The network for 'immune response activating cell surface receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immune response activating cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.

NameDescriptionProbabilityFunc Analog Organism
Cd19CD19 antigen1.000
Inpp5dinositol polyphosphate-5-phosphatase D1.000
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.998
Ikzf1IKAROS family zinc finger 10.998
Cd22CD22 antigen0.998
Icosinducible T-cell co-stimulator0.997
ItkIL2-inducible T-cell kinase0.997
Ptprcprotein tyrosine phosphatase, receptor type, C0.996
FynFyn proto-oncogene0.996
Latlinker for activation of T cells0.996
Ccr2chemokine (C-C motif) receptor 20.993
Ptk2PTK2 protein tyrosine kinase 20.992
Vav1vav 1 oncogene0.984
Dok1docking protein 10.982
Tnftumor necrosis factor0.978
FaslFas ligand (TNF superfamily, member 6)0.978
Sykbspleen tyrosine kinase0.978
Grb2growth factor receptor bound protein 20.965
Ptenphosphatase and tensin homolog0.955
Il2rbinterleukin 2 receptor, beta chain0.953
Klra9killer cell lectin-like receptor subfamily A, member 90.953
Klrd1killer cell lectin-like receptor, subfamily D, member 10.943
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.942
Ptpn6protein tyrosine phosphatase, non-receptor type 60.920
Itgaxintegrin alpha X0.919
FasFas (TNF receptor superfamily member 6)0.917
Lcklymphocyte protein tyrosine kinase0.909
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.901
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.901
Ltalymphotoxin A0.895
Plcg1phospholipase C, gamma 10.889
Itgalintegrin alpha L0.887
WasWiskott-Aldrich syndrome homolog (human)0.885
BlkB lymphoid kinase0.885
Sfpi1SFFV proviral integration 10.874
Il2rginterleukin 2 receptor, gamma chain0.871
Tnfaip3tumor necrosis factor, alpha-induced protein 30.871
Ccr6chemokine (C-C motif) receptor 60.870
Ly9lymphocyte antigen 90.869
Fcgr2bFc receptor, IgG, low affinity IIb0.865
Ighimmunoglobulin heavy chain complex0.864
Cdh5cadherin 50.863
Cd247CD247 antigen0.852
Il10rainterleukin 10 receptor, alpha0.842
BtkBruton agammaglobulinemia tyrosine kinase0.828
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.816
Prdm1PR domain containing 1, with ZNF domain0.813
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.813
Gata4GATA binding protein 40.810
Zap70zeta-chain (TCR) associated protein kinase0.805
Ccr7chemokine (C-C motif) receptor 70.804
Cd7CD7 antigen0.800
Ltblymphotoxin B0.789
Pou2af1POU domain, class 2, associating factor 10.776
Dok2docking protein 20.771
Il10interleukin 100.767
Card11caspase recruitment domain family, member 110.765
Il7rinterleukin 7 receptor0.764
FcrlaFc receptor-like A0.756
Ikzf3IKAROS family zinc finger 30.754
Ctla4cytotoxic T-lymphocyte-associated protein 40.743
Cd2CD2 antigen0.741
Cd5CD5 antigen0.741
Slamf6SLAM family member 60.738
Map3k14mitogen-activated protein kinase kinase kinase 140.737
Cxcr3chemokine (C-X-C motif) receptor 30.736
Cd4CD4 antigen0.734
Cd3gCD3 antigen, gamma polypeptide0.732
CblCasitas B-lineage lymphoma0.730
Sh2d1aSH2 domain protein 1A0.725
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.707
Stat3signal transducer and activator of transcription 30.701
Aoahacyloxyacyl hydrolase0.699
Slamf1signaling lymphocytic activation molecule family member 10.697
Cd6CD6 antigen0.689
Rxraretinoid X receptor alpha0.688
Notch2Notch gene homolog 2 (Drosophila)0.685
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.678
Nkg7natural killer cell group 7 sequence0.668
Cd96CD96 antigen0.665
Foxp3forkhead box P30.664
Cd80CD80 antigen0.662
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.661
Ncf1neutrophil cytosolic factor 10.654
Ncr1natural cytotoxicity triggering receptor 10.632
Sellselectin, lymphocyte0.632
Cd3eCD3 antigen, epsilon polypeptide0.629
Tlr7toll-like receptor 70.615
Cd28CD28 antigen0.607
Ifnginterferon gamma0.605
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.603
Ncoa3nuclear receptor coactivator 30.598
Flt1FMS-like tyrosine kinase 10.597
Ticam1toll-like receptor adaptor molecule 10.594
Gimap7GTPase, IMAP family member 70.591
Lrmplymphoid-restricted membrane protein0.590
Rhohras homolog gene family, member H0.590
Lyz2lysozyme 20.574
Ctswcathepsin W0.572
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.551
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
GRB2growth factor receptor-bound protein 20.999
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.998
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.996
LCKlymphocyte-specific protein tyrosine kinase0.996
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.995
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.993
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.993
SYKspleen tyrosine kinase0.983
PTK2PTK2 protein tyrosine kinase 20.983
LATlinker for activation of T cells0.981
CD80CD80 molecule0.969
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.969
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.963
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.949
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.949
BCL2B-cell CLL/lymphoma 20.948
CD247CD247 molecule0.947
SHC1SHC (Src homology 2 domain containing) transforming protein 10.942
BTKBruton agammaglobulinemia tyrosine kinase0.893
BTN3A2butyrophilin, subfamily 3, member A20.888
GHRgrowth hormone receptor0.881
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.860
FYBFYN binding protein0.848
CD2CD2 molecule0.836
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.829
TFF1trefoil factor 10.827
BCL2L11BCL2-like 11 (apoptosis facilitator)0.827
PTPN1protein tyrosine phosphatase, non-receptor type 10.820
BIRC3baculoviral IAP repeat containing 30.815
BLNKB-cell linker0.813
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.761
BCL2L1BCL2-like 10.743
SH3BP2SH3-domain binding protein 20.736
BAXBCL2-associated X protein0.705
TRAF3TNF receptor-associated factor 30.697
EGFRepidermal growth factor receptor0.692
MPDZmultiple PDZ domain protein0.678
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.677
TNFAIP3tumor necrosis factor, alpha-induced protein 30.677
CD79ACD79a molecule, immunoglobulin-associated alpha0.659
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.657
BTN3A3butyrophilin, subfamily 3, member A30.639
RNF31ring finger protein 310.628
CARD11caspase recruitment domain family, member 110.533
TRAF1TNF receptor-associated factor 10.493
CD40CD40 molecule, TNF receptor superfamily member 50.492
MICAMHC class I polypeptide-related sequence A0.438
BTN3A1butyrophilin, subfamily 3, member A10.435
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.416
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.412
BIDBH3 interacting domain death agonist0.407
VAV1vav 1 guanine nucleotide exchange factor0.401
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.390
SQSTM1sequestosome 10.388
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.313
CD79BCD79b molecule, immunoglobulin-associated beta0.311
MAPK3mitogen-activated protein kinase 30.307
C19orf50chromosome 19 open reading frame 500.303
NCK2NCK adaptor protein 20.275
NUMBLnumb homolog (Drosophila)-like0.267
CTNND1catenin (cadherin-associated protein), delta 10.250
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.250
UBASH3Bubiquitin associated and SH3 domain containing B0.248
HDAC7histone deacetylase 70.246
GRAP2GRB2-related adaptor protein 20.240
PTPN6protein tyrosine phosphatase, non-receptor type 60.240
FYNFYN oncogene related to SRC, FGR, YES0.234
CD163CD163 molecule0.233
BADBCL2-associated agonist of cell death0.231
CD19CD19 molecule0.222
GRB7growth factor receptor-bound protein 70.215
SMURF2SMAD specific E3 ubiquitin protein ligase 20.209
ACTBactin, beta0.207
SMURF1SMAD specific E3 ubiquitin protein ligase 10.203
GAS7growth arrest-specific 70.195
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.191
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.185
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.180
CCR1chemokine (C-C motif) receptor 10.176
RNF11ring finger protein 110.175
FASLGFas ligand (TNF superfamily, member 6)0.174
VAV2vav 2 guanine nucleotide exchange factor0.173
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.172
SPRR2Asmall proline-rich protein 2A0.162
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.158
METmet proto-oncogene (hepatocyte growth factor receptor)0.156
BLKB lymphoid tyrosine kinase0.150
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.148
HCKhemopoietic cell kinase0.148
WIPF1WAS/WASL interacting protein family, member 10.146
CD22CD22 molecule0.141
PSEN2presenilin 2 (Alzheimer disease 4)0.137
FHL2four and a half LIM domains 20.135
PTPRCprotein tyrosine phosphatase, receptor type, C0.134
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.134
SH2D2ASH2 domain containing 2A0.124
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il2rginterleukin 2 receptor, gamma0.081
Sash3SAM and SH3 domain containing 30.043
Cd37CD37 molecule0.033
Sykspleen tyrosine kinase0.021
Cfpcomplement factor properdin0.020
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.019
Vav1vav 1 guanine nucleotide exchange factor0.019
Sirpasignal-regulatory protein alpha0.018
Cd86CD86 molecule0.017
Myo1fmyosin IF0.016
Cd3gCD3 molecule, gamma0.016
Ccr5chemokine (C-C motif) receptor 50.015
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
Cybbcytochrome b-245, beta polypeptide0.012
Stk10serine/threonine kinase 100.012
Ptprcprotein tyrosine phosphatase, receptor type, C0.012
Inpp5dinositol polyphosphate-5-phosphatase D0.012
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.011
Ptpn18protein tyrosine phosphatase, non-receptor type 180.011
Igsf6immunoglobulin superfamily, member 60.011
Casp1caspase 10.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism