The network for 'negative regulation of epithelial cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of epithelial cell proliferation

Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Ptenphosphatase and tensin homolog1.000
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Trp53transformation related protein 531.000
Gli3GLI-Kruppel family member GLI30.999
Apcadenomatosis polyposis coli0.999
Fgfr1fibroblast growth factor receptor 10.999
Trp63transformation related protein 630.998
Bmp4bone morphogenetic protein 40.998
Foxc1forkhead box C10.994
Egfrepidermal growth factor receptor0.993
Ptpn11protein tyrosine phosphatase, non-receptor type 110.992
Hand1heart and neural crest derivatives expressed transcript 10.990
Col1a1collagen, type I, alpha 10.989
Prrx1paired related homeobox 10.988
Fgf8fibroblast growth factor 80.986
Nf1neurofibromatosis 10.983
Tgfbr2transforming growth factor, beta receptor II0.980
Rxraretinoid X receptor alpha0.980
Gli2GLI-Kruppel family member GLI20.979
Tgfb2transforming growth factor, beta 20.977
Retret proto-oncogene0.976
Hoxd13homeobox D130.970
Sox9SRY-box containing gene 90.969
Esr1estrogen receptor 1 (alpha)0.962
Csf1colony stimulating factor 1 (macrophage)0.956
Itgb1integrin beta 1 (fibronectin receptor beta)0.948
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.947
Pitx2paired-like homeodomain transcription factor 20.942
Runx2runt related transcription factor 20.937
Isl1ISL1 transcription factor, LIM/homeodomain0.934
Nos3nitric oxide synthase 3, endothelial cell0.931
Msx1homeobox, msh-like 10.929
Hand2heart and neural crest derivatives expressed transcript 20.928
Rb1retinoblastoma 10.916
Bmpr1abone morphogenetic protein receptor, type 1A0.911
Thbs1thrombospondin 10.910
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.903
Fgf10fibroblast growth factor 100.899
Rararetinoic acid receptor, alpha0.891
Alx4aristaless-like homeobox 40.890
Acvr1activin A receptor, type 10.885
Arandrogen receptor0.882
Pax8paired box gene 80.872
Cav1caveolin 1, caveolae protein0.866
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.866
Cdkn1bcyclin-dependent kinase inhibitor 1B0.864
Pbx1pre B-cell leukemia transcription factor 10.851
Vegfavascular endothelial growth factor A0.833
Twist2twist homolog 2 (Drosophila)0.827
Msx2homeobox, msh-like 20.825
Mdm2transformed mouse 3T3 cell double minute 20.820
Prrx2paired related homeobox 20.819
Ntf3neurotrophin 30.819
Hes1hairy and enhancer of split 1 (Drosophila)0.812
Pax3paired box gene 30.812
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.791
Efnb2ephrin B20.788
Smad3MAD homolog 3 (Drosophila)0.786
Fgfr3fibroblast growth factor receptor 30.778
Hoxa13homeobox A130.775
Hif1ahypoxia inducible factor 1, alpha subunit0.774
Dlg1discs, large homolog 1 (Drosophila)0.754
Ahraryl-hydrocarbon receptor0.754
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.744
Tbx1T-box 10.734
Brca1breast cancer 10.730
Rarbretinoic acid receptor, beta0.730
Krt14keratin 140.720
Smad4MAD homolog 4 (Drosophila)0.718
Smosmoothened homolog (Drosophila)0.700
Tbx3T-box 30.693
Sfrp2secreted frizzled-related protein 20.689
Foxn1forkhead box N10.682
Tbx15T-box 150.676
Nr3c1nuclear receptor subfamily 3, group C, member 10.674
Pax2paired box gene 20.659
Pkd1polycystic kidney disease 1 homolog0.653
Hoxd11homeobox D110.648
Leprleptin receptor0.647
Thrathyroid hormone receptor alpha0.647
Pitx1paired-like homeodomain transcription factor 10.646
Col2a1collagen, type II, alpha 10.646
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.645
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.633
Tcfap2atranscription factor AP-2, alpha0.631
Ptch1patched homolog 10.618
Ror2receptor tyrosine kinase-like orphan receptor 20.611
Kitlkit ligand0.609
Rargretinoic acid receptor, gamma0.602
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.596
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.589
Dkk1dickkopf homolog 1 (Xenopus laevis)0.575
Ccnd1cyclin D10.567
Gata6GATA binding protein 60.566
Irf6interferon regulatory factor 60.561
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ptch2patched 20.585
fgf8afibroblast growth factor 8 a0.520
ift88intraflagellar transport 88 homolog0.384
tp53tumor protein p530.312
tp63tumor protein p630.282
pitx3paired-like homeodomain transcription factor 30.276
krt4keratin 40.259
sema3aasemaphorin 3aa0.258
spry4sprouty (Drosophila) homolog 40.250
tnnt2atroponin T2a, cardiac0.239
fgf3fibroblast growth factor 30.233
cxcr4achemokine (C-X-C motif) receptor 4a0.232
bmp2bbone morphogenetic protein 2b0.230
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.206
unc45aunc-45 homolog A (C. elegans)0.194
lama5laminin, alpha 50.187
sdprbserum deprivation response b0.161
tcf7transcription factor 7 (T-cell specific, HMG-box)0.159
zdhhc8bzinc finger, DHHC-type containing 8b0.154
col10a1collagen, type X, alpha 10.147
jag1bjagged 1b0.147
tbx1T-box 10.142
foxa3forkhead box A30.137
esr1estrogen receptor 10.127
rargaretinoic acid receptor gamma a0.126
fn1fibronectin 10.123
col2a1acollagen type II, alpha-1a0.123
matn4matrilin 40.121
bocbrother of CDO0.121
cluap1clusterin associated protein 10.119
tbx2bT-box 2b0.115
ift57intraflagellar transport protein 570.115
lrrc6leucine rich repeat containing 60.111
prox1prospero-related homeobox gene 10.107
klf2bKruppel-like factor 2b0.105
xbp1X-box binding protein 10.099
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.097
bmp4bone morphogenetic protein 40.097
wnt11rwingless-type MMTV integration site family, member 11, related0.093
notch2notch homolog 20.092
edn1endothelin 10.091
id1inhibitor of DNA binding 10.089
sec61al1Sec61 alpha like 10.089
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.088
notch3notch homolog 30.088
inka1ainduced in neural crest by AP2, 1a0.087
hsp47heat shock protein 470.086
loxl2blysyl oxidase-like 2b0.084
her6hairy-related 60.084
lepre1Lepre1 protein0.084
ccm2cerebral cavernous malformation 20.084
tgfbitransforming growth factor, beta-induced0.082
dlx5adistal-less homeobox gene 5a0.080
gpc4glypican 40.077
rcn3reticulocalbin 3, EF-hand calcium binding domain0.075
idsiduronate 2-sulfatase0.075
klf2aKruppel-like factor 2a0.074
foxaforkhead box A sequence0.073
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.073
s1pr2sphingosine-1-phosphate receptor 20.073
alcamaactivated leukocyte cell adhesion molecule a0.073
skianuclear oncoprotein skia0.072
igf1insulin-like growth factor 10.072
vhlvon Hippel-Lindau tumor suppressor0.071
fzd7bfrizzled homolog 7b0.071
gata3GATA-binding protein 30.070
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.070
col9a3collagen, type IX, alpha 30.068
ift52intraflagellar transport protein 520.068
metmet proto-oncogene (hepatocyte growth factor receptor)0.067
ttc21btetratricopeptide repeat domain 21B0.066
anxa1aannexin A1a0.066
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.065
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.065
satb2SATB homeobox 20.065
sox2SRY-box containing gene 20.065
epb41l5erythrocyte membrane protein band 4.1 like 50.065
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.064
pak2ap21 (CDKN1A)-activated kinase 2a0.064
sox9aSRY-box containing gene 9a0.063
spint1aserine peptidase inhibitor, Kunitz type 1 a0.063
aldobaldolase b, fructose-bisphosphate0.062
gdf11growth differentiation factor 110.061
nkx2.2bNK2 transcription factor related 2b0.061
gli3GLI-Kruppel family member GLI30.060
nrp1aneuropilin 1a0.060
col7a1lcollagen type VII alpha 1-like0.060
cdh1cadherin 1, epithelial0.060
col1a1acollagen, type I, alpha 1a0.060
tmem38atransmembrane protein 38A0.060
sdc2syndecan 20.059
lamc1laminin, gamma 10.059
wnt7bawingless-type MMTV integration site family, member 7Ba0.059
ahr2aryl hydrocarbon receptor 20.059
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA0.758
l(2)gllethal (2) giant larvae0.395
G-oalpha47AG protein oalpha 47A0.370
ftz-f1ftz transcription factor 10.325
DadDaughters against dpp0.264
spensplit ends0.234
MadMothers against dpp0.233
Dhc64CDynein heavy chain 64C0.179
sosine oculis0.178
Syx1ASyntaxin 1A0.145
Ggamma1G protein gamma 10.145
reporeversed polarity0.131
SmoxSmad on X0.123
aPKCatypical protein kinase C0.119
elavembryonic lethal abnormal vision0.118
mbcmyoblast city0.111
beta-Specbeta Spectrin0.105
eyaeyes absent0.101
Pka-C1cAMP-dependent protein kinase 10.098
cicubitus interruptus0.097
drkdownstream of receptor kinase0.093
kenken and barbie0.092
vvlventral veins lacking0.091
AlkCG8250 gene product from transcript CG8250-RA0.084
InRInsulin-like receptor0.083
jingCG9397 gene product from transcript CG9397-RI0.081
Vps25Vacuolar protein sorting 250.080
Tsc1CG6147 gene product from transcript CG6147-RA0.078
Sema-1aCG18405 gene product from transcript CG18405-RD0.074
TrhTryptophan hydroxylase0.074
SceSex combs extra0.073
SaraSmad anchor for receptor activation0.071
Su(H)Suppressor of Hairless0.069
Dap160Dynamin associated protein 1600.067
witwishful thinking0.066
myoglianinCG1838 gene product from transcript CG1838-RD0.065
dlg1discs large 10.065
sogshort gastrulation0.065
emcextra macrochaetae0.063
Ca-P60ACalcium ATPase at 60A0.063
AblAbl tyrosine kinase0.063
frcfringe connection0.062
toytwin of eyeless0.062
raspCG11495 gene product from transcript CG11495-RA0.061
Hsc70-4Heat shock protein cognate 40.060
SNF1ASNF1A/AMP-activated protein kinase0.060
G-salpha60AG protein salpha 60A0.059
stanstarry night0.058
numbCG3779 gene product from transcript CG3779-RB0.056
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha0.998
ESR1estrogen receptor 10.996
TGFB1transforming growth factor, beta 10.993
RXRAretinoid X receptor, alpha0.990
CAV1caveolin 1, caveolae protein, 22kDa0.987
PTPN1protein tyrosine phosphatase, non-receptor type 10.963
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.961
TAL1T-cell acute lymphocytic leukemia 10.929
EGFRepidermal growth factor receptor0.882
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.843
NCK2NCK adaptor protein 20.830
NCOA1nuclear receptor coactivator 10.811
NCOR2nuclear receptor corepressor 20.793
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.752
CDK6cyclin-dependent kinase 60.702
NCOA3nuclear receptor coactivator 30.656
MED25mediator complex subunit 250.652
RUNX1runt-related transcription factor 10.567
CCND1cyclin D10.562
GSK3Bglycogen synthase kinase 3 beta0.558
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.520
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.491
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.482
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.431
CCR5chemokine (C-C motif) receptor 50.415
FGF1fibroblast growth factor 1 (acidic)0.399
PAX3paired box 30.391
FBXL12F-box and leucine-rich repeat protein 120.391
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.370
IL2RBinterleukin 2 receptor, beta0.351
SMAD2SMAD family member 20.333
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.327
SMAD7SMAD family member 70.310
CAV2caveolin 20.307
FSTL1follistatin-like 10.304
AXIN1axin 10.304
CCND3cyclin D30.292
TCF4transcription factor 40.275
MAGED1melanoma antigen family D, 10.266
CDK4cyclin-dependent kinase 40.263
POU3F2POU class 3 homeobox 20.263
POU5F1POU class 5 homeobox 10.261
INSRinsulin receptor0.250
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.247
S100BS100 calcium binding protein B0.239
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.237
KIF5Bkinesin family member 5B0.228
JAK2Janus kinase 20.219
YAP1Yes-associated protein 10.216
MAP3K5mitogen-activated protein kinase kinase kinase 50.209
STK3serine/threonine kinase 30.207
HDAC4histone deacetylase 40.206
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.204
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.200
TGFB3transforming growth factor, beta 30.197
BTRCbeta-transducin repeat containing0.187
LIN7Clin-7 homolog C (C. elegans)0.183
CDC37cell division cycle 37 homolog (S. cerevisiae)0.181
CCL5chemokine (C-C motif) ligand 50.180
SDC2syndecan 20.167
FBLN1fibulin 10.166
PTPN11protein tyrosine phosphatase, non-receptor type 110.163
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.156
UHRF2ubiquitin-like with PHD and ring finger domains 20.154
COL3A1collagen, type III, alpha 10.147
CREBBPCREB binding protein0.146
TIMP3TIMP metallopeptidase inhibitor 30.145
NRP1neuropilin 10.141
MAGED2melanoma antigen family D, 20.140
SMAD4SMAD family member 40.136
PTENphosphatase and tensin homolog0.136
NCOR1nuclear receptor corepressor 10.135
ARandrogen receptor0.135
TERF1telomeric repeat binding factor (NIMA-interacting) 10.134
TERF2telomeric repeat binding factor 20.134
TP53tumor protein p530.134
IRF9interferon regulatory factor 90.127
STAT5Asignal transducer and activator of transcription 5A0.126
FGFR2fibroblast growth factor receptor 20.126
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.123
HIPK2homeodomain interacting protein kinase 20.121
SMN1survival of motor neuron 1, telomeric0.121
ESRRGestrogen-related receptor gamma0.119
IRF4interferon regulatory factor 40.118
F2Rcoagulation factor II (thrombin) receptor0.113
BMPR1Bbone morphogenetic protein receptor, type IB0.113
TGFBR1transforming growth factor, beta receptor 10.112
F11RF11 receptor0.111
PPP5Cprotein phosphatase 5, catalytic subunit0.108
EP300E1A binding protein p3000.108
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.107
CSNK1Ecasein kinase 1, epsilon0.107
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.106
PECAM1platelet/endothelial cell adhesion molecule0.103
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.102
CPEcarboxypeptidase E0.098
SP1Sp1 transcription factor0.098
NR4A1nuclear receptor subfamily 4, group A, member 10.096
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.630
Procprotein C0.520
LOC100362824caveolin 2-like0.389
Cald1caldesmon 10.275
Apoa2apolipoprotein A-II0.201
Cav2caveolin 20.183
Azgp1alpha-2-glycoprotein 1, zinc-binding0.182
Ambpalpha-1-microglobulin/bikunin precursor0.155
Acox2acyl-Coenzyme A oxidase 2, branched chain0.154
Tgfbr2transforming growth factor, beta receptor II0.130
Nedd4neural precursor cell expressed, developmentally down-regulated 40.123
Pzppregnancy-zone protein0.119
Apcsamyloid P component, serum0.111
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.105
Igfbp5insulin-like growth factor binding protein 50.091
Apoa5apolipoprotein A-V0.085
Slco2a1solute carrier organic anion transporter family, member 2a10.083
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.079
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.075
Foxd3forkhead box D30.074
Cd9CD9 molecule0.074
Asgr1asialoglycoprotein receptor 10.067
C4bpacomplement component 4 binding protein, alpha0.065
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.061
Gja5gap junction protein, alpha 50.061
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.060
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.059
Sod3superoxide dismutase 3, extracellular0.059
Bmp6bone morphogenetic protein 60.055
Aqp9aquaporin 90.054
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.054
Nrxn1neurexin 10.053
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.050
Inhbeinhibin beta E0.049
Appamyloid beta (A4) precursor protein0.048
Cacng1calcium channel, voltage-dependent, gamma subunit 10.048
Mpzmyelin protein zero0.046
Agxt2alanine-glyoxylate aminotransferase 20.045
Uoxurate oxidase0.045
Unc5bunc-5 homolog B (C. elegans)0.042
LOC286992peptide HP (rs14)0.040
Fgfr1Fibroblast growth factor receptor 10.040
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.039
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.038
Foxd1forkhead box D10.038
KitlgKIT ligand0.037
Dnase1l3deoxyribonuclease 1-like 30.036
Prrx1paired related homeobox 10.035
Lipclipase, hepatic0.035
Prss2protease, serine, 20.035
Ednrbendothelin receptor type B0.033
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.033
Syt8synaptotagmin VIII0.033
Kng2kininogen 20.032
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.032
Prss1protease, serine, 1 (trypsin 1)0.032
RGD1564327similar to integrin alpha 80.032
Spp2secreted phosphoprotein 20.032
Phkg1phosphorylase kinase, gamma 10.032
Nos3nitric oxide synthase 3, endothelial cell0.032
Gja1gap junction protein, alpha 10.031
Nr5a2nuclear receptor subfamily 5, group A, member 20.031
Gprc5cG protein-coupled receptor, family C, group 5, member C0.031
Foxa3forkhead box A30.030
Prg2proteoglycan 2, bone marrow0.030
Pld3phospholipase D family, member 30.030
Tcf3transcription factor 30.029
Irs3insulin receptor substrate 30.029
LOC299282Serine protease inhibitor0.029
Hoxb7homeo box B70.028
Itih3inter-alpha trypsin inhibitor, heavy chain 30.028
Vom1r97vomeronasal 1 receptor 970.028
C8bcomplement component 8, beta polypeptide0.028
P2ry14purinergic receptor P2Y, G-protein coupled, 140.028
Fgfr2fibroblast growth factor receptor 20.027
Esr1estrogen receptor 10.027
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.026
Timp3TIMP metallopeptidase inhibitor 30.026
Ehd2EH-domain containing 20.026
Ggt5gamma-glutamyltransferase 50.026
Tpsab1tryptase alpha/beta 10.026
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.025
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.025
F2coagulation factor II (thrombin)0.025
Pdzk1ip1PDZK1 interacting protein 10.025
Kynukynureninase (L-kynurenine hydrolase)0.024
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.024
A1bgalpha-1-B glycoprotein0.024
Nbl1neuroblastoma, suppression of tumorigenicity 10.023
Agtr2angiotensin II receptor, type 20.023
Ptgesprostaglandin E synthase0.022
Mcammelanoma cell adhesion molecule0.022
Gulogulonolactone (L-) oxidase0.022
Arsbarylsulfatase B0.022
RGD1309414similar to KIAA0913 protein0.022
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.022
Myo9amyosin IXA0.021
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism