The network for 'endoplasmic reticulum unfolded protein response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

NameDescriptionProbabilityFunc Analog Organism
Hspa5heat shock protein 50.999
Hsp90b1heat shock protein 90, beta (Grp94), member 10.997
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.949
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.882
Manfmesencephalic astrocyte-derived neurotrophic factor0.817
Creld2cysteine-rich with EGF-like domains 20.717
Pdia3protein disulfide isomerase associated 30.714
Uso1USO1 homolog, vesicle docking protein (yeast)0.705
Cdk4cyclin-dependent kinase 40.634
Sdf2l1stromal cell-derived factor 2-like 10.596
Vcpvalosin containing protein0.532
Cdk6cyclin-dependent kinase 60.389
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.365
Pdia6protein disulfide isomerase associated 60.364
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.318
Xbp1X-box binding protein 10.294
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.286
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.247
PycardPYD and CARD domain containing0.239
Serp1stress-associated endoplasmic reticulum protein 10.236
Hspa9heat shock protein 90.230
Edem1ER degradation enhancer, mannosidase alpha-like 10.223
Casp4caspase 4, apoptosis-related cysteine peptidase0.201
Surf4surfeit gene 40.199
Tlr4toll-like receptor 40.194
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.181
Spcs2signal peptidase complex subunit 2 homolog (S. cerevisiae)0.171
H47histocompatibility 470.167
Mgat2mannoside acetylglucosaminyltransferase 20.158
Slc39a7solute carrier family 39 (zinc transporter), member 70.154
Ssr2signal sequence receptor, beta0.150
Rpn2ribophorin II0.144
Spcs3signal peptidase complex subunit 3 homolog (S. cerevisiae)0.139
Hif1ahypoxia inducible factor 1, alpha subunit0.137
Prkcshprotein kinase C substrate 80K-H0.126
Ngly1N-glycanase 10.123
P4hbprolyl 4-hydroxylase, beta polypeptide0.111
Magt1magnesium transporter 10.104
FasFas (TNF receptor superfamily member 6)0.101
Slc30a5solute carrier family 30 (zinc transporter), member 50.099
Trp53transformation related protein 530.087
Slc35b1solute carrier family 35, member B10.086
Stat3signal transducer and activator of transcription 30.083
Casp1caspase 10.081
Rpn1ribophorin I0.079
Uba5ubiquitin-like modifier activating enzyme 50.076
Cdkn1bcyclin-dependent kinase inhibitor 1B0.075
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.073
Atf6activating transcription factor 60.072
Bcl2B-cell leukemia/lymphoma 20.071
Sec23bSEC23B (S. cerevisiae)0.069
Tm9sf3transmembrane 9 superfamily member 30.069
Ssr1signal sequence receptor, alpha0.061
Gbp5guanylate binding protein 50.060
Il18interleukin 180.060
Erp44endoplasmic reticulum protein 440.051
Tram1translocating chain-associating membrane protein 10.050
Rrbp1ribosome binding protein 10.050
GmppbGDP-mannose pyrophosphorylase B0.048
Fndc3afibronectin type III domain containing 3A0.046
Ubxn1UBX domain protein 10.044
Nfe2l2nuclear factor, erythroid derived 2, like 20.043
Txndc5thioredoxin domain containing 50.043
Myd88myeloid differentiation primary response gene 880.043
Lman1lectin, mannose-binding, 10.042
Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)0.042
Tmed7transmembrane emp24 protein transport domain containing 70.041
Stt3aSTT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)0.040
Lyz2lysozyme 20.038
Hspa8heat shock protein 80.037
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.035
Ccnd1cyclin D10.034
Atf4activating transcription factor 40.033
Bak1BCL2-antagonist/killer 10.032
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.032
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.032
Hsph1heat shock 105kDa/110kDa protein 10.032
Rb1retinoblastoma 10.031
Yarstyrosyl-tRNA synthetase0.030
Birc3baculoviral IAP repeat-containing 30.030
Lrrc59leucine rich repeat containing 590.030
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.030
Slc33a1solute carrier family 33 (acetyl-CoA transporter), member 10.030
Ifngr1interferon gamma receptor 10.030
Rag1recombination activating gene 10.030
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.029
Dnm1dynamin 10.029
Mafkv-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)0.029
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.028
Rnf103ring finger protein 1030.028
Arhgap31Rho GTPase activating protein 310.028
Sarsseryl-aminoacyl-tRNA synthetase0.027
Garsglycyl-tRNA synthetase0.027
Eif3beukaryotic translation initiation factor 3, subunit B0.027
Mcfd2multiple coagulation factor deficiency 20.027
Syvn1synovial apoptosis inhibitor 1, synoviolin0.025
Ssr3signal sequence receptor, gamma0.025
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
abu-15Protein ABU-150.994
abu-1Protein ABU-10.989
tag-320Protein TAG-3200.971
abu-11Protein ABU-110.965
hsp-16.2Protein HSP-16.20.960
hsp-70Protein HSP-700.917
hsp-16.1Protein HSP-16.10.906
abu-8Protein ABU-80.860
hsp-16.41Protein HSP-16.410.835
F44E5.4Protein F44E5.40.806
dnj-7Protein DNJ-70.791
pqn-54Protein PQN-540.777
dct-18Protein DCT-180.717
abu-6Protein ABU-60.712
CELE_T05E11.3Protein T05E11.30.700
hsp-16.48Protein HSP-16.480.689
hsp-3Protein HSP-30.627
abu-10Protein ABU-100.619
F13E6.5Protein F13E6.50.607
pqn-74Protein PQN-740.576
Y47D3B.6Protein Y47D3B.60.497
sec-22Protein SEC-220.473
F41E6.11Protein F41E6.110.467
CELE_T06E4.8Protein T06E4.80.436
abu-9Protein ABU-90.397
abu-14Protein ABU-140.378
hsp-4Protein HSP-40.353
pqn-63Protein PQN-630.350
pdi-3Protein PDI-30.305
hsp-17Protein HSP-170.301
erv-46Protein ERV-460.295
pdi-2Protein PDI-20.293
Y94H6A.7Protein Y94H6A.70.290
prp-8Protein PRP-80.290
trap-2Protein TRAP-20.274
CELE_T06E4.9Protein T06E4.90.268
myo-1Protein MYO-10.264
CELE_F20G2.2Protein F20G2.20.264
CELE_F29C12.4Protein F29C12.40.261
dsc-4Protein DSC-40.251
nra-4Protein NRA-40.247
ifd-1Protein IFD-10.226
lys-1Protein LYS-10.215
T25E4.1Protein T25E4.10.215
gst-1Protein GST-10.201
ZK686.3Protein ZK686.30.177
ser-3Protein SER-30.173
stt-3Protein STT-30.171
R03C1.1Protein R03C1.10.165
ostb-1Protein OSTB-10.158
C29F3.7Protein C29F3.70.153
pqn-71Protein PQN-710.146
C53C9.2Protein C53C9.20.145
T14G8.3Protein T14G8.30.144
ZC506.1Protein ZC506.10.140
mboa-3Protein MBOA-30.139
CELE_ZK550.3Protein ZK550.30.133
F53B3.3Protein F53B3.30.132
sgt-1Protein SGT-10.130
ckb-2Protein CKB-20.122
hpo-34Protein HPO-340.120
M02G9.1Protein M02G9.10.118
crt-1Protein CRT-10.114
Y19D2B.1Protein Y19D2B.10.110
tufm-1Protein TUFM-10.108
cdd-1Protein CDD-10.108
eef-1A.1Protein EEF-1A.10.106
hsp-1Protein HSP-10.105
clc-3Protein CLC-30.105
D2096.6Protein D2096.60.103
cut-4Protein CUT-40.102
rpia-1Protein RPIA-10.099
gdi-1Protein GDI-10.097
hsp-16.11Protein HSP-16.110.097
paa-1Protein PAA-10.097
glr-5Protein GLR-50.096
H43E16.1Protein H43E16.10.095
fic-1Protein FIC-10.092
dnpp-1Protein DNPP-10.092
dop-3Protein DOP-30.091
pqn-57Protein PQN-570.090
smp-1Protein SMP-10.086
C30F12.3Protein C30F12.30.086
CELE_Y39B6A.1Protein Y39B6A.10.084
suca-1Protein SUCA-10.084
glod-4Protein GLOD-40.083
nkat-3Protein NKAT-30.081
lec-6Protein LEC-60.081
daf-1Protein DAF-10.078
ubq-1Protein UBQ-10.077
T10B10.3Protein T10B10.30.074
CELE_F38E1.9Protein F38E1.90.073
lron-10Protein LRON-100.072
T08B1.1Protein T08B1.10.072
F47G9.1Protein F47G9.10.071
gale-1Protein GALE-10.070
dnc-2Protein DNC-20.069
ile-2Protein ILE-20.068
ugt-62Protein UGT-620.068
unc-78Protein UNC-780.068
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hspa5heat shock protein 50.964
hsp90b1heat shock protein 90, beta (grp94), member 10.956
hyou1hypoxia up-regulated 10.881
manfmesencephalic astrocyte-derived neurotrophic factor0.856
hspd1heat shock 60kD protein 1 (chaperonin)0.826
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.776
pdia3protein disulfide isomerase family A, member 30.620
calrcalreticulin and calreticulin0.607
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.547
tram1translocating chain-associating membrane protein 10.545
pdip5protein disulfide isomerase-related protein (provisional)0.531
hspa9heat shock protein 90.297
pdia4protein disulfide isomerase associated 40.270
calrlcalreticulin like0.230
yarstyrosyl-tRNA synthetase0.161
ckmacreatine kinase, muscle a0.159
ccng1cyclin G10.143
ttnatitin a0.122
calrl2calreticulin, like 20.120
adra2badrenergic, alpha-2B-, receptor0.114
txnrd1thioredoxin reductase 10.113
pvalb2parvalbumin 20.094
slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.092
mylz3myosin, light polypeptide 3, skeletal muscle0.090
larsleucyl-tRNA synthetase0.086
etf1eukaryotic translation termination factor 10.085
ddostdolichyl-diphosphooligosaccharide-protein glycosyltransferase0.083
nme2b.2non-metastatic cells 2b.2, protein (NM23B) expressed in0.080
hspa4aheat shock protein 4a0.080
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.076
prkcshprotein kinase C substrate 80K-H0.072
rpl4ribosomal protein L40.071
hsp90a.2heat shock protein 90-alpha 20.069
march6membrane-associated ring finger (C3HC4) 60.069
atp2b4ATPase, Ca++ transporting, plasma membrane 40.068
sec61al2Sec61 alpha like 20.067
pcsk5aproprotein convertase subtilisin/kexin type 5a0.065
mtdhametadherin a0.065
vmp1vacuole membrane protein 10.064
tmed9transmembrane emp24 protein transport domain containing 90.062
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.061
zfp36l1azinc finger protein 36, C3H type-like 1a0.058
hspa8heat shock protein 80.057
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.056
ef1aelongation factor 1-alpha0.054
nucb2bnucleobindin 2b0.052
pvalb4parvalbumin 40.052
mapkapk2amitogen-activated protein kinase-activated protein kinase 2a0.051
rpn2ribophorin II0.049
prdx3peroxiredoxin 30.049
dirc2disrupted in renal carcinoma 20.047
tufmTu translation elongation factor, mitochondrial0.046
pdap1pdgfa associated protein 10.046
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.044
tnni2a.4troponin I, skeletal, fast 2a.40.044
cyc1cytochrome c-10.043
tmem170atransmembrane protein 170A0.043
herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.043
syvn1synovial apoptosis inhibitor 1, synoviolin0.040
uqcrc1ubiquinol-cytochrome c reductase core protein I0.040
fzd7bfrizzled homolog 7b0.038
gclcglutamate-cysteine ligase, catalytic subunit0.038
arf2ADP-ribosylation factor 20.037
pdha1apyruvate dehydrogenase (lipoamide) alpha 1a0.036
tnnt3btroponin T3b, skeletal, fast0.036
irf11interferon regulatory factor 110.036
mbnl2muscleblind-like 2 (Drosophila)0.035
zbtb22bzinc finger and BTB domain containing 22b0.035
keap1akelch-like ECH-associated protein 1a0.035
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.034
junjun proto-oncogene0.034
lonp1lon peptidase 1, mitochondrial0.034
ckmbcreatine kinase, muscle b0.034
lman1lectin, mannose-binding, 10.033
tm9sf2transmembrane 9 superfamily member 20.032
odc1ornithine decarboxylase 10.032
aldh1a2aldehyde dehydrogenase 1 family, member A20.032
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.031
cdkrap3CDK5 regulatory subunit associated protein 30.031
yipf3Yip1 domain family, member 30.031
sqrdlsulfide quinone reductase-like (yeast)0.031
desmadesmin a0.031
idh3bisocitrate dehydrogenase 3 (NAD+) beta0.030
lap3leucine aminopeptidase 30.030
ldb3bLIM domain binding 3b0.029
tbc1d23TBC1 domain family, member 230.029
stat3signal transduction and activation of transcription 30.028
scamp2secretory carrier membrane protein 20.028
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.028
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BG4CG12297 gene product from transcript CG12297-RA0.052
chicoCG5686 gene product from transcript CG5686-RB0.017
RagACG11968 gene product from transcript CG11968-RA0.015
CG7371CG7371 gene product from transcript CG7371-RA0.011
Traf4TNF-receptor-associated factor 40.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SYVN1synovial apoptosis inhibitor 1, synoviolin1.000
PDIA3protein disulfide isomerase family A, member 31.000
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.999
BCL2B-cell CLL/lymphoma 20.993
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.991
BCL2L1BCL2-like 10.983
VCPvalosin containing protein0.959
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.953
P4HBprolyl 4-hydroxylase, beta polypeptide0.936
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.928
SELSselenoprotein S0.908
DERL1Der1-like domain family, member 10.884
BAXBCL2-associated X protein0.806
HSPA8heat shock 70kDa protein 80.774
PDIA6protein disulfide isomerase family A, member 60.745
UBE2J1ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)0.740
BCL2L11BCL2-like 11 (apoptosis facilitator)0.691
BADBCL2-associated agonist of cell death0.631
ATF3activating transcription factor 30.630
GHRgrowth hormone receptor0.624
PDIA4protein disulfide isomerase family A, member 40.621
PPIBpeptidylprolyl isomerase B (cyclophilin B)0.455
HSPD1heat shock 60kDa protein 1 (chaperonin)0.443
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.430
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.349
BAK1BCL2-antagonist/killer 10.306
VDAC1voltage-dependent anion channel 10.275
ERO1LERO1-like (S. cerevisiae)0.262
GRB2growth factor receptor-bound protein 20.245
ASNSasparagine synthetase (glutamine-hydrolyzing)0.230
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.212
SOS1son of sevenless homolog 1 (Drosophila)0.187
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.170
EIF2AK3eukaryotic translation initiation factor 2-alpha kinase 30.114
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)0.109
CCND3cyclin D30.097
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.086
ATF2activating transcription factor 20.076
C4orf14chromosome 4 open reading frame 140.070
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.067
DBPD site of albumin promoter (albumin D-box) binding protein0.064
AMFRautocrine motility factor receptor0.062
BAG1BCL2-associated athanogene0.061
ENO1enolase 1, (alpha)0.057
SSR1signal sequence receptor, alpha0.055
STON2stonin 20.055
ERN1endoplasmic reticulum to nucleus signaling 10.051
DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 30.050
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.050
HSPH1heat shock 105kDa/110kDa protein 10.049
RPN1ribophorin I0.048
CDK6cyclin-dependent kinase 60.046
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.045
RABAC1Rab acceptor 1 (prenylated)0.041
TUFMTu translation elongation factor, mitochondrial0.039
RNF144Bring finger protein 144B0.039
IMPDH2IMP (inosine 5'-monophosphate) dehydrogenase 20.039
FKBP4FK506 binding protein 4, 59kDa0.038
NUCB2nucleobindin 20.037
HYOU1hypoxia up-regulated 10.037
ATXN3ataxin 30.037
PTGES3prostaglandin E synthase 3 (cytosolic)0.032
LDHAlactate dehydrogenase A0.031
CDK4cyclin-dependent kinase 40.030
KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.028
CYCScytochrome c, somatic0.027
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.027
STX8syntaxin 80.027
ERO1LBERO1-like beta (S. cerevisiae)0.027
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.026
GOT2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.025
BAG2BCL2-associated athanogene 20.025
BIDBH3 interacting domain death agonist0.024
NSFL1CNSFL1 (p97) cofactor (p47)0.023
C19orf10chromosome 19 open reading frame 100.023
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.022
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.022
HM13histocompatibility (minor) 130.022
DERL2Der1-like domain family, member 20.021
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.021
EIF1eukaryotic translation initiation factor 10.020
LDLRlow density lipoprotein receptor0.020
RPN2ribophorin II0.020
SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 10.019
GANABglucosidase, alpha; neutral AB0.019
HSPA9heat shock 70kDa protein 9 (mortalin)0.018
SERP1stress-associated endoplasmic reticulum protein 10.018
USP46ubiquitin specific peptidase 460.017
ANKRD12ankyrin repeat domain 120.017
PLCG1phospholipase C, gamma 10.017
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.017
DNM1dynamin 10.017
TRAP1TNF receptor-associated protein 10.016
HSPA13heat shock protein 70kDa family, member 130.016
KEAP1kelch-like ECH-associated protein 10.016
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.016
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Manfmesencephalic astrocyte-derived neurotrophic factor0.136
Pdia3protein disulfide isomerase family A, member 30.127
Hsp90b1heat shock protein 90, beta, member 10.105
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.067
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.059
Pdia4protein disulfide isomerase family A, member 40.053
Lrrc59leucine rich repeat containing 590.047
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.034
Creld2cysteine-rich with EGF-like domains 20.034
Pdia6protein disulfide isomerase family A, member 60.033
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.031
Ubxn4UBX domain protein 40.027
Hsph1heat shock 105/110 protein 10.022
Plscr3phospholipid scramblase 30.020
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.019
Srprsignal recognition particle receptor ('docking protein')0.017
Txnrd1thioredoxin reductase 10.015
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.015
Nsfl1cNSFL1 (p97) cofactor (p47)0.015
Hyou1hypoxia up-regulated 10.014
Snd1staphylococcal nuclease and tudor domain containing 10.014
Herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.012
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.011
Btg1B-cell translocation gene 1, anti-proliferative0.011
Hspa5heat shock protein 50.011
P4hbprolyl 4-hydroxylase, beta polypeptide0.011
Hdlbphigh density lipoprotein binding protein0.011
Slc39a7solute carrier family 39 (zinc transporter), member 70.011
Sec23bSec23 homolog B (S. cerevisiae)0.010
Ap2a1adaptor-related protein complex 2, alpha 1 subunit0.010
Yarstyrosyl-tRNA synthetase0.010
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism