The network for 'epithelial cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.999
Fgfr2fibroblast growth factor receptor 20.997
Notch1Notch gene homolog 1 (Drosophila)0.995
Fgfr1fibroblast growth factor receptor 10.995
Foxc1forkhead box C10.994
Gata4GATA binding protein 40.992
Sox9SRY-box containing gene 90.989
Gli3GLI-Kruppel family member GLI30.988
Otx2orthodenticle homolog 2 (Drosophila)0.975
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.973
Neurod1neurogenic differentiation 10.973
Rargretinoic acid receptor, gamma0.972
Fgf8fibroblast growth factor 80.966
Hand1heart and neural crest derivatives expressed transcript 10.966
Tcfap2atranscription factor AP-2, alpha0.931
Pitx2paired-like homeodomain transcription factor 20.899
Hand2heart and neural crest derivatives expressed transcript 20.895
Ptf1apancreas specific transcription factor, 1a0.883
Pax3paired box gene 30.882
Tbx1T-box 10.856
Sox2SRY-box containing gene 20.852
Lhx3LIM homeobox protein 30.832
Pax6paired box gene 60.809
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.805
Foxc2forkhead box C20.804
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.801
Prrx1paired related homeobox 10.797
Emx1empty spiracles homolog 1 (Drosophila)0.772
Alx4aristaless-like homeobox 40.767
Ascl1achaete-scute complex homolog 1 (Drosophila)0.767
Gli2GLI-Kruppel family member GLI20.766
Gata6GATA binding protein 60.765
Eya1eyes absent 1 homolog (Drosophila)0.749
Msx1homeobox, msh-like 10.737
Isl1ISL1 transcription factor, LIM/homeodomain0.696
Tgfb2transforming growth factor, beta 20.691
Pax2paired box gene 20.685
Pax8paired box gene 80.665
Dll1delta-like 1 (Drosophila)0.661
Rxraretinoid X receptor alpha0.652
Foxg1forkhead box G10.635
Pitx1paired-like homeodomain transcription factor 10.605
Prrx2paired related homeobox 20.597
Wnt3awingless-related MMTV integration site 3A0.580
Alx3aristaless-like homeobox 30.578
Nr5a1nuclear receptor subfamily 5, group A, member 10.551
Hes1hairy and enhancer of split 1 (Drosophila)0.550
Dlx5distal-less homeobox 50.486
Gscgoosecoid homeobox0.459
Emx2empty spiracles homolog 2 (Drosophila)0.459
En1engrailed 10.425
Hoxa11homeobox A110.402
Tbx15T-box 150.399
Hoxa1homeobox A10.394
Bmp4bone morphogenetic protein 40.392
Mesp1mesoderm posterior 10.391
Hoxa2homeobox A20.373
Jag1jagged 10.343
Vegfavascular endothelial growth factor A0.333
Hes5hairy and enhancer of split 5 (Drosophila)0.318
Chd7chromodomain helicase DNA binding protein 70.310
Dlx2distal-less homeobox 20.307
Lmx1bLIM homeobox transcription factor 1 beta0.304
Neurog2neurogenin 20.297
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.265
Hoxa13homeobox A130.265
Nhlh1nescient helix loop helix 10.255
Insm1insulinoma-associated 10.253
Hmx1H6 homeobox 10.242
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.234
Nkx6-1NK6 homeobox 10.225
Gbx2gastrulation brain homeobox 20.222
Tbx3T-box 30.221
Onecut1one cut domain, family member 10.213
Pdx1pancreatic and duodenal homeobox 10.211
Foxa2forkhead box A20.190
Fgf10fibroblast growth factor 100.188
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.179
Pitx3paired-like homeodomain transcription factor 30.178
Ror2receptor tyrosine kinase-like orphan receptor 20.177
Smad6MAD homolog 6 (Drosophila)0.170
Lhx5LIM homeobox protein 50.169
Msx2homeobox, msh-like 20.163
Pbx1pre B-cell leukemia transcription factor 10.163
Lhx9LIM homeobox protein 90.156
Tal1T-cell acute lymphocytic leukemia 10.146
Efna2ephrin A20.146
Ece1endothelin converting enzyme 10.146
Smosmoothened homolog (Drosophila)0.145
Sox3SRY-box containing gene 30.142
Lhx1LIM homeobox protein 10.137
Evx2even skipped homeotic gene 2 homolog0.137
Dlx1distal-less homeobox 10.136
Hoxd13homeobox D130.134
Lmx1aLIM homeobox transcription factor 1 alpha0.132
Pax1paired box gene 10.130
Trp63transformation related protein 630.130
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.128
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
jag2jagged 20.858
wt1awilms tumor 1a0.785
osr2odd-skipped related 2 (Drosophila)0.647
dlx2adistal-less homeobox gene 2a0.463
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.411
egr1early growth response 10.408
hnf1baHNF1 homeobox Ba0.381
her12hairy-related 120.301
tbx1T-box 10.283
dlx1adistal-less homeobox gene 1a0.260
rxrgaretinoid x receptor, gamma a0.257
myod1myogenic differentiation 10.205
pax3apaired box gene 3a0.204
dlx4bdistal-less homeobox gene 4b0.194
dlx4adistal-less homeobox gene 4a0.177
dmrt2adoublesex and mab-3 related transcription factor 2a0.174
raraaretinoic acid receptor, alpha a0.167
nr2e1nuclear receptor subfamily 2, group E, member 10.152
ascl1aachaete-scute complex-like 1a (Drosophila)0.148
osr1odd-skipped related 1 (Drosophila)0.147
dlx2bdistal-less homeobox gene 2b0.136
dlx3bdistal-less homeobox gene 3b0.127
lhx1aLIM homeobox 1a0.124
atoh1aatonal homolog 1a0.119
prox1prospero-related homeobox gene 10.116
znfl2azinc finger-like gene 2a0.112
nr2f2nuclear receptor subfamily 2, group F, member 20.109
nkx2.5NK2 transcription factor related 50.104
hnf1bbHNF1 homeobox Bb0.103
fgf8afibroblast growth factor 8 a0.099
mecomMDS1 and EVI1 complex locus0.095
six2asine oculis-related homeobox 2a0.095
sfrp5secreted frizzled-related protein 50.090
itgavintegrin, alpha V0.089
tbx18T-box 180.087
emx3empty spiracles homeobox 30.084
otx2orthodenticle homolog 20.084
her9hairy-related 90.083
ncs1aneuronal calcium sensor 1a0.079
nrp2bneuropilin 2b0.077
pax6apaired box gene 6a0.076
notch1anotch homolog 1a0.070
gdnfglial cell derived neurotrophic factor0.068
sox3SRY-box containing gene 30.066
fezf2FEZ family zinc finger 20.064
fzd7bfrizzled homolog 7b0.063
hhexhematopoietically expressed homeobox0.062
lmx1b.1LIM homeobox transcription factor 1, beta 10.061
pax8paired box gene 80.061
vcanbversican b0.060
sox9aSRY-box containing gene 9a0.060
her8ahairy-related 8a0.058
hoxc6ahomeo box C6a0.056
msxcmuscle segment homeobox C0.055
hoxa9ahomeo box A9a0.055
pax2apaired box gene 2a0.052
etv2ets variant gene 20.051
hey2hairy/enhancer-of-split related with YRPW motif 20.051
sim1asingle-minded homolog 1a (Drosophila)0.050
hey1hairy/enhancer-of-split related with YRPW motif 10.048
fstafollistatin a0.046
msxemuscle segment homeobox E0.044
gata1aGATA binding protein 1a0.044
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.043
irx3airoquois homeobox protein 3a0.042
gad2glutamate decarboxylase 20.040
runx1runt-related transcription factor 10.039
fli1afriend leukemia integration 1a0.039
tbx2aT-box gene 2a0.038
gata5GATA-binding protein 50.038
wt1bwilms tumor 1b0.037
gli2aGLI-Kruppel family member GLI2a0.036
her3hairy-related 30.036
pax6bpaired box gene 6b0.036
pitx3paired-like homeodomain transcription factor 30.036
otpborthopedia homolog b0.036
wnt1wingless-type MMTV integration site family, member 10.035
pou3f3bPOU class 3 homeobox 3b0.034
shhbsonic hedgehog b0.034
rxrgbretinoid X receptor, gamma b0.034
her4.2hairy-related 4.20.034
tead3aTEA domain family member 3 a0.033
mab21l2mab-21-like 20.033
six3bsine oculis homeobox homolog 3b0.033
stmn4stathmin-like 40.032
wnt5bwingless-type MMTV integration site family, member 5b0.032
alcambactivated leukocyte cell adhesion molecule b0.032
ascl1bachaete-scute complex-like 1b (Drosophila)0.031
gata4GATA-binding protein 40.030
rfx2regulatory factor X, 2 (influences HLA class II expression)0.030
rxrabretinoid x receptor, alpha b0.030
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha1.000
NCOA1nuclear receptor coactivator 11.000
RXRAretinoid X receptor, alpha0.999
MED25mediator complex subunit 250.999
JAG1jagged 10.984
TGFB1transforming growth factor, beta 10.981
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.947
FKBP1AFK506 binding protein 1A, 12kDa0.935
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.934
NOTCH1notch 10.933
NOTCH3notch 30.894
BMP2bone morphogenetic protein 20.889
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.779
GDF5growth differentiation factor 50.746
SMAD7SMAD family member 70.651
PROX1prospero homeobox 10.600
TGFB3transforming growth factor, beta 30.556
TGFBR1transforming growth factor, beta receptor 10.553
HNF4Ahepatocyte nuclear factor 4, alpha0.550
ACVR1activin A receptor, type I0.523
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.494
SPOPspeckle-type POZ protein0.487
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.483
FSTL1follistatin-like 10.419
PRKG1protein kinase, cGMP-dependent, type I0.400
MAML1mastermind-like 1 (Drosophila)0.388
GFI1Bgrowth factor independent 1B transcription repressor0.379
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.324
PTCH1patched 10.322
MAPK8mitogen-activated protein kinase 80.251
BMPR1Abone morphogenetic protein receptor, type IA0.242
NR0B2nuclear receptor subfamily 0, group B, member 20.202
FGF1fibroblast growth factor 1 (acidic)0.194
ATXN1Lataxin 1-like0.190
NRP1neuropilin 10.160
NCOR2nuclear receptor corepressor 20.155
RXRBretinoid X receptor, beta0.144
TBX5T-box 50.142
SPENspen homolog, transcriptional regulator (Drosophila)0.139
KANK2KN motif and ankyrin repeat domains 20.129
TAOK1TAO kinase 10.112
DVL3dishevelled, dsh homolog 3 (Drosophila)0.093
NOTCH2notch 20.087
DLL1delta-like 1 (Drosophila)0.085
NR5A2nuclear receptor subfamily 5, group A, member 20.080
HNF1AHNF1 homeobox A0.077
BMP4bone morphogenetic protein 40.076
EGFL7EGF-like-domain, multiple 70.068
PDX1pancreatic and duodenal homeobox 10.064
SREBF2sterol regulatory element binding transcription factor 20.063
NR4A1nuclear receptor subfamily 4, group A, member 10.062
XIAPX-linked inhibitor of apoptosis0.058
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.053
ZNF331zinc finger protein 3310.050
ACVR1Bactivin A receptor, type IB0.043
AXIN1axin 10.043
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.042
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.041
KRT8keratin 80.040
NR5A1nuclear receptor subfamily 5, group A, member 10.040
IQGAP1IQ motif containing GTPase activating protein 10.038
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.038
ZMYND11zinc finger, MYND-type containing 110.037
HOXA10homeobox A100.036
CTBP2C-terminal binding protein 20.036
RARGretinoic acid receptor, gamma0.036
PAX6paired box 60.035
DVL1dishevelled, dsh homolog 1 (Drosophila)0.034
DHHdesert hedgehog0.034
RXRGretinoid X receptor, gamma0.033
HNF1BHNF1 homeobox B0.033
NR1H2nuclear receptor subfamily 1, group H, member 20.032
TGFBR3transforming growth factor, beta receptor III0.032
NCOA6nuclear receptor coactivator 60.029
KLF13Kruppel-like factor 130.029
FGFR2fibroblast growth factor receptor 20.027
NR1I3nuclear receptor subfamily 1, group I, member 30.027
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.027
HAND2heart and neural crest derivatives expressed 20.026
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.026
ITGB1BP2integrin beta 1 binding protein (melusin) 20.026
CEBPACCAAT/enhancer binding protein (C/EBP), alpha0.026
HIPK3homeodomain interacting protein kinase 30.024
PDGFCplatelet derived growth factor C0.024
SMAD6SMAD family member 60.024
SEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G0.022
BBS10Bardet-Biedl syndrome 100.021
ZNF205zinc finger protein 2050.021
TADA3transcriptional adaptor 30.021
JUBjub, ajuba homolog (Xenopus laevis)0.021
FOXA2forkhead box A20.021
ACVR2Bactivin A receptor, type IIB0.021
INHBBinhibin, beta B0.021
CIR1corepressor interacting with RBPJ, 10.020
NR1H3nuclear receptor subfamily 1, group H, member 30.020
HOXA11homeobox A110.020
CDX2caudal type homeobox 20.019
ZNF579zinc finger protein 5790.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism