The network for 'regulation of execution phase of apoptosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of execution phase of apoptosis

Any process that modulates the frequency, rate or extent of execution phase of apoptosis.

NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.937
Casp1caspase 10.812
Gbp5guanylate binding protein 50.802
Gopcgolgi associated PDZ and coiled-coil motif containing0.685
PycardPYD and CARD domain containing0.680
Wnt5awingless-related MMTV integration site 5A0.242
Aim2absent in melanoma 20.232
Fzd8frizzled homolog 8 (Drosophila)0.182
Dlg4discs, large homolog 4 (Drosophila)0.170
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.152
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.145
Sfrp2secreted frizzled-related protein 20.133
Il18interleukin 180.125
Gli3GLI-Kruppel family member GLI30.122
Bcl2B-cell leukemia/lymphoma 20.107
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.104
Tlr4toll-like receptor 40.096
Mrc2mannose receptor, C type 20.091
Gpc3glypican 30.091
Hes1hairy and enhancer of split 1 (Drosophila)0.082
Nlrp3NLR family, pyrin domain containing 30.078
Casp3caspase 30.074
Hif1ahypoxia inducible factor 1, alpha subunit0.072
Plin1perilipin 10.067
Cfdcomplement factor D (adipsin)0.060
Gas1growth arrest specific 10.058
Mfap2microfibrillar-associated protein 20.053
Fzd7frizzled homolog 7 (Drosophila)0.050
Sfrp1secreted frizzled-related protein 10.049
Casp7caspase 70.044
Efsembryonal Fyn-associated substrate0.042
Il1binterleukin 1 beta0.042
Fzd1frizzled homolog 1 (Drosophila)0.041
Sox13SRY-box containing gene 130.041
Fbln1fibulin 10.040
Fgfr2fibroblast growth factor receptor 20.039
Smad3MAD homolog 3 (Drosophila)0.038
Npr3natriuretic peptide receptor 30.038
Gtf2ird1general transcription factor II I repeat domain-containing 10.037
Rbl1retinoblastoma-like 1 (p107)0.037
Rb1retinoblastoma 10.036
Dlg2discs, large homolog 2 (Drosophila)0.035
Tead2TEA domain family member 20.035
Adam10a disintegrin and metallopeptidase domain 100.034
Dlg1discs, large homolog 1 (Drosophila)0.034
Sardhsarcosine dehydrogenase0.033
Bak1BCL2-antagonist/killer 10.033
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.032
Ephb3Eph receptor B30.031
Bcl10B-cell leukemia/lymphoma 100.027
Plxna3plexin A30.027
Pbx1pre B-cell leukemia transcription factor 10.027
Twist1twist homolog 1 (Drosophila)0.027
Mettl5methyltransferase like 50.027
Becn1beclin 1, autophagy related0.027
Ssbp1single-stranded DNA binding protein 10.027
Mdm2transformed mouse 3T3 cell double minute 20.026
Vangl2vang-like 2 (van gogh, Drosophila)0.026
BidBH3 interacting domain death agonist0.026
NmiN-myc (and STAT) interactor0.026
Ptch2patched homolog 20.025
Bbc3BCL2 binding component 30.025
Ptk7PTK7 protein tyrosine kinase 70.025
Cbfbcore binding factor beta0.024
Fzd2frizzled homolog 2 (Drosophila)0.024
Efnb1ephrin B10.022
Col4a5collagen, type IV, alpha 50.022
Wnt7bwingless-related MMTV integration site 7B0.020
Fjx1four jointed box 1 (Drosophila)0.020
Ripk3receptor-interacting serine-threonine kinase 30.020
Gli2GLI-Kruppel family member GLI20.020
Smad6MAD homolog 6 (Drosophila)0.020
Efna4ephrin A40.019
Nfyanuclear transcription factor-Y alpha0.019
Smad5MAD homolog 5 (Drosophila)0.019
Smad2MAD homolog 2 (Drosophila)0.019
Thrspthyroid hormone responsive SPOT14 homolog (Rattus)0.019
Islrimmunoglobulin superfamily containing leucine-rich repeat0.018
Ddah2dimethylarginine dimethylaminohydrolase 20.018
Sema5asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.017
Ephb2Eph receptor B20.017
Rnf111ring finger 1110.016
Cpne1copine I0.016
S1pr3sphingosine-1-phosphate receptor 30.016
Clip2CAP-GLY domain containing linker protein 20.016
Sox4SRY-box containing gene 40.015
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.015
Mdm4transformed mouse 3T3 cell double minute 40.015
Hes5hairy and enhancer of split 5 (Drosophila)0.015
Smoc2SPARC related modular calcium binding 20.015
Fndc1fibronectin type III domain containing 10.015
Cachd1cache domain containing 10.015
Apaf1apoptotic peptidase activating factor 10.014
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.014
Smosmoothened homolog (Drosophila)0.014
Pmpcbpeptidase (mitochondrial processing) beta0.014
Nrcamneuron-glia-CAM-related cell adhesion molecule0.014
Casp8caspase 80.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG11347CG11347 gene product from transcript CG11347-RE0.190
Dcp-1Death caspase-10.125
p53CG33336 gene product from transcript CG33336-RB0.071
NcNedd2-like caspase0.055
Src42ASrc oncogene at 42A0.054
tefutelomere fusion0.046
ik2IkappaB kinase-like 20.045
kibrakibra ortholog0.041
RalaRas-related protein0.038
argosCG4531 gene product from transcript CG4531-RA0.036
CG7686CG7686 gene product from transcript CG7686-RA0.033
nonAno on or off transient A0.031
sinaseven in absentia0.024
S6kIIRPS6-protein kinase-II0.021
JraJun-related antigen0.020
mldmolting defective0.020
edlETS-domain lacking0.019
Hsc70-3Heat shock protein cognate 30.019
eIF-3p40Eukaryotic initiation factor 3 p40 subunit0.017
BuffyCG8238 gene product from transcript CG8238-RA0.017
grimCG4345 gene product from transcript CG4345-RA0.017
TomTwin of m40.016
Iap2Inhibitor of apoptosis 20.015
GgaCG3002 gene product from transcript CG3002-RB0.015
opa1-likeoptic atrophy 1-like0.013
ParpPoly-(ADP-ribose) polymerase0.013
Atg1Autophagy-specific gene 10.012
Tsc1CG6147 gene product from transcript CG6147-RA0.011
HtrA2CG8464 gene product from transcript CG8464-RA0.010
eastenhanced adult sensory threshold0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
BCL2L1BCL2-like 11.000
BAXBCL2-associated X protein0.994
BCL2L11BCL2-like 11 (apoptosis facilitator)0.970
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.884
CASP9caspase 9, apoptosis-related cysteine peptidase0.839
CASP3caspase 3, apoptosis-related cysteine peptidase0.760
BIDBH3 interacting domain death agonist0.630
XIAPX-linked inhibitor of apoptosis0.445
BAK1BCL2-antagonist/killer 10.395
BADBCL2-associated agonist of cell death0.371
CCR5chemokine (C-C motif) receptor 50.264
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.177
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.173
CCR2chemokine (C-C motif) receptor 20.132
APAF1apoptotic peptidase activating factor 10.123
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.094
DFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)0.080
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.070
CXCL9chemokine (C-X-C motif) ligand 90.068
IFNGinterferon, gamma0.061
IL2RBinterleukin 2 receptor, beta0.060
CCL5chemokine (C-C motif) ligand 50.058
BECN1beclin 1, autophagy related0.055
CCL22chemokine (C-C motif) ligand 220.043
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.038
BIKBCL2-interacting killer (apoptosis-inducing)0.033
TP53BP2tumor protein p53 binding protein, 20.031
CASP8caspase 8, apoptosis-related cysteine peptidase0.031
CCR7chemokine (C-C motif) receptor 70.029
CXCR6chemokine (C-X-C motif) receptor 60.029
IRF4interferon regulatory factor 40.029
CD40LGCD40 ligand0.029
CCR4chemokine (C-C motif) receptor 40.027
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.027
AMBRA1autophagy/beclin-1 regulator 10.027
SH3RF3SH3 domain containing ring finger 30.023
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.021
CXCR3chemokine (C-X-C motif) receptor 30.019
BIRC2baculoviral IAP repeat containing 20.019
BBC3BCL2 binding component 30.019
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.019
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.017
WASLWiskott-Aldrich syndrome-like0.017
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.017
IL16interleukin 16 (lymphocyte chemoattractant factor)0.015
CCL4chemokine (C-C motif) ligand 40.015
SLAMF7SLAM family member 70.015
NCF2neutrophil cytosolic factor 20.015
BCL2L2BCL2-like 20.014
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.014
TNFSF8tumor necrosis factor (ligand) superfamily, member 80.014
MDM2Mdm2 p53 binding protein homolog (mouse)0.013
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.013
HDAC6histone deacetylase 60.013
HUWE1HECT, UBA and WWE domain containing 10.012
CCL3chemokine (C-C motif) ligand 30.012
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.011
LRRK2leucine-rich repeat kinase 20.011
CCR6chemokine (C-C motif) receptor 60.011
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.011
CCR8chemokine (C-C motif) receptor 80.011
RHOUras homolog gene family, member U0.010
CLEC7AC-type lectin domain family 7, member A0.010
IQGAP2IQ motif containing GTPase activating protein 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism