The network for 'mitochondrial calcium ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitochondrial calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.

NameDescriptionProbabilityFunc Analog Organism
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.844
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.516
Ldb3LIM domain binding 30.419
Idh3aisocitrate dehydrogenase 3 (NAD+) alpha0.282
SrcRous sarcoma oncogene0.227
Got1glutamate oxaloacetate transaminase 1, soluble0.186
Actn2actinin alpha 20.149
Vimvimentin0.143
Mrpl3mitochondrial ribosomal protein L30.090
Trftransferrin0.077
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.054
C1qbpcomplement component 1, q subcomponent binding protein0.053
Fcgr3Fc receptor, IgG, low affinity III0.051
Pf4platelet factor 40.050
Darsaspartyl-tRNA synthetase0.048
Fh1fumarate hydratase 10.047
Mdh1malate dehydrogenase 1, NAD (soluble)0.040
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.039
Lap3leucine aminopeptidase 30.037
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.037
Actbactin, beta0.032
Vdac1voltage-dependent anion channel 10.030
Aco1aconitase 10.025
Vdac2voltage-dependent anion channel 20.025
Bpnt1bisphosphate 3'-nucleotidase 10.024
NadkNAD kinase0.024
Myom2myomesin 20.023
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.023
Ndufa10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 100.021
Dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.021
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.021
Pttg1ippituitary tumor-transforming 1 interacting protein0.020
Prmt5protein arginine N-methyltransferase 50.019
Pmpcapeptidase (mitochondrial processing) alpha0.019
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.019
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.019
Qrsl1glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 10.018
Ckmt2creatine kinase, mitochondrial 20.017
Eno1enolase 1, alpha non-neuron0.017
Ppa1pyrophosphatase (inorganic) 10.016
Cscitrate synthase0.015
Cycscytochrome c, somatic0.015
Immtinner membrane protein, mitochondrial0.014
Tnnc2troponin C2, fast0.014
Pdhxpyruvate dehydrogenase complex, component X0.013
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.013
Fundc2FUN14 domain containing 20.013
Pgam1phosphoglycerate mutase 10.013
Slc25a5solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 50.013
Hspd1heat shock protein 1 (chaperonin)0.013
Anxa2annexin A20.013
Epas1endothelial PAS domain protein 10.012
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.012
Tnni2troponin I, skeletal, fast 20.012
Mrps23mitochondrial ribosomal protein S230.012
Cyb5bcytochrome b5 type B0.011
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.011
BC031181cDNA sequence BC0311810.011
Ino80cINO80 complex subunit C0.011
Prkcbprotein kinase C, beta0.011
Gsk3bglycogen synthase kinase 3 beta0.011
Mvpmajor vault protein0.011
Tmem48transmembrane protein 480.011
Tmem70transmembrane protein 700.011
Tnnt3troponin T3, skeletal, fast0.010
Zdhhc5zinc finger, DHHC domain containing 50.010
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.010
Myh4myosin, heavy polypeptide 4, skeletal muscle0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FIS1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.989
BCAP31B-cell receptor-associated protein 310.984
PTPLBprotein tyrosine phosphatase-like (proline instead of catalytic arginine), member b0.818
SEC61BSec61 beta subunit0.793
DERL1Der1-like domain family, member 10.583
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.329
MAP1Amicrotubule-associated protein 1A0.316
DCTN3dynactin 3 (p22)0.230
CANXcalnexin0.208
CCDC109Acoiled-coil domain containing 109A0.200
ACTN2actinin, alpha 20.182
C3complement component 30.153
CBARA1calcium binding atopy-related autoantigen 10.142
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.121
ZNHIT1zinc finger, HIT-type containing 10.116
TRAF3IP1TNF receptor-associated factor 3 interacting protein 10.111
MEMO1mediator of cell motility 10.082
FN1fibronectin 10.077
KIFAP3kinesin-associated protein 30.070
CASP8caspase 8, apoptosis-related cysteine peptidase0.065
VKORC1vitamin K epoxide reductase complex, subunit 10.052
PLCD1phospholipase C, delta 10.052
PRDX5peroxiredoxin 50.049
PRKCAprotein kinase C, alpha0.048
BRAFv-raf murine sarcoma viral oncogene homolog B10.046
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.045
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.043
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.040
SYNE1spectrin repeat containing, nuclear envelope 10.039
C16orf61chromosome 16 open reading frame 610.037
UBL4Aubiquitin-like 4A0.036
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)0.036
THBS1thrombospondin 10.033
ARF5ADP-ribosylation factor 50.032
HSD17B10hydroxysteroid (17-beta) dehydrogenase 100.030
MYOZ1myozenin 10.029
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.028
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)0.027
SPTBN4spectrin, beta, non-erythrocytic 40.026
SEPW1selenoprotein W, 10.025
CHMP2Achromatin modifying protein 2A0.025
HSPG2heparan sulfate proteoglycan 20.024
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.024
CCDC141coiled-coil domain containing 1410.024
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.023
BCL2L1BCL2-like 10.022
RPL3ribosomal protein L30.021
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.021
ATF5activating transcription factor 50.021
A2Malpha-2-macroglobulin0.020
RPN2ribophorin II0.020
CREB3cAMP responsive element binding protein 30.019
SDHBsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.018
DDRGK1DDRGK domain containing 10.017
VDAC2voltage-dependent anion channel 20.017
GTF3Ageneral transcription factor IIIA0.017
TRAM1translocation associated membrane protein 10.017
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 10.016
PPIApeptidylprolyl isomerase A (cyclophilin A)0.015
TUBA1Btubulin, alpha 1b0.015
RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 20.015
KALRNkalirin, RhoGEF kinase0.014
VDAC1voltage-dependent anion channel 10.014
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.014
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.014
IDH3Gisocitrate dehydrogenase 3 (NAD+) gamma0.014
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.013
HIGD2AHIG1 hypoxia inducible domain family, member 2A0.013
TMEM176Atransmembrane protein 176A0.013
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.012
STAB1stabilin 10.012
CEP57L1centrosomal protein 57kDa-like 10.012
C12orf62chromosome 12 open reading frame 620.012
GUK1guanylate kinase 10.012
BIKBCL2-interacting killer (apoptosis-inducing)0.011
UXTubiquitously-expressed transcript0.011
MYT1Lmyelin transcription factor 1-like0.011
AP2S1adaptor-related protein complex 2, sigma 1 subunit0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.521
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.106
Mdh1malate dehydrogenase 1, NAD (soluble)0.077
Oaz1ornithine decarboxylase antizyme 10.041
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.022
Uqcrc2ubiquinol cytochrome c reductase core protein 20.020
Prdx1peroxiredoxin 10.019
Psma3proteasome (prosome, macropain) subunit, alpha type 30.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism