The network for 'negative regulation of myeloid leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of myeloid leukocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.992
Gata4GATA binding protein 40.989
Robo1roundabout homolog 1 (Drosophila)0.982
Rxraretinoid X receptor alpha0.969
Runx1runt related transcription factor 10.856
Ptpn11protein tyrosine phosphatase, non-receptor type 110.756
Ptprcprotein tyrosine phosphatase, receptor type, C0.613
Fgfr2fibroblast growth factor receptor 20.611
Rararetinoic acid receptor, alpha0.585
Gata1GATA binding protein 10.572
Trp53transformation related protein 530.508
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.496
Notch1Notch gene homolog 1 (Drosophila)0.493
Robo2roundabout homolog 2 (Drosophila)0.472
Rag1recombination activating gene 10.415
Ighimmunoglobulin heavy chain complex0.405
Gata6GATA binding protein 60.349
TcraT-cell receptor alpha chain0.317
Bmp4bone morphogenetic protein 40.308
Dok1docking protein 10.298
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.298
Dok2docking protein 20.297
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.287
Apcadenomatosis polyposis coli0.265
Fgf10fibroblast growth factor 100.251
Rargretinoic acid receptor, gamma0.240
Lcklymphocyte protein tyrosine kinase0.212
Efnb2ephrin B20.211
Jak3Janus kinase 30.206
Smad4MAD homolog 4 (Drosophila)0.205
Card11caspase recruitment domain family, member 110.184
Bmpr1abone morphogenetic protein receptor, type 1A0.179
Jag1jagged 10.174
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.170
Gli2GLI-Kruppel family member GLI20.168
Psen1presenilin 10.163
Sox9SRY-box containing gene 90.163
Rarbretinoic acid receptor, beta0.156
Dll1delta-like 1 (Drosophila)0.154
Cd19CD19 antigen0.151
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.148
Tal1T-cell acute lymphocytic leukemia 10.140
Kitkit oncogene0.140
Latlinker for activation of T cells0.140
Pax2paired box gene 20.137
Ptenphosphatase and tensin homolog0.134
Cd247CD247 antigen0.132
Foxp3forkhead box P30.132
Slit1slit homolog 1 (Drosophila)0.131
Notch2Notch gene homolog 2 (Drosophila)0.130
Gata5GATA binding protein 50.110
Il2rbinterleukin 2 receptor, beta chain0.106
WasWiskott-Aldrich syndrome homolog (human)0.106
Gsk3bglycogen synthase kinase 3 beta0.105
BlnkB-cell linker0.105
Zfpm2zinc finger protein, multitype 20.105
Plcg2phospholipase C, gamma 20.103
Il10rainterleukin 10 receptor, alpha0.102
Tbx3T-box 30.096
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.095
Sox4SRY-box containing gene 40.094
Snai1snail homolog 1 (Drosophila)0.094
Fli1Friend leukemia integration 10.092
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.086
Sorbs3sorbin and SH3 domain containing 30.079
Ccr1chemokine (C-C motif) receptor 10.078
Lyz2lysozyme 20.075
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.073
Il2interleukin 20.073
Tnftumor necrosis factor0.072
Gpr97G protein-coupled receptor 970.070
Map3k14mitogen-activated protein kinase kinase kinase 140.069
Zfpm1zinc finger protein, multitype 10.068
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.067
Hoxa5homeobox A50.067
CblCasitas B-lineage lymphoma0.066
Pax3paired box gene 30.066
Eporerythropoietin receptor0.065
Hcls1hematopoietic cell specific Lyn substrate 10.065
Pitx2paired-like homeodomain transcription factor 20.065
Il2rginterleukin 2 receptor, gamma chain0.064
Tgfb1transforming growth factor, beta 10.062
Il4interleukin 40.059
Slit2slit homolog 2 (Drosophila)0.058
Prkceprotein kinase C, epsilon0.056
Fcgr2bFc receptor, IgG, low affinity IIb0.056
Inpp5dinositol polyphosphate-5-phosphatase D0.055
Zap70zeta-chain (TCR) associated protein kinase0.054
Pou2af1POU domain, class 2, associating factor 10.054
Gli3GLI-Kruppel family member GLI30.053
Tcf21transcription factor 210.052
Ccr6chemokine (C-C motif) receptor 60.052
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.051
Nf2neurofibromatosis 20.049
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.049
Numbnumb gene homolog (Drosophila)0.049
Ptpreprotein tyrosine phosphatase, receptor type, E0.048
Dok3docking protein 30.048
Fgfr1fibroblast growth factor receptor 10.047
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.668
wnt8awingless-type MMTV integration site family, member 8a0.531
spry4sprouty (Drosophila) homolog 40.235
pou5f1POU domain, class 5, transcription factor 10.211
fzd7bfrizzled homolog 7b0.191
etv2ets variant gene 20.189
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.182
hhexhematopoietically expressed homeobox0.150
tal1T-cell acute lymphocytic leukemia 10.124
mychmyelocytomatosis oncogene homolog0.111
nkx2.5NK2 transcription factor related 50.106
etv5bets variant 5b0.091
lfnglunatic fringe homolog0.089
aplnrbapelin receptor b0.083
lmo2LIM domain only 2 (rhombotin-like 1)0.073
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.068
celf1cugbp, Elav-like family member 10.061
nf1bneurofibromin 1b0.061
sulf1sulfatase 10.061
mmp13amatrix metalloproteinase 13a0.060
cxcr4achemokine (C-X-C motif) receptor 4a0.055
id1inhibitor of DNA binding 10.054
fzd7afrizzled homolog 7a0.050
stab2stabilin 20.049
glud1aglutamate dehydrogenase 1a0.047
ptgs1prostaglandin-endoperoxide synthase 10.045
wnt11rwingless-type MMTV integration site family, member 11, related0.043
lcp1lymphocyte cytosolic plastin 10.042
lmo4aLIM domain only 4a0.041
znf703zinc finger protein 7030.041
fn1fibronectin 10.040
rargaretinoic acid receptor gamma a0.039
dusp5dual specificity phosphatase 50.039
fbp1bfructose-1,6-bisphosphatase 1b0.038
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.038
gata1aGATA binding protein 1a0.037
fli1bfriend leukemia integration 1b0.037
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.037
tmem88atransmembrane protein 88 a0.035
prrx1apaired related homeobox 1a0.035
nf1aneurofibromin 1a0.034
btkBruton agammaglobulinemia tyrosine kinase0.033
irf8interferon regulatory factor 80.033
nrarpanotch-regulated ankyrin repeat protein a0.032
klf4Kruppel-like factor 40.031
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.031
lrrc33leucine rich repeat containing 330.030
efnb2aephrin B2a0.029
bmpr1aabone morphogenetic protein receptor, type 1aa0.029
otx1borthodenticle homolog 1b0.029
znf711zinc finger protein 7110.028
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.028
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.027
bucbucky ball0.027
bmperBMP binding endothelial regulator0.025
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.025
crip2cysteine-rich protein 20.024
sox19bSRY-box containing gene 19b0.024
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.024
ets2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.024
sox2SRY-box containing gene 20.024
osr1odd-skipped related 1 (Drosophila)0.023
bmpr1abbone morphogenetic protein receptor, type 1ab0.022
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.022
stac3SH3 and cysteine rich domain 30.021
egr2bearly growth response 2b0.021
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.020
ehmt2euchromatic histone-lysine N-methyltransferase 20.020
kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.020
col7a1lcollagen type VII alpha 1-like0.020
rnaset2ribonuclease T20.019
mapk3mitogen-activated protein kinase 30.019
nrg2bneuregulin 2b0.019
ntn2netrin 20.019
vasavasa homolog0.019
ca15acarbonic anhydrase XV a0.018
pdcd2programmed cell death 20.018
grnbgranulin b0.018
LOC572344hypothetical protein LOC5723440.018
cpsf6cleavage and polyadenylation specific factor 60.018
ptprcprotein tyrosine phosphatase, receptor type, C0.017
mpxmyeloid-specific peroxidase0.017
blfbloody fingers0.017
numblnumb homolog (Drosophila)-like0.017
angptl2angiopoietin-like 20.017
sfrp1bsecreted frizzled-related protein 1b0.017
hspa12bheat shock protein 12B0.017
znf503zinc finger protein 5030.017
nkd2naked cuticle homolog 2 and naked 2a0.016
hsp47heat shock protein 470.016
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.016
tgfbr1btransforming growth factor, beta receptor 1 b0.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ZNF43zinc finger protein 430.991
ZNF273zinc finger protein 2730.946
CCR5chemokine (C-C motif) receptor 50.930
IL4Rinterleukin 4 receptor0.919
PTPN6protein tyrosine phosphatase, non-receptor type 60.917
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.915
ZNF253zinc finger protein 2530.863
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.853
PILRApaired immunoglobin-like type 2 receptor alpha0.806
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.787
ZNF675zinc finger protein 6750.782
RXRAretinoid X receptor, alpha0.701
GHRgrowth hormone receptor0.694
C1QAcomplement component 1, q subcomponent, A chain0.584
TAL1T-cell acute lymphocytic leukemia 10.505
CCL4chemokine (C-C motif) ligand 40.504
HOXA10homeobox A100.382
ZNF708zinc finger protein 7080.314
CCL8chemokine (C-C motif) ligand 80.289
ZNF93zinc finger protein 930.262
ZNF91zinc finger protein 910.256
ZNF680zinc finger protein 6800.238
DPP4dipeptidyl-peptidase 40.233
MDM2Mdm2 p53 binding protein homolog (mouse)0.212
RUNX1runt-related transcription factor 10.177
SH3BP2SH3-domain binding protein 20.176
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.175
HOXB5homeobox B50.172
CCL13chemokine (C-C motif) ligand 130.152
HOXB3homeobox B30.143
ZNF430zinc finger protein 4300.142
IL2RGinterleukin 2 receptor, gamma0.141
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.127
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.125
RBBP4retinoblastoma binding protein 40.117
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.115
CXCL9chemokine (C-X-C motif) ligand 90.109
HOXA4homeobox A40.107
SIGLEC7sialic acid binding Ig-like lectin 70.101
TGFB1transforming growth factor, beta 10.091
IL8interleukin 80.090
C1QCcomplement component 1, q subcomponent, C chain0.089
MED25mediator complex subunit 250.088
HOXB7homeobox B70.086
ZNF85zinc finger protein 850.082
HOXB9homeobox B90.082
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.082
CD14CD14 molecule0.077
CCR1chemokine (C-C motif) receptor 10.076
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.075
SKP1S-phase kinase-associated protein 10.074
TP53tumor protein p530.067
HOXA11homeobox A110.066
RARAretinoic acid receptor, alpha0.064
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.063
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.062
HOXA6homeobox A60.060
EPORerythropoietin receptor0.058
MAXMYC associated factor X0.058
SLAMF8SLAM family member 80.057
ZNF254zinc finger protein 2540.057
IDEinsulin-degrading enzyme0.056
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.055
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.054
DOCK7dedicator of cytokinesis 70.050
CCR7chemokine (C-C motif) receptor 70.049
CREBBPCREB binding protein0.048
ZNF117zinc finger protein 1170.044
PTPRBprotein tyrosine phosphatase, receptor type, B0.043
ZNF92zinc finger protein 920.042
ZNF682zinc finger protein 6820.040
HK3hexokinase 3 (white cell)0.040
CDK6cyclin-dependent kinase 60.037
MARCOmacrophage receptor with collagenous structure0.036
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.032
BMP2bone morphogenetic protein 20.032
PTAFRplatelet-activating factor receptor0.032
CCL19chemokine (C-C motif) ligand 190.031
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.031
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.031
IFNGinterferon, gamma0.031
HOXA5homeobox A50.030
CCL2chemokine (C-C motif) ligand 20.030
NCOA1nuclear receptor coactivator 10.028
CXCL10chemokine (C-X-C motif) ligand 100.028
SKIv-ski sarcoma viral oncogene homolog (avian)0.028
TMSB4Xthymosin beta 4, X-linked0.028
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.027
CCND1cyclin D10.027
EXT2exostosin 20.027
ZNF107zinc finger protein 1070.026
INHBAinhibin, beta A0.026
HOXB6homeobox B60.025
HOXC10homeobox C100.024
TYMPthymidine phosphorylase0.024
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.024
CXCL13chemokine (C-X-C motif) ligand 130.023
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.023
HCKhemopoietic cell kinase0.023
PMLpromyelocytic leukemia0.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism