The network for 'organelle disassembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organelle disassembly

The disaggregation of an organelle into its constituent components.

NameDescriptionProbabilityFunc Analog Organism
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.995
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.886
Hsph1heat shock 105kDa/110kDa protein 10.812
Klc1kinesin light chain 10.690
Hspd1heat shock protein 1 (chaperonin)0.686
Iqcb1IQ calmodulin-binding motif containing 10.652
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.645
Clstn1calsyntenin 10.558
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.537
Rpgrip1lRpgrip1-like0.467
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.393
Spag9sperm associated antigen 90.331
Eif3jeukaryotic translation initiation factor 3, subunit J0.272
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.264
Hspa5heat shock protein 50.242
Ncoa2nuclear receptor coactivator 20.208
Cacybpcalcyclin binding protein0.199
Stip1stress-induced phosphoprotein 10.199
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.197
Fam98afamily with sequence similarity 98, member A0.179
Hspa4heat shock protein 40.171
Kif5ckinesin family member 5C0.151
Kpna1karyopherin (importin) alpha 10.147
Nsfl1cNSFL1 (p97) cofactor (p47)0.130
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.122
Strapserine/threonine kinase receptor associated protein0.118
Narsasparaginyl-tRNA synthetase0.117
Caprin1cell cycle associated protein 10.117
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.116
Hspa8heat shock protein 80.109
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.096
Ufd1lubiquitin fusion degradation 1 like0.092
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.090
Hdac6histone deacetylase 60.089
Mapk8mitogen-activated protein kinase 80.089
Eif2s1eukaryotic translation initiation factor 2, subunit 1 alpha0.085
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.084
Tarsthreonyl-tRNA synthetase0.081
Hap1huntingtin-associated protein 10.080
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.080
Eif4g2eukaryotic translation initiation factor 4, gamma 20.078
Hsp90b1heat shock protein 90, beta (Grp94), member 10.076
Eif5beukaryotic translation initiation factor 5B0.076
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.071
Igbp1immunoglobulin (CD79A) binding protein 10.069
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.066
Ahi1Abelson helper integration site 10.065
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.063
Bzw1basic leucine zipper and W2 domains 10.061
Azin1antizyme inhibitor 10.059
Iarsisoleucine-tRNA synthetase0.059
Eprsglutamyl-prolyl-tRNA synthetase0.059
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.058
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.058
Ddx3xDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked0.056
Stk30serine/threonine kinase 300.055
Naa15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.054
Kpna3karyopherin (importin) alpha 30.052
Klc2kinesin light chain 20.051
Vamp2vesicle-associated membrane protein 20.049
Rarsarginyl-tRNA synthetase0.048
Morf4l2mortality factor 4 like 20.048
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.047
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.046
Lrpprcleucine-rich PPR-motif containing0.045
Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked0.044
Dtnbdystrobrevin, beta0.044
Ideinsulin degrading enzyme0.044
Homer1homer homolog 1 (Drosophila)0.041
Ipo7importin 70.041
Cct8chaperonin containing Tcp1, subunit 8 (theta)0.040
Ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.039
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.038
Utp6UTP6, small subunit (SSU) processome component, homolog (yeast)0.038
NapbN-ethylmaleimide sensitive fusion protein attachment protein beta0.037
Api5apoptosis inhibitor 50.036
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.035
Rad23bRAD23b homolog (S. cerevisiae)0.034
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.032
Cse1lchromosome segregation 1-like (S. cerevisiae)0.031
Hspa1bheat shock protein 1B0.031
Rusc1RUN and SH3 domain containing 10.031
Mark4MAP/microtubule affinity-regulating kinase 40.031
Ptges3prostaglandin E synthase 3 (cytosolic)0.029
Pno1partner of NOB1 homolog (S. cerevisiae)0.029
Kif5akinesin family member 5A0.029
Rab1RAB1, member RAS oncogene family0.028
Snap25synaptosomal-associated protein 250.028
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.028
Pcbp1poly(rC) binding protein 10.028
G3bp2GTPase activating protein (SH3 domain) binding protein 20.027
Ckbcreatine kinase, brain0.027
Arf4ADP-ribosylation factor 40.027
Sept7septin 70.027
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.026
Sec63SEC63-like (S. cerevisiae)0.026
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.025
Tuba4atubulin, alpha 4A0.025
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.025
Nus1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)0.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rpn-1Protein RPN-10.171
paa-1Protein PAA-10.044
daf-21Protein DAF-210.036
hsp-1Protein HSP-10.032
tars-1Protein TARS-10.028
tbb-1Protein TBB-10.028
tsr-1Protein TSR-10.025
prp-8Protein PRP-80.025
acs-4Protein ACS-40.023
tbb-2Protein TBB-20.021
mrp-4Protein MRP-40.017
T22F3.3Protein T22F3.30.017
eef-1A.1Protein EEF-1A.10.017
mig-15Protein MIG-150.016
chc-1Protein CHC-10.016
F52C9.7Protein F52C9.70.016
frm-2Protein FRM-20.015
cst-1Protein CST-10.014
hsp-4Protein HSP-40.014
cgh-1Protein CGH-10.014
C30C11.4Protein C30C11.40.014
F33G12.5Protein F33G12.50.013
sax-3Protein SAX-30.013
fkb-6Protein FKB-60.013
C52E12.1Protein C52E12.10.013
cct-2Protein CCT-20.012
sago-2Protein SAGO-20.012
ash-2Protein ASH-20.012
ima-3Protein IMA-30.012
T03F1.1Protein T03F1.10.012
D1044.6Protein D1044.60.012
pam-1Protein PAM-10.012
clu-1Protein CLU-10.011
rpt-3Protein RPT-30.011
ztf-7Protein ZTF-70.011
ama-1Protein AMA-10.011
mog-4Protein MOG-40.011
rpn-3Protein RPN-30.011
F01G4.4Protein F01G4.40.011
R90.1Protein R90.10.010
nra-1Protein NRA-10.010
ubxn-4Protein UBXN-40.010
vps-35Protein VPS-350.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
phlpole hole0.027
wgwingless0.025
DlDelta0.021
CG9344CG9344 gene product from transcript CG9344-RA0.018
NNotch0.017
EgfrEpidermal growth factor receptor0.016
CG2862CG2862 gene product from transcript CG2862-RA0.016
CG11267CG11267 gene product from transcript CG11267-RA0.016
dppdecapentaplegic0.015
EcREcdysone receptor0.013
CG4866CG4866 gene product from transcript CG4866-RB0.012
CG7603CG7603 gene product from transcript CG7603-RA0.011
l(2)06225lethal (2) 062250.011
l(1)G0230lethal (1) G02300.011
fufused0.010
CG9922CG9922 gene product from transcript CG9922-RA0.010
CG8928CG8928 gene product from transcript CG8928-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.625
HSPA1Bheat shock 70kDa protein 1B0.584
HSPA1Aheat shock 70kDa protein 1A0.352
CCT8chaperonin containing TCP1, subunit 8 (theta)0.233
MCTS1malignant T cell amplified sequence 10.179
CHEK2CHK2 checkpoint homolog (S. pombe)0.151
DENRdensity-regulated protein0.104
PABPC1poly(A) binding protein, cytoplasmic 10.060
LRSAM1leucine rich repeat and sterile alpha motif containing 10.058
UFD1Lubiquitin fusion degradation 1 like (yeast)0.056
BAG1BCL2-associated athanogene0.049
SEPT2septin 20.039
BAG3BCL2-associated athanogene 30.028
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.027
TNPO1transportin 10.024
UBE4Bubiquitination factor E4B (UFD2 homolog, yeast)0.021
HSPH1heat shock 105kDa/110kDa protein 10.020
SIRT2sirtuin 20.019
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.017
GTSE1G-2 and S-phase expressed 10.013
ETF1eukaryotic translation termination factor 10.013
PRNPprion protein0.012
TCP1t-complex 10.012
KCNE3potassium voltage-gated channel, Isk-related family, member 30.011
NSFL1CNSFL1 (p97) cofactor (p47)0.010
ITSN1intersectin 1 (SH3 domain protein)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
STI1Sti1p0.110
CDC48Cdc48p0.073
BUD4Bud4p0.055
SSA2Ssa2p0.054
CDC10Cdc10p0.052
CDC3Cdc3p0.042
YDJ1Ydj1p0.030
CDC37Cdc37p0.023
SIS1Sis1p0.022
CDC12Cdc12p0.019
CLB3Clb3p0.017
MYO2Myo2p0.015
MDJ1Mdj1p0.014
NUP49Nup49p0.014
STU2Stu2p0.014
SSE1Sse1p0.013
SSA4Ssa4p0.013
UFD1Ufd1p0.013
PIM1Pim1p0.013
YLR264C-Ahypothetical protein0.012
SRD1Srd1p0.012
CDC15Cdc15p0.012
CLU1Clu1p0.012
CDC14Cdc14p0.012
ARP10Arp10p0.012
NUD1Nud1p0.011
UBA1Uba1p0.011
LEU2Leu2p0.011
YLR162Whypothetical protein0.011
ZDS1Zds1p0.011
KIP1Kip1p0.011
YHB1Yhb1p0.011
STE4Ste4p0.011
YOL038C-Ahypothetical protein0.011
ARG8Arg8p0.011
CUP1-1Cup1-1p0.010
CHA1Cha1p0.010
CDC16Cdc16p0.010
OTU1Otu1p0.010
SSA1Ssa1p0.010
CAB3Cab3p0.010