The network for 'negative regulation of viral genome replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of viral genome replication

Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.

NameDescriptionProbabilityFunc Analog Organism
Irf7interferon regulatory factor 71.000
Rsad2radical S-adenosyl methionine domain containing 21.000
Usp18ubiquitin specific peptidase 181.000
Isg15ISG15 ubiquitin-like modifier1.000
Oas1a2'-5' oligoadenylate synthetase 1A0.998
Oasl22'-5' oligoadenylate synthetase-like 20.997
Rtp4receptor transporter protein 40.996
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.995
Ifit3interferon-induced protein with tetratricopeptide repeats 30.977
Mx2myxovirus (influenza virus) resistance 20.976
Oasl12'-5' oligoadenylate synthetase-like 10.972
Ifi44interferon-induced protein 440.971
Oas22'-5' oligoadenylate synthetase 20.969
Zbp1Z-DNA binding protein 10.963
Oas32'-5' oligoadenylate synthetase 30.904
Ifit1interferon-induced protein with tetratricopeptide repeats 10.900
Trim30atripartite motif-containing 30A0.890
Mx1myxovirus (influenza virus) resistance 10.866
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.865
Ifitm3interferon induced transmembrane protein 30.849
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.847
Irf9interferon regulatory factor 90.813
Ube2l6ubiquitin-conjugating enzyme E2L 60.801
Parp14poly (ADP-ribose) polymerase family, member 140.772
Uba7ubiquitin-like modifier activating enzyme 70.770
Slfn4schlafen 40.726
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.691
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.676
Ifi27l2ainterferon, alpha-inducible protein 27 like 2A0.628
Isg20interferon-stimulated protein0.512
Tor3atorsin family 3, member A0.510
Trim30dtripartite motif-containing 30D0.483
Tmem106atransmembrane protein 106A0.442
BC006779cDNA sequence BC0067790.388
Stat2signal transducer and activator of transcription 20.376
Oas1b2'-5' oligoadenylate synthetase 1B0.321
Ifih1interferon induced with helicase C domain 10.315
Ly6alymphocyte antigen 6 complex, locus A0.307
Irgm1immunity-related GTPase family M member 10.289
Ifitm2interferon induced transmembrane protein 20.252
Lgals9lectin, galactose binding, soluble 90.247
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.223
Cxcl10chemokine (C-X-C motif) ligand 100.171
Neurod1neurogenic differentiation 10.169
Mndalmyeloid nuclear differentiation antigen like0.149
Saa3serum amyloid A 30.145
Bst2bone marrow stromal cell antigen 20.140
Parp12poly (ADP-ribose) polymerase family, member 120.124
Ifi203interferon activated gene 2030.123
Plac8placenta-specific 80.120
Lcn2lipocalin 20.119
Gbp7guanylate binding protein 70.115
Apol9aapolipoprotein L 9a0.112
Fcgr4Fc receptor, IgG, low affinity IV0.107
Traf3TNF receptor-associated factor 30.105
Pyhin1pyrin and HIN domain family, member 10.100
Casp4caspase 4, apoptosis-related cysteine peptidase0.097
Herc6hect domain and RLD 60.089
Il18bpinterleukin 18 binding protein0.078
Epsti1epithelial stromal interaction 1 (breast)0.070
Hsph1heat shock 105kDa/110kDa protein 10.070
Hnrnpcheterogeneous nuclear ribonucleoprotein C0.069
Xaf1XIAP associated factor 10.067
Slfn2schlafen 20.065
Slfn8schlafen 80.064
Gch1GTP cyclohydrolase 10.056
Batf2basic leucine zipper transcription factor, ATF-like 20.053
Igtpinterferon gamma induced GTPase0.052
Hckhemopoietic cell kinase0.045
Ifitm1interferon induced transmembrane protein 10.044
Ly6c2lymphocyte antigen 6 complex, locus C20.042
H2-T24histocompatibility 2, T region locus 240.042
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.041
Tmem176btransmembrane protein 176B0.036
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.036
Pmlpromyelocytic leukemia0.035
Ifi35interferon-induced protein 350.035
Fcgr1Fc receptor, IgG, high affinity I0.033
Zc3hav1zinc finger CCCH type, antiviral 10.033
Parp9poly (ADP-ribose) polymerase family, member 90.033
Gsdmdgasdermin D0.032
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.031
Sp100nuclear antigen Sp1000.029
Sykbspleen tyrosine kinase0.029
Mlklmixed lineage kinase domain-like0.029
Dtx3ldeltex 3-like (Drosophila)0.029
Tmem176atransmembrane protein 176A0.028
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.027
AI607873expressed sequence AI6078730.027
Znfx1zinc finger, NFX1-type containing 10.027
Samhd1SAM domain and HD domain, 10.026
Unc93b1unc-93 homolog B1 (C. elegans)0.025
Ifitm6interferon induced transmembrane protein 60.024
Cxcl9chemokine (C-X-C motif) ligand 90.023
Samd9lsterile alpha motif domain containing 9-like0.022
Trim34atripartite motif-containing 34A0.020
Irgm2immunity-related GTPase family M member 20.018
Ly6elymphocyte antigen 6 complex, locus E0.018
Ifi47interferon gamma inducible protein 470.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
phlpole hole0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IFIT3interferon-induced protein with tetratricopeptide repeats 30.999
IFI44Linterferon-induced protein 44-like0.995
IFI44interferon-induced protein 440.995
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.994
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.990
SRPK2SRSF protein kinase 20.978
IFIT1interferon-induced protein with tetratricopeptide repeats 10.970
IFITM1interferon induced transmembrane protein 1 (9-27)0.969
SP110SP110 nuclear body protein0.953
IFITM3interferon induced transmembrane protein 3 (1-8U)0.949
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.947
ISG15ISG15 ubiquitin-like modifier0.938
PARP9poly (ADP-ribose) polymerase family, member 90.931
IFIT2interferon-induced protein with tetratricopeptide repeats 20.890
IFIH1interferon induced with helicase C domain 10.885
CCR5chemokine (C-C motif) receptor 50.814
PLSCR1phospholipid scramblase 10.800
DTX3Ldeltex 3-like (Drosophila)0.779
HERC5hect domain and RLD 50.751
SAMD9Lsterile alpha motif domain containing 9-like0.715
SP100SP100 nuclear antigen0.702
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.662
SRPK1SRSF protein kinase 10.637
XAF1XIAP associated factor 10.633
SAMD9sterile alpha motif domain containing 90.584
PARP12poly (ADP-ribose) polymerase family, member 120.560
MX2myxovirus (influenza virus) resistance 2 (mouse)0.559
CCL4chemokine (C-C motif) ligand 40.506
IFITM2interferon induced transmembrane protein 2 (1-8D)0.495
EPSTI1epithelial stromal interaction 1 (breast)0.370
CHERPcalcium homeostasis endoplasmic reticulum protein0.367
UBE2L6ubiquitin-conjugating enzyme E2L 60.350
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.345
IFIT5interferon-induced protein with tetratricopeptide repeats 50.316
IFI6interferon, alpha-inducible protein 60.316
CXCL10chemokine (C-X-C motif) ligand 100.302
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.289
RSAD2radical S-adenosyl methionine domain containing 20.288
GBP1guanylate binding protein 1, interferon-inducible0.245
IRF9interferon regulatory factor 90.240
CCL8chemokine (C-C motif) ligand 80.235
OASL2'-5'-oligoadenylate synthetase-like0.233
CXCL9chemokine (C-X-C motif) ligand 90.222
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.209
CCL2chemokine (C-C motif) ligand 20.188
NMIN-myc (and STAT) interactor0.185
IFI35interferon-induced protein 350.177
BST2bone marrow stromal cell antigen 20.174
IFI16interferon, gamma-inducible protein 160.168
NCBP1nuclear cap binding protein subunit 1, 80kDa0.163
IFI27interferon, alpha-inducible protein 270.149
CXCL11chemokine (C-X-C motif) ligand 110.140
TRIM22tripartite motif containing 220.132
IDEinsulin-degrading enzyme0.123
CCR1chemokine (C-C motif) receptor 10.120
RBM8ARNA binding motif protein 8A0.119
CCL5chemokine (C-C motif) ligand 50.102
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.098
TMEM173transmembrane protein 1730.096
THOC4THO complex 40.095
HNF4Ahepatocyte nuclear factor 4, alpha0.089
RTP4receptor (chemosensory) transporter protein 40.079
RNPS1RNA binding protein S1, serine-rich domain0.077
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.072
CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.063
C19orf66chromosome 19 open reading frame 660.059
PRMT6protein arginine methyltransferase 60.057
C17orf85chromosome 17 open reading frame 850.053
IL6interleukin 6 (interferon, beta 2)0.052
CCR7chemokine (C-C motif) receptor 70.049
RAB6ARAB6A, member RAS oncogene family0.049
STAT1signal transducer and activator of transcription 1, 91kDa0.048
NAMPTnicotinamide phosphoribosyltransferase0.047
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.046
PI3peptidase inhibitor 3, skin-derived0.044
DHX58DEXH (Asp-Glu-X-His) box polypeptide 580.044
LY6Elymphocyte antigen 6 complex, locus E0.044
ZNFX1zinc finger, NFX1-type containing 10.042
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.038
TRIM38tripartite motif containing 380.037
SAFBscaffold attachment factor B0.037
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)0.037
CCL7chemokine (C-C motif) ligand 70.034
IRF7interferon regulatory factor 70.033
TRIM14tripartite motif containing 140.033
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.032
CXCL13chemokine (C-X-C motif) ligand 130.031
RAB5ARAB5A, member RAS oncogene family0.030
CCL3chemokine (C-C motif) ligand 30.029
IFNGinterferon, gamma0.029
MMP12matrix metallopeptidase 12 (macrophage elastase)0.029
CCL22chemokine (C-C motif) ligand 220.028
USP18ubiquitin specific peptidase 180.028
ARRB1arrestin, beta 10.028
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.028
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.027
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.026
LAMP3lysosomal-associated membrane protein 30.026
CLTCclathrin, heavy chain (Hc)0.026
APOL1apolipoprotein L, 10.025
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Irf7interferon regulatory factor 70.994
Ifit3interferon-induced protein with tetratricopeptide repeats 30.787
Usp18ubiquitin specific peptidase 180.783
Mx1myxovirus (influenza virus) resistance 10.725
Oas1a2'-5' oligoadenylate synthetase 1A0.588
Isg15ISG15 ubiquitin-like modifier0.386
Ifitm3interferon induced transmembrane protein 30.183
Oasl2'-5'-oligoadenylate synthetase-like0.103
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.071
Rnf213ring finger protein 2130.056
Cxcl10chemokine (C-X-C motif) ligand 100.055
Sp110SP110 nuclear body protein0.052
Gbp2guanylate binding protein 20.046
Rtp4receptor (chemosensory) transporter protein 40.046
Nkg7natural killer cell group 7 sequence0.044
Irf9interferon regulatory factor 90.039
Ly6cLy6-C antigen0.029
Klrd1killer cell lectin-like receptor, subfamily D, member 10.028
Mx2myxovirus (influenza virus) resistance 20.022
Ifi44linterferon-induced protein 44-like0.022
RT1-S3RT1 class Ib, locus S30.021
RT1-T24-3RT1 class I, locus T24, gene 30.021
Ifitm1interferon induced transmembrane protein 10.021
Ube2l6ubiquitin-conjugating enzyme E2L 60.021
LOC100366216nuclear antigen Sp100-like0.021
Stat2signal transducer and activator of transcription 20.020
Ifi44interferon-induced protein 440.020
Mgpmatrix Gla protein0.019
Parp14poly (ADP-ribose) polymerase family, member 140.018
Slfn3schlafen 30.017
S100a11S100 calcium binding protein A11 (calizzarin)0.016
Ifitm2interferon induced transmembrane protein 20.016
Isg20interferon stimulated exonuclease gene 200.015
Ifi35interferon-induced protein 350.015
Timp1TIMP metallopeptidase inhibitor 10.014
Herc6hect domain and RLD 60.014
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.013
Cfbcomplement factor B0.011
Shisa5shisa homolog 5 (Xenopus laevis)0.011
Cxcl13chemokine (C-X-C motif) ligand 130.011
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.010
Sp140SP140 nuclear body protein0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism