The network for 'liver development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.993
Cdkn1bcyclin-dependent kinase inhibitor 1B0.987
Bmp4bone morphogenetic protein 40.980
Gata4GATA binding protein 40.977
Rxraretinoid X receptor alpha0.975
Pitx2paired-like homeodomain transcription factor 20.965
Pax3paired box gene 30.948
Chd7chromodomain helicase DNA binding protein 70.944
Hes1hairy and enhancer of split 1 (Drosophila)0.934
Apoeapolipoprotein E0.911
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.904
Trp53transformation related protein 530.902
Meox2mesenchyme homeobox 20.895
Rargretinoic acid receptor, gamma0.885
Gli3GLI-Kruppel family member GLI30.882
Acvr1activin A receptor, type 10.874
Tgfbr2transforming growth factor, beta receptor II0.871
Onecut1one cut domain, family member 10.861
Hhexhematopoietically expressed homeobox0.856
Rb1retinoblastoma 10.846
Stat3signal transducer and activator of transcription 30.842
Pkd1polycystic kidney disease 1 homolog0.832
Apcadenomatosis polyposis coli0.831
Fgfr2fibroblast growth factor receptor 20.817
Foxc1forkhead box C10.813
Smad4MAD homolog 4 (Drosophila)0.790
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.786
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.765
Shhsonic hedgehog0.737
Alx4aristaless-like homeobox 40.719
Fgf8fibroblast growth factor 80.714
Ptpn11protein tyrosine phosphatase, non-receptor type 110.707
Notch1Notch gene homolog 1 (Drosophila)0.685
Vegfavascular endothelial growth factor A0.675
Tbx3T-box 30.670
Hand2heart and neural crest derivatives expressed transcript 20.664
Ascl1achaete-scute complex homolog 1 (Drosophila)0.654
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.652
AxlAXL receptor tyrosine kinase0.640
Nf1neurofibromatosis 10.618
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.616
Nos3nitric oxide synthase 3, endothelial cell0.612
Nodalnodal0.605
Nognoggin0.561
Gata6GATA binding protein 60.549
Mks1Meckel syndrome, type 10.547
Itgb1integrin beta 1 (fibronectin receptor beta)0.547
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.524
Invsinversin0.523
Sox4SRY-box containing gene 40.510
Dll1delta-like 1 (Drosophila)0.505
Hnf4ahepatic nuclear factor 4, alpha0.484
Apoa1apolipoprotein A-I0.482
Foxa2forkhead box A20.468
Isl1ISL1 transcription factor, LIM/homeodomain0.461
Ptk2PTK2 protein tyrosine kinase 20.454
Jag1jagged 10.426
FosFBJ osteosarcoma oncogene0.415
Gdf5growth differentiation factor 50.412
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.404
Sox17SRY-box containing gene 170.402
Tefthyrotroph embryonic factor0.392
Nr3c1nuclear receptor subfamily 3, group C, member 10.391
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.389
Vangl2vang-like 2 (van gogh, Drosophila)0.389
Ptgs2prostaglandin-endoperoxide synthase 20.364
Smad6MAD homolog 6 (Drosophila)0.362
Erbb2ipErbb2 interacting protein0.361
Tcfap2atranscription factor AP-2, alpha0.361
Bmp7bone morphogenetic protein 70.359
Cdk6cyclin-dependent kinase 60.359
Ece1endothelin converting enzyme 10.352
Tal1T-cell acute lymphocytic leukemia 10.339
Kitkit oncogene0.337
Col1a1collagen, type I, alpha 10.321
Ctnnb1catenin (cadherin associated protein), beta 10.320
Tgfb1transforming growth factor, beta 10.318
Csf1colony stimulating factor 1 (macrophage)0.316
Lrp1low density lipoprotein receptor-related protein 10.310
Hdac1histone deacetylase 10.303
Bicc1bicaudal C homolog 1 (Drosophila)0.295
Shesrc homology 2 domain-containing transforming protein E0.293
Sox18SRY-box containing gene 180.291
Gli2GLI-Kruppel family member GLI20.284
Hspg2perlecan (heparan sulfate proteoglycan 2)0.282
Notch2Notch gene homolog 2 (Drosophila)0.265
Hand1heart and neural crest derivatives expressed transcript 10.260
Tbx2T-box 20.249
Alx3aristaless-like homeobox 30.244
Tgfb2transforming growth factor, beta 20.243
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.235
Psen1presenilin 10.232
Tbx1T-box 10.230
Axin2axin20.228
Ptch1patched homolog 10.227
Tyro3TYRO3 protein tyrosine kinase 30.224
Engendoglin0.220
Fgfr1fibroblast growth factor receptor 10.219
Ppargperoxisome proliferator activated receptor gamma0.218
Mvdmevalonate (diphospho) decarboxylase0.210
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.995
gata5GATA-binding protein 50.983
gata6GATA-binding protein 60.977
hnf1baHNF1 homeobox Ba0.970
bmp2abone morphogenetic protein 2a0.970
kdrlkinase insert domain receptor like0.966
wnt5bwingless-type MMTV integration site family, member 5b0.959
bmp2bbone morphogenetic protein 2b0.942
flhfloating head0.929
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.879
tp53tumor protein p530.877
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.842
metmet proto-oncogene (hepatocyte growth factor receptor)0.818
tcf7transcription factor 7 (T-cell specific, HMG-box)0.816
cdh1cadherin 1, epithelial0.809
foxa3forkhead box A30.807
dkk1bdickkopf 1b0.802
fgf3fibroblast growth factor 30.757
sox9bSRY-box containing gene 9b0.742
ahr2aryl hydrocarbon receptor 20.733
fzd8afrizzled homolog 8a0.717
jag2jagged 20.685
ndr2nodal-related 20.675
cdx4caudal type homeo box transcription factor 40.656
egr2bearly growth response 2b0.649
jag1bjagged 1b0.599
wnt4awingless-type MMTV integration site family, member 4a0.536
sox17SRY-box containing gene 170.527
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.521
gata3GATA-binding protein 30.517
pcdh8protocadherin 80.491
fn1fibronectin 10.489
fzd7afrizzled homolog 7a0.477
slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.474
lft1lefty10.470
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.433
dlddeltaD0.431
sfrp1asecreted frizzled-related protein 1a0.427
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.425
ccm2cerebral cavernous malformation 20.423
rarabretinoic acid receptor, alpha b0.423
her7hairy and enhancer of split related-70.421
gata4GATA-binding protein 40.412
sfrp1bsecreted frizzled-related protein 1b0.408
nf1aneurofibromin 1a0.403
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.380
rbm19RNA binding motif protein 190.376
hhexhematopoietically expressed homeobox0.372
gli1GLI-Kruppel family member 10.368
bhlhe40basic helix-loop-helix family, member e400.363
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.359
gpiaglucose phosphate isomerase a0.355
mpxmyeloid-specific peroxidase0.352
ahctf1AT hook containing transcription factor 10.350
slc2a12solute carrier family 2 (facilitated glucose transporter), member 120.349
fgf10afibroblast growth factor 10a0.343
tal1T-cell acute lymphocytic leukemia 10.335
bmpr1aabone morphogenetic protein receptor, type 1aa0.334
slc2a11bsolute carrier family 2 (facilitated glucose transporter), member 11b0.330
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.329
slc2a1bsolute carrier family 2 (facilitated glucose transporter), member 1b0.320
LOC560358solute carrier family 2, facilitated glucose transporter member 11-like0.316
eya1eyes absent homolog 10.311
klf4Kruppel-like factor 40.310
tbx2bT-box 2b0.307
wif1wnt inhibitory factor 10.305
wnt3wingless-type MMTV integration site family, member 30.300
tjp3tight junction protein 30.297
wnt11wingless-type MMTV integration site family, member 110.296
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.296
copebcore promoter element binding protein0.287
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.282
pax6bpaired box gene 6b0.282
sox2SRY-box containing gene 20.279
gdf6agrowth differentiation factor 6a0.275
socs1suppressor of cytokine signaling 10.274
neo1neogenin 10.270
slc2a9l2solute carrier family 2 (facilitated glucose transporter), member 9-like 20.269
smad3bMAD, mothers against decapentaplegic homolog 3b (Drosophila)0.267
dharmadharma0.266
crabp2acellular retinoic acid binding protein 2, a0.263
traf4atnf receptor-associated factor 4a0.262
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.261
tyrtyrosinase0.260
c11orf2c11orf2 homolog (H. sapiens)0.258
wnt8bwingless-type MMTV integration site family, member 8b0.254
smad1MAD homolog 1 (Drosophila)0.254
gata2aGATA-binding protein 2a0.250
bmp3bone morphogenetic protein 30.247
ventventral expressed homeobox0.243
notch3notch homolog 30.242
krt4keratin 40.241
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.237
lfnglunatic fringe homolog0.225
prnprs3prion protein, related sequence 30.225
gli2aGLI-Kruppel family member GLI2a0.223
aldobaldolase b, fructose-bisphosphate0.221
id1inhibitor of DNA binding 10.221
dladeltaA0.218
otpborthopedia homolog b0.214
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 10.359
CCNE1cyclin E10.327
JAG1jagged 10.249
HNF4Ahepatocyte nuclear factor 4, alpha0.207
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.150
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.127
NOTCH3notch 30.101
DDIT3DNA-damage-inducible transcript 30.098
SC4MOLsterol-C4-methyl oxidase-like0.085
UHRF2ubiquitin-like with PHD and ring finger domains 20.082
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.059
JUNjun proto-oncogene0.057
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.053
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.053
MDM2Mdm2 p53 binding protein homolog (mouse)0.052
IDI1isopentenyl-diphosphate delta isomerase 10.051
CASP8caspase 8, apoptosis-related cysteine peptidase0.049
MED25mediator complex subunit 250.047
GARSglycyl-tRNA synthetase0.042
BMPR1Abone morphogenetic protein receptor, type IA0.039
CCND3cyclin D30.037
DHCR77-dehydrocholesterol reductase0.033
EGFRepidermal growth factor receptor0.028
PTPN1protein tyrosine phosphatase, non-receptor type 10.023
CDK6cyclin-dependent kinase 60.022
PKD2polycystic kidney disease 2 (autosomal dominant)0.021
BRCA1breast cancer 1, early onset0.021
GHRgrowth hormone receptor0.020
SMAD1SMAD family member 10.020
BBS10Bardet-Biedl syndrome 100.020
SETD7SET domain containing (lysine methyltransferase) 70.019
FGF1fibroblast growth factor 1 (acidic)0.019
CASP10caspase 10, apoptosis-related cysteine peptidase0.018
RXRAretinoid X receptor, alpha0.017
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.017
PKD1polycystic kidney disease 1 (autosomal dominant)0.017
NOTCH2notch 20.016
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.015
CCND1cyclin D10.015
BBS1Bardet-Biedl syndrome 10.015
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.014
CFLARCASP8 and FADD-like apoptosis regulator0.014
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.014
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.013
NCOA1nuclear receptor coactivator 10.013
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.013
CSNK1Ecasein kinase 1, epsilon0.013
PDX1pancreatic and duodenal homeobox 10.012
KLF4Kruppel-like factor 4 (gut)0.012
NCK2NCK adaptor protein 20.012
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.012
VAC14Vac14 homolog (S. cerevisiae)0.012
FN1fibronectin 10.012
NCOR2nuclear receptor corepressor 20.012
ATF3activating transcription factor 30.011
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.011
ARNTaryl hydrocarbon receptor nuclear translocator0.011
APOEapolipoprotein E0.011
CDK2cyclin-dependent kinase 20.011
SRFserum response factor (c-fos serum response element-binding transcription factor)0.010
CDK19cyclin-dependent kinase 190.010
ALDH1A1aldehyde dehydrogenase 1 family, member A10.010
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.854
Plgplasminogen0.762
Fabp1fatty acid binding protein 1, liver0.669
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.667
Mbl2mannose-binding lectin (protein C) 20.638
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.632
Azgp1alpha-2-glycoprotein 1, zinc-binding0.593
Mug1murinoglobulin 10.584
Otcornithine carbamoyltransferase0.579
Pzppregnancy-zone protein0.563
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.558
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.528
Dhfrdihydrofolate reductase0.477
LOC293989cytochrome P450-like0.461
Gbp2guanylate binding protein 20.460
Agxt2alanine-glyoxylate aminotransferase 20.454
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.454
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.435
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.424
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.409
Sc4molsterol-C4-methyl oxidase-like0.395
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.395
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.388
Aldobaldolase B, fructose-bisphosphate0.373
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.364
Akr1c14aldo-keto reductase family 1, member C140.356
Cyp51cytochrome P450, family 510.350
Anpepalanyl (membrane) aminopeptidase0.340
Ahsgalpha-2-HS-glycoprotein0.331
Metmet proto-oncogene0.309
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.299
Lipclipase, hepatic0.290
Gsta5glutathione S-transferase Yc2 subunit0.281
Slco2a1solute carrier organic anion transporter family, member 2a10.279
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.279
Cpb2carboxypeptidase B2 (plasma)0.277
Nr1d2nuclear receptor subfamily 1, group D, member 20.264
DbpD site of albumin promoter (albumin D-box) binding protein0.262
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.260
Nr1d1nuclear receptor subfamily 1, group D, member 10.247
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.242
Ptprqprotein tyrosine phosphatase, receptor type, Q0.237
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.233
Arandrogen receptor0.233
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.230
Apobapolipoprotein B0.229
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.227
Fgfr2fibroblast growth factor receptor 20.225
Slc17a1solute carrier family 17 (sodium phosphate), member 10.219
Ces1ccarboxylesterase 1C0.217
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.217
Sardhsarcosine dehydrogenase0.215
Galmgalactose mutarotase (aldose 1-epimerase)0.211
Tgfbr2transforming growth factor, beta receptor II0.205
Mvpmajor vault protein0.204
Dnase1l3deoxyribonuclease 1-like 30.197
C8bcomplement component 8, beta polypeptide0.197
Apoa2apolipoprotein A-II0.196
Gsta2glutathione S-transferase A20.196
Mettl7bmethyltransferase like 7B0.194
Mbl1mannose-binding lectin (protein A) 10.190
Prodh2proline dehydrogenase (oxidase) 20.184
Il1rapinterleukin 1 receptor accessory protein0.183
Fbp1fructose-1,6-bisphosphatase 10.181
Pklrpyruvate kinase, liver and RBC0.180
Fgafibrinogen alpha chain0.179
Mgst2microsomal glutathione S-transferase 20.172
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.169
Stat2signal transducer and activator of transcription 20.167
RT1-EC2RT1 class Ib, locus EC20.167
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.165
Prlrprolactin receptor0.164
LOC100365106rCG32755-like0.162
Hnf4ahepatocyte nuclear factor 4, alpha0.162
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.160
Apohapolipoprotein H (beta-2-glycoprotein I)0.153
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.152
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.150
Vom2r27vomeronasal 2 receptor, 270.149
Casp12caspase 120.149
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.147
Rup2urinary protein 20.144
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.144
Nr1h4nuclear receptor subfamily 1, group H, member 40.143
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.142
Clpscolipase, pancreatic0.140
Gstm2glutathione S-transferase mu 20.139
Gcgroup specific component0.136
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.135
Dpysdihydropyrimidinase0.135
Ctsccathepsin C0.132
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.129
Tpi1triosephosphate isomerase 10.129
Dpep1dipeptidase 1 (renal)0.129
Anxa1annexin A10.128
RGD1305347similar to RIKEN cDNA 2610528J110.126
LOC100361864UDP-glucuronosyltransferase 2B3-like0.124
AhnakAHNAK nucleoprotein0.123
Bmp7bone morphogenetic protein 70.123
Acox3acyl-Coenzyme A oxidase 3, pristanoyl0.122
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism