The network for 'muscle adaptation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle adaptation

A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

NameDescriptionProbabilityFunc Analog Organism
Mef2dmyocyte enhancer factor 2D1.000
Nos3nitric oxide synthase 3, endothelial cell0.995
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.992
Vegfavascular endothelial growth factor A0.986
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.970
Hey2hairy/enhancer-of-split related with YRPW motif 20.962
Nos1nitric oxide synthase 1, neuronal0.948
Tnni2troponin I, skeletal, fast 20.945
Hrchistidine rich calcium binding protein0.901
Hand2heart and neural crest derivatives expressed transcript 20.901
Mef2cmyocyte enhancer factor 2C0.892
Mef2amyocyte enhancer factor 2A0.881
Xirp1xin actin-binding repeat containing 10.863
Ppargperoxisome proliferator activated receptor gamma0.841
Trim63tripartite motif-containing 630.759
Ank1ankyrin 1, erythroid0.742
Dusp1dual specificity phosphatase 10.727
Gata4GATA binding protein 40.714
Trim55tripartite motif-containing 550.689
Ldb3LIM domain binding 30.683
Yap1yes-associated protein 10.682
Pitx2paired-like homeodomain transcription factor 20.675
Tnnc2troponin C2, fast0.664
Myogmyogenin0.651
Mybphmyosin binding protein H0.648
Nos2nitric oxide synthase 2, inducible0.644
Zfpm2zinc finger protein, multitype 20.643
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.571
Ptgs2prostaglandin-endoperoxide synthase 20.566
Tnnt3troponin T3, skeletal, fast0.559
Actn2actinin alpha 20.553
Iduaiduronidase, alpha-L-0.516
Tnnt2troponin T2, cardiac0.487
Ednraendothelin receptor type A0.466
Ptprbprotein tyrosine phosphatase, receptor type, B0.430
Bmp4bone morphogenetic protein 40.423
Tnni1troponin I, skeletal, slow 10.403
Epas1endothelial PAS domain protein 10.403
Ren1renin 1 structural0.396
Hdac5histone deacetylase 50.392
Ttntitin0.388
Vdrvitamin D receptor0.387
Tcaptitin-cap0.383
Ptpn11protein tyrosine phosphatase, non-receptor type 110.377
Myf6myogenic factor 60.374
Nppanatriuretic peptide type A0.364
Chrna1cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)0.355
Spna1spectrin alpha 10.355
Actc1actin, alpha, cardiac muscle 10.354
Klf6Kruppel-like factor 60.342
Gdf5growth differentiation factor 50.340
Pax7paired box gene 70.332
Agtr1aangiotensin II receptor, type 1a0.325
Tgfb2transforming growth factor, beta 20.324
Gtf2igeneral transcription factor II I0.322
Casq2calsequestrin 20.322
Pthlhparathyroid hormone-like peptide0.316
Slc4a1solute carrier family 4 (anion exchanger), member 10.314
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.310
Cacng1calcium channel, voltage-dependent, gamma subunit 10.309
Smad3MAD homolog 3 (Drosophila)0.307
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.303
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.301
Spnb2spectrin beta 20.299
Myl3myosin, light polypeptide 30.296
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.294
Tbx1T-box 10.292
Smad6MAD homolog 6 (Drosophila)0.289
Dmddystrophin, muscular dystrophy0.288
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.279
Arandrogen receptor0.278
Ryr2ryanodine receptor 2, cardiac0.274
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.269
Wwtr1WW domain containing transcription regulator 10.264
Gtf2ird1general transcription factor II I repeat domain-containing 10.263
Gata5GATA binding protein 50.261
Ryr1ryanodine receptor 1, skeletal muscle0.257
Grb10growth factor receptor bound protein 100.255
Gdf6growth differentiation factor 60.254
Myom2myomesin 20.251
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.251
Casq1calsequestrin 10.244
Fstfollistatin0.236
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.234
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.230
Myh4myosin, heavy polypeptide 4, skeletal muscle0.225
Klf3Kruppel-like factor 3 (basic)0.225
Cav3caveolin 30.223
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.223
Hspb7heat shock protein family, member 7 (cardiovascular)0.218
Drd2dopamine receptor D20.216
Mpzmyelin protein zero0.208
Tnnc1troponin C, cardiac/slow skeletal0.206
Prkceprotein kinase C, epsilon0.203
Csrp3cysteine and glycine-rich protein 30.198
Hand1heart and neural crest derivatives expressed transcript 10.197
Hey1hairy/enhancer-of-split related with YRPW motif 10.197
Myod1myogenic differentiation 10.197
Cdh23cadherin 23 (otocadherin)0.194
Msx1homeobox, msh-like 10.187
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Tm2Tropomyosin 20.031
wupAwings up A0.024
upupheld0.023
CG12558CG12558 gene product from transcript CG12558-RA0.020
Orct2Organic cation transporter 20.020
CG17658CG17658 gene product from transcript CG17658-RA0.016
Spn31ASerpin 31A0.016
Jon65AiiJonah 65Aii0.016
CG14061CG14061 gene product from transcript CG14061-RA0.015
staistathmin0.015
crolcrooked legs0.014
CG11912CG11912 gene product from transcript CG11912-RA0.014
Mlc2Myosin light chain 20.014
mbtmushroom bodies tiny0.014
Sema-1aCG18405 gene product from transcript CG18405-RD0.014
Act88FActin 88F0.014
MhcMyosin heavy chain0.013
Cf2Chorion factor 20.013
TobCG9214 gene product from transcript CG9214-RA0.013
Jon65AiJonah 65Ai0.013
blowblown fuse0.013
vlcvulcan0.013
Mlp84BMuscle LIM protein at 84B0.012
CG14684CG14684 gene product from transcript CG14684-RA0.012
apapterous0.012
srstripe0.012
Zasp66Z band alternatively spliced PDZ-motif protein 660.012
CG17838CG17838 gene product from transcript CG17838-RA0.012
Rab35CG9575 gene product from transcript CG9575-RA0.012
itpion transport peptide0.012
homerCG11324 gene product from transcript CG11324-RC0.012
TieTie-like receptor tyrosine kinase0.012
CG11911CG11911 gene product from transcript CG11911-RA0.012
nAcRalpha-80Bnicotinic Acetylcholine Receptor alpha 80B0.012
CG10909CG10909 gene product from transcript CG10909-RA0.012
CG10472CG10472 gene product from transcript CG10472-RA0.011
ProsapCG30483 gene product from transcript CG30483-RA0.011
flnflightin0.011
Mlc1Myosin alkali light chain 10.011
AcslAcyl-CoA synthetase long-chain0.011
CG3708CG3708 gene product from transcript CG3708-RA0.011
Pk61CProtein kinase 61C0.011
CG14216CG14216 gene product from transcript CG14216-RA0.011
Acp76AAccessory gland-specific peptide 76A0.011
Pkc98EProtein C kinase 98E0.011
SerSerrate0.011
fasfaint sausage0.011
CG1387CG1387 gene product from transcript CG1387-RA0.011
CanA1Calcineurin A10.011
NPFR1neuropeptide F receptor0.011
CG13424CG13424 gene product from transcript CG13424-RA0.011
CG12057CG12057 gene product from transcript CG12057-RA0.011
CG10063CG10063 gene product from transcript CG10063-RA0.011
TpnC73FTroponin C at 73F0.011
Jon25BiiiJonah 25Biii0.010
D19BCG10270 gene product from transcript CG10270-RA0.010
tnatonalli0.010
PGRP-SC2CG14745 gene product from transcript CG14745-RA0.010
CG7573CG7573 gene product from transcript CG7573-RB0.010
CG14932CG14932 gene product from transcript CG14932-RC0.010
Spn77BbSerpin 77Bb0.010
DatDopamine N acetyltransferase0.010
BG642163CG34102 gene product from transcript CG34102-RA0.010
PH4alphaNE3prolyl-4-hydroxylase-alpha NE30.010
sqzsqueeze0.010
TpnC47DTroponin C at 47D0.010
Pak3CG14895 gene product from transcript CG14895-RA0.010
CG14840CG14840 gene product from transcript CG14840-RA0.010
shakBshaking B0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TNNI1troponin I type 1 (skeletal, slow)0.850
TRIM63tripartite motif containing 630.825
TNNC1troponin C type 1 (slow)0.809
TTNtitin0.744
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.532
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.455
SNTG2syntrophin, gamma 20.390
MYOZ1myozenin 10.291
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.268
KLF6Kruppel-like factor 60.251
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.232
MRPL41mitochondrial ribosomal protein L410.198
EP300E1A binding protein p3000.195
BMPR1Bbone morphogenetic protein receptor, type IB0.187
ESR1estrogen receptor 10.178
ITGB1BP3integrin beta 1 binding protein 30.169
RICTORRPTOR independent companion of MTOR, complex 20.132
MEF2Amyocyte enhancer factor 2A0.130
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.130
HDAC4histone deacetylase 40.124
MAPTmicrotubule-associated protein tau0.100
EIF3Feukaryotic translation initiation factor 3, subunit F0.091
ACTA1actin, alpha 1, skeletal muscle0.090
TNNT2troponin T type 2 (cardiac)0.089
TNNI2troponin I type 2 (skeletal, fast)0.087
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.086
TRPC3transient receptor potential cation channel, subfamily C, member 30.077
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.069
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.066
DESdesmin0.063
MEF2Cmyocyte enhancer factor 2C0.058
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.057
HDAC9histone deacetylase 90.055
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.051
TCAPtitin-cap (telethonin)0.049
ACTN2actinin, alpha 20.048
CREBBPCREB binding protein0.047
CALCAcalcitonin-related polypeptide alpha0.046
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.045
MAPK1mitogen-activated protein kinase 10.042
IGF2Rinsulin-like growth factor 2 receptor0.042
CYLDcylindromatosis (turban tumor syndrome)0.040
NRIP1nuclear receptor interacting protein 10.039
MBNL1muscleblind-like (Drosophila)0.039
C3orf15chromosome 3 open reading frame 150.037
TNNT1troponin T type 1 (skeletal, slow)0.036
CASP10caspase 10, apoptosis-related cysteine peptidase0.036
TRIM55tripartite motif containing 550.035
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.035
MYOZ2myozenin 20.033
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.033
COASYCoA synthase0.033
PDPK13-phosphoinositide dependent protein kinase-10.032
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.031
ITPR3inositol 1,4,5-trisphosphate receptor, type 30.031
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.031
MYH7myosin, heavy chain 7, cardiac muscle, beta0.031
TBX5T-box 50.030
NCOR1nuclear receptor corepressor 10.030
YAP1Yes-associated protein 10.029
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.029
MYCBPc-myc binding protein0.028
SP1Sp1 transcription factor0.028
JUNjun proto-oncogene0.027
KLF13Kruppel-like factor 130.027
NCOA1nuclear receptor coactivator 10.026
ETNK2ethanolamine kinase 20.026
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.026
TNNI3troponin I type 3 (cardiac)0.025
NOMO1NODAL modulator 10.024
CASP8caspase 8, apoptosis-related cysteine peptidase0.024
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.023
ACACAacetyl-CoA carboxylase alpha0.022
MYL2myosin, light chain 2, regulatory, cardiac, slow0.022
MYLK2myosin light chain kinase 20.022
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.021
SMURF2SMAD specific E3 ubiquitin protein ligase 20.021
CKMcreatine kinase, muscle0.021
CTBP1C-terminal binding protein 10.021
NCOA3nuclear receptor coactivator 30.021
TNNT3troponin T type 3 (skeletal, fast)0.020
TRIM43tripartite motif containing 430.019
DLG2discs, large homolog 2 (Drosophila)0.019
HDAC5histone deacetylase 50.019
ARandrogen receptor0.019
DCNdecorin0.018
MYOGmyogenin (myogenic factor 4)0.018
LDB3LIM domain binding 30.018
PTGISprostaglandin I2 (prostacyclin) synthase0.018
MAPK6mitogen-activated protein kinase 60.018
FGFR1fibroblast growth factor receptor 10.018
NOGnoggin0.018
PKD2polycystic kidney disease 2 (autosomal dominant)0.017
PRKCQprotein kinase C, theta0.017
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.017
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.017
FAF1Fas (TNFRSF6) associated factor 10.017
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.017
OPRD1opioid receptor, delta 10.017
NEBnebulin0.017
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism