The network for 'regulation of protein binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein binding

Any process that modulates the frequency, rate or extent of protein binding.

NameDescriptionProbabilityFunc Analog Organism
Mef2dmyocyte enhancer factor 2D0.952
Ptenphosphatase and tensin homolog0.831
Arrb1arrestin, beta 10.769
Meox2mesenchyme homeobox 20.701
SrcRous sarcoma oncogene0.679
Tlr4toll-like receptor 40.673
Dvl2dishevelled 2, dsh homolog (Drosophila)0.613
Axin1axin 10.596
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.586
Pax3paired box gene 30.570
Ncoa3nuclear receptor coactivator 30.564
Klc1kinesin light chain 10.555
Tgfbr2transforming growth factor, beta receptor II0.542
Psen1presenilin 10.522
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.514
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.496
Smad3MAD homolog 3 (Drosophila)0.494
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.483
Gsk3bglycogen synthase kinase 3 beta0.476
Thrathyroid hormone receptor alpha0.453
FynFyn proto-oncogene0.418
Smad4MAD homolog 4 (Drosophila)0.408
Ctnnb1catenin (cadherin associated protein), beta 10.364
Mapk8mitogen-activated protein kinase 80.360
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.354
Pea15aphosphoprotein enriched in astrocytes 15A0.324
Myd88myeloid differentiation primary response gene 880.318
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.317
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.309
Fgfr2fibroblast growth factor receptor 20.276
Ncoa2nuclear receptor coactivator 20.268
Dvl3dishevelled 3, dsh homolog (Drosophila)0.267
Tgfbr3transforming growth factor, beta receptor III0.261
Apcadenomatosis polyposis coli0.258
Arrb2arrestin, beta 20.256
Stk3serine/threonine kinase 3 (Ste20, yeast homolog)0.246
CblCasitas B-lineage lymphoma0.246
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.238
Rassf5Ras association (RalGDS/AF-6) domain family member 50.230
Ednraendothelin receptor type A0.229
Trp53transformation related protein 530.227
Cdh5cadherin 50.223
Tcf7transcription factor 7, T-cell specific0.222
Gm5806predicted gene 58060.221
Prkceprotein kinase C, epsilon0.216
Bptfbromodomain PHD finger transcription factor0.216
Pkd1polycystic kidney disease 1 homolog0.213
Notch2Notch gene homolog 2 (Drosophila)0.213
Atf4activating transcription factor 40.213
Eporerythropoietin receptor0.213
Rargretinoic acid receptor, gamma0.212
Rxraretinoid X receptor alpha0.209
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.205
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.204
Sox9SRY-box containing gene 90.200
Hdac7histone deacetylase 70.200
Appamyloid beta (A4) precursor protein0.199
Cd19CD19 antigen0.194
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.193
Pitx2paired-like homeodomain transcription factor 20.189
Gli2GLI-Kruppel family member GLI20.185
Hdac5histone deacetylase 50.182
Clstn1calsyntenin 10.182
Gata1GATA binding protein 10.179
Gata6GATA binding protein 60.178
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.175
Inpp5dinositol polyphosphate-5-phosphatase D0.174
Gata4GATA binding protein 40.173
Kitkit oncogene0.173
Mpripmyosin phosphatase Rho interacting protein0.171
Ephb2Eph receptor B20.168
Tgfb2transforming growth factor, beta 20.168
WasWiskott-Aldrich syndrome homolog (human)0.166
Spnb1spectrin beta 10.165
Mef2cmyocyte enhancer factor 2C0.165
Spnb2spectrin beta 20.158
Dag1dystroglycan 10.158
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.155
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.154
Csf1colony stimulating factor 1 (macrophage)0.154
Fbn1fibrillin 10.153
Plxna1plexin A10.149
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.149
Vangl2vang-like 2 (van gogh, Drosophila)0.148
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.145
Mrc1mannose receptor, C type 10.143
Ikzf1IKAROS family zinc finger 10.143
Igf1rinsulin-like growth factor I receptor0.143
St3gal2ST3 beta-galactoside alpha-2,3-sialyltransferase 20.142
Epb4.1l2erythrocyte protein band 4.1-like 20.141
Notch1Notch gene homolog 1 (Drosophila)0.140
Tcfcp2l1transcription factor CP2-like 10.140
Mapk3mitogen-activated protein kinase 30.137
Nf1neurofibromatosis 10.136
Phldb1pleckstrin homology-like domain, family B, member 10.135
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.135
Cd14CD14 antigen0.131
Rac1RAS-related C3 botulinum substrate 10.130
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
smyhc1slow myosin heavy chain 10.634
slc4a1asolute carrier family 4, anion exchanger, member 1a0.487
robo3roundabout homolog 30.484
alcamaactivated leukocyte cell adhesion molecule a0.410
mapk1mitogen-activated protein kinase 10.402
bmp2bbone morphogenetic protein 2b0.385
tnnt2atroponin T2a, cardiac0.383
mef2camyocyte enhancer factor 2ca0.378
hsp90a.1heat shock protein 90-alpha 10.271
mapk12mitogen-activated protein kinase 120.268
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.260
col7a1lcollagen type VII alpha 1-like0.252
nrg2aneuregulin 2a0.245
aldh1a2aldehyde dehydrogenase 1 family, member A20.244
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.243
smad9MAD homolog 9 (Drosophila)0.236
mapk4mitogen-activated protein kinase 40.233
fbn2bfibrillin 2b0.226
fbln4fibulin 40.221
tp53tumor protein p530.217
wnt11rwingless-type MMTV integration site family, member 11, related0.214
ptf1apancreas specific transcription factor, 1a0.202
ruvbl2RuvB-like 2 (E. coli)0.184
mapk6mitogen-activated protein kinase 60.181
sox11bSRY-box containing gene 11b0.178
cdh2cadherin 2, neuronal0.178
mapk7mitogen-activated protein kinase 70.160
efnb2aephrin B2a0.159
actc1bactin, alpha, cardiac muscle 1b0.159
sh3gl1bSH3-domain GRB2-like 1b0.156
neurodneurogenic differentiation0.156
spna2spectrin alpha 20.155
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.154
ctnnb1catenin (cadherin-associated protein), beta 10.154
rbpms2RNA binding protein with multiple splicing 20.153
ntn2netrin 20.151
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.151
nrg1neuregulin 10.147
hs3st3b1aheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a0.144
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.142
ptenaphosphatase and tensin homolog A0.138
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.135
hspa12bheat shock protein 12B0.134
hsp90a.2heat shock protein 90-alpha 20.127
flot1bflotillin 1b0.127
tnnc1btroponin C type 1b (slow)0.124
fabp7afatty acid binding protein 7, brain, a0.119
ndrg4N-myc downstream regulated gene 40.116
nr2e3nuclear receptor subfamily 2, group E, member 30.114
gdf6agrowth differentiation factor 6a0.109
tfe3atranscription factor binding to IGHM enhancer 3a0.109
crip2cysteine-rich protein 20.107
hlxb9lahomeo box HB9 like a0.107
bmp4bone morphogenetic protein 40.107
ube2i2ubiquitin-conjugating enzyme E2I20.105
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.101
dusp6dual specificity phosphatase 60.100
hs3st1l1heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like10.098
mfn2mitofusin 20.097
prom1aprominin 1a0.097
appaamyloid beta (A4) precursor protein a0.097
bcl2B-cell leukemia/lymphoma 20.096
tcf7transcription factor 7 (T-cell specific, HMG-box)0.095
foxd3forkhead box D30.095
gle1GLE1 RNA export mediator homolog (yeast)0.091
itga3bintegrin, alpha 3b0.088
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.088
foxo3bforkhead box O3b0.088
ahctf1AT hook containing transcription factor 10.087
epha4aeph receptor A4a0.087
igfbp5ainsulin-like growth factor binding protein 5a0.083
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.083
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.083
neo1neogenin 10.083
clic4chloride intracellular channel 40.081
mapk3mitogen-activated protein kinase 30.081
dkk1bdickkopf 1b0.080
eif3ceukaryotic translation initiation factor 3, subunit C0.080
pcdh10bprotocadherin 10b0.079
smad5MAD homolog 5 (Drosophila)0.079
ntn1anetrin 1a0.078
cpsf1cleavage and polyadenylation specific factor 10.078
extl3exostoses (multiple)-like 30.078
cadm3cell adhesion molecule 30.077
hspb1heat shock protein, alpha-crystallin-related, 10.076
frem3Fras1 related extracellular matrix 30.075
wnt10awingless-type MMTV integration site family, member 10a0.074
prox1prospero-related homeobox gene 10.074
sec13SEC13 homolog (S. cerevisiae)0.074
pdx1pancreatic and duodenal homeobox 10.074
warstryptophanyl-tRNA synthetase0.073
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.073
hmgb3ahigh-mobility group box 3a0.073
stac3SH3 and cysteine rich domain 30.073
hey2hairy/enhancer-of-split related with YRPW motif 20.072
crxcone-rod homeobox0.072
pabpc1apoly A binding protein, cytoplasmic 1 a0.072
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CaMKIICalcium/calmodulin-dependent protein kinase II0.011
PICK1CG6167 gene product from transcript CG6167-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.999
FHL2four and a half LIM domains 20.955
PSEN1presenilin 10.911
BCL2L1BCL2-like 10.902
C1QAcomplement component 1, q subcomponent, A chain0.875
IFIT1interferon-induced protein with tetratricopeptide repeats 10.830
ARRB1arrestin, beta 10.794
FLNAfilamin A, alpha0.761
IFIT3interferon-induced protein with tetratricopeptide repeats 30.649
NCOR2nuclear receptor corepressor 20.625
TP53tumor protein p530.581
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.538
BCL2L11BCL2-like 11 (apoptosis facilitator)0.533
DVL3dishevelled, dsh homolog 3 (Drosophila)0.498
CCR5chemokine (C-C motif) receptor 50.496
FN1fibronectin 10.490
MPDZmultiple PDZ domain protein0.448
TRAF1TNF receptor-associated factor 10.447
MAPK8mitogen-activated protein kinase 80.429
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.427
ZMYND11zinc finger, MYND-type containing 110.385
CREBBPCREB binding protein0.379
ESR1estrogen receptor 10.374
IFIT2interferon-induced protein with tetratricopeptide repeats 20.368
TRAF2TNF receptor-associated factor 20.368
PDIA3protein disulfide isomerase family A, member 30.361
LRP6low density lipoprotein receptor-related protein 60.340
APPamyloid beta (A4) precursor protein0.337
CBX5chromobox homolog 50.321
BTBD2BTB (POZ) domain containing 20.298
CSNK1Ecasein kinase 1, epsilon0.290
FLNBfilamin B, beta0.272
TGFB1transforming growth factor, beta 10.271
ARandrogen receptor0.267
CCL4chemokine (C-C motif) ligand 40.267
MAP2K4mitogen-activated protein kinase kinase 40.265
ABI2abl-interactor 20.264
CD40CD40 molecule, TNF receptor superfamily member 50.255
IFIT5interferon-induced protein with tetratricopeptide repeats 50.246
AKT1v-akt murine thymoma viral oncogene homolog 10.240
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.230
TRAF3TNF receptor-associated factor 30.229
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.219
BADBCL2-associated agonist of cell death0.218
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.215
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.215
BMPR1Abone morphogenetic protein receptor, type IA0.214
MDM2Mdm2 p53 binding protein homolog (mouse)0.211
TPM1tropomyosin 1 (alpha)0.209
TCF4transcription factor 40.209
VCAM1vascular cell adhesion molecule 10.207
EPS8epidermal growth factor receptor pathway substrate 80.207
FASFas (TNF receptor superfamily, member 6)0.206
DVL1dishevelled, dsh homolog 1 (Drosophila)0.206
CXCL9chemokine (C-X-C motif) ligand 90.201
PTENphosphatase and tensin homolog0.201
C1QCcomplement component 1, q subcomponent, C chain0.201
ATF2activating transcription factor 20.189
MAPK1mitogen-activated protein kinase 10.181
SMAD7SMAD family member 70.173
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.173
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.166
MAP3K1mitogen-activated protein kinase kinase kinase 10.163
THBS1thrombospondin 10.160
IRAK2interleukin-1 receptor-associated kinase 20.160
SPTBN1spectrin, beta, non-erythrocytic 10.157
MMP12matrix metallopeptidase 12 (macrophage elastase)0.149
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.144
C1QBcomplement component 1, q subcomponent, B chain0.141
PSEN2presenilin 2 (Alzheimer disease 4)0.139
TPM2tropomyosin 2 (beta)0.138
MEF2Amyocyte enhancer factor 2A0.137
SMURF1SMAD specific E3 ubiquitin protein ligase 10.137
CCL8chemokine (C-C motif) ligand 80.136
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.135
CORO1Ccoronin, actin binding protein, 1C0.134
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.130
IRAK1interleukin-1 receptor-associated kinase 10.129
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.126
CXCL10chemokine (C-X-C motif) ligand 100.125
ATXN1ataxin 10.122
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.120
INCENPinner centromere protein antigens 135/155kDa0.119
STK4serine/threonine kinase 40.117
MAPK14mitogen-activated protein kinase 140.113
SPTBspectrin, beta, erythrocytic0.112
ZNF512Bzinc finger protein 512B0.111
GSK3Bglycogen synthase kinase 3 beta0.111
TERF1telomeric repeat binding factor (NIMA-interacting) 10.111
CCL7chemokine (C-C motif) ligand 70.111
CCL2chemokine (C-C motif) ligand 20.106
ITGB5integrin, beta 50.106
SOCS3suppressor of cytokine signaling 30.105
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.102
CCL20chemokine (C-C motif) ligand 200.099
TNFRSF9tumor necrosis factor receptor superfamily, member 90.099
AXIN1axin 10.099
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.099
RASSF5Ras association (RalGDS/AF-6) domain family member 50.098
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
St13suppression of tumorigenicity 130.019
Eif4heukaryotic translation initiation factor 4H0.016
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.012
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.011
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.011
Stip1stress-induced phosphoprotein 10.010
Zmym2zinc finger, MYM-type 20.010
Hspd1heat shock protein 1 (chaperonin)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism