The network for 'negative regulation of defense response to virus by host' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of defense response to virus by host

Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.

NameDescriptionProbabilityFunc Analog Organism
Ifit1interferon-induced protein with tetratricopeptide repeats 10.905
Usp18ubiquitin specific peptidase 180.850
Ifi35interferon-induced protein 350.825
Irgm2immunity-related GTPase family M member 20.810
Igtpinterferon gamma induced GTPase0.801
Irgm1immunity-related GTPase family M member 10.677
Trim21tripartite motif-containing 210.655
Ifit3interferon-induced protein with tetratricopeptide repeats 30.618
Stat1signal transducer and activator of transcription 10.524
Isg15ISG15 ubiquitin-like modifier0.520
Tgtp2T-cell specific GTPase 20.394
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.352
Gbp3guanylate binding protein 30.315
Irf9interferon regulatory factor 90.299
Stat2signal transducer and activator of transcription 20.295
Gbp7guanylate binding protein 70.295
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.255
Ifi47interferon gamma inducible protein 470.246
Oasl22'-5' oligoadenylate synthetase-like 20.246
Gbp2guanylate binding protein 20.240
Irf8interferon regulatory factor 80.207
Iigp1interferon inducible GTPase 10.194
Ifih1interferon induced with helicase C domain 10.153
Rsad2radical S-adenosyl methionine domain containing 20.135
Sfpi1SFFV proviral integration 10.134
Uba7ubiquitin-like modifier activating enzyme 70.121
TapbpTAP binding protein0.103
AW112010expressed sequence AW1120100.102
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.102
Irf7interferon regulatory factor 70.100
H2-K1histocompatibility 2, K1, K region0.094
Rtp4receptor transporter protein 40.089
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.072
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.062
Parp12poly (ADP-ribose) polymerase family, member 120.053
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.050
Sp100nuclear antigen Sp1000.047
Znfx1zinc finger, NFX1-type containing 10.046
1810019J16RikRIKEN cDNA 1810019J16 gene0.045
Cxcl10chemokine (C-X-C motif) ligand 100.044
Parp14poly (ADP-ribose) polymerase family, member 140.044
Parp9poly (ADP-ribose) polymerase family, member 90.044
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.042
H2-Q7histocompatibility 2, Q region locus 70.038
Ifi44interferon-induced protein 440.034
Ikzf1IKAROS family zinc finger 10.034
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.033
Lgals9lectin, galactose binding, soluble 90.032
Ifi27l2ainterferon, alpha-inducible protein 27 like 2A0.031
Trim30atripartite motif-containing 30A0.030
Bcl3B-cell leukemia/lymphoma 30.030
Ighimmunoglobulin heavy chain complex0.028
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.026
H2-D1histocompatibility 2, D region locus 10.026
Bst2bone marrow stromal cell antigen 20.025
C920025E04RikRIKEN cDNA C920025E04 gene0.024
Ifitm3interferon induced transmembrane protein 30.024
Trim25tripartite motif-containing 250.024
Ltblymphotoxin B0.023
Tnfaip3tumor necrosis factor, alpha-induced protein 30.023
Ifit2interferon-induced protein with tetratricopeptide repeats 20.023
Irf4interferon regulatory factor 40.021
Oas1a2'-5' oligoadenylate synthetase 1A0.020
BC006779cDNA sequence BC0067790.020
Gbp6guanylate binding protein 60.020
Parp10poly (ADP-ribose) polymerase family, member 100.019
Zbp1Z-DNA binding protein 10.019
H2-DMahistocompatibility 2, class II, locus DMa0.019
Psmb10proteasome (prosome, macropain) subunit, beta type 100.019
Tor3atorsin family 3, member A0.017
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.016
H2-Aahistocompatibility 2, class II antigen A, alpha0.016
Ube2l6ubiquitin-conjugating enzyme E2L 60.015
Cd79bCD79B antigen0.015
FasFas (TNF receptor superfamily member 6)0.015
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.015
H2-Eb1histocompatibility 2, class II antigen E beta0.014
B2mbeta-2 microglobulin0.014
NmiN-myc (and STAT) interactor0.014
Ifnar2interferon (alpha and beta) receptor 20.014
Sfnstratifin0.014
Oas22'-5' oligoadenylate synthetase 20.013
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.013
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.013
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.012
Gbp10guanylate-binding protein 100.011
Dtx3ldeltex 3-like (Drosophila)0.011
Pih1d1PIH1 domain containing 10.011
Mx1myxovirus (influenza virus) resistance 10.011
Cd19CD19 antigen0.011
Rnf31ring finger protein 310.011
C1racomplement component 1, r subcomponent A0.011
Apol9aapolipoprotein L 9a0.010
Socs3suppressor of cytokine signaling 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IFIT1interferon-induced protein with tetratricopeptide repeats 10.999
IFIT3interferon-induced protein with tetratricopeptide repeats 30.995
IFIT2interferon-induced protein with tetratricopeptide repeats 20.979
IFIT5interferon-induced protein with tetratricopeptide repeats 50.968
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.565
ISG15ISG15 ubiquitin-like modifier0.370
IFI44interferon-induced protein 440.290
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.122
IFI44Linterferon-induced protein 44-like0.116
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.088
EPSTI1epithelial stromal interaction 1 (breast)0.071
HERC5hect domain and RLD 50.070
DICER1dicer 1, ribonuclease type III0.049
SAMD9sterile alpha motif domain containing 90.042
RSAD2radical S-adenosyl methionine domain containing 20.040
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.039
CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.036
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.032
IFIH1interferon induced with helicase C domain 10.026
STAT1signal transducer and activator of transcription 1, 91kDa0.019
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.019
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.019
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.018
SAMD9Lsterile alpha motif domain containing 9-like0.015
IFI6interferon, alpha-inducible protein 60.015
LAP3leucine aminopeptidase 30.015
PIAS4protein inhibitor of activated STAT, 40.015
USP18ubiquitin specific peptidase 180.014
APOL6apolipoprotein L, 60.013
TDRD7tudor domain containing 70.013
OASL2'-5'-oligoadenylate synthetase-like0.013
DTX3Ldeltex 3-like (Drosophila)0.011
ZNFX1zinc finger, NFX1-type containing 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism