The network for 'branched chain amino acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

branched chain amino acid metabolic process

The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.

NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.687
Stat5asignal transducer and activator of transcription 5A0.487
Stat5bsignal transducer and activator of transcription 5B0.430
Lepleptin0.152
Irf9interferon regulatory factor 90.104
Foxp3forkhead box P30.097
Esr1estrogen receptor 1 (alpha)0.094
Arandrogen receptor0.077
Stat1signal transducer and activator of transcription 10.076
Ghrgrowth hormone receptor0.046
Il6stinterleukin 6 signal transducer0.044
Stat3signal transducer and activator of transcription 30.042
Trp53transformation related protein 530.028
Kitkit oncogene0.028
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.027
Stat2signal transducer and activator of transcription 20.022
Il4rainterleukin 4 receptor, alpha0.019
Myd88myeloid differentiation primary response gene 880.018
Il1r1interleukin 1 receptor, type I0.016
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.015
Nr3c1nuclear receptor subfamily 3, group C, member 10.015
Cdkn1bcyclin-dependent kinase inhibitor 1B0.014
Mutmethylmalonyl-Coenzyme A mutase0.013
Il10interleukin 100.013
Prlrprolactin receptor0.013
Ahraryl-hydrocarbon receptor0.013
TapbpTAP binding protein0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ghrbgrowth hormone receptor b0.950
aldh7a1aldehyde dehydrogenase 7 family, member A10.673
ghragrowth hormone receptor a0.554
mdh1amalate dehydrogenase 1a, NAD (soluble)0.486
ivdisovaleryl Coenzyme A dehydrogenase0.416
gcm2glial cells missing homolog 2 (Drosophila)0.351
angptl2angiopoietin-like 20.254
aldh6a1aldehyde dehydrogenase 6 family, member A10.216
dlstdihydrolipoamide S-succinyltransferase0.128
sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.123
dhtkd1dehydrogenase E1 and transketolase domain containing 10.121
gamtguanidinoacetate N-methyltransferase0.092
bhmtbetaine-homocysteine methyltransferase0.092
zgc:64133zgc:641330.092
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.076
sucla2succinate-CoA ligase, ADP-forming, beta subunit0.068
deptorDEP domain containing MTOR-interacting protein0.068
rbp4retinol binding protein 4, plasma0.065
mgaMAX gene associated0.054
ahcyS-adenosylhomocysteine hydrolase0.051
gyg1glycogenin 10.046
echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.044
etfaelectron-transfer-flavoprotein, alpha polypeptide0.040
ucp1uncoupling protein 10.038
pahphenylalanine hydroxylase0.038
slc38a4solute carrier family 38, member 40.036
aldobaldolase b, fructose-bisphosphate0.035
pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.032
zgc:56136zgc:561360.030
timp2atissue inhibitor of metalloproteinase 2a0.028
LOC566708FL cytokine receptor-like0.024
mpdu1amannose-P-dolichol utilization defect 1a0.024
mcoln1mucolipin 10.024
mutmethylmalonyl Coenzyme A mutase0.024
serpinc1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 10.024
lmo7aLIM domain only 7a0.022
foxi3aforkhead box I3a0.022
lpar1lysophosphatidic acid receptor 10.022
zgc:194131zgc:1941310.022
zgc:56518zgc:565180.021
mat1amethionine adenosyltransferase I, alpha0.020
pdhbpyruvate dehydrogenase (lipoamide) beta0.020
hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.020
aldh9a1aaldehyde dehydrogenase 9 family, member A1a0.019
dldhdihydrolipoamide dehydrogenase0.019
ech1enoyl CoA hydratase 1, peroxisomal0.018
zgc:162544zgc:1625440.018
acsf2acyl-CoA synthetase family member 20.018
col12a1collagen, type XII, alpha 10.018
sepp1aselenoprotein P, plasma, 1a0.018
dnm2ldynamin2-like0.018
igf2binsulin-like growth factor 2b0.017
pdcd8programmed cell death 8 (apoptosis-inducing factor)0.017
ktn1kinectin 10.017
bcat2branched chain aminotransferase 2, mitochondrial0.017
pomt1protein-O-mannosyltransferase 10.016
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.016
ogdhoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)0.016
zgc:136894zgc:1368940.016
atp5gATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)0.016
bckdhbbranched chain ketoacid dehydrogenase E1, beta polypeptide0.016
tkttransketolase0.016
adkbadenosine kinase b0.016
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.016
ldhbalactate dehydrogenase Ba0.015
aldh4a1aldehyde dehydrogenase 4 family, member A10.015
hgdhomogentisate 1,2-dioxygenase0.015
sfrp1bsecreted frizzled-related protein 1b0.015
eif4a1beukaryotic translation initiation factor 4A, isoform 1B0.015
zgc:92090zgc:920900.015
ef1aelongation factor 1-alpha0.014
st8sia6ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 60.014
tattyrosine aminotransferase0.014
slc25a32asolute carrier family 25, member 32a0.014
slc27a1asolute carrier family 27 (fatty acid transporter), member 1a0.014
sept7bseptin 7b0.014
celf1cugbp, Elav-like family member 10.013
slc2a1bsolute carrier family 2 (facilitated glucose transporter), member 1b0.013
msrb3methionine sulfoxide reductase B30.013
ak4adenylate kinase 40.013
tob1atransducer of ERBB2, 1a0.013
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.013
pgm1phosphoglucomutase 10.013
metap1methionyl aminopeptidase 10.013
mbnl2muscleblind-like 2 (Drosophila)0.013
chchd3coiled-coil-helix-coiled-coil-helix domain containing 30.013
aco2aconitase 2, mitochondrial0.013
sykspleen tyrosine kinase0.012
zbtb4zinc finger and BTB domain containing 40.012
tcea3transcription elongation factor A (SII), 30.012
acox1acyl-Coenzyme A oxidase 1, palmitoyl0.012
rrm2bribonucleotide reductase M2 b0.012
slc25a11solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 110.012
brp44brain protein 440.011
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.011
bhlhe40basic helix-loop-helix family, member e400.011
aglamylo-1, 6-glucosidase, 4-alpha-glucanotransferase0.011
fbxo9F-box protein 90.011
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.011
acat1acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 11.000
INSRinsulin receptor0.998
BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide0.941
PTPRBprotein tyrosine phosphatase, receptor type, B0.671
JAK2Janus kinase 20.575
PTPN3protein tyrosine phosphatase, non-receptor type 30.563
STAT5Asignal transducer and activator of transcription 5A0.453
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.341
MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha)0.244
PTPN2protein tyrosine phosphatase, non-receptor type 20.238
EGFRepidermal growth factor receptor0.227
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.193
CAV1caveolin 1, caveolae protein, 22kDa0.184
BCAR1breast cancer anti-estrogen resistance 10.173
METmet proto-oncogene (hepatocyte growth factor receptor)0.172
EPORerythropoietin receptor0.130
LATlinker for activation of T cells0.125
ECH1enoyl CoA hydratase 1, peroxisomal0.110
PTPN9protein tyrosine phosphatase, non-receptor type 90.108
BCKDHAbranched chain keto acid dehydrogenase E1, alpha polypeptide0.100
C21orf33chromosome 21 open reading frame 330.083
IL2RBinterleukin 2 receptor, beta0.083
STAP2signal transducing adaptor family member 20.082
IGF1Rinsulin-like growth factor 1 receptor0.080
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.069
ACADSBacyl-CoA dehydrogenase, short/branched chain0.065
BCKDKbranched chain ketoacid dehydrogenase kinase0.056
IRS1insulin receptor substrate 10.054
SOCS2suppressor of cytokine signaling 20.053
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.052
HIBADH3-hydroxyisobutyrate dehydrogenase0.048
NNTnicotinamide nucleotide transhydrogenase0.043
CPT2carnitine palmitoyltransferase 20.041
ALDOAaldolase A, fructose-bisphosphate0.038
ALDH6A1aldehyde dehydrogenase 6 family, member A10.037
DECR12,4-dienoyl CoA reductase 1, mitochondrial0.036
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.035
CATcatalase0.031
STAT5Bsignal transducer and activator of transcription 5B0.030
SUCLG2succinate-CoA ligase, GDP-forming, beta subunit0.028
PHYHphytanoyl-CoA 2-hydroxylase0.027
AKR7A2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.027
JAK1Janus kinase 10.026
HADHhydroxyacyl-CoA dehydrogenase0.024
DUSP7dual specificity phosphatase 70.022
PIGPphosphatidylinositol glycan anchor biosynthesis, class P0.021
SCP2sterol carrier protein 20.019
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.017
ECI2enoyl-CoA delta isomerase 20.016
PEX7peroxisomal biogenesis factor 70.015
BCRbreakpoint cluster region0.015
GHRgrowth hormone receptor0.015
NCOA2nuclear receptor coactivator 20.015
CYB5Acytochrome b5 type A (microsomal)0.014
TRAPPC6Atrafficking protein particle complex 6A0.014
DHTKD1dehydrogenase E1 and transketolase domain containing 10.013
ACAD8acyl-CoA dehydrogenase family, member 80.012
PRMT2protein arginine methyltransferase 20.011
PEX19peroxisomal biogenesis factor 190.011
ACADVLacyl-CoA dehydrogenase, very long chain0.011
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.010
C8orf40chromosome 8 open reading frame 400.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gcdhglutaryl-Coenzyme A dehydrogenase0.519
Adkadenosine kinase0.450
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.354
Mccc2methylcrotonoyl-Coenzyme A carboxylase 2 (beta)0.262
Pccapropionyl-coenzyme A carboxylase, alpha polypeptide0.193
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.156
Adhfe1alcohol dehydrogenase, iron containing, 10.100
Acat1acetyl-coenzyme A acetyltransferase 10.099
Aldh6a1aldehyde dehydrogenase 6 family, member A10.087
Hibadh3-hydroxyisobutyrate dehydrogenase0.067
Acsl1acyl-CoA synthetase long-chain family member 10.062
Nfs1NFS1 nitrogen fixation 1 homolog (S. cerevisiae)0.057
Acadsbacyl-Coenzyme A dehydrogenase, short/branched chain0.055
Mutmethylmalonyl-Coenzyme A mutase0.051
Tstthiosulfate sulfurtransferase0.051
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.044
Dhtkd1dehydrogenase E1 and transketolase domain containing 10.040
Etfdhelectron-transferring-flavoprotein dehydrogenase0.040
Pccbpropionyl coenzyme A carboxylase, beta polypeptide0.035
Ghrgrowth hormone receptor0.033
Scp2sterol carrier protein 20.032
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.030
Nntnicotinamide nucleotide transhydrogenase0.030
Isoc1isochorismatase domain containing 10.028
Josd2Josephin domain containing 20.026
DdtD-dopachrome tautomerase0.026
Ctf1cardiotrophin 10.025
Adi1acireductone dioxygenase 10.025
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.024
Glud1glutamate dehydrogenase 10.022
Suoxsulfite oxidase0.022
Bphlbiphenyl hydrolase-like (serine hydrolase)0.022
Clyblcitrate lyase beta like0.022
Suclg1succinate-CoA ligase, alpha subunit0.022
Mipepmitochondrial intermediate peptidase0.020
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.020
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.019
Ivdisovaleryl coenzyme A dehydrogenase0.019
Pxmp2peroxisomal membrane protein 20.019
Akr1c14aldo-keto reductase family 1, member C140.018
Gipc1GIPC PDZ domain containing family, member 10.017
Ube2mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.017
Gstm7glutathione S-transferase, mu 70.017
Coq7coenzyme Q7 homolog, ubiquinone (yeast)0.017
Nfianuclear factor I/A0.016
Mtus1mitochondrial tumor suppressor 10.016
Nqo2NAD(P)H dehydrogenase, quinone 20.016
Abhd14babhydrolase domain containing 14b0.015
Capn1calpain 10.015
Aldh2aldehyde dehydrogenase 2 family (mitochondrial)0.015
Hrsp12heat-responsive protein 120.015
Dcxrdicarbonyl L-xylulose reductase0.014
Aldh4a1aldehyde dehydrogenase 4 family, member A10.014
Cmblcarboxymethylenebutenolidase homolog (Pseudomonas)0.014
Pecrperoxisomal trans-2-enoyl-CoA reductase0.013
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.013
Bckdhbbranched chain keto acid dehydrogenase E1, beta polypeptide0.013
Ubxn6UBX domain protein 60.013
Catcatalase0.013
Mccc1methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)0.012
Pdk2pyruvate dehydrogenase kinase, isozyme 20.012
ClpbClpB caseinolytic peptidase B homolog (E. coli)0.012
Gstm2glutathione S-transferase mu 20.012
Klf15Kruppel-like factor 150.012
Calcrlcalcitonin receptor-like0.012
Yipf3Yip1 domain family, member 30.012
Ddostdolichyl-diphosphooligosaccharide-protein glycosyltransferase0.011
Cishcytokine inducible SH2-containing protein0.011
Etfaelectron-transfer-flavoprotein, alpha polypeptide0.011
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.011
Hint3histidine triad nucleotide binding protein 30.011
Scand1SCAN domain-containing 10.011
Ddr1discoidin domain receptor tyrosine kinase 10.010
Isoc2bisochorismatase domain containing 2b0.010
Acot2acyl-CoA thioesterase 20.010
Cd36CD36 molecule (thrombospondin receptor)0.010
RGD1303003homolog of zebrafish ES10.010
Insrinsulin receptor0.010
Pcdhga11protocadherin gamma subfamily A, 110.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
BAT1Bat1p0.945
LEU9Leu9p0.837
OAC1Oac1p0.689
ILV3Ilv3p0.667
ILV2Ilv2p0.331
MAE1Mae1p0.290
LEU1Leu1p0.237
ILV5Ilv5p0.232
ILV6Ilv6p0.206
ALD5Ald5p0.148
ARO9Aro9p0.128
URA2Ura2p0.124
LYS4Lys4p0.108
BAT2Bat2p0.107
LEU2Leu2p0.098
YDL157Chypothetical protein0.083
ARF2Arf2p0.075
ARG8Arg8p0.070
GDH1Gdh1p0.059
DPS1Dps1p0.056
MDH1Mdh1p0.054
ARO4Aro4p0.051
LYS12Lys12p0.049
YLR179Chypothetical protein0.047
LAT1Lat1p0.046
COX2Cox2p0.045
CHA1Cha1p0.045
BIO2Bio2p0.045
LEU4Leu4p0.044
HSP60Hsp60p0.043
YLR264C-Ahypothetical protein0.034
INM1Inm1p0.034
SRD1Srd1p0.033
ALD6Ald6p0.033
TOS4Tos4p0.033
IDP1Idp1p0.031
MER1Mer1p0.030
YAR068Whypothetical protein0.029
ARP10Arp10p0.029
CIN2Cin2p0.029
YLR162Whypothetical protein0.028
IMD2Imd2p0.027
GLT1Glt1p0.027
YOL038C-Ahypothetical protein0.026
CUP1-1Cup1-1p0.024
ARO3Aro3p0.024
NDE1Nde1p0.024
DCD1Dcd1p0.024
NSE5Nse5p0.023
ATP6Atp6p0.022
YAR066Whypothetical protein0.022
DIC1Dic1p0.022
YBT1Ybt1p0.022
FIT2Fit2p0.022
SCM4Scm4p0.021
IDH1Idh1p0.021
YPR157Whypothetical protein0.021
REE1Ree1p0.021
YLR042Chypothetical protein0.021
AUA1Aua1p0.020
HPF1Hpf1p0.020
URA3Ura3p0.020
ZPS1Zps1p0.020
ACM1Acm1p0.020
GNA1Gna1p0.020
BSC1Bsc1p0.020
HXT3Hxt3p0.019
YBR013Chypothetical protein0.019
YMC1Ymc1p0.019
YJL181Whypothetical protein0.019
ENA5Ena5p0.019
SPL2Spl2p0.019
YMR122W-Ahypothetical protein0.018
DUG1Dug1p0.018
FMT1Fmt1p0.018
YOL013W-Ahypothetical protein0.018
CDC60Cdc60p0.018
JLP2Jlp2p0.018
FCY21Fcy21p0.018
HOHop0.018
TSC3Tsc3p0.017
SAM4Sam4p0.017
MF(ALPHA)2Mf(alpha)2p0.017
UPS3Ups3p0.017
YCH1Ych1p0.017
OPT2Opt2p0.016
CPD1Cpd1p0.016
SWC7Swc7p0.016
YJL160Chypothetical protein0.016
ADH2Adh2p0.016
YIR035Chypothetical protein0.016
YPR063Chypothetical protein0.016
YLR040Chypothetical protein0.016
ATO3Ato3p0.016
GLN1Gln1p0.016
YAL037C-Ahypothetical protein0.016
PTR2Ptr2p0.016
YAL064Whypothetical protein0.015
LYS9Lys9p0.015
YPR096Chypothetical protein0.015