The network for 'dna replication initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna replication initiation

The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cdt1chromatin licensing and DNA replication factor 10.996
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.978
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.871
Ccne1cyclin E10.703
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.673
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.558
Cdk2cyclin-dependent kinase 20.455
Prim1DNA primase, p49 subunit0.277
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.236
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.235
Timelesstimeless homolog (Drosophila)0.189
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.184
Orc1origin recognition complex, subunit 10.148
Orc6origin recognition complex, subunit 60.132
Tcf19transcription factor 190.117
Cdc45cell division cycle 45 homolog (S. cerevisiae)0.109
Prim2DNA primase, p58 subunit0.103
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.101
Rrm2ribonucleotide reductase M20.074
Rpgrip1lRpgrip1-like0.054
Wdhd1WD repeat and HMG-box DNA binding protein 10.053
Cdca7cell division cycle associated 70.051
Kdm5blysine (K)-specific demethylase 5B0.050
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.046
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.043
Chaf1bchromatin assembly factor 1, subunit B (p60)0.032
Hdac1histone deacetylase 10.031
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.028
Lig1ligase I, DNA, ATP-dependent0.028
Lrrk2leucine-rich repeat kinase 20.023
Iqcb1IQ calmodulin-binding motif containing 10.022
Ccna2cyclin A20.020
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.019
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.018
Hellshelicase, lymphoid specific0.017
Sept7septin 70.016
Rcc1regulator of chromosome condensation 10.015
Orc2origin recognition complex, subunit 20.014
Gtse1G two S phase expressed protein 10.013
Aurkaaurora kinase A0.013
Rad51ap1RAD51 associated protein 10.013
Rrm1ribonucleotide reductase M10.012
Unguracil DNA glycosylase0.012
Pola1polymerase (DNA directed), alpha 10.012
Srebf2sterol regulatory element binding factor 20.012
Rnf220ring finger protein 2200.010
Ezh2enhancer of zeste homolog 2 (Drosophila)0.010
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Orc2Origin recognition complex subunit 20.976
dpadisc proliferation abnormal0.806
hdhumpty dumpty0.795
Mcm5Minichromosome maintenance 50.640
dupdouble parked0.559
Mcm2Minichromosome maintenance 20.531
Orc5Origin recognition complex subunit 50.409
dapdacapo0.353
mus209mutagen-sensitive 2090.293
DNApol-alpha60DNA polymerase alpha 60kD0.260
Mcm6Minichromosome maintenance 60.186
mus101mutagen-sensitive 1010.176
RnrSRibonucleoside diphosphate reductase small subunit0.115
Ndc80CG9938 gene product from transcript CG9938-RA0.100
Mcm10Sensitized chromosome inheritance modifier 190.087
CG3430CG3430 gene product from transcript CG3430-RA0.076
CDC45LCG3658 gene product from transcript CG3658-RA0.072
Mcm3Minichromosome maintenance 30.061
prodproliferation disrupter0.061
vtdverthandi0.056
RfC4Replication factor C subunit 40.046
DNApol-alpha73DNA polymerase alpha 73kD0.037
Caf1Chromatin assembly factor 1 subunit0.037
RnrLRibonucleoside diphosphate reductase large subunit0.034
RbfRetinoblastoma-family protein0.033
SlbpStem-loop binding protein0.032
SMC2CG10212 gene product from transcript CG10212-RA0.032
DNApol-alpha50DNA polymerase alpha 50kD0.031
nebnebbish0.030
stgstring0.029
cdc2cCG10498 gene product from transcript CG10498-RC0.028
BubR1Bub1-related kinase0.028
barrbarren0.026
Dcp-1Death caspase-10.026
Cks30ACyclin-dependent kinase subunit 30A0.025
DNApol-deltaDNA-polymerase-delta0.024
Caf1-105CG12892 gene product from transcript CG12892-RA0.024
Mcm7Minichromosome maintenance 70.020
rodrough deal0.018
WRNexoWRN exonuclease0.017
asf1anti-silencing factor 10.017
RecQ4CG7487 gene product from transcript CG7487-RA0.016
Ets97DEts at 97D0.016
Orc6Origin recognition complex subunit 60.015
CycJCyclin J0.014
cmetCENP-meta0.014
Klp67AKinesin-like protein at 67A0.013
mus301mutagen-sensitive 3010.013
gemininCG3183 gene product from transcript CG3183-RA0.012
Pole2CG10489 gene product from transcript CG10489-RA0.011
latlatheo0.011
CG13350CG13350 gene product from transcript CG13350-RA0.011
pavpavarotti0.011
SseSeparase0.011
ncdnon-claret disjunctional0.011
Klp61FKinesin-like protein at 61F0.011
spn-Aspindle A0.011
Orc4Origin recognition complex subunit 40.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MCM3minichromosome maintenance complex component 31.000
CDK2cyclin-dependent kinase 21.000
MCM2minichromosome maintenance complex component 21.000
CDC6cell division cycle 6 homolog (S. cerevisiae)1.000
MCM4minichromosome maintenance complex component 41.000
MCM6minichromosome maintenance complex component 61.000
ORC2origin recognition complex, subunit 21.000
ORC1origin recognition complex, subunit 11.000
ORC5origin recognition complex, subunit 51.000
MCM7minichromosome maintenance complex component 70.999
MCM10minichromosome maintenance complex component 100.998
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.998
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.996
ORC3origin recognition complex, subunit 30.996
CDC45cell division cycle 45 homolog (S. cerevisiae)0.994
ORC6origin recognition complex, subunit 60.967
CCNE1cyclin E10.953
CDC7cell division cycle 7 homolog (S. cerevisiae)0.940
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.803
MCM5minichromosome maintenance complex component 50.750
CDT1chromatin licensing and DNA replication factor 10.742
CHAF1Achromatin assembly factor 1, subunit A (p150)0.685
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.577
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.567
MCMBPminichromosome maintenance complex binding protein0.543
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.381
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.333
MMS22LMMS22-like, DNA repair protein0.253
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.229
GMNNgeminin, DNA replication inhibitor0.222
RPA1replication protein A1, 70kDa0.186
ORC4origin recognition complex, subunit 40.184
CDC25Acell division cycle 25 homolog A (S. pombe)0.180
ANAPC4anaphase promoting complex subunit 40.164
SSRP1structure specific recognition protein 10.148
DBF4DBF4 homolog (S. cerevisiae)0.118
UHRF2ubiquitin-like with PHD and ring finger domains 20.112
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.107
MCM8minichromosome maintenance complex component 80.094
SKP2S-phase kinase-associated protein 2 (p45)0.089
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.088
CCNB2cyclin B20.074
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.061
ANAPC1anaphase promoting complex subunit 10.055
PRIM2primase, DNA, polypeptide 2 (58kDa)0.050
RPA2replication protein A2, 32kDa0.042
E2F1E2F transcription factor 10.038
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.034
CCDC6coiled-coil domain containing 60.033
RBL1retinoblastoma-like 1 (p107)0.031
CDC25Bcell division cycle 25 homolog B (S. pombe)0.031
MORF4L1mortality factor 4 like 10.029
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.021
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.020
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.018
GINS2GINS complex subunit 2 (Psf2 homolog)0.018
CDR2cerebellar degeneration-related protein 2, 62kDa0.016
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.015
HCFC1host cell factor C1 (VP16-accessory protein)0.014
MRFAP1Morf4 family associated protein 10.014
CDC26cell division cycle 26 homolog (S. cerevisiae)0.013
SMC1Astructural maintenance of chromosomes 1A0.010
CLSPNclaspin0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MCM5Mcm5p0.999
ORC2Orc2p0.998
CDC45Cdc45p0.996
MCM2Mcm2p0.996
MCM4Mcm4p0.996
MCM3Mcm3p0.993
ORC3Orc3p0.987
MCM7Mcm7p0.982
ORC1Orc1p0.981
MCM6Mcm6p0.978
CDC6Cdc6p0.974
CLB5Clb5p0.972
ORC6Orc6p0.961
DBF4Dbf4p0.949
SLD5Sld5p0.923
ORC5Orc5p0.916
SLD3Sld3p0.913
MCM10Mcm10p0.893
CHL1Chl1p0.867
MRC1Mrc1p0.857
DIA2Dia2p0.770
PSF1Psf1p0.682
SLD2Sld2p0.660
ORC4Orc4p0.649
RAD53Rad53p0.610
POL1Pol1p0.524
DPB2Dpb2p0.498
SIN3Sin3p0.453
SDS3Sds3p0.453
HST1Hst1p0.441
MDN1Mdn1p0.430
POL32Pol32p0.370
TAH11Tah11p0.340
DPB11Dpb11p0.327
POL12Pol12p0.300
SIR2Sir2p0.228
TOF1Tof1p0.218
SUM1Sum1p0.217
PHO23Pho23p0.215
PDS1Pds1p0.207
NOC3Noc3p0.201
SYF1Syf1p0.196
RAD9Rad9p0.182
HAT1Hat1p0.174
HST3Hst3p0.158
RLF2Rlf2p0.138
CTF18Ctf18p0.136
CDC7Cdc7p0.134
CDC14Cdc14p0.133
PDS5Pds5p0.114
BMH1Bmh1p0.112
POL2Pol2p0.111
SNT1Snt1p0.110
PSF2Psf2p0.107
CLB6Clb6p0.107
BUB1Bub1p0.105
UME1Ume1p0.101
PRI1Pri1p0.099
SIC1Sic1p0.097
CDC34Cdc34p0.088
YOR060Chypothetical protein0.083
CTF4Ctf4p0.082
CTI6Cti6p0.080
SPT21Spt21p0.079
RCO1Rco1p0.079
FOB1Fob1p0.078
IPI3Ipi3p0.076
RSC4Rsc4p0.074
NDD1Ndd1p0.073
RIF1Rif1p0.067
MSA1Msa1p0.065
NOG1Nog1p0.057
HAL5Hal5p0.056
TOP1Top1p0.054
RSA1Rsa1p0.052
SCC2Scc2p0.052
SET3Set3p0.050
SET2Set2p0.049
TFA1Tfa1p0.049
FKH2Fkh2p0.048
MET4Met4p0.048
EAF3Eaf3p0.048
POL31Pol31p0.045
RPF1Rpf1p0.045
OPT2Opt2p0.044
MOT3Mot3p0.044
YLR257Whypothetical protein0.044
UME6Ume6p0.043
SPT5Spt5p0.043
YNR014Whypothetical protein0.042
HOS4Hos4p0.042
VMA13Vma13p0.042
YCG1Ycg1p0.041
LEU2Leu2p0.041
ADH2Adh2p0.041
MRK1Mrk1p0.040
HOP1Hop1p0.040
YLR177Whypothetical protein0.039
RFC4Rfc4p0.039
MIF2Mif2p0.039