The network for 'positive regulation of interleukin 6 secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of interleukin 6 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.

NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.873
Casp4caspase 4, apoptosis-related cysteine peptidase0.803
Aim2absent in melanoma 20.688
Gbp5guanylate binding protein 50.660
Hspa5heat shock protein 50.257
Creld2cysteine-rich with EGF-like domains 20.077
Manfmesencephalic astrocyte-derived neurotrophic factor0.058
Prrx2paired related homeobox 20.053
Becn1beclin 1, autophagy related0.047
Nlrp3NLR family, pyrin domain containing 30.045
Snai2snail homolog 2 (Drosophila)0.043
Phldb2pleckstrin homology-like domain, family B, member 20.042
Serp1stress-associated endoplasmic reticulum protein 10.042
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.034
Capn6calpain 60.034
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.031
Gli2GLI-Kruppel family member GLI20.031
H47histocompatibility 470.030
Igf2bp2insulin-like growth factor 2 mRNA binding protein 20.030
Vimvimentin0.028
Krt7keratin 70.027
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.027
Gas1growth arrest specific 10.027
Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.026
Tlr4toll-like receptor 40.025
Tead2TEA domain family member 20.025
Efnb1ephrin B10.024
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.024
Gpx7glutathione peroxidase 70.024
Trip6thyroid hormone receptor interactor 60.021
Mfap2microfibrillar-associated protein 20.021
Krt18keratin 180.021
Mcfd2multiple coagulation factor deficiency 20.019
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.018
Cdh1cadherin 10.018
Dkk2dickkopf homolog 2 (Xenopus laevis)0.018
IkbipIKBKB interacting protein0.018
Ets1E26 avian leukemia oncogene 1, 5' domain0.017
Il18interleukin 180.017
Sdf2l1stromal cell-derived factor 2-like 10.017
Vegfcvascular endothelial growth factor C0.017
Wwtr1WW domain containing transcription regulator 10.016
Tpm2tropomyosin 2, beta0.016
Fstl1follistatin-like 10.015
Fkbp10FK506 binding protein 100.015
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.015
Krt19keratin 190.015
Leprel4leprecan-like 40.014
Yap1yes-associated protein 10.014
Marveld1MARVEL (membrane-associating) domain containing 10.014
Rrbp1ribosome binding protein 10.014
Edem1ER degradation enhancer, mannosidase alpha-like 10.014
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.013
MdficMyoD family inhibitor domain containing0.013
RradRas-related associated with diabetes0.013
Pkdccprotein kinase domain containing, cytoplasmic0.013
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.013
Uso1USO1 homolog, vesicle docking protein (yeast)0.012
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.012
Irf6interferon regulatory factor 60.012
Chrnb1cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)0.012
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.012
Sfrp2secreted frizzled-related protein 20.012
Rab34RAB34, member of RAS oncogene family0.012
Col16a1collagen, type XVI, alpha 10.012
Hmga2high mobility group AT-hook 20.011
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.011
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.011
Hoxc8homeobox C80.011
Meox2mesenchyme homeobox 20.011
Fbln2fibulin 20.011
Cnn3calponin 3, acidic0.011
Tpm4tropomyosin 40.011
Epha2Eph receptor A20.011
Lpar1lysophosphatidic acid receptor 10.011
Pdia6protein disulfide isomerase associated 60.011
Gfpt2glutamine fructose-6-phosphate transaminase 20.010
Surf4surfeit gene 40.010
Ckap4cytoskeleton-associated protein 40.010
Vcanversican0.010
Ccdc80coiled-coil domain containing 800.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NLRC4NLR family, CARD domain containing 40.278
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.215
RUNX1runt-related transcription factor 10.099
GATA2GATA binding protein 20.037
SETD8SET domain containing (lysine methyltransferase) 80.035
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.034
MEFVMediterranean fever0.030
PYDC2pyrin domain containing 20.019
RIPK2receptor-interacting serine-threonine kinase 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism