The network for 'regulation of mitochondrial fission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mitochondrial fission

Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.

NameDescriptionProbabilityFunc Analog Organism
Lrrk2leucine-rich repeat kinase 20.785
Bak1BCL2-antagonist/killer 10.778
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.615
Mfn2mitofusin 20.523
Ptp4a1protein tyrosine phosphatase 4a10.485
Hccsholocytochrome c synthetase0.378
Atl2atlastin GTPase 20.348
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.292
Namptnicotinamide phosphoribosyltransferase0.277
Kpna1karyopherin (importin) alpha 10.248
Ndrg2N-myc downstream regulated gene 20.206
Sod2superoxide dismutase 2, mitochondrial0.179
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)0.178
Rab18RAB18, member RAS oncogene family0.171
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.171
Sncaipsynuclein, alpha interacting protein (synphilin)0.142
Pptc7PTC7 protein phosphatase homolog (S. cerevisiae)0.138
Isca1iron-sulfur cluster assembly 1 homolog (S. cerevisiae)0.138
TctaT-cell leukemia translocation altered gene0.114
Hbs1lHbs1-like (S. cerevisiae)0.111
March5membrane-associated ring finger (C3HC4) 50.110
Pick1protein interacting with C kinase 10.109
Ugp2UDP-glucose pyrophosphorylase 20.106
Tchptrichoplein, keratin filament binding0.103
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.101
Cycscytochrome c, somatic0.099
Nos3nitric oxide synthase 3, endothelial cell0.096
Ghitmgrowth hormone inducible transmembrane protein0.088
Uba3ubiquitin-like modifier activating enzyme 30.085
Pgk1phosphoglycerate kinase 10.079
Pdk2pyruvate dehydrogenase kinase, isoenzyme 20.078
Pdha1pyruvate dehydrogenase E1 alpha 10.077
Sncasynuclein, alpha0.071
Hspa9heat shock protein 90.068
Egln1EGL nine homolog 1 (C. elegans)0.068
Slc30a9solute carrier family 30 (zinc transporter), member 90.067
Dlddihydrolipoamide dehydrogenase0.064
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.059
Lpin1lipin 10.058
Eif3jeukaryotic translation initiation factor 3, subunit J0.053
Dcaf8DDB1 and CUL4 associated factor 80.051
Mfn1mitofusin 10.050
Opa1optic atrophy 1 homolog (human)0.050
Sh3gl2SH3-domain GRB2-like 20.047
Eif2ak3eukaryotic translation initiation factor 2 alpha kinase 30.044
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.043
Dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.043
Gkap1G kinase anchoring protein 10.042
Mlycdmalonyl-CoA decarboxylase0.040
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.040
Trappc10trafficking protein particle complex 100.040
Bnip3BCL2/adenovirus E1B interacting protein 30.039
Gbe1glucan (1,4-alpha-), branching enzyme 10.036
Ubr3ubiquitin protein ligase E3 component n-recognin 30.035
Mdh1malate dehydrogenase 1, NAD (soluble)0.035
Etfdhelectron transferring flavoprotein, dehydrogenase0.034
Rcl1RNA terminal phosphate cyclase-like 10.032
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.032
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.032
IscuIscU iron-sulfur cluster scaffold homolog (E. coli)0.032
Endogendonuclease G0.032
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.031
Slc25a46solute carrier family 25, member 460.030
Ccng1cyclin G10.030
Adipor1adiponectin receptor 10.030
Pdk1pyruvate dehydrogenase kinase, isoenzyme 10.029
Pgm2phosphoglucomutase 20.029
Aglamylo-1,6-glucosidase, 4-alpha-glucanotransferase0.029
2310044G17RikRIKEN cDNA 2310044G17 gene0.027
Mul1mitochondrial ubiquitin ligase activator of NFKB 10.027
Nkiras1NFKB inhibitor interacting Ras-like protein 10.026
Vdac2voltage-dependent anion channel 20.026
Ranbp9RAN binding protein 90.026
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.025
Dnajb2DnaJ (Hsp40) homolog, subfamily B, member 20.025
Becn1beclin 1, autophagy related0.025
Rnf11ring finger protein 110.025
2310061I04RikRIKEN cDNA 2310061I04 gene0.025
Klf9Kruppel-like factor 90.024
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.023
Ryr2ryanodine receptor 2, cardiac0.023
Akap1A kinase (PRKA) anchor protein 10.023
Cul2cullin 20.022
Ccrn4lCCR4 carbon catabolite repression 4-like (S. cerevisiae)0.022
1110008F13RikRIKEN cDNA 1110008F13 gene0.022
Serinc1serine incorporator 10.022
Fam134bfamily with sequence similarity 134, member B0.022
Gde1glycerophosphodiester phosphodiesterase 10.021
Scocshort coiled-coil protein0.021
Acsl1acyl-CoA synthetase long-chain family member 10.021
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.021
Mkrn2makorin, ring finger protein, 20.021
1810026J23RikRIKEN cDNA 1810026J23 gene0.020
Usp2ubiquitin specific peptidase 20.020
Lrpprcleucine-rich PPR-motif containing0.020
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.020
Zscan2zinc finger and SCAN domain containing 20.019
Vdac1voltage-dependent anion channel 10.019
Adck3aarF domain containing kinase 30.019
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pink1PTEN-induced putative kinase 10.981
opa1-likeoptic atrophy 1-like0.303
ref(2)Prefractory to sigma P0.175
Hsc70-5Heat shock protein cognate 50.065
porinCG6647 gene product from transcript CG6647-RA0.049
MiroMitochondrial Rho0.036
trpmltransient receptor potential mucolipin0.033
dj-1betaCG1349 gene product from transcript CG1349-RA0.032
CG8443CG8443 gene product from transcript CG8443-RA0.031
MarfMitochondrial assembly regulatory factor0.030
Ube3aUbiquitin protein ligase E3A0.025
mib2mind bomb 20.024
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.021
certceramide transfer protein0.020
HtrA2CG8464 gene product from transcript CG8464-RA0.020
Letm1CG4589 gene product from transcript CG4589-RB0.017
Npc1aNiemann-Pick type C-1a0.016
p38bCG7393 gene product from transcript CG7393-RA0.015
Lk6CG17342 gene product from transcript CG17342-RA0.014
CG8709CG8709 gene product from transcript CG8709-RK0.013
LaspCG3849 gene product from transcript CG3849-RB0.013
SNF1ASNF1A/AMP-activated protein kinase0.012
Surf1Surfeit 10.011
desat1CG5887 gene product from transcript CG5887-RA0.011
Aats-trpTryptophanyl-tRNA synthetase0.011
Eps-15Epidermal growth factor receptor pathway substrate clone 150.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DNM1Ldynamin 1-like0.880
FBXO7F-box protein 70.523
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.392
BCAP31B-cell receptor-associated protein 310.371
FIS1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.287
ZNF746zinc finger protein 7460.248
MFN2mitofusin 20.135
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.133
TMEM11transmembrane protein 110.070
UBE2R2ubiquitin-conjugating enzyme E2R 20.068
GNB5guanine nucleotide binding protein (G protein), beta 50.035
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)0.032
YPEL5yippee-like 5 (Drosophila)0.029
UBASH3Bubiquitin associated and SH3 domain containing B0.026
OPA1optic atrophy 1 (autosomal dominant)0.024
DCTN3dynactin 3 (p22)0.021
RABAC1Rab acceptor 1 (prenylated)0.020
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.017
BCL2B-cell CLL/lymphoma 20.016
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.016
ELK1ELK1, member of ETS oncogene family0.014
MKRN1makorin ring finger protein 10.013
KDM3Alysine (K)-specific demethylase 3A0.012
PDCD2programmed cell death 20.011
SQSTM1sequestosome 10.011
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism