The network for 'regulation of blood vessel size' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of blood vessel size

Any process that modulates the size of blood vessels.

NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.998
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.930
Leprleptin receptor0.883
Ptgs2prostaglandin-endoperoxide synthase 20.870
Tgfbr2transforming growth factor, beta receptor II0.830
Arandrogen receptor0.761
Ren1renin 1 structural0.745
Klk1b21kallikrein 1-related peptidase b210.709
Nos1nitric oxide synthase 1, neuronal0.707
Esr1estrogen receptor 1 (alpha)0.697
Smad4MAD homolog 4 (Drosophila)0.695
Vegfavascular endothelial growth factor A0.617
Ptenphosphatase and tensin homolog0.589
Bbs4Bardet-Biedl syndrome 4 (human)0.575
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.554
Gpr12G-protein coupled receptor 120.536
Sstr4somatostatin receptor 40.531
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.506
Crhr1corticotropin releasing hormone receptor 10.448
Dmgdhdimethylglycine dehydrogenase precursor0.434
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.422
Lepleptin0.417
Col4a3collagen, type IV, alpha 30.403
Klk1b5kallikrein 1-related peptidase b50.397
Ece1endothelin converting enzyme 10.395
Fbn1fibrillin 10.394
Pgrprogesterone receptor0.381
Pcdh12protocadherin 120.377
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.367
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.355
Dmddystrophin, muscular dystrophy0.351
Fgf10fibroblast growth factor 100.349
Klk1b11kallikrein 1-related peptidase b110.342
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.336
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.331
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.324
Acvr1activin A receptor, type 10.321
Gclmglutamate-cysteine ligase, modifier subunit0.315
Klk1kallikrein 10.313
Wnt7awingless-related MMTV integration site 7A0.304
Cry2cryptochrome 2 (photolyase-like)0.303
Galr1galanin receptor 10.300
Drd2dopamine receptor D20.292
Lmx1bLIM homeobox transcription factor 1 beta0.281
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.279
Rem1rad and gem related GTP binding protein 10.276
Klk1b1kallikrein 1-related peptidase b10.270
Apoc4apolipoprotein C-IV0.263
Foxc1forkhead box C10.261
Bmp4bone morphogenetic protein 40.259
Mpzmyelin protein zero0.257
F12coagulation factor XII (Hageman factor)0.256
Gclcglutamate-cysteine ligase, catalytic subunit0.256
Ldlrlow density lipoprotein receptor0.249
Esr2estrogen receptor 2 (beta)0.247
G6pc2glucose-6-phosphatase, catalytic, 20.246
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.245
Fzd8frizzled homolog 8 (Drosophila)0.240
Cckbrcholecystokinin B receptor0.231
2210010C04RikRIKEN cDNA 2210010C04 gene0.227
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.225
Prkg1protein kinase, cGMP-dependent, type I0.221
Klk1b16kallikrein 1-related peptidase b160.221
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.219
Cav1caveolin 1, caveolae protein0.216
Mycsmyc-like oncogene, s-myc protein0.213
Vipvasoactive intestinal polypeptide0.212
Sstr3somatostatin receptor 30.206
Ccl2chemokine (C-C motif) ligand 20.205
Mc5rmelanocortin 5 receptor0.204
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.204
Ramp2receptor (calcitonin) activity modifying protein 20.201
Pnpla2patatin-like phospholipase domain containing 20.196
Per1period homolog 1 (Drosophila)0.194
Klklotho0.193
Ppargperoxisome proliferator activated receptor gamma0.193
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.192
Loxlysyl oxidase0.192
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.190
Agtr2angiotensin II receptor, type 20.188
Mesp1mesoderm posterior 10.187
Scn7asodium channel, voltage-gated, type VII, alpha0.184
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.184
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.184
Adra2aadrenergic receptor, alpha 2a0.183
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.177
Bdkrb2bradykinin receptor, beta 20.173
Edn1endothelin 10.173
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.172
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.171
Klk1b9kallikrein 1-related peptidase b90.170
Sstsomatostatin0.169
Klk1b27kallikrein 1-related peptidase b270.169
Fggfibrinogen gamma chain0.169
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.166
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.165
Scn5asodium channel, voltage-gated, type V, alpha0.163
Sardhsarcosine dehydrogenase0.162
Pzppregnancy zone protein0.161
Grid1glutamate receptor, ionotropic, delta 10.160
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
epas1bendothelial PAS domain protein 1b0.596
ccm2cerebral cavernous malformation 20.478
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.242
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.236
calcrlacalcitonin receptor-like a0.213
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.184
adrb2aadrenergic receptor, beta 2a0.178
cx36.7connexin 36.70.151
actc1aactin, alpha, cardiac muscle 1a0.127
LOC100003514protein kinase C alpha type-like0.122
vegfcvascular endothelial growth factor c0.116
hat1histone acetyltransferase 10.108
fgf20bfibroblast growth factor 20b0.108
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.103
ptgs1prostaglandin-endoperoxide synthase 10.100
col2a1acollagen type II, alpha-1a0.099
rargbretinoic acid receptor, gamma b0.097
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.097
ctsbacathepsin B, a0.097
ctsccathepsin C0.096
inhbaainhibin, beta Aa0.093
snapc4small nuclear RNA activating complex, polypeptide 40.092
foxc1aforkhead box C1a0.092
nrarpanotch-regulated ankyrin repeat protein a0.089
twist1atwist1a0.089
fgfrl1afibroblast growth factor receptor-like 1a0.087
gclcglutamate-cysteine ligase, catalytic subunit0.087
nesnestin0.086
dbhdopamine beta hydroxylase0.084
hbbe1.1hemoglobin beta embryonic-1.10.083
adrb2badrenergic receptor, beta 2b0.082
zgc:112056zgc:1120560.081
nf1aneurofibromin 1a0.080
gcm2glial cells missing homolog 2 (Drosophila)0.079
osr1odd-skipped related 1 (Drosophila)0.079
junjun proto-oncogene0.078
hrh3histamine receptor H30.077
starsteroidogenic acute regulatory protein0.077
zgc:172136zgc:1721360.074
rhagRhesus blood group-associated glycoprotein0.074
sod1superoxide dismutase 1, soluble0.074
lmnalamin A0.072
si:ch211-14k19.8si:ch211-14k19.80.072
sc:d812sc:d8120.072
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.071
plcg1phospholipase C, gamma 10.071
wt1bwilms tumor 1b0.070
vclvinculin0.070
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.069
podxlpodocalyxin-like0.069
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.069
si:dkey-8l13.4si:dkey-8l13.40.067
aqp8a.1aquaporin 8a, tandem duplicate 10.066
tram1translocating chain-associating membrane protein 10.066
ldb1aLIM-domain binding factor 1a0.066
rdh10bretinol dehydrogenase 10b0.065
icnictacalcin0.065
nf1bneurofibromin 1b0.065
spns2spinster homolog 2 (Drosophila)0.064
arhgap29aRho GTPase activating protein 29a0.064
crhbpcorticotropin releasing hormone binding protein0.063
krt8keratin 80.063
ppargperoxisome proliferator activated receptor gamma0.062
bmpr1aabone morphogenetic protein receptor, type 1aa0.062
adcyap1aadenylate cyclase activating polypeptide 1a0.061
wnt10awingless-type MMTV integration site family, member 10a0.060
ihhaIndian hedgehog homolog a0.060
pdgfrb2platelet derived growth factor receptor beta 20.060
tmem2transmembrane protein 20.060
nr5a5nuclear receptor subfamily 5, group A, member 50.059
cftrcystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)0.059
dmrt2adoublesex and mab-3 related transcription factor 2a0.059
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.059
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.058
mc2rmelanocortin 2 receptor0.057
mbtps1membrane-bound transcription factor protease, site 10.057
ahsgalpha-2-HS-glycoprotein0.057
tmco1transmembrane and coiled-coil domains 10.057
ptgs2aprostaglandin-endoperoxide synthase 2a0.057
vdrbvitamin D receptor b0.057
ahr2aryl hydrocarbon receptor 20.056
ambplalpha-1-microglobulin/bikunin precursor, like0.056
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.056
igfbp1binsulin-like growth factor binding protein 1b0.056
cnn2calponin 20.056
zgc:63721zgc:637210.056
trim3atripartite motif-containing 3a0.055
sod2superoxide dismutase 2, mitochondrial0.055
aplnrbapelin receptor b0.055
alx4aaristaless-like homeobox 4a0.055
vipr2vasoactive intestinal peptide receptor 20.054
zgc:195195zgc:1951950.054
zgc:110010zgc:1100100.054
fzd7bfrizzled homolog 7b0.054
hdchistidine decarboxylase0.054
inhbbinhibin, beta B0.054
tnnc1atroponin C type 1a (slow)0.053
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.053
apoc2apolipoprotein C-II0.053
rykreceptor-like tyrosine kinase0.053
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial0.995
PTENphosphatase and tensin homolog0.944
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.918
FGAfibrinogen alpha chain0.905
PRKG1protein kinase, cGMP-dependent, type I0.884
NOTCH1notch 10.831
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.827
FGBfibrinogen beta chain0.783
DRD2dopamine receptor D20.769
NOSTRINnitric oxide synthase trafficker0.719
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.658
ACTN2actinin, alpha 20.624
CAV2caveolin 20.616
A2Malpha-2-macroglobulin0.601
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.568
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.511
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.501
MAPK12mitogen-activated protein kinase 120.500
COTL1coactosin-like 1 (Dictyostelium)0.437
MPDZmultiple PDZ domain protein0.431
RLN3relaxin 30.416
TIMP3TIMP metallopeptidase inhibitor 30.416
FGGfibrinogen gamma chain0.399
IL8interleukin 80.392
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.354
JAG1jagged 10.338
NAMPTnicotinamide phosphoribosyltransferase0.326
BCAR1breast cancer anti-estrogen resistance 10.306
GCLCglutamate-cysteine ligase, catalytic subunit0.263
GCLMglutamate-cysteine ligase, modifier subunit0.241
CRPC-reactive protein, pentraxin-related0.240
VAC14Vac14 homolog (S. cerevisiae)0.224
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.196
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.189
PTPN1protein tyrosine phosphatase, non-receptor type 10.177
CRELD2cysteine-rich with EGF-like domains 20.173
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.144
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.140
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.133
FASFas (TNF receptor superfamily, member 6)0.133
ALBalbumin0.118
TBC1D10ATBC1 domain family, member 10A0.116
EGFRepidermal growth factor receptor0.107
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.105
TIMP2TIMP metallopeptidase inhibitor 20.105
ADORA1adenosine A1 receptor0.093
ADORA2Aadenosine A2a receptor0.084
PEBP4phosphatidylethanolamine-binding protein 40.077
THBS2thrombospondin 20.076
RB1retinoblastoma 10.074
MYH11myosin, heavy chain 11, smooth muscle0.073
HPhaptoglobin0.072
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.072
ADAM15ADAM metallopeptidase domain 150.070
CDH5cadherin 5, type 2 (vascular endothelium)0.069
PTPN11protein tyrosine phosphatase, non-receptor type 110.063
CYSLTR2cysteinyl leukotriene receptor 20.062
PTGISprostaglandin I2 (prostacyclin) synthase0.061
TECPR1tectonin beta-propeller repeat containing 10.057
SSTR3somatostatin receptor 30.055
NFIL3nuclear factor, interleukin 3 regulated0.055
LRP1low density lipoprotein receptor-related protein 10.053
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.050
FYBFYN binding protein0.050
CALCRLcalcitonin receptor-like0.050
KAT2BK(lysine) acetyltransferase 2B0.049
LMNAlamin A/C0.048
NCOA6nuclear receptor coactivator 60.048
ACVR1activin A receptor, type I0.044
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.042
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.042
PXNpaxillin0.040
MAPTmicrotubule-associated protein tau0.039
MYOZ1myozenin 10.038
DDR2discoidin domain receptor tyrosine kinase 20.037
F2coagulation factor II (thrombin)0.036
TKTtransketolase0.036
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.036
ADRB2adrenergic, beta-2-, receptor, surface0.035
ABCC9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.034
SDPRserum deprivation response0.033
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.033
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.032
RETret proto-oncogene0.032
APOC1apolipoprotein C-I0.032
MYH9myosin, heavy chain 9, non-muscle0.031
SDF2L1stromal cell-derived factor 2-like 10.031
BBS10Bardet-Biedl syndrome 100.031
GLRX3glutaredoxin 30.031
TP73tumor protein p730.030
BAG1BCL2-associated athanogene0.030
HYOU1hypoxia up-regulated 10.030
IGF1insulin-like growth factor 1 (somatomedin C)0.030
MAPK8mitogen-activated protein kinase 80.030
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.029
EGLN3egl nine homolog 3 (C. elegans)0.028
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.028
PROCRprotein C receptor, endothelial0.028
ENGendoglin0.027
PRKCDBPprotein kinase C, delta binding protein0.027
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.484
Chrm1cholinergic receptor, muscarinic 10.446
Olr416olfactory receptor 4160.406
Nrg1neuregulin 10.391
Agtr2angiotensin II receptor, type 20.370
Magmyelin-associated glycoprotein0.368
Pnlippancreatic lipase0.360
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.356
Dlg4discs, large homolog 4 (Drosophila)0.334
Mmp3matrix metallopeptidase 30.334
Htr75-hydroxytryptamine (serotonin) receptor 70.333
Fgf2fibroblast growth factor 20.328
Gfapglial fibrillary acidic protein0.323
Olr226olfactory receptor 2260.317
Csf3colony stimulating factor 3 (granulocyte)0.287
Gpr182G protein-coupled receptor 1820.281
Gfra1GDNF family receptor alpha 10.281
Ush1cUsher syndrome 1C homolog (human)0.280
Flt1FMS-related tyrosine kinase 10.268
Rgs9regulator of G-protein signaling 90.266
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.261
Nmuneuromedin U0.261
Neurog3neurogenin 30.258
LOC299282Serine protease inhibitor0.250
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.248
Ptafrplatelet-activating factor receptor0.246
Trhrthyrotropin releasing hormone receptor0.243
Galgalanin prepropeptide0.242
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.240
Sstr5somatostatin receptor 50.239
LOC100362824caveolin 2-like0.237
Adora1adenosine A1 receptor0.231
Lifleukemia inhibitory factor0.224
Trhr2thyrotropin releasing hormone receptor 20.221
Ptprhprotein tyrosine phosphatase, receptor type, H0.213
Gucy1b3guanylate cyclase 1, soluble, beta 30.212
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.212
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.207
Cdh17cadherin 170.207
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.203
Grm7glutamate receptor, metabotropic 70.199
Strnstriatin, calmodulin binding protein0.198
Mmp7matrix metallopeptidase 70.198
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.197
Tacr3tachykinin receptor 30.196
Tff1trefoil factor 10.193
Nfascneurofascin0.191
Aqp6aquaporin 6, kidney specific0.191
Cav2caveolin 20.190
Il1rninterleukin 1 receptor antagonist0.188
Foxe3forkhead box E30.182
RorbRAR-related orphan receptor B0.182
Testintestin gene0.178
RGD1565859RGD15658590.176
Tnftumor necrosis factor (TNF superfamily, member 2)0.176
Vipvasoactive intestinal peptide0.174
Hrhairless0.171
Calcbcalcitonin-related polypeptide, beta0.171
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.167
GperG protein-coupled estrogen receptor 10.165
Galr3galanin receptor 30.165
Slco2b1solute carrier organic anion transporter family, member 2b10.163
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.163
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.162
Tbxa2rthromboxane A2 receptor0.159
Notch3Notch homolog 3 (Drosophila)0.158
Gng7guanine nucleotide binding protein (G protein), gamma 70.157
Vom2r27vomeronasal 2 receptor, 270.156
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.154
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.153
Rgs8regulator of G-protein signaling 80.150
Capn13calpain 130.148
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.145
Nos3nitric oxide synthase 3, endothelial cell0.145
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.142
Mmp10matrix metallopeptidase 100.141
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.140
Aqp4aquaporin 40.140
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.139
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.139
Foxd3forkhead box D30.138
Ngfnerve growth factor (beta polypeptide)0.138
Pspparotid secretory protein0.136
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.136
Adap1ArfGAP with dual PH domains 10.135
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.133
Cd4Cd4 molecule0.133
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.133
Prkcgprotein kinase C, gamma0.132
Chrna6cholinergic receptor, nicotinic, alpha 60.131
Pdynprodynorphin0.130
Pipprolactin induced protein0.129
Folh1folate hydrolase 10.129
Chrna7cholinergic receptor, nicotinic, alpha 70.129
Mca32mast cell antigen 320.126
Sprr3small proline-rich protein 30.126
Cav1caveolin 1, caveolae protein0.126
Rgs14regulator of G-protein signaling 140.125
Rapgef3Rap guanine nucleotide exchange factor (GEF) 30.125
Smad3SMAD family member 30.124
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism