The network for 'heme biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heme biosynthetic process

The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

NameDescriptionProbabilityFunc Analog Organism
Spna1spectrin alpha 10.747
Exoc6exocyst complex component 60.493
Hbb-b2hemoglobin, beta adult minor chain0.487
Ank1ankyrin 1, erythroid0.347
Slc4a1solute carrier family 4 (anion exchanger), member 10.340
Hbb-b1hemoglobin, beta adult major chain0.324
Spnb1spectrin beta 10.165
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.148
Hba-a2hemoglobin alpha, adult chain 20.088
Klf1Kruppel-like factor 1 (erythroid)0.082
Hmbshydroxymethylbilane synthase0.069
Urosuroporphyrinogen III synthase0.061
Epb4.1erythrocyte protein band 4.10.058
Glrx5glutaredoxin 5 homolog (S. cerevisiae)0.038
Tfrctransferrin receptor0.037
Beta-shemoglobin subunit beta-1-like0.037
Abcb7ATP-binding cassette, sub-family B (MDR/TAP), member 70.034
Ahspalpha hemoglobin stabilizing protein0.034
Taldo1transaldolase 10.031
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.030
Fechferrochelatase0.029
Catcatalase0.026
Chukconserved helix-loop-helix ubiquitous kinase0.024
Dhrs4dehydrogenase/reductase (SDR family) member 40.024
Pnpopyridoxine 5'-phosphate oxidase0.023
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.019
Hfehemochromatosis0.018
Aladaminolevulinate, delta-, dehydratase0.016
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.014
Fbxl5F-box and leucine-rich repeat protein 50.014
Ak2adenylate kinase 20.014
Pgls6-phosphogluconolactonase0.014
Ebpphenylalkylamine Ca2+ antagonist (emopamil) binding protein0.014
Txnrd2thioredoxin reductase 20.014
Atp5g3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)0.012
Blvrbbiliverdin reductase B (flavin reductase (NADPH))0.012
Sncasynuclein, alpha0.012
Tkttransketolase0.012
Slc25a10solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 100.011
Slc25a39solute carrier family 25, member 390.011
Etfbelectron transferring flavoprotein, beta polypeptide0.011
Prdx2peroxiredoxin 20.010
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.010
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.848
hbae3hemoglobin alpha embryonic-30.523
urosuroporphyrinogen III synthase0.144
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.097
uroduroporphyrinogen decarboxylase0.088
slc4a1asolute carrier family 4, anion exchanger, member 1a0.069
ppoxprotoporphyrinogen oxidase0.062
slc25a37solute carrier family 25, member 370.040
fechferrochelatase0.037
sptbspectrin, beta, erythrocytic0.030
hbbe2hemoglobin beta embryonic-20.029
klfdKruppel-like factor d0.029
hbbe3hemoglobin beta embryonic-30.026
gata1aGATA binding protein 1a0.026
glrx5glutaredoxin 5 homolog (S. cerevisiae)0.025
alas2aminolevulinate, delta-, synthetase 20.024
hmbsbhydroxymethylbilane synthase, b0.022
iba57IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)0.020
tspotranslocator protein0.016
uqcrbubiquinol-cytochrome c reductase binding protein0.016
tmem14ctransmembrane protein 14C0.015
cox5abcytochrome c oxidase subunit Vab0.014
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.014
atp5ibATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, duplicate b0.013
zgc:92745zgc:927450.012
si:ch211-233e16.1si:ch211-233e16.10.012
zgc:194876zgc:1948760.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.163
QARSglutaminyl-tRNA synthetase0.019
ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.014
RPL3ribosomal protein L30.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.708
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.703
Mdh1malate dehydrogenase 1, NAD (soluble)0.370
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.127
Cox4i1cytochrome c oxidase subunit IV isoform 10.108
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.092
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.082
Oaz1ornithine decarboxylase antizyme 10.078
Hmbshydroxymethylbilane synthase0.077
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.059
Akr7a2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.056
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.043
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.041
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.040
Atp5g3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)0.038
Vdac2voltage-dependent anion channel 20.036
Pkm2pyruvate kinase, muscle0.032
Hspd1heat shock protein 1 (chaperonin)0.029
Cycscytochrome c, somatic0.027
Pgam1phosphoglycerate mutase 1 (brain)0.024
Ghitmgrowth hormone inducible transmembrane protein0.023
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.022
Sdhcsuccinate dehydrogenase complex, subunit C, integral membrane protein0.018
ApehN-acylaminoacyl-peptide hydrolase0.017
Ldhblactate dehydrogenase B0.017
Gpx4glutathione peroxidase 40.015
Atp6v1e1ATPase, H+ transporting, lysosomal V1 subunit E10.015
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.015
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.015
Prdx1peroxiredoxin 10.015
Mosc2MOCO sulphurase C-terminal domain containing 20.015
Mpstmercaptopyruvate sulfurtransferase0.014
Idh2isocitrate dehydrogenase 2 (NADP+), mitochondrial0.013
Fh1fumarate hydratase 10.013
Sephs2selenophosphate synthetase 20.012
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.012
Cox7bcytochrome c oxidase subunit VIIb0.012
Trap1TNF receptor-associated protein 10.011
Fechferrochelatase0.011
Ldhalactate dehydrogenase A0.011
Cox8acytochrome c oxidase subunit VIIIa0.011
Tmem14ctransmembrane protein 14C0.011
Uqcrc2ubiquinol cytochrome c reductase core protein 20.011
Uroduroporphyrinogen decarboxylase0.010
Ccscopper chaperone for superoxide dismutase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HEM2Hem2p0.286
HEM12Hem12p0.069
HEM3Hem3p0.050
MIR1Mir1p0.036
GLT1Glt1p0.032
YHR009Chypothetical protein0.031
COX18Cox18p0.030
PUS6Pus6p0.024
SRD1Srd1p0.024
PUF3Puf3p0.023
YLR264C-Ahypothetical protein0.023
LEU2Leu2p0.023
CYC1Cyc1p0.022
PDI1Pdi1p0.022
AIM38Aim38p0.021
ARG8Arg8p0.021
ALE1Ale1p0.021
YOL038C-Ahypothetical protein0.020
BIO2Bio2p0.020
CPD1Cpd1p0.020
MTM1Mtm1p0.020
MER1Mer1p0.019
ARP10Arp10p0.019
YLR162Whypothetical protein0.019
HEM13Hem13p0.019
YLR177Whypothetical protein0.019
SCT1Sct1p0.019
COX2Cox2p0.018
TOM20Tom20p0.018
COA2Coa2p0.018
YCH1Ych1p0.018
YPR157Whypothetical protein0.018
YLR042Chypothetical protein0.017
BSC1Bsc1p0.017
YNR014Whypothetical protein0.017
PDC6Pdc6p0.017
CUP1-1Cup1-1p0.017
COX5BCox5bp0.017
OPT2Opt2p0.017
CWP1Cwp1p0.016
BAP3Bap3p0.016
DIC1Dic1p0.016
HPF1Hpf1p0.016
SPL2Spl2p0.016
UPS3Ups3p0.016
MET6Met6p0.016
TOM40Tom40p0.016
URA6Ura6p0.016
YAR068Whypothetical protein0.016
MF(ALPHA)2Mf(alpha)2p0.016
ADH2Adh2p0.016
ICS2Ics2p0.016
BNA5Bna5p0.015
MFA2Mfa2p0.015
MET16Met16p0.015
AUA1Aua1p0.015
YBR013Chypothetical protein0.015
YOL013W-Ahypothetical protein0.015
SCM4Scm4p0.015
ZPS1Zps1p0.015
FMT1Fmt1p0.015
ATP6Atp6p0.015
BIO4Bio4p0.015
YIR035Chypothetical protein0.015
YML6Yml6p0.014
UTR4Utr4p0.014
HOR2Hor2p0.014
MET8Met8p0.014
NAM8Nam8p0.014
YAL064Whypothetical protein0.014
ALT2Alt2p0.014
COS12Cos12p0.014
YJR120Whypothetical protein0.014
THO1Tho1p0.013
YJL181Whypothetical protein0.013
URA3Ura3p0.013
YAR066Whypothetical protein0.013
HXT3Hxt3p0.013
CAB2Cab2p0.013
PTR2Ptr2p0.013
TIR3Tir3p0.013
SCS3Scs3p0.013
LSB6Lsb6p0.013
RNP1Rnp1p0.013
YPL067Chypothetical protein0.013
NRG2Nrg2p0.013
SUL2Sul2p0.013
MF(ALPHA)1Mf(alpha)1p0.013
WSC4Wsc4p0.013
TNA1Tna1p0.013
CAM1Cam1p0.013
DLD1Dld1p0.013
SUT1Sut1p0.013
YJL160Chypothetical protein0.013
YMR317Whypothetical protein0.013
BAT2Bat2p0.012
SWC7Swc7p0.012
YAL037C-Ahypothetical protein0.012
YLR040Chypothetical protein0.012
YJL218Whypothetical protein0.012