The network for 't cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell activation

The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.999
Ptpn11protein tyrosine phosphatase, non-receptor type 110.999
Cdkn1bcyclin-dependent kinase inhibitor 1B0.999
Smad4MAD homolog 4 (Drosophila)0.998
Stat3signal transducer and activator of transcription 30.998
Trp53transformation related protein 530.998
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.998
Foxp3forkhead box P30.997
Tnftumor necrosis factor0.997
Jak2Janus kinase 20.997
Cd40CD40 antigen0.996
FasFas (TNF receptor superfamily member 6)0.994
Cd28CD28 antigen0.992
Nf1neurofibromatosis 10.991
Efnb2ephrin B20.990
Ptenphosphatase and tensin homolog0.990
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.990
Leprleptin receptor0.986
Apcadenomatosis polyposis coli0.986
Csf1colony stimulating factor 1 (macrophage)0.985
Socs1suppressor of cytokine signaling 10.982
Icosinducible T-cell co-stimulator0.979
Ptprcprotein tyrosine phosphatase, receptor type, C0.976
Gata4GATA binding protein 40.976
Card11caspase recruitment domain family, member 110.975
FynFyn proto-oncogene0.975
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.972
Itgb1integrin beta 1 (fibronectin receptor beta)0.972
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.971
Notch1Notch gene homolog 1 (Drosophila)0.971
Rb1retinoblastoma 10.966
Fgfr2fibroblast growth factor receptor 20.963
TcraT-cell receptor alpha chain0.958
Bcl2B-cell leukemia/lymphoma 20.957
Map3k14mitogen-activated protein kinase kinase kinase 140.956
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.953
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.953
Tbx3T-box 30.952
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.951
Ccr7chemokine (C-C motif) receptor 70.951
Zap70zeta-chain (TCR) associated protein kinase0.950
Lcklymphocyte protein tyrosine kinase0.947
Nlrp3NLR family, pyrin domain containing 30.946
Ephb2Eph receptor B20.945
Il1r1interleukin 1 receptor, type I0.945
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.944
Hes1hairy and enhancer of split 1 (Drosophila)0.943
Ctnnb1catenin (cadherin associated protein), beta 10.941
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.936
Cxcr4chemokine (C-X-C motif) receptor 40.935
Cd247CD247 antigen0.933
Casp4caspase 4, apoptosis-related cysteine peptidase0.931
Latlinker for activation of T cells0.928
Ccl2chemokine (C-C motif) ligand 20.927
Jag1jagged 10.917
Il1binterleukin 1 beta0.916
Trp63transformation related protein 630.913
Il2rbinterleukin 2 receptor, beta chain0.910
Il4rainterleukin 4 receptor, alpha0.907
Cd44CD44 antigen0.899
Rag1recombination activating gene 10.899
Tgfb1transforming growth factor, beta 10.898
Ptk2PTK2 protein tyrosine kinase 20.898
Batfbasic leucine zipper transcription factor, ATF-like0.896
Wnt3awingless-related MMTV integration site 3A0.896
Gli3GLI-Kruppel family member GLI30.895
Ifnginterferon gamma0.894
CblCasitas B-lineage lymphoma0.893
Hif1ahypoxia inducible factor 1, alpha subunit0.893
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.889
Smad3MAD homolog 3 (Drosophila)0.886
Birc3baculoviral IAP repeat-containing 30.881
Plcg1phospholipase C, gamma 10.881
C3ar1complement component 3a receptor 10.876
Sh2d2aSH2 domain protein 2A0.875
Myd88myeloid differentiation primary response gene 880.872
Smad6MAD homolog 6 (Drosophila)0.867
Grb10growth factor receptor bound protein 100.864
Lyz2lysozyme 20.862
Zeb1zinc finger E-box binding homeobox 10.860
Il2rginterleukin 2 receptor, gamma chain0.854
Tnfaip3tumor necrosis factor, alpha-induced protein 30.854
Clec4nC-type lectin domain family 4, member n0.854
Ccr1chemokine (C-C motif) receptor 10.851
BrafBraf transforming gene0.850
Stat5bsignal transducer and activator of transcription 5B0.849
Cd4CD4 antigen0.846
Il27rainterleukin 27 receptor, alpha0.845
Lag3lymphocyte-activation gene 30.838
Tlr4toll-like receptor 40.835
Dlg4discs, large homolog 4 (Drosophila)0.831
Fgfr1fibroblast growth factor receptor 10.830
Ntf3neurotrophin 30.829
Efna1ephrin A10.826
Erbb2ipErbb2 interacting protein0.823
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.822
Gdnfglial cell line derived neurotrophic factor0.818
Prf1perforin 1 (pore forming protein)0.815
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.812
Relreticuloendotheliosis oncogene0.807
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.535
runx2arunt-related transcription factor 2a0.531
tp63tumor protein p630.349
mmp9matrix metalloproteinase 90.319
coro1acoronin, actin binding protein, 1A0.280
rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.241
gata1aGATA binding protein 1a0.241
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.215
fgf3fibroblast growth factor 30.211
lcp1lymphocyte cytosolic plastin 10.210
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.201
cxcr4achemokine (C-X-C motif) receptor 4a0.185
il7rinterleukin 7 receptor0.176
cmybtranscription factor cmyb0.116
runx3runt-related transcription factor 30.116
mychmyelocytomatosis oncogene homolog0.114
hspa5heat shock protein 50.113
ighzimmunoglobulin heavy constant zeta0.102
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.081
foxa3forkhead box A30.078
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.073
cd8aCD8 antigen, alpha polypeptide0.066
tfe3btranscription factor binding to IGHM enhancer 3b0.064
foxa2forkhead box A20.057
dll4delta-like 4 (Drosophila)0.056
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.055
cldneclaudin e0.054
nrp2bneuropilin 2b0.050
fgf4fibroblast growth factor 40.048
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.048
il6rinterleukin 6 receptor0.044
bmperBMP binding endothelial regulator0.042
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.039
dnmt4DNA (cytosine-5-)-methyltransferase 40.038
tnfatumor necrosis factor a (TNF superfamily, member 2)0.038
casp3acaspase 3, apoptosis-related cysteine protease a0.037
per3period homolog 3 (Drosophila)0.037
dnttdeoxynucleotidyltransferase, terminal0.035
rspo3R-spondin 3 homolog (Xenopus laevis)0.034
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.034
fgf20afibroblast growth factor 20a0.033
csrp1acysteine and glycine-rich protein 1a0.031
ihhaIndian hedgehog homolog a0.030
sema3aasemaphorin 3aa0.030
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.029
cldn5bclaudin 5b0.028
cdh1cadherin 1, epithelial0.027
lef1lymphocyte enhancer binding factor 10.026
tlr3toll-like receptor 30.026
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.026
flhfloating head0.025
lgals2alectin, galactoside-binding, soluble, 2a0.025
rag1recombination activating gene 10.025
shhasonic hedgehog a0.025
il12bbinterleukin 12B, b0.024
slc30a7solute carrier family 30 (zinc transporter), member 70.024
pfn1profilin 10.023
cdx4caudal type homeo box transcription factor 40.022
pdgfaaplatelet-derived growth factor alpha a0.022
gfi1.1growth factor independent 1.10.022
rad21RAD21 homolog (S. pombe)0.021
LOC553366hypothetical protein LOC5533660.021
ccnd1cyclin D10.021
rpl23aribosomal protein L23a0.021
gata3GATA-binding protein 30.021
fesfeline sarcoma oncogene0.020
ikzf1IKAROS family zinc finger 1 (Ikaros)0.020
her6hairy-related 60.020
anxa1aannexin A1a0.019
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.019
cd247CD247 antigen0.019
mmp15bmatrix metallopeptidase 15b0.018
rpl7aribosomal protein L7a0.018
nkx2.5NK2 transcription factor related 50.017
mpllmyeloproliferative leukemia virus oncogene, like0.017
LOC100151531zinc finger protein Gfi-1b-like0.017
eomesbeomesodermin homolog b0.017
pdcd2programmed cell death 20.017
cd74CD74 molecule, major histocompatibility complex, class II invariant chain0.016
otx1borthodenticle homolog 1b0.016
tshz1teashirt family zinc finger 10.016
pax5paired box gene 50.016
plcg1phospholipase C, gamma 10.016
foxa1forkhead box A10.016
scdstearoyl-CoA desaturase (delta-9-desaturase)0.015
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.015
LOC100003514protein kinase C alpha type-like0.015
lgals3llectin, galactoside-binding, soluble, 3 (galectin 3)-like0.015
ptprcprotein tyrosine phosphatase, receptor type, C0.014
smoc2secreted modular calcium binding protein 20.014
rpe65bretinal pigment epithelium-specific protein 65b0.014
dusp6dual specificity phosphatase 60.014
runx2brunt-related transcription factor 2b0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase1.000
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.995
CD2CD2 molecule0.994
SYKspleen tyrosine kinase0.983
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.981
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.979
SH2D1ASH2 domain containing 1A0.971
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.970
EGFRepidermal growth factor receptor0.966
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.959
GRB2growth factor receptor-bound protein 20.958
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.953
PMLpromyelocytic leukemia0.946
FHL2four and a half LIM domains 20.938
PSEN1presenilin 10.928
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.925
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.924
TP53tumor protein p530.916
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.907
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.890
CXCL9chemokine (C-X-C motif) ligand 90.887
ICAM1intercellular adhesion molecule 10.884
NCOR2nuclear receptor corepressor 20.881
ITKIL2-inducible T-cell kinase0.872
FASLGFas ligand (TNF superfamily, member 6)0.871
PTPRCprotein tyrosine phosphatase, receptor type, C0.867
CDC37cell division cycle 37 homolog (S. cerevisiae)0.862
CD247CD247 molecule0.859
TGIF1TGFB-induced factor homeobox 10.842
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.817
IL2RBinterleukin 2 receptor, beta0.813
BCL3B-cell CLL/lymphoma 30.812
CAV1caveolin 1, caveolae protein, 22kDa0.799
NOTCH1notch 10.795
CCR5chemokine (C-C motif) receptor 50.786
CASP8caspase 8, apoptosis-related cysteine peptidase0.779
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.770
BTN3A1butyrophilin, subfamily 3, member A10.761
CCL4chemokine (C-C motif) ligand 40.757
HLA-Amajor histocompatibility complex, class I, A0.754
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.746
FYBFYN binding protein0.746
SIGLEC7sialic acid binding Ig-like lectin 70.739
HLA-Bmajor histocompatibility complex, class I, B0.737
HCKhemopoietic cell kinase0.734
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.719
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.704
HLA-DMBmajor histocompatibility complex, class II, DM beta0.683
CD6CD6 molecule0.679
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.678
CD80CD80 molecule0.677
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.676
PPARAperoxisome proliferator-activated receptor alpha0.663
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.663
RUNX1runt-related transcription factor 10.658
VAV1vav 1 guanine nucleotide exchange factor0.658
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.656
PTPN6protein tyrosine phosphatase, non-receptor type 60.653
CD3DCD3d molecule, delta (CD3-TCR complex)0.652
CCL5chemokine (C-C motif) ligand 50.646
SHC1SHC (Src homology 2 domain containing) transforming protein 10.642
IFNGinterferon, gamma0.631
CTLA4cytotoxic T-lymphocyte-associated protein 40.612
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.610
CCL22chemokine (C-C motif) ligand 220.603
HLA-Fmajor histocompatibility complex, class I, F0.603
CXCL10chemokine (C-X-C motif) ligand 100.599
IL1R1interleukin 1 receptor, type I0.571
MDM2Mdm2 p53 binding protein homolog (mouse)0.562
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.547
BIRC3baculoviral IAP repeat containing 30.547
IRF4interferon regulatory factor 40.515
HLA-Emajor histocompatibility complex, class I, E0.506
CFLARCASP8 and FADD-like apoptosis regulator0.505
SIN3ASIN3 homolog A, transcription regulator (yeast)0.490
CTBP1C-terminal binding protein 10.488
MTORmechanistic target of rapamycin (serine/threonine kinase)0.470
HDAC7histone deacetylase 70.460
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.454
CD28CD28 molecule0.450
FYNFYN oncogene related to SRC, FGR, YES0.450
IL2RGinterleukin 2 receptor, gamma0.445
ZFYVE9zinc finger, FYVE domain containing 90.434
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.431
STAT4signal transducer and activator of transcription 40.430
CD86CD86 molecule0.425
FCN1ficolin (collagen/fibrinogen domain containing) 10.420
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.418
CD3GCD3g molecule, gamma (CD3-TCR complex)0.417
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.415
BCL10B-cell CLL/lymphoma 100.409
CCR2chemokine (C-C motif) receptor 20.398
DLG1discs, large homolog 1 (Drosophila)0.393
APLFaprataxin and PNKP like factor0.391
SH3KBP1SH3-domain kinase binding protein 10.386
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.383
PRKCQprotein kinase C, theta0.381
BTN3A2butyrophilin, subfamily 3, member A20.379
NOTCH3notch 30.378
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.941
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.817
Cd5Cd5 molecule0.812
RT1-DaRT1 class II, locus Da0.801
TcrbT-cell receptor beta chain0.773
Cd37CD37 molecule0.631
Bin2bridging integrator 20.625
Cd4Cd4 molecule0.563
Cd2Cd2 molecule0.553
RT1-BbRT1 class II, locus Bb0.523
Lyz2lysozyme 20.518
Cd247Cd247 molecule0.503
RT1-Db1RT1 class II, locus Db10.433
Cd53Cd53 molecule0.389
Laptm5lysosomal protein transmembrane 50.337
Il2rbinterleukin 2 receptor, beta0.328
Hckhemopoietic cell kinase0.322
Anxa5annexin A50.256
RT1-DMbRT1 class II, locus DMb0.243
Il1binterleukin 1 beta0.222
Junbjun B proto-oncogene0.215
Igh-6immunoglobulin heavy chain 60.209
Latlinker for activation of T cells0.205
Ehfets homologous factor0.198
Anxa2annexin A20.196
Cxcr3chemokine (C-X-C motif) receptor 30.153
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.152
Il6interleukin 60.146
Ly86lymphocyte antigen 860.142
Cxcr4chemokine (C-X-C motif) receptor 40.141
Ptprcprotein tyrosine phosphatase, receptor type, C0.135
Ccr5chemokine (C-C motif) receptor 50.129
Casp1caspase 10.123
Vav1vav 1 guanine nucleotide exchange factor0.116
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.109
Cd44Cd44 molecule0.108
Itgb7integrin, beta 70.107
Jak1Janus kinase 10.105
Tgfbr2transforming growth factor, beta receptor II0.100
Arhgap4Rho GTPase activating protein 40.100
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.097
Il1r1interleukin 1 receptor, type I0.095
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.094
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.091
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.090
Gzmkgranzyme K0.090
Ccr2chemokine (C-C motif) receptor 20.088
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.088
Ctsbcathepsin B0.087
Tgfbr3transforming growth factor, beta receptor III0.083
Pecam1platelet/endothelial cell adhesion molecule 10.079
Ciitaclass II, major histocompatibility complex, transactivator0.079
Itgb1integrin, beta 10.076
Mylk2myosin light chain kinase 20.076
Cd86CD86 molecule0.076
Prf1perforin 1 (pore forming protein)0.074
Gna15guanine nucleotide binding protein, alpha 150.071
Map4k1mitogen activated protein kinase kinase kinase kinase 10.069
Ccl5chemokine (C-C motif) ligand 50.068
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.066
FcrlaFc receptor-like A0.066
Flt1FMS-related tyrosine kinase 10.065
FosFBJ osteosarcoma oncogene0.064
Marcksmyristoylated alanine rich protein kinase C substrate0.064
Ptger4prostaglandin E receptor 4 (subtype EP4)0.063
Cd3gCD3 molecule, gamma0.063
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.062
Rfc1replication factor C (activator 1) 10.062
Hspe1heat shock protein 1 (chaperonin 10)0.061
Gimap4GTPase, IMAP family member 40.061
Ddr1discoidin domain receptor tyrosine kinase 10.059
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.058
Batf3basic leucine zipper transcription factor, ATF-like 30.058
LOC100361706lambda-chain C1-region-like0.057
Ggt1gamma-glutamyltransferase 10.057
Atp2a3ATPase, Ca++ transporting, ubiquitous0.054
Lcp2lymphocyte cytosolic protein 20.051
Cfpcomplement factor properdin0.050
Pld1phospholipase D10.050
Irf5interferon regulatory factor 50.050
Gja4gap junction protein, alpha 40.050
RGD1304644similar to RIKEN cDNA 2310046K010.050
Icosinducible T-cell co-stimulator0.048
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.047
Gucy2dguanylate cyclase 2d0.047
Ptpn7protein tyrosine phosphatase, non-receptor type 70.047
Sh2d2aSH2 domain protein 2A0.046
Fgfr2fibroblast growth factor receptor 20.046
Foxs1forkhead box S10.045
Cd80Cd80 molecule0.045
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.044
Phemxpan hematopoietic expression0.044
Myo1fmyosin IF0.044
Plcg2phospholipase C, gamma 20.043
Prss8protease, serine, 80.042
Aif1allograft inflammatory factor 10.042
Fmnl1formin-like 10.042
Gckrglucokinase (hexokinase 4) regulator0.040
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism