The network for 'forebrain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Shhsonic hedgehog1.000
Sox2SRY-box containing gene 21.000
Emx1empty spiracles homolog 1 (Drosophila)1.000
Gli3GLI-Kruppel family member GLI31.000
Pax6paired box gene 61.000
Fgf8fibroblast growth factor 81.000
Fgf10fibroblast growth factor 101.000
Foxg1forkhead box G11.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Pax3paired box gene 31.000
Pax2paired box gene 20.999
Fgfr2fibroblast growth factor receptor 20.999
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.999
Pitx2paired-like homeodomain transcription factor 20.998
Foxc1forkhead box C10.997
Eya1eyes absent 1 homolog (Drosophila)0.997
Tbx3T-box 30.997
Psen1presenilin 10.996
Rargretinoic acid receptor, gamma0.996
Lhx1LIM homeobox protein 10.996
Isl1ISL1 transcription factor, LIM/homeodomain0.995
Dab1disabled homolog 1 (Drosophila)0.995
Emx2empty spiracles homolog 2 (Drosophila)0.994
Hand1heart and neural crest derivatives expressed transcript 10.993
Msx1homeobox, msh-like 10.992
Pitx1paired-like homeodomain transcription factor 10.992
Gli2GLI-Kruppel family member GLI20.992
Leprleptin receptor0.991
Wnt6wingless-related MMTV integration site 60.988
Msx2homeobox, msh-like 20.988
Hes1hairy and enhancer of split 1 (Drosophila)0.987
Ikzf1IKAROS family zinc finger 10.986
Notch1Notch gene homolog 1 (Drosophila)0.985
Pax8paired box gene 80.985
Efnb2ephrin B20.985
Hes5hairy and enhancer of split 5 (Drosophila)0.985
Insm1insulinoma-associated 10.985
Lmx1bLIM homeobox transcription factor 1 beta0.984
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.983
Foxc2forkhead box C20.982
Lhx3LIM homeobox protein 30.982
Ascl1achaete-scute complex homolog 1 (Drosophila)0.982
Onecut1one cut domain, family member 10.982
Alx4aristaless-like homeobox 40.981
Drd2dopamine receptor D20.981
Gdnfglial cell line derived neurotrophic factor0.980
Sim1single-minded homolog 1 (Drosophila)0.979
Tcfap2atranscription factor AP-2, alpha0.978
Sox9SRY-box containing gene 90.977
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.976
Cckbrcholecystokinin B receptor0.975
Sox3SRY-box containing gene 30.975
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.974
Chd7chromodomain helicase DNA binding protein 70.971
Hand2heart and neural crest derivatives expressed transcript 20.970
Zic3zinc finger protein of the cerebellum 30.968
Smad3MAD homolog 3 (Drosophila)0.968
Col2a1collagen, type II, alpha 10.968
Hoxd13homeobox D130.965
Lmx1aLIM homeobox transcription factor 1 alpha0.965
Hoxa1homeobox A10.962
Bdnfbrain derived neurotrophic factor0.960
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.959
Wnt1wingless-related MMTV integration site 10.959
Otx1orthodenticle homolog 1 (Drosophila)0.959
Foxf1aforkhead box F1a0.959
Fgfr3fibroblast growth factor receptor 30.958
Foxh1forkhead box H10.957
Sall3sal-like 3 (Drosophila)0.953
Hoxa13homeobox A130.950
Wnt3awingless-related MMTV integration site 3A0.950
Fgfr1fibroblast growth factor receptor 10.947
Fgf3fibroblast growth factor 30.945
Appamyloid beta (A4) precursor protein0.945
Pou3f3POU domain, class 3, transcription factor 30.944
Itgb1integrin beta 1 (fibronectin receptor beta)0.937
Prrx1paired related homeobox 10.937
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.935
Hoxa2homeobox A20.935
Ptenphosphatase and tensin homolog0.934
UncxUNC homeobox0.934
Nr5a1nuclear receptor subfamily 5, group A, member 10.933
Epha4Eph receptor A40.933
Tcfap2ctranscription factor AP-2, gamma0.929
Pbx1pre B-cell leukemia transcription factor 10.928
Nr2e1nuclear receptor subfamily 2, group E, member 10.926
Gata4GATA binding protein 40.925
Vangl2vang-like 2 (van gogh, Drosophila)0.925
Neurog3neurogenin 30.924
Dlx5distal-less homeobox 50.923
Ptf1apancreas specific transcription factor, 1a0.922
Bmp7bone morphogenetic protein 70.921
Snai1snail homolog 1 (Drosophila)0.918
Tlx3T-cell leukemia, homeobox 30.917
Smad6MAD homolog 6 (Drosophila)0.914
Fgf4fibroblast growth factor 40.909
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.998
shhasonic hedgehog a0.997
otpaorthopedia homolog a0.996
sox2SRY-box containing gene 20.992
lhx2bLIM homeobox 2b0.991
gli1GLI-Kruppel family member 10.989
ascl1aachaete-scute complex-like 1a (Drosophila)0.989
ndr2nodal-related 20.986
gli2aGLI-Kruppel family member GLI2a0.985
atoh1aatonal homolog 1a0.981
eya1eyes absent homolog 10.978
tbx1T-box 10.977
jag2jagged 20.975
fgf8afibroblast growth factor 8 a0.973
rx3retinal homeobox gene 30.973
six3bsine oculis homeobox homolog 3b0.961
notch1anotch homolog 1a0.953
wnt11wingless-type MMTV integration site family, member 110.944
fezf2FEZ family zinc finger 20.937
otpborthopedia homolog b0.936
pax2apaired box gene 2a0.935
lef1lymphocyte enhancer binding factor 10.933
bmp2abone morphogenetic protein 2a0.930
lmo3LIM domain only 30.918
myod1myogenic differentiation 10.912
axin2axin 2 (conductin, axil)0.909
cdh2cadherin 2, neuronal0.908
robo3roundabout homolog 30.903
foxp2forkhead box P20.896
nr2e1nuclear receptor subfamily 2, group E, member 10.893
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.885
pax6apaired box gene 6a0.882
ntn1bnetrin 1b0.876
mibmind bomb0.871
six3asine oculis homeobox homolog 3a0.868
aldh1a2aldehyde dehydrogenase 1 family, member A20.868
lfnglunatic fringe homolog0.866
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.864
eomesaeomesodermin homolog a0.863
eng2bengrailed 2b0.859
notch3notch homolog 30.857
otx1borthodenticle homolog 1b0.853
fgfr2fibroblast growth factor receptor 20.847
bocbrother of CDO0.842
dlx2adistal-less homeobox gene 2a0.839
bmp2bbone morphogenetic protein 2b0.836
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.828
epha4aeph receptor A4a0.826
col2a1acollagen type II, alpha-1a0.815
rx2retinal homeobox gene 20.814
sim1asingle-minded homolog 1a (Drosophila)0.803
robo2roundabout homolog 20.798
lhx5LIM homeobox 50.789
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.781
foxg1aforkhead box G1a0.781
cxcr4achemokine (C-X-C motif) receptor 4a0.778
nkx2.1bNK2 homeobox 1b0.777
gata3GATA-binding protein 30.764
prox1prospero-related homeobox gene 10.763
pomcaproopiomelanocortin a0.759
fgfr3fibroblast growth factor receptor 30.759
fgf10afibroblast growth factor 10a0.759
tbx2bT-box 2b0.755
pax8paired box gene 80.754
traf4atnf receptor-associated factor 4a0.752
wnt2bbwingless-type MMTV integration site family, member 2Bb0.741
dbx1adeveloping brain homeobox 1a0.740
hey1hairy/enhancer-of-split related with YRPW motif 10.731
barhl2BarH-like 20.720
pcdh19protocadherin 190.710
shhbsonic hedgehog b0.694
dkk1bdickkopf 1b0.684
wnt8bwingless-type MMTV integration site family, member 8b0.673
foxa1forkhead box A10.671
wnt5bwingless-type MMTV integration site family, member 5b0.665
tp53tumor protein p530.663
klf4Kruppel-like factor 40.661
fzd8afrizzled homolog 8a0.657
nrp2bneuropilin 2b0.653
neurodneurogenic differentiation0.647
nkx2.1aNK2 homeobox 1a0.646
fgfr4fibroblast growth factor receptor 40.640
ntlano tail a0.639
pcdh8protocadherin 80.629
sox1aSRY-box containing gene 1a0.616
her6hairy-related 60.611
six4bsine oculis homeobox homolog 4b0.603
jag1bjagged 1b0.600
rargaretinoic acid receptor gamma a0.591
foxa2forkhead box A20.586
emx3empty spiracles homeobox 30.583
dmbx1adiencephalon/mesencephalon homeobox 1a0.572
zic5zic family member 5 (odd-paired homolog, Drosophila)0.570
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.998
E(spl)Enhancer of split0.996
cicubitus interruptus0.967
HLHm7E(spl) region transcript m70.955
ctpcut up0.863
ash2absent, small, or homeotic discs 20.859
shotshort stop0.807
Atg1Autophagy-specific gene 10.759
Stat92ESignal-transducer and activator of transcription protein at 92E0.752
HLHmbetaE(spl) region transcript mbeta0.748
vvlventral veins lacking0.736
sosine oculis0.728
Trim9CG31721 gene product from transcript CG31721-RB0.727
sogshort gastrulation0.723
MadMothers against dpp0.713
HLHm5E(spl) region transcript m50.709
PoxnPox neuro0.704
spensplit ends0.671
CtBPC-terminal Binding Protein0.637
osaCG7467 gene product from transcript CG7467-RD0.623
salmspalt major0.613
CG12424CG12424 gene product from transcript CG12424-RC0.602
emsempty spiracles0.584
InRInsulin-like receptor0.571
Gyc76CGuanylyl cyclase at 76C0.551
trioCG18214 gene product from transcript CG18214-RA0.546
Fas2Fasciclin 20.544
CG13253CG13253 gene product from transcript CG13253-RB0.528
foxoforkhead box, sub-group O0.512
amosabsent MD neurons and olfactory sensilla0.491
HLHmgammaE(spl) region transcript mgamma0.483
slp1sloppy paired 10.481
CkIIalphaCasein kinase II alpha subunit0.470
jingCG9397 gene product from transcript CG9397-RI0.469
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.457
RanBPMRan-binding protein M0.450
AtpalphaNa pump alpha subunit0.426
stumpsCG31317 gene product from transcript CG31317-RC0.415
Ras85DRas oncogene at 85D0.412
lolalongitudinals lacking0.403
gcmglial cells missing0.395
Syx1ASyntaxin 1A0.385
TBPHCG10327 gene product from transcript CG10327-RC0.382
Taf1TBP-associated factor 10.360
l(3)82FdCG32464 gene product from transcript CG32464-RR0.357
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR1fibroblast growth factor receptor 10.996
TP53tumor protein p530.916
PEX14peroxisomal biogenesis factor 140.864
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.844
GSK3Bglycogen synthase kinase 3 beta0.806
XIAPX-linked inhibitor of apoptosis0.760
QKIquaking homolog, KH domain RNA binding (mouse)0.750
POU3F2POU class 3 homeobox 20.743
HDAC2histone deacetylase 20.741
NCOR2nuclear receptor corepressor 20.726
ESR1estrogen receptor 10.606
PAX3paired box 30.539
CASP9caspase 9, apoptosis-related cysteine peptidase0.536
UBR1ubiquitin protein ligase E3 component n-recognin 10.518
FGF1fibroblast growth factor 1 (acidic)0.487
BMP2bone morphogenetic protein 20.476
CTBP1C-terminal binding protein 10.469
MAP3K5mitogen-activated protein kinase kinase kinase 50.451
SOX1SRY (sex determining region Y)-box 10.449
JAG1jagged 10.426
MAPTmicrotubule-associated protein tau0.414
PSEN1presenilin 10.413
SMAD3SMAD family member 30.412
VEGFAvascular endothelial growth factor A0.385
BMPR1Abone morphogenetic protein receptor, type IA0.357
NR4A1nuclear receptor subfamily 4, group A, member 10.353
HDAC1histone deacetylase 10.320
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.314
AXIN1axin 10.314
MYOD1myogenic differentiation 10.294
FOXD3forkhead box D30.292
NCOR1nuclear receptor corepressor 10.284
APPamyloid beta (A4) precursor protein0.284
PAX7paired box 70.279
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.278
SOX11SRY (sex determining region Y)-box 110.276
CRHR1corticotropin releasing hormone receptor 10.269
CASP3caspase 3, apoptosis-related cysteine peptidase0.266
ZHX1zinc fingers and homeoboxes 10.264
TMEM173transmembrane protein 1730.249
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.247
NOTCH1notch 10.246
SOX21SRY (sex determining region Y)-box 210.238
SORBS3sorbin and SH3 domain containing 30.223
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.216
BMP7bone morphogenetic protein 70.214
RBBP8retinoblastoma binding protein 80.209
SMAD2SMAD family member 20.202
PMLpromyelocytic leukemia0.196
TBX5T-box 50.189
BCL2L1BCL2-like 10.186
HIC1hypermethylated in cancer 10.183
BBS4Bardet-Biedl syndrome 40.173
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.167
NCOA1nuclear receptor coactivator 10.161
EPAS1endothelial PAS domain protein 10.160
PAX6paired box 60.159
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.154
LBX1ladybird homeobox 10.148
LAMC1laminin, gamma 1 (formerly LAMB2)0.148
SFRP1secreted frizzled-related protein 10.145
NEDD4neural precursor cell expressed, developmentally down-regulated 40.144
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.144
ATXN1ataxin 10.143
PAX8paired box 80.141
TCF4transcription factor 40.139
FGF3fibroblast growth factor 30.138
SCHIP1schwannomin interacting protein 10.138
SMAD7SMAD family member 70.137
TAL1T-cell acute lymphocytic leukemia 10.134
WNT1wingless-type MMTV integration site family, member 10.134
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.133
PDX1pancreatic and duodenal homeobox 10.121
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.120
LAMB1laminin, beta 10.120
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.118
PTCH1patched 10.118
FBLN1fibulin 10.115
DAXXdeath-domain associated protein0.113
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.113
SMAD4SMAD family member 40.110
BCL2B-cell CLL/lymphoma 20.108
TSC2tuberous sclerosis 20.106
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.105
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.105
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.103
SIX6SIX homeobox 60.103
FOXA2forkhead box A20.102
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.102
CHD3chromodomain helicase DNA binding protein 30.101
C1QL1complement component 1, q subcomponent-like 10.101
APCadenomatous polyposis coli0.100
GAS6growth arrest-specific 60.099
PBX1pre-B-cell leukemia homeobox 10.098
HOXC8homeobox C80.097
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.096
CTNND1catenin (cadherin-associated protein), delta 10.096
MSX1msh homeobox 10.096
USP46ubiquitin specific peptidase 460.096
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.095
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Htr65-hydroxytryptamine (serotonin) receptor 60.600
Cckbrcholecystokinin B receptor0.578
Fgfr2fibroblast growth factor receptor 20.465
DbpD site of albumin promoter (albumin D-box) binding protein0.392
Galr3galanin receptor 30.387
Chrm1cholinergic receptor, muscarinic 10.351
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.339
RorbRAR-related orphan receptor B0.333
Dlg4discs, large homolog 4 (Drosophila)0.332
Hrh2histamine receptor H 20.313
Chrna7cholinergic receptor, nicotinic, alpha 70.306
Cgaglycoprotein hormones, alpha polypeptide0.290
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.290
Lim2lens intrinsic membrane protein 20.284
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.275
Adora3adenosine A3 receptor0.269
Iappislet amyloid polypeptide0.262
Crhbpcorticotropin releasing hormone binding protein0.257
Lhbluteinizing hormone beta0.244
Dlgap3discs, large (Drosophila) homolog-associated protein 30.241
Mc5rmelanocortin 5 receptor0.241
Grik1glutamate receptor, ionotropic, kainate 10.240
LOC246267resection-induced TPI (rs11)0.237
Gad2glutamate decarboxylase 20.234
Grm1glutamate receptor, metabotropic 10.228
Eporerythropoietin receptor0.224
Tnrtenascin R0.224
Robo1roundabout homolog 1 (Drosophila)0.224
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.224
Nrxn3neurexin 30.221
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.221
Drd1adopamine receptor D1A0.217
Arandrogen receptor0.214
Gcm1glial cells missing homolog 1 (Drosophila)0.213
Prlrprolactin receptor0.211
Arnt2aryl hydrocarbon receptor nuclear translocator 20.209
Avparginine vasopressin0.209
Pou3f2POU class 3 homeobox 20.207
Gng7guanine nucleotide binding protein (G protein), gamma 70.207
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.206
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.205
Myo1dmyosin ID0.204
Prrx1paired related homeobox 10.203
Hes3hairy and enhancer of split 3 (Drosophila)0.202
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.198
Bcl2B-cell CLL/lymphoma 20.198
Olr287olfactory receptor 2870.194
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.193
Lama5laminin, alpha 50.191
Dlx5distal-less homeobox 50.190
Sirpasignal-regulatory protein alpha0.186
Pcdhgc3protocadherin gamma subfamily C, 30.185
Neurod2neurogenic differentiation 20.185
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.184
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.183
Myt1lmyelin transcription factor 1-like0.182
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.182
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.178
Ompolfactory marker protein0.177
Ddr1discoidin domain receptor tyrosine kinase 10.177
Oprm1opioid receptor, mu 10.175
Npy5rneuropeptide Y receptor Y50.173
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.172
Egr3early growth response 30.171
Cpb1carboxypeptidase B1 (tissue)0.170
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.170
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.164
Cst8cystatin 8 (cystatin-related epididymal specific)0.163
Scn10asodium channel, voltage-gated, type X, alpha subunit0.162
Gria4glutamate receptor, ionotrophic, AMPA 40.162
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.159
Olr1078olfactory receptor 10780.159
Adrb1adrenergic, beta-1-, receptor0.158
Olr226olfactory receptor 2260.157
Gad1glutamate decarboxylase 10.156
Barhl1BarH-like homeobox 10.155
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.151
Hoxa2homeo box A20.150
Wt1Wilms tumor 10.150
Shox2short stature homeobox 20.149
Ptprcprotein tyrosine phosphatase, receptor type, C0.147
Ube2d4ubiquitin-conjugating enzyme E2D 40.147
Drd2dopamine receptor D20.146
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.146
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.143
Ptger1prostaglandin E receptor 1 (subtype EP1)0.143
Itgamintegrin, alpha M0.141
Ednrbendothelin receptor type B0.140
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.140
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.139
Lnpepleucyl/cystinyl aminopeptidase0.139
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.138
Akap5A kinase (PRKA) anchor protein 50.138
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.137
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.137
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.137
Prdm2PR domain containing 2, with ZNF domain0.136
Hoxb7homeo box B70.133
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism