The network for 'pattern recognition receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pattern recognition receptor signaling pathway

Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.

NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 881.000
Tlr4toll-like receptor 41.000
Traf6TNF receptor-associated factor 60.999
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.998
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.996
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.995
Ptprcprotein tyrosine phosphatase, receptor type, C0.995
Tnftumor necrosis factor0.982
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.979
Gnrh1gonadotropin releasing hormone 10.975
Esr1estrogen receptor 1 (alpha)0.975
Map3k8mitogen-activated protein kinase kinase kinase 80.971
Irf7interferon regulatory factor 70.967
Casp4caspase 4, apoptosis-related cysteine peptidase0.964
Trim30atripartite motif-containing 30A0.944
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.937
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.931
Tnfaip3tumor necrosis factor, alpha-induced protein 30.900
Irf9interferon regulatory factor 90.862
Klra9killer cell lectin-like receptor subfamily A, member 90.857
Birc3baculoviral IAP repeat-containing 30.856
Stat1signal transducer and activator of transcription 10.827
Il10interleukin 100.826
FasFas (TNF receptor superfamily member 6)0.822
AxlAXL receptor tyrosine kinase0.797
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.794
Ticam1toll-like receptor adaptor molecule 10.793
Pyhin1pyrin and HIN domain family, member 10.772
Ighimmunoglobulin heavy chain complex0.769
Tlr2toll-like receptor 20.760
Cd40CD40 antigen0.755
Gbp7guanylate binding protein 70.732
Cd44CD44 antigen0.726
Ifit1interferon-induced protein with tetratricopeptide repeats 10.707
Lyz2lysozyme 20.707
Ccr2chemokine (C-C motif) receptor 20.693
Il1rninterleukin 1 receptor antagonist0.681
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.663
Trim21tripartite motif-containing 210.660
Ncr1natural cytotoxicity triggering receptor 10.654
Mavsmitochondrial antiviral signaling protein0.638
Cd19CD19 antigen0.597
Cd180CD180 antigen0.596
Ifnginterferon gamma0.583
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.582
Plcg2phospholipase C, gamma 20.575
Il18rapinterleukin 18 receptor accessory protein0.566
Arrb2arrestin, beta 20.565
Usp18ubiquitin specific peptidase 180.562
Casp1caspase 10.553
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.544
Unc93b1unc-93 homolog B1 (C. elegans)0.541
Sfpi1SFFV proviral integration 10.525
Irf1interferon regulatory factor 10.523
Tnfaip2tumor necrosis factor, alpha-induced protein 20.520
Uba7ubiquitin-like modifier activating enzyme 70.511
Parp14poly (ADP-ribose) polymerase family, member 140.510
Gzmbgranzyme B0.498
Sykbspleen tyrosine kinase0.492
Map3k7mitogen-activated protein kinase kinase kinase 70.490
Csf1colony stimulating factor 1 (macrophage)0.489
Isg15ISG15 ubiquitin-like modifier0.486
Ifi203interferon activated gene 2030.476
Stat3signal transducer and activator of transcription 30.469
Nlrp3NLR family, pyrin domain containing 30.440
Irgm1immunity-related GTPase family M member 10.434
Irak4interleukin-1 receptor-associated kinase 40.429
Rsad2radical S-adenosyl methionine domain containing 20.421
Clec4eC-type lectin domain family 4, member e0.418
Rtp4receptor transporter protein 40.408
Arrb1arrestin, beta 10.402
Sfnstratifin0.401
Aoahacyloxyacyl hydrolase0.395
FaslFas ligand (TNF superfamily, member 6)0.394
Il2rginterleukin 2 receptor, gamma chain0.394
Prdm1PR domain containing 1, with ZNF domain0.394
Cd80CD80 antigen0.392
Il10rainterleukin 10 receptor, alpha0.391
Il1r1interleukin 1 receptor, type I0.390
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.388
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.385
Cxcl10chemokine (C-X-C motif) ligand 100.383
Mapk14mitogen-activated protein kinase 140.377
Inpp5dinositol polyphosphate-5-phosphatase D0.374
Itgalintegrin alpha L0.371
Map3k14mitogen-activated protein kinase kinase kinase 140.364
Irgm2immunity-related GTPase family M member 20.363
Tyro3TYRO3 protein tyrosine kinase 30.351
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.347
Clec4dC-type lectin domain family 4, member d0.342
Gbp3guanylate binding protein 30.338
Cyldcylindromatosis (turban tumor syndrome)0.329
Cd33CD33 antigen0.329
Icosinducible T-cell co-stimulator0.323
Ccl4chemokine (C-C motif) ligand 40.320
Ccl2chemokine (C-C motif) ligand 20.316
Relreticuloendotheliosis oncogene0.315
BC006779cDNA sequence BC0067790.311
Ifih1interferon induced with helicase C domain 10.300
Ifit3interferon-induced protein with tetratricopeptide repeats 30.298
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.109
tlr18toll-like receptor 180.079
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.058
relv-rel reticuloendotheliosis viral oncogene homolog0.056
pdcd2programmed cell death 20.055
nos2anitric oxide synthase 2a, inducible0.046
ip6k2inositol hexaphosphate kinase 20.043
hdrhematopoietic death receptor0.037
cpoxcoproporphyrinogen oxidase0.031
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.031
zgc:112161zgc:1121610.029
tfr1atransferrin receptor 1a0.026
ecscrendothelial cell-specific chemotaxis regulator0.025
LOC557072caspase recruitment domain-containing protein 11-like0.022
epas1bendothelial PAS domain protein 1b0.022
efna2ephrin A20.021
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.019
terttelomerase reverse transcriptase0.019
LOC566708FL cytokine receptor-like0.019
LOC100534776toll-like receptor 7-like0.018
f2rcoagulation factor II (thrombin) receptor0.017
card14caspase recruitment domain family, member 140.016
aplp2amyloid beta (A4) precursor-like protein 20.015
plk3polo-like kinase 3 (Drosophila)0.015
stat1asignal transduction and activation of transcription 1a0.015
itih2inter-alpha (globulin) inhibitor H20.014
pacrgPARK2 co-regulated0.013
fibplfibroblast growth factor (acidic) intracellular binding protein, like0.013
stat1bsignal transducer and activator of transcription 1b0.012
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.012
tlr20atoll-like receptor 20a0.012
cd40lgCD40 ligand0.012
tlr3toll-like receptor 30.011
jak1Janus kinase 10.010
ifnphi1interferon phi 10.010
tlr9toll-like receptor 90.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
AttAAttacin-A0.990
PGRP-SAPeptidoglycan recognition protein SA0.970
grassGram-positive Specific Serine protease0.940
SPESpatzle-Processing Enzyme0.921
PGRP-LCPeptidoglycan recognition protein LC0.902
DptBDiptericin B0.897
PGRP-SDCG7496 gene product from transcript CG7496-RA0.833
RelRelish0.754
MtkMetchnikowin0.703
Toll-7CG8595 gene product from transcript CG8595-RA0.695
modSPmodular serine protease0.655
AttCAttacin-C0.609
Sp7Serine protease 70.574
IrcImmune-regulated catalase0.494
spzspatzle0.476
CG32185CG32185 gene product from transcript CG32185-RA0.451
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.445
pirkpoor Imd response upon knock-in0.425
Spn27ASerpin 27A0.374
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.348
DrsDrosomycin0.323
imdimmune deficiency0.315
HcfHost cell factor0.313
IM1Immune induced molecule 10.310
Spn1Serine protease inhibitor 10.302
CG5791CG5791 gene product from transcript CG5791-RA0.281
TlToll0.269
Toll-6CG7250 gene product from transcript CG7250-RA0.263
fonfondue0.260
IM10Immune induced molecule 100.252
DuoxDual oxidase0.247
CG15065CG15065 gene product from transcript CG15065-RA0.244
GltGlutactin0.235
p38bCG7393 gene product from transcript CG7393-RA0.232
CG16836CG16836 gene product from transcript CG16836-RA0.219
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.214
CG18067CG18067 gene product from transcript CG18067-RA0.210
DreddDeath related ced-3/Nedd2-like protein0.199
Myd88CG2078 gene product from transcript CG2078-RA0.190
Spn88EbSerpin 88Eb0.180
PGRP-LBPeptidoglycan recognition protein LB0.170
TM9SF4CG7364 gene product from transcript CG7364-RA0.153
IM2Immune induced molecule 20.144
Mpk2CG5475 gene product from transcript CG5475-RB0.141
nimC1nimrod C10.130
Spn28DSerpin 28D0.129
GNBP1Gram-negative bacteria binding protein 10.126
spiritSerine Protease Immune Response Integrator0.119
CG18594CG18594 gene product from transcript CG18594-RA0.118
eaterCG6124 gene product from transcript CG6124-RB0.115
IM4Immune induced molecule 40.115
GNBP3Gram-negative bacteria binding protein 30.114
l(3)mbnlethal (3) malignant blood neoplasm0.112
CG9184CG9184 gene product from transcript CG9184-RB0.111
IM18Immune induced molecule 180.110
CG6038CG6038 gene product from transcript CG6038-RA0.108
LIMK1LIM-kinase10.103
panpangolin0.102
Idgf2Imaginal disc growth factor 20.101
upd2unpaired 20.100
Gadd45CG11086 gene product from transcript CG11086-RA0.099
IM23Immune induced molecule 230.095
ftfat0.093
ird1immune response deficient 10.093
CG6361CG6361 gene product from transcript CG6361-RA0.092
sinusinuous0.092
pshpersephone0.091
TepIIIThiolester containing protein III0.091
PGRP-LFPeptidoglycan recognition protein LF0.090
CG9691CG9691 gene product from transcript CG9691-RB0.090
DptDiptericin0.089
necnecrotic0.089
HeHemese0.087
CG16713CG16713 gene product from transcript CG16713-RA0.085
CctgammaCG8977 gene product from transcript CG8977-RC0.080
CecCCecropin C0.080
toytwin of eyeless0.078
Nhe3Na[+]/H[+] hydrogen exchanger 30.066
AGO2Argonaute 20.066
CG10260CG10260 gene product from transcript CG10260-RB0.064
DroDrosocin0.064
rutrutabaga0.063
CG15067CG15067 gene product from transcript CG15067-RA0.062
CG15917CG15917 gene product from transcript CG15917-RA0.061
Akt1CG4006 gene product from transcript CG4006-RA0.059
ird5immune response deficient 50.057
upd3unpaired 30.057
hebeCG1623 gene product from transcript CG1623-RD0.056
CG12943CG12943 gene product from transcript CG12943-RA0.052
CG8121CG8121 gene product from transcript CG8121-RA0.050
bbgbig bang0.049
CG9917CG9917 gene product from transcript CG9917-RA0.049
chrbcharybde0.049
proPO-A1prophenol oxidase A10.048
CG13085CG13085 gene product from transcript CG13085-RA0.047
ininturned0.046
CG6426CG6426 gene product from transcript CG6426-RA0.046
Vap-33-1CG5014 gene product from transcript CG5014-RB0.045
dsdachsous0.042
dnr1defense repressor 10.041
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.999
IRAK1interleukin-1 receptor-associated kinase 10.999
MYD88myeloid differentiation primary response gene (88)0.999
BIRC3baculoviral IAP repeat containing 30.999
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.998
TRAF6TNF receptor-associated factor 60.996
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.992
IRAK2interleukin-1 receptor-associated kinase 20.992
TNFAIP3tumor necrosis factor, alpha-induced protein 30.987
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.950
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.911
FKBP4FK506 binding protein 4, 59kDa0.863
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.800
S100A16S100 calcium binding protein A160.790
IFIH1interferon induced with helicase C domain 10.779
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.771
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.768
TNIP2TNFAIP3 interacting protein 20.727
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.723
S100A14S100 calcium binding protein A140.706
S100A1S100 calcium binding protein A10.674
TRAF1TNF receptor-associated factor 10.664
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.656
TLR2toll-like receptor 20.646
SAMD9sterile alpha motif domain containing 90.642
MAPK14mitogen-activated protein kinase 140.633
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.620
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.568
RXRAretinoid X receptor, alpha0.566
TLR4toll-like receptor 40.559
IFI44interferon-induced protein 440.535
BIRC2baculoviral IAP repeat containing 20.517
S100BS100 calcium binding protein B0.503
MAP3K8mitogen-activated protein kinase kinase kinase 80.483
SP100SP100 nuclear antigen0.452
S100A6S100 calcium binding protein A60.451
IRF7interferon regulatory factor 70.440
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.426
PELI3pellino homolog 3 (Drosophila)0.407
ARRB1arrestin, beta 10.384
TRIM22tripartite motif containing 220.339
IFIT3interferon-induced protein with tetratricopeptide repeats 30.339
RIPK2receptor-interacting serine-threonine kinase 20.323
TLR1toll-like receptor 10.322
IRAK3interleukin-1 receptor-associated kinase 30.322
SAMD9Lsterile alpha motif domain containing 9-like0.297
MAPK1mitogen-activated protein kinase 10.290
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.284
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.282
MED15mediator complex subunit 150.275
MAP3K14mitogen-activated protein kinase kinase kinase 140.269
MDM2Mdm2 p53 binding protein homolog (mouse)0.262
MAP3K5mitogen-activated protein kinase kinase kinase 50.239
TMEM173transmembrane protein 1730.239
S100A9S100 calcium binding protein A90.237
AKT1v-akt murine thymoma viral oncogene homolog 10.229
SP110SP110 nuclear body protein0.228
IRAK4interleukin-1 receptor-associated kinase 40.218
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.213
CCR1chemokine (C-C motif) receptor 10.206
TRIM21tripartite motif containing 210.206
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.201
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.187
TRAF3TNF receptor-associated factor 30.183
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.180
CD80CD80 molecule0.176
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.176
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.170
NMIN-myc (and STAT) interactor0.157
TNIP1TNFAIP3 interacting protein 10.153
KLRD1killer cell lectin-like receptor subfamily D, member 10.152
TRIM38tripartite motif containing 380.148
PILRApaired immunoglobin-like type 2 receptor alpha0.145
SIGLEC7sialic acid binding Ig-like lectin 70.142
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.141
BTN3A3butyrophilin, subfamily 3, member A30.140
CCR2chemokine (C-C motif) receptor 20.136
NCOR2nuclear receptor corepressor 20.135
PARP12poly (ADP-ribose) polymerase family, member 120.131
AGERadvanced glycosylation end product-specific receptor0.130
TP53tumor protein p530.130
CREBBPCREB binding protein0.123
TYMPthymidine phosphorylase0.122
GBP1guanylate binding protein 1, interferon-inducible0.122
CTSScathepsin S0.121
S100A8S100 calcium binding protein A80.120
NOD2nucleotide-binding oligomerization domain containing 20.118
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.115
GBP3guanylate binding protein 30.114
PTAFRplatelet-activating factor receptor0.113
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.106
TRIM5tripartite motif containing 50.101
CRPC-reactive protein, pentraxin-related0.098
CYBBcytochrome b-245, beta polypeptide0.089
HSPB1heat shock 27kDa protein 10.089
CAMPcathelicidin antimicrobial peptide0.084
MX2myxovirus (influenza virus) resistance 2 (mouse)0.084
ZNF263zinc finger protein 2630.083
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.082
IRF1interferon regulatory factor 10.082
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.775
Parp9poly (ADP-ribose) polymerase family, member 90.110
Zfp36zinc finger protein 360.105
Nr1d2nuclear receptor subfamily 1, group D, member 20.096
Cfhcomplement factor H0.087
Hcls1hematopoietic cell specific Lyn substrate 10.056
Agaaspartylglucosaminidase0.042
Mmp12matrix metallopeptidase 120.040
Irak3interleukin-1 receptor-associated kinase 30.036
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.034
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.034
RGD1305793similar to hypothetical protein FLJ201540.033
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.029
LOC100363783rCG53773-like0.023
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A30.022
Hsph1heat shock 105/110 protein 10.022
Ppicpeptidylprolyl isomerase C0.022
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.022
Bcl2l1Bcl2-like 10.022
Cd38CD38 molecule0.020
Lpllipoprotein lipase0.020
Cpceruloplasmin0.020
Fabp4fatty acid binding protein 4, adipocyte0.018
Gsk3bglycogen synthase kinase 3 beta0.018
Dtx3ldeltex 3-like (Drosophila)0.017
Prtfdc1phosphoribosyl transferase domain containing 10.017
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.016
Lilrb3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.015
Mobpmyelin-associated oligodendrocyte basic protein0.015
Hspa8heat shock protein 80.015
TifaTRAF-interacting protein with forkhead-associated domain0.014
Ddr2discoidin domain receptor tyrosine kinase 20.014
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.013
Mca32mast cell antigen 320.013
Tnip1TNFAIP3 interacting protein 10.013
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.013
Magmyelin-associated glycoprotein0.013
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.012
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.012
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.012
Lcn2lipocalin 20.012
Gpr34G protein-coupled receptor 340.012
Ctsdcathepsin D0.012
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.012
Npepl1aminopeptidase-like 10.011
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.011
Lhfplipoma HMGIC fusion partner0.010
Pnpla2patatin-like phospholipase domain containing 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism