The network for 'aorta morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

aorta morphogenesis

The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax3paired box gene 30.999
Gli3GLI-Kruppel family member GLI30.999
Tbx3T-box 30.999
Hand1heart and neural crest derivatives expressed transcript 10.998
Fgfr2fibroblast growth factor receptor 20.998
Pitx2paired-like homeodomain transcription factor 20.998
Tcfap2atranscription factor AP-2, alpha0.997
Foxc1forkhead box C10.997
Foxc2forkhead box C20.995
Prrx1paired related homeobox 10.995
Col1a1collagen, type I, alpha 10.995
Hand2heart and neural crest derivatives expressed transcript 20.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.991
Bmp4bone morphogenetic protein 40.980
Eya1eyes absent 1 homolog (Drosophila)0.979
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.974
Otx2orthodenticle homolog 2 (Drosophila)0.973
Foxg1forkhead box G10.968
Meox2mesenchyme homeobox 20.963
Sox11SRY-box containing gene 110.960
Ror2receptor tyrosine kinase-like orphan receptor 20.953
Notch1Notch gene homolog 1 (Drosophila)0.952
Sox2SRY-box containing gene 20.951
Tgfb2transforming growth factor, beta 20.938
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.930
Msx1homeobox, msh-like 10.926
Fgfr1fibroblast growth factor receptor 10.923
Fgfr3fibroblast growth factor receptor 30.889
Runx2runt related transcription factor 20.881
Dll1delta-like 1 (Drosophila)0.863
Pitx1paired-like homeodomain transcription factor 10.860
Hes1hairy and enhancer of split 1 (Drosophila)0.857
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.840
Chd7chromodomain helicase DNA binding protein 70.840
Zeb1zinc finger E-box binding homeobox 10.839
Nos3nitric oxide synthase 3, endothelial cell0.817
Col3a1collagen, type III, alpha 10.815
Hes5hairy and enhancer of split 5 (Drosophila)0.808
Kdrkinase insert domain protein receptor0.807
Fgf8fibroblast growth factor 80.781
Smad6MAD homolog 6 (Drosophila)0.772
Efnb2ephrin B20.752
Dll4delta-like 4 (Drosophila)0.740
Jag1jagged 10.738
Tbx1T-box 10.699
Nodalnodal0.678
Gscgoosecoid homeobox0.673
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.661
Hey2hairy/enhancer-of-split related with YRPW motif 20.660
Col1a2collagen, type I, alpha 20.632
Col2a1collagen, type II, alpha 10.625
Gata4GATA binding protein 40.617
Bmp7bone morphogenetic protein 70.595
Hey1hairy/enhancer-of-split related with YRPW motif 10.550
Vangl2vang-like 2 (van gogh, Drosophila)0.529
Ptch1patched homolog 10.460
Zic3zinc finger protein of the cerebellum 30.455
Tbx2T-box 20.442
Flt4FMS-like tyrosine kinase 40.380
Wnt3awingless-related MMTV integration site 3A0.370
Pax1paired box gene 10.370
Lrp6low density lipoprotein receptor-related protein 60.369
Dlx5distal-less homeobox 50.365
Hspg2perlecan (heparan sulfate proteoglycan 2)0.333
Nognoggin0.326
Tlx3T-cell leukemia, homeobox 30.320
Notch2Notch gene homolog 2 (Drosophila)0.315
Alx4aristaless-like homeobox 40.308
Prrx2paired related homeobox 20.296
Psen1presenilin 10.288
Pkd1polycystic kidney disease 1 homolog0.286
Shesrc homology 2 domain-containing transforming protein E0.282
Pthlhparathyroid hormone-like peptide0.280
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.279
Col6a1collagen, type VI, alpha 10.270
Alx1ALX homeobox 10.267
Gli2GLI-Kruppel family member GLI20.264
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.264
Smosmoothened homolog (Drosophila)0.251
Fbn1fibrillin 10.248
Tcfap2ctranscription factor AP-2, gamma0.245
Alx3aristaless-like homeobox 30.228
Dlx1distal-less homeobox 10.227
Ighmbp2immunoglobulin mu binding protein 20.222
Ctnnb1catenin (cadherin associated protein), beta 10.208
Pou5f1POU domain, class 5, transcription factor 10.198
Rb1retinoblastoma 10.196
Notch3Notch gene homolog 3 (Drosophila)0.191
Isl1ISL1 transcription factor, LIM/homeodomain0.190
Sox9SRY-box containing gene 90.186
Pbx1pre B-cell leukemia transcription factor 10.180
Apaf1apoptotic peptidase activating factor 10.178
Bcl6bB-cell CLL/lymphoma 6, member B0.160
Sox7SRY-box containing gene 70.159
Emx1empty spiracles homolog 1 (Drosophila)0.154
Vegfavascular endothelial growth factor A0.153
Ascl1achaete-scute complex homolog 1 (Drosophila)0.152
Itgb1integrin beta 1 (fibronectin receptor beta)0.151
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.151
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tal1T-cell acute lymphocytic leukemia 10.981
tbx1T-box 10.978
hhexhematopoietically expressed homeobox0.932
pax2apaired box gene 2a0.759
hnf1baHNF1 homeobox Ba0.706
ascl1aachaete-scute complex-like 1a (Drosophila)0.633
tbx16T-box gene 160.629
dladeltaA0.625
kdrlkinase insert domain receptor like0.599
lmx1b.1LIM homeobox transcription factor 1, beta 10.581
edn1endothelin 10.554
dlddeltaD0.522
hey2hairy/enhancer-of-split related with YRPW motif 20.496
gata2aGATA-binding protein 2a0.496
dlcdeltaC0.491
mibmind bomb0.452
pax8paired box gene 80.439
tfap2atranscription factor AP-2 alpha0.420
foxi1forkhead box I10.402
jag1bjagged 1b0.388
eya1eyes absent homolog 10.388
ndr2nodal-related 20.369
dlbdeltaB0.362
nkx2.5NK2 transcription factor related 50.345
gdnfglial cell derived neurotrophic factor0.297
wnt11wingless-type MMTV integration site family, member 110.265
gli2aGLI-Kruppel family member GLI2a0.262
notch1bnotch homolog 1b0.250
eng2aengrailed 2a0.243
ccm2cerebral cavernous malformation 20.240
notch1anotch homolog 1a0.239
vangl2vang-like 2 (van gogh, Drosophila)0.231
fli1afriend leukemia integration 1a0.207
gli1GLI-Kruppel family member 10.199
prox1prospero-related homeobox gene 10.197
pou5f1POU domain, class 5, transcription factor 10.183
her7hairy and enhancer of split related-70.181
sox32SRY-box containing gene 320.178
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.176
fgf3fibroblast growth factor 30.175
isl1islet10.174
pcdh10bprotocadherin 10b0.173
tp53tumor protein p530.171
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.168
eng2bengrailed 2b0.162
pitx3paired-like homeodomain transcription factor 30.156
cdh2cadherin 2, neuronal0.149
lrrc50leucine rich repeat containing 500.146
cdx4caudal type homeo box transcription factor 40.145
otpborthopedia homolog b0.140
nkx2.2aNK2 transcription factor related 2a0.137
sox3SRY-box containing gene 30.134
notch3notch homolog 30.133
pcdh8protocadherin 80.131
irf6interferon regulatory factor 60.121
gata6GATA-binding protein 60.120
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.120
sox10SRY-box containing gene 100.119
foxn4forkhead box N40.118
tbx20T-box 200.114
jag2jagged 20.109
cxcr4achemokine (C-X-C motif) receptor 4a0.109
dlx4bdistal-less homeobox gene 4b0.105
lmo2LIM domain only 2 (rhombotin-like 1)0.102
unc45aunc-45 homolog A (C. elegans)0.101
myf5myogenic factor 50.098
myod1myogenic differentiation 10.094
insm1binsulinoma-associated 1b0.093
furinafurin (paired basic amino acid cleaving enzyme) a0.090
six1bsine oculis homeobox homolog 1b0.085
six2asine oculis-related homeobox 2a0.084
mmp2matrix metalloproteinase 20.083
etv2ets variant gene 20.083
birc2baculoviral IAP repeat-containing 20.082
hey1hairy/enhancer-of-split related with YRPW motif 10.081
flhfloating head0.080
gata1aGATA binding protein 1a0.079
irx3airoquois homeobox protein 3a0.079
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.078
irx1airoquois homeobox protein 1, a0.072
gbx2gastrulation brain homeo box 20.072
apcadenomatosis polyposis coli0.072
plxnd1plexin D10.071
wnt5bwingless-type MMTV integration site family, member 5b0.070
her4.2hairy-related 4.20.069
hand2heart and neural crest derivatives expressed transcript 20.069
ripply2ripply20.067
jag1ajagged 1a0.067
otx2orthodenticle homolog 20.066
neurog1neurogenin 10.064
tp73tumor protein p730.060
tbx6T-box gene 60.057
alcamaactivated leukocyte cell adhesion molecule a0.057
pdlim3bPDZ and LIM domain 3b0.056
nr2f2nuclear receptor subfamily 2, group F, member 20.056
her5hairy-related 50.054
antxr1anthrax toxin receptor 10.054
tbx24T-box 240.049
rbm24aRNA binding motif protein 24a0.049
ascl1bachaete-scute complex-like 1b (Drosophila)0.048
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 10.996
NOTCH3notch 30.865
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.795
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.720
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.524
TAL1T-cell acute lymphocytic leukemia 10.224
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.210
MKL1megakaryoblastic leukemia (translocation) 10.193
NCOR2nuclear receptor corepressor 20.173
COL1A2collagen, type I, alpha 20.166
COL1A1collagen, type I, alpha 10.130
SPENspen homolog, transcriptional regulator (Drosophila)0.127
MAML1mastermind-like 1 (Drosophila)0.125
PTCH1patched 10.111
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.105
NOTCH2notch 20.104
COL6A1collagen, type VI, alpha 10.099
MYOCDmyocardin0.085
PDGFAplatelet-derived growth factor alpha polypeptide0.084
ATXN1Lataxin 1-like0.083
HNF4Ahepatocyte nuclear factor 4, alpha0.082
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.077
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.076
BCAR1breast cancer anti-estrogen resistance 10.075
SEC23ASec23 homolog A (S. cerevisiae)0.071
NR4A1nuclear receptor subfamily 4, group A, member 10.068
COL4A1collagen, type IV, alpha 10.056
ABI1abl-interactor 10.055
CAV1caveolin 1, caveolae protein, 22kDa0.051
MDFIMyoD family inhibitor0.046
MYOGmyogenin (myogenic factor 4)0.040
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.037
FGFR1fibroblast growth factor receptor 10.034
DLL1delta-like 1 (Drosophila)0.034
REREarginine-glutamic acid dipeptide (RE) repeats0.034
MARCKSL1MARCKS-like 10.032
SMAD3SMAD family member 30.032
CTBP2C-terminal binding protein 20.031
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.031
SIRT1sirtuin 10.031
PTENphosphatase and tensin homolog0.031
MKL2MKL/myocardin-like 20.030
COL4A2collagen, type IV, alpha 20.030
JAG2jagged 20.029
CTTNcortactin0.029
SOCS5suppressor of cytokine signaling 50.028
SMAD9SMAD family member 90.026
EDNRAendothelin receptor type A0.026
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.025
SLASrc-like-adaptor0.024
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.023
EFNB2ephrin-B20.023
RUNX1runt-related transcription factor 10.022
LOXlysyl oxidase0.022
GAB1GRB2-associated binding protein 10.022
NR5A2nuclear receptor subfamily 5, group A, member 20.022
HES1hairy and enhancer of split 1, (Drosophila)0.021
COL5A2collagen, type V, alpha 20.021
PUM1pumilio homolog 1 (Drosophila)0.021
LATlinker for activation of T cells0.019
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.018
SCAF8SR-related CTD-associated factor 80.017
SOS1son of sevenless homolog 1 (Drosophila)0.017
EPAS1endothelial PAS domain protein 10.017
RAB21RAB21, member RAS oncogene family0.017
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.017
COL5A1collagen, type V, alpha 10.017
PXDNperoxidasin homolog (Drosophila)0.017
PDGFCplatelet derived growth factor C0.016
MYOD1myogenic differentiation 10.016
FOXO3forkhead box O30.016
NID2nidogen 2 (osteonidogen)0.016
GAB2GRB2-associated binding protein 20.016
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.015
JAG1jagged 10.015
UBE2G1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.015
EYA2eyes absent homolog 2 (Drosophila)0.015
PIK3C2Aphosphoinositide-3-kinase, class 2, alpha polypeptide0.015
DCNdecorin0.014
SIAH1seven in absentia homolog 1 (Drosophila)0.014
MCCmutated in colorectal cancers0.014
IGFBP5insulin-like growth factor binding protein 50.014
PPARAperoxisome proliferator-activated receptor alpha0.014
LMO2LIM domain only 2 (rhombotin-like 1)0.014
ANGPTL2angiopoietin-like 20.014
MBL2mannose-binding lectin (protein C) 2, soluble0.014
FEM1Cfem-1 homolog c (C. elegans)0.013
PAPPApregnancy-associated plasma protein A, pappalysin 10.013
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.013
EP300E1A binding protein p3000.013
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.013
MMP14matrix metallopeptidase 14 (membrane-inserted)0.013
NID1nidogen 10.013
EYA1eyes absent homolog 1 (Drosophila)0.013
CIR1corepressor interacting with RBPJ, 10.013
CSNK1Ecasein kinase 1, epsilon0.013
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.013
CALD1caldesmon 10.012
XIAPX-linked inhibitor of apoptosis0.012
PLCG1phospholipase C, gamma 10.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism