppressor of variegation 2-100.013
l(1)dd4lethal (1) discs degenerate 40.013
slmbsupernumerary limbs0.012
CG10990CG10990 gene product from transcript CG10990-RB0.012
Deaf1Deformed epidermal autoregulatory factor-10.010
Gr28bGustatory receptor 28b0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 11.000
SIN3ASIN3 homolog A, transcription regulator (yeast)0.789
NCOR2nuclear receptor corepressor 20.749
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.592
MDM2Mdm2 p53 binding protein homolog (mouse)0.540
C2orf65chromosome 2 open reading frame 650.329
RB1retinoblastoma 10.313
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.268
EP300E1A binding protein p3000.226
KAT2BK(lysine) acetyltransferase 2B0.212
CHEK2CHK2 checkpoint homolog (S. pombe)0.176
EPAS1endothelial PAS domain protein 10.163
PPARGperoxisome proliferator-activated receptor gamma0.147
SP1Sp1 transcription factor0.137
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.129
SIRT1sirtuin 10.121
AXIN1axin 10.118
ESR1estrogen receptor 10.116
AHRaryl hydrocarbon receptor0.101
PJA1praja ring finger 10.099
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.099
ADORA2Aadenosine A2a receptor0.099
CLOCKclock homolog (mouse)0.097
HNF4Ahepatocyte nuclear factor 4, alpha0.089
TP53tumor protein p530.089
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.081
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.070
ESRRGestrogen-related receptor gamma0.068
KDM1Alysine (K)-specific demethylase 1A0.060
CSNK1Ecasein kinase 1, epsilon0.052
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.051
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.051
ACACAacetyl-CoA carboxylase alpha0.050
MTA3metastasis associated 1 family, member 30.048
MAGED2melanoma antigen family D, 20.045
HES1hairy and enhancer of split 1, (Drosophila)0.043
MAGEA2melanoma antigen family A, 20.040
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.035
EEDembryonic ectoderm development0.035
NR4A1nuclear receptor subfamily 4, group A, member 10.033
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.028
HDAC2histone deacetylase 20.027
ZNF217zinc finger protein 2170.026
RARAretinoic acid receptor, alpha0.026
CSNK1A1casein kinase 1, alpha 10.026
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.025
CHD9chromodomain helicase DNA binding protein 90.025
HDAC3histone deacetylase 30.024
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.022
TRIB3tribbles homolog 3 (Drosophila)0.022
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.020
CREBZFCREB/ATF bZIP transcription factor0.020
PER1period homolog 1 (Drosophila)0.020
SMAD3SMAD family member 30.019
MDM4Mdm4 p53 binding protein homolog (mouse)0.019
VEGFAvascular endothelial growth factor A0.018
BBS10Bardet-Biedl syndrome 100.018
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.018
NFIL3nuclear factor, interleukin 3 regulated0.018
EGLN1egl nine homolog 1 (C. elegans)0.018
BTRCbeta-transducin repeat containing0.017
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.017
L3MBTL2l(3)mbt-like 2 (Drosophila)0.016
RCOR1REST corepressor 10.016
ZMYND11zinc finger, MYND-type containing 110.015
MCCmutated in colorectal cancers0.015
CUX1cut-like homeobox 10.014
KLF10Kruppel-like factor 100.014
FAM83Dfamily with sequence similarity 83, member D0.013
EGLN3egl nine homolog 3 (C. elegans)0.013
MTA2metastasis associated 1 family, member 20.013
IFRD1interferon-related developmental regulator 10.013
PMLpromyelocytic leukemia0.012
PPARAperoxisome proliferator-activated receptor alpha0.012
BCL3B-cell CLL/lymphoma 30.012
SALL2sal-like 2 (Drosophila)0.012
POLR2Cpolymerase (RNA) II (DNA directed) polypeptide C, 33kDa0.011
TAOK1TAO kinase 10.011
CCND1cyclin D10.011
FBXW11F-box and WD repeat domain containing 110.010
BCL6B-cell CLL/lymphoma 60.010
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.876
Nr1d2nuclear receptor subfamily 1, group D, member 20.726
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.265
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.235
Serinc1serine incorporator 10.224
Tefthyrotrophic embryonic factor0.215
RGD1359529similar to chromosome 1 open reading frame 630.161
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.121
Ube2iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.117
F2rl1coagulation factor II (thrombin) receptor-like 10.115
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.103
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.103
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.101
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.093
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.091
Cnot7CCR4-NOT transcription complex, subunit 70.090
Pnnpinin, desmosome associated protein0.074
Metmet proto-oncogene0.073
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.069
Hdac2histone deacetylase 20.066
Dusp1dual specificity phosphatase 10.064
Errfi1ERBB receptor feedback inhibitor 10.064
Klf9Kruppel-like factor 90.061
Sfrs11splicing factor, arginine/serine-rich 110.060
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.059
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.059
Npap60nuclear pore associated protein0.058
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.057
Fam126bfamily with sequence similarity 126, member B0.056
Arntaryl hydrocarbon receptor nuclear translocator0.056
Mef2dmyocyte enhancer factor 2D0.054
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.054
Aldh6a1aldehyde dehydrogenase 6 family, member A10.053
Atxn3ataxin 30.051
Arl6ip6ADP-ribosylation-like factor 6 interacting protein 60.051
Giprgastric inhibitory polypeptide receptor0.048
MGC112830similar to transcription factor0.048
Rab7aRAB7A, member RAS oncogene family0.046
Tubb5tubulin, beta 50.045
Hnf4ahepatocyte nuclear factor 4, alpha0.043
Rpa2replication protein A20.043
Thtyrosine hydroxylase0.043
Degs2degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)0.042
Eif4heukaryotic translation initiation factor 4H0.040
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.040
Ush1cUsher syndrome 1C homolog (human)0.040
C1galt1core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 10.039
Kdm6blysine (K)-specific demethylase 6B0.038
Junbjun B proto-oncogene0.038
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.037
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.037
Ldlrlow density lipoprotein receptor0.037
Mat2amethionine adenosyltransferase II, alpha0.037
Acyp2acylphosphatase 2, muscle type0.036
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.034
Wbp11WW domain binding protein 110.034
Btg2BTG family, member 20.034
Matr3matrin 30.033
Per3period homolog 3 (Drosophila)0.032
Nxf1nuclear RNA export factor 10.032
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.032
Nr4a1nuclear receptor subfamily 4, group A, member 10.032
Flt1FMS-related tyrosine kinase 10.032
Pfkfb46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 40.031
Arf1ADP-ribosylation factor 10.031
Sh3bp1SH3-domain binding protein 10.030
Mep1ameprin 1 alpha0.030
Ddx26bDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B0.029
Zfc3h1zinc finger, C3H1-type containing0.029
Ddit4DNA-damage-inducible transcript 40.029
Trhr2thyrotropin releasing hormone receptor 20.029
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.028
LOC682914similar to Zinc finger protein 326 (Zinc finger protein-associated with nuclear matrix of 75 kDa)0.027
Cry2cryptochrome 2 (photolyase-like)0.027
Pcnaproliferating cell nuclear antigen0.027
Otud1OTU domain containing 10.027
Ccdc112coiled-coil domain containing 1120.027
Pim3pim-3 oncogene0.027
Egr1early growth response 10.026
Gabrr2gamma-aminobutyric acid (GABA) receptor, rho 20.026
Cyb5bcytochrome b5 type B (outer mitochondrial membrane)0.026
Zfp36zinc finger protein 360.025
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.025
Nr1d1nuclear receptor subfamily 1, group D, member 10.025
Vps52vacuolar protein sorting 52 homolog (S. cerevisiae)0.025
Prph2peripherin 20.025
Myo9amyosin IXA0.025
Usp2ubiquitin specific peptidase 20.025
Cnot2CCR4-NOT transcription complex, subunit 20.025
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.024
Bhlhe40basic helix-loop-helix family, member e400.024
Ell2elongation factor RNA polymerase II 20.024
Gjb1gap junction protein, beta 10.024
Brd2bromodomain containing 20.024
Eif5aeukaryotic translation initiation factor 5A0.024
Psme2proteasome (prosome, macropain) activator subunit 20.024
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism