The network for 'histamine uptake' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histamine uptake

The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

NameDescriptionProbabilityFunc Analog Organism
Slc22a2solute carrier family 22 (organic cation transporter), member 20.988
Slc22a6solute carrier family 22 (organic anion transporter), member 60.896
Slc6a20bsolute carrier family 6 (neurotransmitter transporter), member 20B0.838
Slc12a1solute carrier family 12, member 10.577
Acsm2acyl-CoA synthetase medium-chain family member 20.442
Slc22a12solute carrier family 22 (organic anion/cation transporter), member 120.325
Clcnkachloride channel Ka0.274
Slc34a1solute carrier family 34 (sodium phosphate), member 10.257
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.234
Slc22a1solute carrier family 22 (organic cation transporter), member 10.194
Slc6a18solute carrier family 6 (neurotransmitter transporter), member 180.168
Ostaorganic solute transporter alpha0.157
DaoD-amino acid oxidase0.118
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.098
Prodh2proline dehydrogenase (oxidase) 20.085
Hgdhomogentisate 1, 2-dioxygenase0.074
Keg1kidney expressed gene 10.069
Slc5a11solute carrier family 5 (sodium/glucose cotransporter), member 110.068
Cubncubilin (intrinsic factor-cobalamin receptor)0.067
BC021785cDNA sequence BC0217850.066
Col4a4collagen, type IV, alpha 40.063
Cyp24a1cytochrome P450, family 24, subfamily a, polypeptide 10.060
Aspdhaspartate dehydrogenase domain containing0.058
Kapkidney androgen regulated protein0.057
Slc22a8solute carrier family 22 (organic anion transporter), member 80.057
G6pcglucose-6-phosphatase, catalytic0.056
Aqp2aquaporin 20.056
Guca2bguanylate cyclase activator 2b (retina)0.054
Hnf4ahepatic nuclear factor 4, alpha0.053
Slc22a13solute carrier family 22 (organic cation transporter), member 130.050
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.049
Cldn2claudin 20.049
Slc2a9solute carrier family 2 (facilitated glucose transporter), member 90.049
Adra2badrenergic receptor, alpha 2b0.048
Clrn3clarin 30.043
Hoxa9homeobox A90.041
Mep1ameprin 1 alpha0.039
Hsd3b4hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 40.039
Abca4ATP-binding cassette, sub-family A (ABC1), member 40.039
Nphs2nephrosis 2 homolog, podocin (human)0.038
Slc6a13solute carrier family 6 (neurotransmitter transporter, GABA), member 130.035
Mioxmyo-inositol oxygenase0.035
Dnase1deoxyribonuclease I0.035
Slc17a1solute carrier family 17 (sodium phosphate), member 10.033
Slc22a18solute carrier family 22 (organic cation transporter), member 180.033
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.032
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.031
Kif12kinesin family member 120.031
Pdzd3PDZ domain containing 30.029
Clcnkbchloride channel Kb0.029
Ggnbp1gametogenetin binding protein 10.029
Upk3auroplakin 3A0.029
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.027
Aqp7aquaporin 70.026
Slc22a7solute carrier family 22 (organic anion transporter), member 70.025
Slc12a3solute carrier family 12, member 30.025
Timd2T-cell immunoglobulin and mucin domain containing 20.023
Golt1agolgi transport 1 homolog A (S. cerevisiae)0.022
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.021
Tcfap2btranscription factor AP-2 beta0.021
Procprotein C0.021
Rab17RAB17, member RAS oncogene family0.021
Iydiodotyrosine deiodinase0.020
IhhIndian hedgehog0.020
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.019
Gcgrglucagon receptor0.019
Rhpn1rhophilin, Rho GTPase binding protein 10.019
Slc13a3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 30.019
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.019
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.018
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.018
Pparaperoxisome proliferator activated receptor alpha0.018
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.017
Atp6v0a4ATPase, H+ transporting, lysosomal V0 subunit A40.017
Pramel7preferentially expressed antigen in melanoma like 70.017
Akr1c21aldo-keto reductase family 1, member C210.016
Cldn19claudin 190.016
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.016
Kcns1K+ voltage-gated channel, subfamily S, 10.016
Pahphenylalanine hydroxylase0.015
Myo7bmyosin VIIB0.015
Egfepidermal growth factor0.015
Aadataminoadipate aminotransferase0.015
Tmem174transmembrane protein 1740.015
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.014
Mogat2monoacylglycerol O-acyltransferase 20.014
Gjb1gap junction protein, beta 10.014
Pbld1phenazine biosynthesis-like protein domain containing 10.014
Defb29defensin beta 290.014
Kcna7potassium voltage-gated channel, shaker-related subfamily, member 70.014
Srcrb4dscavenger receptor cysteine rich domain containing, group B (4 domains)0.013
Azgp1alpha-2-glycoprotein 1, zinc0.013
Col19a1collagen, type XIX, alpha 10.012
Olfm3olfactomedin 30.012
Adra1aadrenergic receptor, alpha 1a0.012
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism