The network for 'protein import into peroxisome matrix' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein import into peroxisome matrix

The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix.

NameDescriptionProbabilityFunc Analog Organism
Rab9RAB9, member RAS oncogene family0.446
Etfaelectron transferring flavoprotein, alpha polypeptide0.360
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.293
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.227
Lypla1lysophospholipase 10.125
Tmco1transmembrane and coiled-coil domains 10.118
Ormdl1ORM1-like 1 (S. cerevisiae)0.118
Ebag9estrogen receptor-binding fragment-associated gene 90.105
Pex7peroxisomal biogenesis factor 70.102
Aampangio-associated migratory protein0.099
Cbr4carbonyl reductase 40.097
Sar1bSAR1 gene homolog B (S. cerevisiae)0.088
Itfg1integrin alpha FG-GAP repeat containing 10.068
Fbxo8F-box protein 80.066
Pex3peroxisomal biogenesis factor 30.064
Pts6-pyruvoyl-tetrahydropterin synthase0.056
Pxmp3peroxisomal membrane protein 30.046
0610009B22RikRIKEN cDNA 0610009B22 gene0.045
Scp2sterol carrier protein 2, liver0.039
Mrpl50mitochondrial ribosomal protein L500.036
Akr7a5aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)0.035
Hrsp12heat-responsive protein 120.035
Lactb2lactamase, beta 20.035
Chpt1choline phosphotransferase 10.034
Ring1ring finger protein 10.034
Mtx2metaxin 20.032
Mocs2molybdenum cofactor synthesis 20.032
Bet1blocked early in transport 1 homolog (S. cerevisiae)0.031
Hsdl2hydroxysteroid dehydrogenase like 20.031
Echdc1enoyl Coenzyme A hydratase domain containing 10.030
Gbe1glucan (1,4-alpha-), branching enzyme 10.030
Acad11acyl-Coenzyme A dehydrogenase family, member 110.029
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.028
Atl2atlastin GTPase 20.027
Lyrm5LYR motif containing 50.026
Etfdhelectron transferring flavoprotein, dehydrogenase0.026
Btf3l4basic transcription factor 3-like 40.025
Commd6COMM domain containing 60.025
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.024
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.024
1110002N22RikRIKEN cDNA 1110002N22 gene0.023
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.022
Zfand6zinc finger, AN1-type domain 60.022
Ccdc90bcoiled-coil domain containing 90B0.022
Zfand1zinc finger, AN1-type domain 10.022
Ndufaf1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 10.021
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.021
Cyhr1cysteine and histidine rich 10.021
Ptgr2prostaglandin reductase 20.021
Tysnd1trypsin domain containing 10.020
Zfp931zinc finger protein 9310.020
Akap8lA kinase (PRKA) anchor protein 8-like0.020
Mutmethylmalonyl-Coenzyme A mutase0.020
Acat1acetyl-Coenzyme A acetyltransferase 10.019
Actr6ARP6 actin-related protein 6 homolog (yeast)0.019
Spns1spinster homolog 1 (Drosophila)0.019
Phyhphytanoyl-CoA hydroxylase0.019
Dlddihydrolipoamide dehydrogenase0.019
Slc33a1solute carrier family 33 (acetyl-CoA transporter), member 10.019
Smpd2sphingomyelin phosphodiesterase 2, neutral0.019
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.018
Fbxl4F-box and leucine-rich repeat protein 40.017
Nr2f6nuclear receptor subfamily 2, group F, member 60.017
Suclg2succinate-Coenzyme A ligase, GDP-forming, beta subunit0.017
Glod4glyoxalase domain containing 40.016
Ak3adenylate kinase 30.016
Mettl5methyltransferase like 50.015
Sorcs3sortilin-related VPS10 domain containing receptor 30.015
Ugp2UDP-glucose pyrophosphorylase 20.014
Hrh3histamine receptor H30.014
Dgcr2DiGeorge syndrome critical region gene 20.014
Pex13peroxisomal biogenesis factor 130.014
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.014
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.014
Fam96afamily with sequence similarity 96, member A0.014
Mlycdmalonyl-CoA decarboxylase0.014
Acad8acyl-Coenzyme A dehydrogenase family, member 80.013
Man2c1mannosidase, alpha, class 2C, member 10.013
Jtbjumping translocation breakpoint0.013
CutccutC copper transporter homolog (E.coli)0.013
Akt1s1AKT1 substrate 1 (proline-rich)0.013
Ogfod22-oxoglutarate and iron-dependent oxygenase domain containing 20.013
Unc50unc-50 homolog (C. elegans)0.013
1110002B05RikRIKEN cDNA 1110002B05 gene0.013
Ghitmgrowth hormone inducible transmembrane protein0.012
Ngly1N-glycanase 10.012
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.012
Ivdisovaleryl coenzyme A dehydrogenase0.012
Ehhadhenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase0.011
H2-Ke6H2-K region expressed gene 60.011
Elmod3ELMO/CED-12 domain containing 30.011
Tfamtranscription factor A, mitochondrial0.011
Abcd3ATP-binding cassette, sub-family D (ALD), member 30.011
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.011
Entpd5ectonucleoside triphosphate diphosphohydrolase 50.011
Stard10START domain containing 100.011
Atg2aATG2 autophagy related 2 homolog A (S. cerevisiae)0.011
Pmpcbpeptidase (mitochondrial processing) beta0.011
Sacm1lSAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)0.010
Rnf13ring finger protein 130.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
pex2peroxin 20.995
pex16peroxin 160.255
Cog7CG31040 gene product from transcript CG31040-RA0.224
pex1peroxin 10.154
CG7795CG7795 gene product from transcript CG7795-RD0.024
EndoGEndonuclease G0.021
cortcortex0.020
SyndSyndapin0.017
CG11208CG11208 gene product from transcript CG11208-RA0.015
CG7970CG7970 gene product from transcript CG7970-RA0.014
cbxcrossbronx0.013
bolboule0.010
CG5590CG5590 gene product from transcript CG5590-RA0.010
CG2540CG2540 gene product from transcript CG2540-RA0.010
CG9527CG9527 gene product from transcript CG9527-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PEX19peroxisomal biogenesis factor 191.000
PEX14peroxisomal biogenesis factor 141.000
PEX13peroxisomal biogenesis factor 130.999
PEX5peroxisomal biogenesis factor 50.998
ABCD3ATP-binding cassette, sub-family D (ALD), member 30.989
PEX11Bperoxisomal biogenesis factor 11 beta0.986
PEX3peroxisomal biogenesis factor 30.982
PEX12peroxisomal biogenesis factor 120.975
PEX16peroxisomal biogenesis factor 160.949
PXMP2peroxisomal membrane protein 2, 22kDa0.930
SLC25A17solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 170.622
PEX10peroxisomal biogenesis factor 100.179
PEX2peroxisomal biogenesis factor 20.158
PEX26peroxisomal biogenesis factor 260.156
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.138
KIFAP3kinesin-associated protein 30.117
DHRS4dehydrogenase/reductase (SDR family) member 40.061
MED8mediator complex subunit 80.046
SUFUsuppressor of fused homolog (Drosophila)0.036
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.029
ECH1enoyl CoA hydratase 1, peroxisomal0.019
C14orf129chromosome 14 open reading frame 1290.019
TMEM128transmembrane protein 1280.016
GBASglioblastoma amplified sequence0.014
SNUPNsnurportin 10.012
SMAD2SMAD family member 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PEX12Pex12p0.986
PEX14Pex14p0.980
PEX5Pex5p0.961
PEX11Pex11p0.955
PEX8Pex8p0.953
PEX10Pex10p0.932
PEX6Pex6p0.849
PEX7Pex7p0.805
PEX15Pex15p0.803
PEX2Pex2p0.726
PEX1Pex1p0.655
PEX17Pex17p0.611
PEX13Pex13p0.559
PEX4Pex4p0.373
PEX19Pex19p0.330
YJR012Chypothetical protein0.064
PEX21Pex21p0.039
PEX3Pex3p0.025
SRD1Srd1p0.022
DLD1Dld1p0.020
CUE4Cue4p0.020
CUP1-1Cup1-1p0.019
LEU2Leu2p0.019
CIR1Cir1p0.018
YOL038C-Ahypothetical protein0.017
HXT3Hxt3p0.017
MER1Mer1p0.017
ARP10Arp10p0.017
PEX28Pex28p0.017
YLR264C-Ahypothetical protein0.017
YLR162Whypothetical protein0.016
LEU5Leu5p0.016
ARG8Arg8p0.016
YAR068Whypothetical protein0.015
ZPS1Zps1p0.015
YBR013Chypothetical protein0.014
ATP6Atp6p0.014
ICS2Ics2p0.014
YLR042Chypothetical protein0.014
POT1Pot1p0.014
SPL2Spl2p0.014
YKR075Chypothetical protein0.014
OPT2Opt2p0.013
AUA1Aua1p0.013
YIR035Chypothetical protein0.013
SEC20Sec20p0.013
YPR157Whypothetical protein0.013
IZH4Izh4p0.013
CHA1Cha1p0.013
CRP1Crp1p0.013
FMT1Fmt1p0.013
CPD1Cpd1p0.013
HPF1Hpf1p0.012
YOL013W-Ahypothetical protein0.012
YLL053Chypothetical protein0.012
BNA4Bna4p0.012
AQY2Aqy2p0.012
SCM4Scm4p0.012
ECM13Ecm13p0.012
UPS3Ups3p0.012
YDR034W-Bhypothetical protein0.012
REE1Ree1p0.012
PEX18Pex18p0.011
PTI1Pti1p0.011
PEX22Pex22p0.011
BSC1Bsc1p0.011
HOR2Hor2p0.011
YIL151Chypothetical protein0.011
YPL014Whypothetical protein0.011
TYE7Tye7p0.011
ALT2Alt2p0.011
MDM34Mdm34p0.011
YAL037C-Ahypothetical protein0.011
NRG2Nrg2p0.011
MET8Met8p0.011
YML003Whypothetical protein0.011
PRS2Prs2p0.011
YAL064Whypothetical protein0.011
LPX1Lpx1p0.011
DIC1Dic1p0.010
CUP1-2Cup1-2p0.010
YPR096Chypothetical protein0.010
MF(ALPHA)2Mf(alpha)2p0.010
KNH1Knh1p0.010