The network for 'regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

NameDescriptionProbabilityFunc Analog Organism
Ighimmunoglobulin heavy chain complex1.000
Tnftumor necrosis factor0.999
Cd40CD40 antigen0.998
Cd19CD19 antigen0.996
Ltalymphotoxin A0.993
Stat3signal transducer and activator of transcription 30.991
Il4interleukin 40.989
Lyz2lysozyme 20.988
FasFas (TNF receptor superfamily member 6)0.984
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.984
Ifnginterferon gamma0.977
Ccr1chemokine (C-C motif) receptor 10.969
Ccl2chemokine (C-C motif) ligand 20.955
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.936
Icosinducible T-cell co-stimulator0.927
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.909
B2mbeta-2 microglobulin0.903
Ikzf1IKAROS family zinc finger 10.897
Traf6TNF receptor-associated factor 60.891
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.877
Jak2Janus kinase 20.867
Pax5paired box gene 50.859
Cd22CD22 antigen0.857
Foxp3forkhead box P30.841
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.825
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.824
H2-Aahistocompatibility 2, class II antigen A, alpha0.822
Il4rainterleukin 4 receptor, alpha0.821
Il1binterleukin 1 beta0.807
H2-Eb1histocompatibility 2, class II antigen E beta0.806
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.785
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.783
Cd28CD28 antigen0.782
Batfbasic leucine zipper transcription factor, ATF-like0.753
H2-Ab1histocompatibility 2, class II antigen A, beta 10.739
Ccr7chemokine (C-C motif) receptor 70.701
Socs1suppressor of cytokine signaling 10.692
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.686
Ccl4chemokine (C-C motif) ligand 40.675
Ccr6chemokine (C-C motif) receptor 60.674
Bcl6B-cell leukemia/lymphoma 60.645
H2-K1histocompatibility 2, K1, K region0.645
Ciitaclass II transactivator0.610
TapbpTAP binding protein0.605
Casp4caspase 4, apoptosis-related cysteine peptidase0.603
Casp8caspase 80.597
Ltblymphotoxin B0.596
Il10interleukin 100.595
Clec4dC-type lectin domain family 4, member d0.591
Pdcd1programmed cell death 10.589
Tnfaip3tumor necrosis factor, alpha-induced protein 30.588
Stat6signal transducer and activator of transcription 60.581
Klrd1killer cell lectin-like receptor, subfamily D, member 10.570
Il12rb2interleukin 12 receptor, beta 20.570
BlkB lymphoid kinase0.569
Cd5CD5 antigen0.564
Map3k14mitogen-activated protein kinase kinase kinase 140.564
H2-DMb2histocompatibility 2, class II, locus Mb20.561
Prf1perforin 1 (pore forming protein)0.555
Cd40lgCD40 ligand0.550
Il6interleukin 60.544
Il1rl1interleukin 1 receptor-like 10.544
Traf2TNF receptor-associated factor 20.543
Prdm1PR domain containing 1, with ZNF domain0.539
Rc3h1RING CCCH (C3H) domains 10.532
C3complement component 30.531
Itgb2integrin beta 20.530
Gpr132G protein-coupled receptor 1320.526
Klrk1killer cell lectin-like receptor subfamily K, member 10.525
BtkBruton agammaglobulinemia tyrosine kinase0.509
Ccl8chemokine (C-C motif) ligand 80.507
Leprleptin receptor0.505
Cxcl9chemokine (C-X-C motif) ligand 90.491
Gdf3growth differentiation factor 30.491
Hbb-b1hemoglobin, beta adult major chain0.491
Cishcytokine inducible SH2-containing protein0.490
Ccr2chemokine (C-C motif) receptor 20.483
Ifngr1interferon gamma receptor 10.473
Sh2d2aSH2 domain protein 2A0.459
Il10rainterleukin 10 receptor, alpha0.452
FaslFas ligand (TNF superfamily, member 6)0.452
Igkimmunoglobulin kappa chain complex0.449
Cxcl13chemokine (C-X-C motif) ligand 130.448
Fcnaficolin A0.443
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.442
H2-D1histocompatibility 2, D region locus 10.436
Pitx1paired-like homeodomain transcription factor 10.408
Myd88myeloid differentiation primary response gene 880.406
Cd4CD4 antigen0.394
Stat5asignal transducer and activator of transcription 5A0.393
Il18rapinterleukin 18 receptor accessory protein0.388
H2-Q7histocompatibility 2, Q region locus 70.386
Stat5bsignal transducer and activator of transcription 5B0.382
Clec4eC-type lectin domain family 4, member e0.381
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.377
Ggt5gamma-glutamyltransferase 50.375
Pnp2purine-nucleoside phosphorylase 20.364
NanogNanog homeobox0.360
Pdcd1lg2programmed cell death 1 ligand 20.356
Cxcr5chemokine (C-X-C motif) receptor 50.355
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
B2Mbeta-2-microglobulin0.989
HLA-Gmajor histocompatibility complex, class I, G0.965
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.960
HLA-Cmajor histocompatibility complex, class I, C0.956
PTPN6protein tyrosine phosphatase, non-receptor type 60.932
HLA-Amajor histocompatibility complex, class I, A0.913
HLA-Bmajor histocompatibility complex, class I, B0.904
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.880
IL4Rinterleukin 4 receptor0.865
SYKspleen tyrosine kinase0.864
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.800
HLA-Fmajor histocompatibility complex, class I, F0.731
TAPBPTAP binding protein (tapasin)0.682
TRAF3TNF receptor-associated factor 30.661
LCKlymphocyte-specific protein tyrosine kinase0.656
IL2RGinterleukin 2 receptor, gamma0.610
BIRC3baculoviral IAP repeat containing 30.602
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.505
CCR5chemokine (C-C motif) receptor 50.493
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.483
LTAlymphotoxin alpha (TNF superfamily, member 1)0.472
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.469
CD40CD40 molecule, TNF receptor superfamily member 50.461
CCL4chemokine (C-C motif) ligand 40.442
HLA-DMBmajor histocompatibility complex, class II, DM beta0.438
CXCL9chemokine (C-X-C motif) ligand 90.436
HLA-Emajor histocompatibility complex, class I, E0.420
TRAF6TNF receptor-associated factor 60.404
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.360
CCL5chemokine (C-C motif) ligand 50.336
TRAF1TNF receptor-associated factor 10.331
CASP8caspase 8, apoptosis-related cysteine peptidase0.299
GRAP2GRB2-related adaptor protein 20.294
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.288
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.281
CCR1chemokine (C-C motif) receptor 10.273
TGIF1TGFB-induced factor homeobox 10.273
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.264
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.259
HK3hexokinase 3 (white cell)0.233
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.204
AIF1allograft inflammatory factor 10.192
CCR7chemokine (C-C motif) receptor 70.191
LAIR1leukocyte-associated immunoglobulin-like receptor 10.145
HLA-DRB5major histocompatibility complex, class II, DR beta 50.140
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.137
CD2CD2 molecule0.136
HDAC9histone deacetylase 90.129
ICAM1intercellular adhesion molecule 10.127
SIGLEC7sialic acid binding Ig-like lectin 70.124
PILRApaired immunoglobin-like type 2 receptor alpha0.121
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.112
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.111
CCL22chemokine (C-C motif) ligand 220.108
CD22CD22 molecule0.106
CCL19chemokine (C-C motif) ligand 190.104
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.100
TNFtumor necrosis factor0.097
TRAF5TNF receptor-associated factor 50.095
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.094
IRF4interferon regulatory factor 40.094
TNFRSF9tumor necrosis factor receptor superfamily, member 90.091
FRA10AC1fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 10.091
FCN1ficolin (collagen/fibrinogen domain containing) 10.089
CLEC10AC-type lectin domain family 10, member A0.088
PTAFRplatelet-activating factor receptor0.087
FPR3formyl peptide receptor 30.086
CD48CD48 molecule0.085
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.085
THOC5THO complex 50.084
TRAF2TNF receptor-associated factor 20.078
FASLGFas ligand (TNF superfamily, member 6)0.078
IL4interleukin 40.075
CFHcomplement factor H0.074
CCL13chemokine (C-C motif) ligand 130.073
ZMYND11zinc finger, MYND-type containing 110.072
IL6interleukin 6 (interferon, beta 2)0.068
IL2RBinterleukin 2 receptor, beta0.068
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.067
CASP10caspase 10, apoptosis-related cysteine peptidase0.067
IFNGinterferon, gamma0.066
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.064
SH2D1ASH2 domain containing 1A0.062
CCL8chemokine (C-C motif) ligand 80.060
TYROBPTYRO protein tyrosine kinase binding protein0.054
PVRL4poliovirus receptor-related 40.053
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.053
CXCL10chemokine (C-X-C motif) ligand 100.053
IL10RAinterleukin 10 receptor, alpha0.052
CXCL13chemokine (C-X-C motif) ligand 130.050
PLEKpleckstrin0.049
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.049
CD33CD33 molecule0.048
SQSTM1sequestosome 10.047
IGSF6immunoglobulin superfamily, member 60.046
CCR4chemokine (C-C motif) receptor 40.046
SMURF1SMAD specific E3 ubiquitin protein ligase 10.045
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.045
ENGendoglin0.044
TRAF3IP3TRAF3 interacting protein 30.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.343
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.092
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.074
Cd37CD37 molecule0.071
RT1-DaRT1 class II, locus Da0.070
Hsph1heat shock 105/110 protein 10.065
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.063
Fggfibrinogen gamma chain0.062
RT1-S3RT1 class Ib, locus S30.048
RT1-BaRT1 class II, locus Ba0.041
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.037
RT1-DMbRT1 class II, locus DMb0.037
RT1-CE12RT1 class I, locus CE120.036
Casp1caspase 10.027
Slfn2schlafen 20.026
Aif1allograft inflammatory factor 10.024
Oas1a2'-5' oligoadenylate synthetase 1A0.022
RT1-Db1RT1 class II, locus Db10.021
Ripk3receptor-interacting serine-threonine kinase 30.020
RT1-N3RT1 class Ib, locus N30.019
Irf7interferon regulatory factor 70.017
Cxcl10chemokine (C-X-C motif) ligand 100.017
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
Hspb1heat shock protein 10.014
Plaurplasminogen activator, urokinase receptor0.013
Hckhemopoietic cell kinase0.013
Apol3apolipoprotein L, 30.013
Cd53Cd53 molecule0.013
Icam1intercellular adhesion molecule 10.013
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.012
RT1-ClRT1 class Ib, locus Cl0.011
Dnase1l3deoxyribonuclease 1-like 30.011
Tpt1tumor protein, translationally-controlled 10.011
Rsad2radical S-adenosyl methionine domain containing 20.011
Gbp2guanylate binding protein 20.010
Plcg2phospholipase C, gamma 20.010
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism