The network for 'negative regulation of dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of dna replication

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Brca1breast cancer 10.975
Smc1astructural maintenance of chromosomes 1A0.975
Nbnnibrin0.949
Atmataxia telangiectasia mutated homolog (human)0.941
Trp73transformation related protein 730.898
Smc3structural maintenace of chromosomes 30.896
Ptenphosphatase and tensin homolog0.864
Terf1telomeric repeat binding factor 10.845
Rbl1retinoblastoma-like 1 (p107)0.786
Mdm4transformed mouse 3T3 cell double minute 40.765
SkilSKI-like0.758
Mdm2transformed mouse 3T3 cell double minute 20.738
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.727
Rb1retinoblastoma 10.649
Msh2mutS homolog 2 (E. coli)0.591
Mybl2myeloblastosis oncogene-like 20.579
Apcadenomatosis polyposis coli0.469
Rararetinoic acid receptor, alpha0.449
Kitlkit ligand0.439
Chukconserved helix-loop-helix ubiquitous kinase0.432
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.383
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.376
DaxxFas death domain-associated protein0.362
E2f1E2F transcription factor 10.356
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.342
Mecp2methyl CpG binding protein 20.329
Brca2breast cancer 20.323
Rad21RAD21 homolog (S. pombe)0.307
Tsc2tuberous sclerosis 20.299
Col1a1collagen, type I, alpha 10.269
Acdadrenocortical dysplasia0.259
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.252
Smad3MAD homolog 3 (Drosophila)0.239
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.224
Leprleptin receptor0.224
Trp63transformation related protein 630.218
Mlh1mutL homolog 1 (E. coli)0.200
Fgfr2fibroblast growth factor receptor 20.199
Nf1neurofibromatosis 10.189
Tsc1tuberous sclerosis 10.188
Suz12suppressor of zeste 12 homolog (Drosophila)0.180
Mycmyelocytomatosis oncogene0.133
Parp1poly (ADP-ribose) polymerase family, member 10.126
Wdr43WD repeat domain 430.118
Cdkn1bcyclin-dependent kinase inhibitor 1B0.117
WrnWerner syndrome homolog (human)0.116
Huwe1HECT, UBA and WWE domain containing 10.113
Cav1caveolin 1, caveolae protein0.111
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.111
Stk11serine/threonine kinase 110.110
Pkdccprotein kinase domain containing, cytoplasmic0.109
Ctnnb1catenin (cadherin associated protein), beta 10.105
Hellshelicase, lymphoid specific0.104
Men1multiple endocrine neoplasia 10.103
Mapk14mitogen-activated protein kinase 140.103
Nr3c1nuclear receptor subfamily 3, group C, member 10.100
Tfdp2transcription factor Dp 20.098
Shhsonic hedgehog0.098
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.094
Stat1signal transducer and activator of transcription 10.093
Stat6signal transducer and activator of transcription 60.090
BrafBraf transforming gene0.090
Cxcr4chemokine (C-X-C motif) receptor 40.086
Nup54nucleoporin 540.086
Sox2SRY-box containing gene 20.086
Arntlaryl hydrocarbon receptor nuclear translocator-like0.086
Rbl2retinoblastoma-like 20.085
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.081
Rrs1RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)0.081
Gli3GLI-Kruppel family member GLI30.080
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.079
Yap1yes-associated protein 10.078
Ep300E1A binding protein p3000.076
Cdkn2acyclin-dependent kinase inhibitor 2A0.076
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.076
Copz2coatomer protein complex, subunit zeta 20.076
Ltv1LTV1 homolog (S. cerevisiae)0.075
Stk4serine/threonine kinase 40.072
Wlswntless homolog (Drosophila)0.071
En1engrailed 10.069
Dna2DNA replication helicase 2 homolog (yeast)0.068
Smn1survival motor neuron 10.067
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.067
Rint1RAD50 interactor 10.067
Dok1docking protein 10.065
Actr6ARP6 actin-related protein 6 homolog (yeast)0.064
Arid1bAT rich interactive domain 1B (SWI-like)0.064
Sox9SRY-box containing gene 90.064
Rad50RAD50 homolog (S. cerevisiae)0.063
Ints9integrator complex subunit 90.063
Hcfc1host cell factor C10.059
Atad5ATPase family, AAA domain containing 50.059
Smad2MAD homolog 2 (Drosophila)0.059
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.058
Twist1twist homolog 1 (Drosophila)0.058
CebpzCCAAT/enhancer binding protein zeta0.056
Esr1estrogen receptor 1 (alpha)0.056
Bmpr1abone morphogenetic protein receptor, type 1A0.056
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.055
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.144
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.123
gpiaglucose phosphate isomerase a0.119
zgc:64114zgc:641140.098
zgc:171553zgc:1715530.097
mapk14amitogen-activated protein kinase 14a0.095
sox11bSRY-box containing gene 11b0.090
paf1paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.081
eif3ceukaryotic translation initiation factor 3, subunit C0.076
mef2amyocyte enhancer factor 2a0.070
nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.068
zff9zinc finger protein 90.068
smad5MAD homolog 5 (Drosophila)0.062
mbnl2muscleblind-like 2 (Drosophila)0.061
ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.058
ca15bcarbonic anhydrase XV b0.058
hcfc1ahost cell factor C1a0.056
nap1l1nucleosome assembly protein 1, like 10.052
smc1alstructural maintenance of chromosomes 1A, like0.051
mapk1mitogen-activated protein kinase 10.051
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.051
mapk6mitogen-activated protein kinase 60.050
mapk3mitogen-activated protein kinase 30.050
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.049
col5a1procollagen, type V, alpha 10.048
cacnb2bcalcium channel, voltage-dependent, beta 2b0.048
cx43.4connexin 43.40.046
zgc:73273zgc:732730.045
frem3Fras1 related extracellular matrix 30.045
crhcorticotropin releasing hormone0.044
sparcsecreted acidic cysteine rich glycoprotein0.043
stmn4stathmin-like 40.043
fabp11afatty acid binding protein 11a0.042
zgc:123178zgc:1231780.042
smc3structural maintenance of chromosomes 30.042
gro2groucho 20.041
leprleptin receptor0.041
si:ch211-57k11.10si:ch211-57k11.100.041
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.041
tnfatumor necrosis factor a (TNF superfamily, member 2)0.041
pinx1pin2/trf1-interacting protein 10.040
sh3gl1bSH3-domain GRB2-like 1b0.040
ctgfconnective tissue growth factor0.039
dnmt5DNA (cytosine-5-)-methyltransferase 50.039
lzts2aleucine zipper, putative tumor suppressor 2a0.039
chrna6cholinergic receptor, nicotinic, alpha 60.039
stmn2bstathmin-like 2b0.038
bactin1bactin10.038
rorcaRAR-related orphan receptor C a0.038
satb2SATB homeobox 20.038
nacanascent polypeptide-associated complex alpha polypeptide0.038
nr0b1nuclear receptor subfamily 0, group B, member 10.037
morc2MORC family CW-type zinc finger 20.037
col10a1collagen, type X, alpha 10.036
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.036
dnmt1DNA (cytosine-5-)-methyltransferase 10.036
igf2binsulin-like growth factor 2b0.034
rad21RAD21 homolog (S. pombe)0.033
si:dkey-228g21.4si:dkey-228g21.40.033
srrm2serine/arginine repetitive matrix 20.033
twist1atwist1a0.033
ripply1ripply10.032
sid4secreted immunoglobulin domain 40.032
valopbvertebrate ancient long opsin b0.032
ccnecyclin E0.031
vsx2visual system homeobox 20.031
pck1phosphoenolpyruvate carboxykinase 1 (soluble)0.031
srsf4serine/arginine-rich splicing factor 40.031
fgf8afibroblast growth factor 8 a0.031
palb2partner and localizer of BRCA20.031
igfbp3insulin-like growth factor binding protein 30.030
p2rx8purinergic receptor P2X, ligand-gated ion channel, 80.030
spry4sprouty (Drosophila) homolog 40.030
im:7153552im:71535520.030
ephb4beph receptor B4b0.030
si:dkey-67c22.2si:dkey-67c22.20.030
zgc:154063zgc:1540630.030
zgc:112986zgc:1129860.029
th2tyrosine hydroxylase 20.029
matr3lmatrin 3-like0.029
cpceruloplasmin0.029
pdlim1PDZ and LIM domain 1 (elfin)0.028
sox9bSRY-box containing gene 9b0.028
kiss1rbKISS1 receptor b0.028
celf1cugbp, Elav-like family member 10.028
zgc:63947zgc:639470.028
prpf4bPRP4 pre-mRNA processing factor 4 homolog B0.028
rykreceptor-like tyrosine kinase0.027
myod1myogenic differentiation 10.027
junbjun B proto-oncogene0.027
gpibglucose phosphate isomerase b0.027
trpm6transient receptor potential cation channel, subfamily M, member 60.027
gng8guanine nucleotide binding protein (G protein), gamma 80.027
irf2bp2binterferon regulatory factor 2 binding protein 2b0.027
stat1bsignal transducer and activator of transcription 1b0.027
dhfrdihydrofolate reductase0.026
lmnalamin A0.026
eif4ebp3leukaryotic translation initiation factor 4E binding protein 3, like0.026
eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)0.026
sass6spindle assembly 6 homolog (C. elegans)0.026
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
RbfRetinoblastoma-family protein0.114
debcldeath executioner Bcl-2 homologue0.066
pngpan gu0.049
DpDP transcription factor0.033
tefutelomere fusion0.029
CG9772CG9772 gene product from transcript CG9772-RB0.020
dapdacapo0.016
CG10414CG10414 gene product from transcript CG10414-RA0.015
Cdk4Cyclin-dependent kinase 40.013
lunaCG33473 gene product from transcript CG33473-RB0.013
mus304mutagen-sensitive 3040.012
rad50CG6339 gene product from transcript CG6339-RD0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMC1Astructural maintenance of chromosomes 1A0.985
STAG2stromal antigen 20.982
STAG1stromal antigen 10.980
WAPALwings apart-like homolog (Drosophila)0.976
RAD21RAD21 homolog (S. pombe)0.952
SMC3structural maintenance of chromosomes 30.952
NBNnibrin0.892
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.863
RBL2retinoblastoma-like 2 (p130)0.861
RAD50RAD50 homolog (S. cerevisiae)0.719
TERF1telomeric repeat binding factor (NIMA-interacting) 10.702
PDS5APDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.680
PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.655
BRCA1breast cancer 1, early onset0.594
RB1retinoblastoma 10.554
TERF2telomeric repeat binding factor 20.532
TINF2TERF1 (TRF1)-interacting nuclear factor 20.474
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.431
ATMataxia telangiectasia mutated0.347
CDK2cyclin-dependent kinase 20.345
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.334
RFC1replication factor C (activator 1) 1, 145kDa0.306
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.296
NR2E3nuclear receptor subfamily 2, group E, member 30.246
TERF2IPtelomeric repeat binding factor 2, interacting protein0.235
ENGendoglin0.190
RBBP8retinoblastoma binding protein 80.176
RBL1retinoblastoma-like 1 (p107)0.161
MDM2Mdm2 p53 binding protein homolog (mouse)0.147
CNOT2CCR4-NOT transcription complex, subunit 20.126
CCNE1cyclin E10.122
MDM4Mdm4 p53 binding protein homolog (mouse)0.116
CDC26cell division cycle 26 homolog (S. cerevisiae)0.115
UHRF2ubiquitin-like with PHD and ring finger domains 20.115
EZRezrin0.112
C17orf28chromosome 17 open reading frame 280.110
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.099
MMS22LMMS22-like, DNA repair protein0.094
INSRinsulin receptor0.093
SCHIP1schwannomin interacting protein 10.092
TBC1D10ATBC1 domain family, member 10A0.079
E2F5E2F transcription factor 5, p130-binding0.079
WRNWerner syndrome, RecQ helicase-like0.075
CNOT7CCR4-NOT transcription complex, subunit 70.074
INO80BINO80 complex subunit B0.074
LIN9lin-9 homolog (C. elegans)0.068
ACDadrenocortical dysplasia homolog (mouse)0.068
SKP2S-phase kinase-associated protein 2 (p45)0.064
ORC2origin recognition complex, subunit 20.061
CCDC6coiled-coil domain containing 60.060
CNOT1CCR4-NOT transcription complex, subunit 10.059
FSTL1follistatin-like 10.057
LARP7La ribonucleoprotein domain family, member 70.056
LIN54lin-54 homolog (C. elegans)0.055
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.054
SSU72SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)0.053
RAD9ARAD9 homolog A (S. pombe)0.053
EP300E1A binding protein p3000.052
TGFB1transforming growth factor, beta 10.049
JUBjub, ajuba homolog (Xenopus laevis)0.048
SORBS1sorbin and SH3 domain containing 10.048
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.043
BLMBloom syndrome, RecQ helicase-like0.042
FANCD2Fanconi anemia, complementation group D20.040
NUP153nucleoporin 153kDa0.039
HIPK2homeodomain interacting protein kinase 20.038
DEKDEK oncogene0.036
BTRCbeta-transducin repeat containing0.036
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit0.034
E2F1E2F transcription factor 10.034
TGFB3transforming growth factor, beta 30.034
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.034
RIF1RAP1 interacting factor homolog (yeast)0.033
BAZ1Abromodomain adjacent to zinc finger domain, 1A0.033
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.033
MYH9myosin, heavy chain 9, non-muscle0.032
CUL1cullin 10.031
RAD1RAD1 homolog (S. pombe)0.030
ATRXalpha thalassemia/mental retardation syndrome X-linked0.030
AFF1AF4/FMR2 family, member 10.030
AFF4AF4/FMR2 family, member 40.030
NRP1neuropilin 10.029
RAD17RAD17 homolog (S. pombe)0.029
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.029
CNOT8CCR4-NOT transcription complex, subunit 80.028
HNRNPKheterogeneous nuclear ribonucleoprotein K0.027
DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)0.026
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.026
DAXXdeath-domain associated protein0.025
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.025
RHOAras homolog gene family, member A0.025
MSNmoesin0.025
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.024
CCNT1cyclin T10.024
CKS2CDC28 protein kinase regulatory subunit 20.023
TAF1ATATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa0.023
BANPBTG3 associated nuclear protein0.023
E2F4E2F transcription factor 4, p107/p130-binding0.023
SIN3ASIN3 homolog A, transcription regulator (yeast)0.022
ANAPC4anaphase promoting complex subunit 40.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD53Rad53p0.330
MRC1Mrc1p0.242
NOP10Nop10p0.217
CDC34Cdc34p0.132
EST1Est1p0.127
HRK1Hrk1p0.115
PTK2Ptk2p0.102
POL1Pol1p0.082
DUN1Dun1p0.072
RIO1Rio1p0.072
PDS1Pds1p0.068
CSM3Csm3p0.066
TEN1Ten1p0.065
PDS5Pds5p0.062
DIA2Dia2p0.060
RAD5Rad5p0.054
MMS1Mms1p0.049
PSY2Psy2p0.049
POL12Pol12p0.046
TOF2Tof2p0.046
YPL260Whypothetical protein0.046
HSL1Hsl1p0.044
ESF1Esf1p0.042
TOR1Tor1p0.042
NOP7Nop7p0.040
RRM3Rrm3p0.039
PRI1Pri1p0.037
NET1Net1p0.036
GAR1Gar1p0.036
CMK2Cmk2p0.035
PAM1Pam1p0.035
IRC8Irc8p0.034
HOP1Hop1p0.034
YLR177Whypothetical protein0.033
SAE2Sae2p0.032
TOF1Tof1p0.031
DDC1Ddc1p0.028
CDC14Cdc14p0.028
MDS3Mds3p0.028
TEL1Tel1p0.027
EST2Est2p0.026
VID22Vid22p0.026
CDH1Cdh1p0.025
HAL5Hal5p0.025
UTR1Utr1p0.024
TCO89Tco89p0.024
CTF18Ctf18p0.024
POP2Pop2p0.024
YPS1Yps1p0.023
RAD9Rad9p0.023
MEC1Mec1p0.022
CDC13Cdc13p0.022
CDC4Cdc4p0.022
SEF1Sef1p0.022
CDC20Cdc20p0.022
YNL234Whypothetical protein0.022
RGC1Rgc1p0.022
NAF1Naf1p0.022
ADE16Ade16p0.022
YPK1Ypk1p0.021
YLR162Whypothetical protein0.021
RMI1Rmi1p0.021
MCM4Mcm4p0.021
RED1Red1p0.021
NUP157Nup157p0.020
RAD24Rad24p0.020
RRP36Rrp36p0.020
AKL1Akl1p0.019
CDC9Cdc9p0.019
CDC23Cdc23p0.019
MCM10Mcm10p0.019
RTS1Rts1p0.019
YIL151Chypothetical protein0.019
SCH9Sch9p0.019
SCC2Scc2p0.019
OSH2Osh2p0.019
ROD1Rod1p0.018
VHS1Vhs1p0.018
SIA1Sia1p0.018
PRI2Pri2p0.018
MBF1Mbf1p0.018
MSI1Msi1p0.017
NUR1Nur1p0.017
YGR071Chypothetical protein0.016
RCK2Rck2p0.016
RIF1Rif1p0.016
YLR257Whypothetical protein0.016
KOG1Kog1p0.016
AZF1Azf1p0.016
YBL081Whypothetical protein0.015
HOG1Hog1p0.015
YTM1Ytm1p0.015
DIN7Din7p0.015
YOR385Whypothetical protein0.015
SRD1Srd1p0.015
SMC6Smc6p0.015
SAK1Sak1p0.015
ZPS1Zps1p0.015
TOP1Top1p0.015
YLR264C-Ahypothetical protein0.014