The network for 'endocrine process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocrine process

The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.

NameDescriptionProbabilityFunc Analog Organism
Klk1b5kallikrein 1-related peptidase b50.833
Ren1renin 1 structural0.827
Per2period homolog 2 (Drosophila)0.522
Klk1b26kallikrein 1-related petidase b260.470
Clockcircadian locomotor output cycles kaput0.450
Amhr2anti-Mullerian hormone type 2 receptor0.420
C1qacomplement component 1, q subcomponent, alpha polypeptide0.419
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.363
Pcdh12protocadherin 120.312
Agtr1aangiotensin II receptor, type 1a0.311
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.310
Ctrb1chymotrypsinogen B10.305
Klk1b8kallikrein 1-related peptidase b80.293
Ednrbendothelin receptor type B0.285
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.269
Umoduromodulin0.260
Egfrepidermal growth factor receptor0.260
Klk1b11kallikrein 1-related peptidase b110.255
Arntlaryl hydrocarbon receptor nuclear translocator-like0.251
C1qccomplement component 1, q subcomponent, C chain0.237
Nr3c1nuclear receptor subfamily 3, group C, member 10.230
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.224
Cela2achymotrypsin-like elastase family, member 2A0.215
Slc12a1solute carrier family 12, member 10.212
Scn5asodium channel, voltage-gated, type V, alpha0.211
Bdkrb2bradykinin receptor, beta 20.206
Klk1b4kallikrein 1-related pepidase b40.204
Leprleptin receptor0.203
Try5trypsin 50.201
Klk1kallikrein 10.200
Wnt5awingless-related MMTV integration site 5A0.198
Klk1b21kallikrein 1-related peptidase b210.190
Pparaperoxisome proliferator activated receptor alpha0.187
Edaectodysplasin-A0.185
Pahphenylalanine hydroxylase0.180
H2-M9histocompatibility 2, M region locus 90.165
Pthlhparathyroid hormone-like peptide0.164
Sod3superoxide dismutase 3, extracellular0.162
Per1period homolog 1 (Drosophila)0.161
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.154
Cma1chymase 1, mast cell0.150
Efnb2ephrin B20.147
Fzd8frizzled homolog 8 (Drosophila)0.144
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.143
Tpsb2tryptase beta 20.139
Sardhsarcosine dehydrogenase0.137
Klk1b1kallikrein 1-related peptidase b10.134
Nkx3-1NK-3 transcription factor, locus 1 (Drosophila)0.133
2210010C04RikRIKEN cDNA 2210010C04 gene0.129
G6pcglucose-6-phosphatase, catalytic0.128
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.128
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.127
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.127
Gzmcgranzyme C0.126
Gnrh1gonadotropin releasing hormone 10.121
Igfbp1insulin-like growth factor binding protein 10.116
Klk1b27kallikrein 1-related peptidase b270.113
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.111
Lhx4LIM homeobox protein 40.110
Sprr1bsmall proline-rich protein 1B0.107
F2coagulation factor II0.106
Il1ainterleukin 1 alpha0.105
Zg16zymogen granule protein 160.105
KelKell blood group0.105
Pkp1plakophilin 10.105
Pigrpolymeric immunoglobulin receptor0.104
Mc2rmelanocortin 2 receptor0.103
Jag1jagged 10.103
Igfbp4insulin-like growth factor binding protein 40.101
Oprm1opioid receptor, mu 10.099
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.099
Egfbp2epidermal growth factor binding protein type B0.099
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.098
Aqp8aquaporin 80.095
Cxcl12chemokine (C-X-C motif) ligand 120.095
Klk1b9kallikrein 1-related peptidase b90.095
Svaseminal vesicle antigen0.094
Xcl1chemokine (C motif) ligand 10.093
Htr45 hydroxytryptamine (serotonin) receptor 40.092
CrpC-reactive protein, pentraxin-related0.092
Clpscolipase, pancreatic0.090
Agtr2angiotensin II receptor, type 20.089
Ccl22chemokine (C-C motif) ligand 220.088
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.087
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.087
Afmafamin0.087
Mcpt4mast cell protease 40.086
Spry4sprouty homolog 4 (Drosophila)0.085
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.084
Prss32protease, serine, 320.084
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.083
Epha4Eph receptor A40.083
Serpinb6cserine (or cysteine) peptidase inhibitor, clade B, member 6c0.083
Prpmp5proline-rich protein MP50.083
G6pc2glucose-6-phosphatase, catalytic, 20.083
Col4a3collagen, type IV, alpha 30.082
Mpzmyelin protein zero0.082
Cst9cystatin 90.082
C1qbcomplement component 1, q subcomponent, beta polypeptide0.081
Srrm4serine/arginine repetitive matrix 40.081
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pomcaproopiomelanocortin a0.835
prlprolactin0.823
tefthyrotroph embryonic factor0.678
per2period homolog 2 (Drosophila)0.639
starsteroidogenic acute regulatory protein0.591
igf3insulin-like growth factor 30.585
cry3cryptochrome 30.512
tshbthyroid stimulating hormone, beta subunit0.496
inhainhibin, alpha0.487
pitx3paired-like homeodomain transcription factor 30.470
pou1f1POU domain, class 1, transcription factor 10.452
inhbabinhibin, beta Ab0.443
inhbaainhibin, beta Aa0.419
hsf2heat shock factor 20.353
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.322
gdf9growth differentiation factor 90.311
adrb2aadrenergic receptor, beta 2a0.258
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.254
ptpn11bprotein tyrosine phosphatase, non-receptor type 11, b0.252
acvr2aactivin receptor IIa0.240
lhcgrluteinizing hormone/choriogonadotropin receptor0.226
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.222
hcrthypocretin (orexin) neuropeptide precursor0.211
paqr8progestin and adipoQ receptor family member VIII0.206
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.204
rhcgbRhesus blood group, C glycoprotein b0.185
si:dkey-258f14.5si:dkey-258f14.50.181
hbae1hemoglobin alpha embryonic-10.180
plxnd1plexin D10.176
si:dkey-177p2.6si:dkey-177p2.60.175
sc:d812sc:d8120.168
zp3zona pellucida glycoprotein 30.165
st3gal5lST3 beta-galactoside alpha-2,3-sialyltransferase 5, like0.155
acvr2bactivin receptor IIb0.155
cnr1cannabinoid receptor 10.140
itgavintegrin, alpha V0.137
arl6ADP-ribosylation factor-like 60.125
cry1bcryptochrome 1b0.121
hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.116
synpo2lasynaptopodin 2-like a0.116
gh1growth hormone 10.103
tnfatumor necrosis factor a (TNF superfamily, member 2)0.101
klf2aKruppel-like factor 2a0.099
prox1bprospero-related homeobox gene 1b0.099
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.098
foxe3forkhead box E30.098
scg3secretogranin III0.098
atp6v1fATPase, H+ transporting, V1 subunit F0.097
cry1acryptochrome 1a0.091
ddb2damage-specific DNA binding protein 20.091
isl2aislet2a0.089
nr1i2nuclear receptor subfamily 1, group I, member 20.088
lhx5LIM homeobox 50.088
fshbfollicle stimulating hormone, beta polypeptide0.087
si:dkey-12o15.1si:dkey-12o15.10.087
agrpagouti related protein homolog0.086
cpla2cytosolic phospholipase a20.084
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.084
dbx1adeveloping brain homeobox 1a0.083
dmbx1adiencephalon/mesencephalon homeobox 1a0.081
wt1bwilms tumor 1b0.079
sgk1serum/glucocorticoid regulated kinase 10.079
zgc:171495zgc:1714950.077
ppp4cbprotein phosphatase 4 (formerly X), catalytic subunit b0.077
nr0b1nuclear receptor subfamily 0, group B, member 10.075
ptgs2aprostaglandin-endoperoxide synthase 2a0.072
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.072
dab1adisabled homolog 1a (Drosophila)0.072
etv2ets variant gene 20.072
stab2stabilin 20.071
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.070
zbtb4zinc finger and BTB domain containing 40.070
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.069
epas1bendothelial PAS domain protein 1b0.069
znf395bzinc finger protein 395b0.069
zic6zic family member 60.068
gngt2aguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a0.068
nr1d2anuclear receptor subfamily 1, group D, member 2a0.067
gria4aglutamate receptor, ionotropic, AMPA 4a0.066
hif1alhypoxia-inducible factor 1, alpha subunit, like0.066
vsg1vessel-specific 10.065
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.065
sox7SRY-box containing gene 70.064
ip6k2inositol hexaphosphate kinase 20.064
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.064
fabp11afatty acid binding protein 11a0.063
cry5cryptochrome 50.063
abhd2aabhydrolase domain containing 2a0.063
wnt7aawingless-type MMTV integration site family, member 7Aa0.063
fam43bfamily with sequence similarity 43, member B0.062
cps1carbamoyl-phosphate synthase 1, mitochondrial0.062
cnga5cyclic nucleotide gated channel alpha 50.061
wu:fj39b01wu:fj39b010.060
chatcholine acetyltransferase0.060
slc16a9asolute carrier family 16 (monocarboxylic acid transporters), member 9a0.059
rradRas-related associated with diabetes0.058
gna12guanine nucleotide binding protein (G protein) alpha 120.057
arhgap29aRho GTPase activating protein 29a0.057
rhoaaras homolog gene family, member Aa0.057
cyp2p6cytochrome P450, family 2, subfamily P, polypeptide 60.056
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.998
C1QCcomplement component 1, q subcomponent, C chain0.855
NOSTRINnitric oxide synthase trafficker0.731
CRHR1corticotropin releasing hormone receptor 10.662
CRHcorticotropin releasing hormone0.621
DVL3dishevelled, dsh homolog 3 (Drosophila)0.581
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.575
IL1R1interleukin 1 receptor, type I0.571
PAX8paired box 80.487
CAV1caveolin 1, caveolae protein, 22kDa0.347
C1QBcomplement component 1, q subcomponent, B chain0.343
VAC14Vac14 homolog (S. cerevisiae)0.324
CAV2caveolin 20.208
TDGF1teratocarcinoma-derived growth factor 10.203
SPDEFSAM pointed domain containing ets transcription factor0.156
SSTR2somatostatin receptor 20.135
MCCmutated in colorectal cancers0.135
OCLNoccludin0.131
IL1RAPinterleukin 1 receptor accessory protein0.108
TJP1tight junction protein 1 (zona occludens 1)0.095
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.092
SMAD3SMAD family member 30.087
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.086
FRS2fibroblast growth factor receptor substrate 20.083
DYNC1I1dynein, cytoplasmic 1, intermediate chain 10.082
CTSAcathepsin A0.080
DVL2dishevelled, dsh homolog 2 (Drosophila)0.076
FAM110Cfamily with sequence similarity 110, member C0.073
IL1RNinterleukin 1 receptor antagonist0.069
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.069
IL8interleukin 80.068
FAM110Afamily with sequence similarity 110, member A0.068
FSHBfollicle stimulating hormone, beta polypeptide0.066
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase0.065
MYO6myosin VI0.063
CADM4cell adhesion molecule 40.062
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.059
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.058
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.058
GAB1GRB2-associated binding protein 10.053
TIMP3TIMP metallopeptidase inhibitor 30.050
CYP17A1cytochrome P450, family 17, subfamily A, polypeptide 10.049
PSAPprosaposin0.048
ARHGEF1Rho guanine nucleotide exchange factor (GEF) 10.047
AVPR2arginine vasopressin receptor 20.047
CCL20chemokine (C-C motif) ligand 200.045
FGF4fibroblast growth factor 40.044
CXCL2chemokine (C-X-C motif) ligand 20.044
HES1hairy and enhancer of split 1, (Drosophila)0.044
GNA13guanine nucleotide binding protein (G protein), alpha 130.043
TGFB3transforming growth factor, beta 30.043
HIPK3homeodomain interacting protein kinase 30.042
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.042
TAL1T-cell acute lymphocytic leukemia 10.042
CCKBRcholecystokinin B receptor0.042
STAB1stabilin 10.041
TKTtransketolase0.041
NDPNorrie disease (pseudoglioma)0.040
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.040
SSTR3somatostatin receptor 30.040
EPAS1endothelial PAS domain protein 10.039
SMURF2SMAD specific E3 ubiquitin protein ligase 20.038
TAOK1TAO kinase 10.038
CRAMP1LCrm, cramped-like (Drosophila)0.037
CGB5chorionic gonadotropin, beta polypeptide 50.037
DVL1dishevelled, dsh homolog 1 (Drosophila)0.036
TUBB8tubulin, beta 80.036
PCDHA4protocadherin alpha 40.035
GLP1Rglucagon-like peptide 1 receptor0.034
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.032
CXCL3chemokine (C-X-C motif) ligand 30.031
IGSF21immunoglobin superfamily, member 210.031
ZBTB16zinc finger and BTB domain containing 160.031
ITM2Bintegral membrane protein 2B0.031
GRM6glutamate receptor, metabotropic 60.030
PTGER3prostaglandin E receptor 3 (subtype EP3)0.030
GJD2gap junction protein, delta 2, 36kDa0.028
DUSP9dual specificity phosphatase 90.028
PLAURplasminogen activator, urokinase receptor0.028
NR0B2nuclear receptor subfamily 0, group B, member 20.028
TNFAIP6tumor necrosis factor, alpha-induced protein 60.027
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.027
HSPB1heat shock 27kDa protein 10.027
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.027
MARCOmacrophage receptor with collagenous structure0.026
CALCAcalcitonin-related polypeptide alpha0.026
MUC4mucin 4, cell surface associated0.026
AXIN1axin 10.026
TMPRSS2transmembrane protease, serine 20.026
TM4SF5transmembrane 4 L six family member 50.025
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.025
GTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDa0.025
SIX2SIX homeobox 20.025
MPZL1myelin protein zero-like 10.024
ADRA1Dadrenergic, alpha-1D-, receptor0.024
FAM162Bfamily with sequence similarity 162, member B0.024
TBXA2Rthromboxane A2 receptor0.023
GNSglucosamine (N-acetyl)-6-sulfatase0.023
TGFBR1transforming growth factor, beta receptor 10.023
APOEapolipoprotein E0.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Avparginine vasopressin0.168
Trhthyrotropin releasing hormone0.116
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.115
Citcitron0.091
Agxt2alanine-glyoxylate aminotransferase 20.085
Ahsgalpha-2-HS-glycoprotein0.082
Pnocprepronociceptin0.081
Mmp10matrix metallopeptidase 100.079
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.076
Cckarcholecystokinin A receptor0.073
Mchr1melanin-concentrating hormone receptor 10.064
Adra2aadrenergic, alpha-2A-, receptor0.064
Vipvasoactive intestinal peptide0.062
Gja6gap junction protein, alpha 60.059
Edn2endothelin 20.056
Pmfbp1polyamine modulated factor 1 binding protein 10.050
Apoa5apolipoprotein A-V0.047
Atxn1ataxin 10.047
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.041
Necab1N-terminal EF-hand calcium binding protein 10.041
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.041
Col10a1collagen, type X, alpha 10.041
Hcrthypocretin0.040
Akr1c18aldo-keto reductase family 1, member C180.040
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.040
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.039
Olr416olfactory receptor 4160.039
Cgaglycoprotein hormones, alpha polypeptide0.037
Myl1myosin, light chain 10.037
Procprotein C0.036
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.036
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.035
Zg16zymogen granule protein 160.035
Mcpt2mast cell protease 20.035
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.035
Prm3protamine 30.035
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.034
Testintestin gene0.034
Cckbrcholecystokinin B receptor0.034
Dmrta1DMRT-like family A10.034
Nmuneuromedin U0.034
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.034
Cnga1cyclic nucleotide gated channel alpha 10.033
Mmp13matrix metallopeptidase 130.033
Csf3colony stimulating factor 3 (granulocyte)0.032
Smgbneonatal submandibular gland protein B0.032
Aqp2aquaporin 2 (collecting duct)0.031
Magmyelin-associated glycoprotein0.031
Tacr2tachykinin receptor 20.031
Cmklr1chemokine-like receptor 10.030
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.030
C5ar1complement component 5a receptor 10.030
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.030
Lim2lens intrinsic membrane protein 20.030
Foxe3forkhead box E30.030
Fgf14fibroblast growth factor 140.029
Olr287olfactory receptor 2870.028
F9coagulation factor IX0.028
Ghsrgrowth hormone secretagogue receptor0.028
Prl2a1Prolactin family 2, subfamily a, member 10.028
Crhbpcorticotropin releasing hormone binding protein0.028
Chrm2cholinergic receptor, muscarinic 20.028
LOC299282Serine protease inhibitor0.028
Kcnt1potassium channel, subfamily T, member 10.027
Aardalanine and arginine rich domain containing protein0.027
Pzppregnancy-zone protein0.027
Aqp8aquaporin 80.027
Accn3amiloride-sensitive cation channel 30.027
Tontonin0.026
Syt8synaptotagmin VIII0.026
Galr1galanin receptor 10.026
Trhr2thyrotropin releasing hormone receptor 20.026
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.026
Grem1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)0.025
Chrm5cholinergic receptor, muscarinic 50.025
Mmp3matrix metallopeptidase 30.025
Kiss1rKISS1 receptor0.025
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.024
Hes2hairy and enhancer of split 2 (Drosophila)0.024
Hes3hairy and enhancer of split 3 (Drosophila)0.024
Sycnsyncollin0.024
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.024
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.024
C1qtnf6C1q and tumor necrosis factor related protein 60.024
Esr2estrogen receptor 2 (ER beta)0.024
Ush1cUsher syndrome 1C homolog (human)0.023
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.023
Prss21protease, serine, 210.023
Lalbalactalbumin, alpha0.023
Il4interleukin 40.022
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.022
Syn3synapsin III0.022
Pitx3paired-like homeodomain 30.022
Insl3insulin-like 30.022
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.022
Gpr6G protein-coupled receptor 60.021
Iappislet amyloid polypeptide0.021
Foxd3forkhead box D30.021
Olr1523olfactory receptor 15230.021
Gad2glutamate decarboxylase 20.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism