The network for 'cell activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell activation involved in immune response

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.999
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.984
Ptprcprotein tyrosine phosphatase, receptor type, C0.984
Cd28CD28 antigen0.970
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.941
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.940
Lyz2lysozyme 20.926
Il10rainterleukin 10 receptor, alpha0.907
Casp4caspase 4, apoptosis-related cysteine peptidase0.899
Prf1perforin 1 (pore forming protein)0.895
Cd40CD40 antigen0.890
Leprleptin receptor0.889
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.885
Il2rginterleukin 2 receptor, gamma chain0.882
Il4interleukin 40.855
Stat3signal transducer and activator of transcription 30.848
Cd247CD247 antigen0.832
Ccr2chemokine (C-C motif) receptor 20.817
Myd88myeloid differentiation primary response gene 880.811
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.793
FynFyn proto-oncogene0.782
Cd19CD19 antigen0.768
Il2rbinterleukin 2 receptor, beta chain0.758
Map3k14mitogen-activated protein kinase kinase kinase 140.755
Jak2Janus kinase 20.753
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.738
Tbx3T-box 30.730
Bcl3B-cell leukemia/lymphoma 30.723
Tnftumor necrosis factor0.715
Irf5interferon regulatory factor 50.697
Rag1recombination activating gene 10.695
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.667
Klrk1killer cell lectin-like receptor subfamily K, member 10.661
FasFas (TNF receptor superfamily member 6)0.661
Ldb3LIM domain binding 30.647
Prdm1PR domain containing 1, with ZNF domain0.647
Stat6signal transducer and activator of transcription 60.645
Ccl2chemokine (C-C motif) ligand 20.637
Il10interleukin 100.635
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.634
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.626
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.623
Klrg1killer cell lectin-like receptor subfamily G, member 10.621
Klra9killer cell lectin-like receptor subfamily A, member 90.615
Ptenphosphatase and tensin homolog0.610
Cd180CD180 antigen0.587
Inpp5dinositol polyphosphate-5-phosphatase D0.580
MefvMediterranean fever0.577
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.572
Slamf1signaling lymphocytic activation molecule family member 10.571
Gzmkgranzyme K0.561
Il18rapinterleukin 18 receptor accessory protein0.560
Ccl4chemokine (C-C motif) ligand 40.555
Pitx1paired-like homeodomain transcription factor 10.554
Map3k8mitogen-activated protein kinase kinase kinase 80.547
Zeb1zinc finger E-box binding homeobox 10.547
Emx1empty spiracles homolog 1 (Drosophila)0.540
Socs1suppressor of cytokine signaling 10.537
Klrd1killer cell lectin-like receptor, subfamily D, member 10.537
Itgaxintegrin alpha X0.529
Runx1runt related transcription factor 10.522
Selpselectin, platelet0.506
Itgalintegrin alpha L0.503
Stat5bsignal transducer and activator of transcription 5B0.498
Ptpn11protein tyrosine phosphatase, non-receptor type 110.494
Ncr1natural cytotoxicity triggering receptor 10.490
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.487
Stat1signal transducer and activator of transcription 10.479
ItkIL2-inducible T-cell kinase0.478
Cd86CD86 antigen0.468
Nlrp3NLR family, pyrin domain containing 30.457
Irf4interferon regulatory factor 40.452
Il6interleukin 60.441
Il1r1interleukin 1 receptor, type I0.440
Tnfaip3tumor necrosis factor, alpha-induced protein 30.437
Batfbasic leucine zipper transcription factor, ATF-like0.436
AF251705cDNA sequence AF2517050.433
Fgf10fibroblast growth factor 100.431
Dok1docking protein 10.428
Lcp2lymphocyte cytosolic protein 20.428
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.425
Tbx21T-box 210.423
Traf6TNF receptor-associated factor 60.421
Cd7CD7 antigen0.418
Il4rainterleukin 4 receptor, alpha0.414
Sellselectin, lymphocyte0.412
Clec7aC-type lectin domain family 7, member a0.409
Gpr132G protein-coupled receptor 1320.409
Cishcytokine inducible SH2-containing protein0.398
Kitkit oncogene0.389
Icosinducible T-cell co-stimulator0.387
Sfpi1SFFV proviral integration 10.375
Ifnginterferon gamma0.375
Cd96CD96 antigen0.373
Il1binterleukin 1 beta0.370
Il1rninterleukin 1 receptor antagonist0.370
Ccr6chemokine (C-C motif) receptor 60.369
Hcsthematopoietic cell signal transducer0.361
Socs3suppressor of cytokine signaling 30.360
Stat5asignal transducer and activator of transcription 5A0.343
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.992
BRCA1breast cancer 1, early onset0.965
FHL2four and a half LIM domains 20.927
SYKspleen tyrosine kinase0.744
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.672
GRAP2GRB2-related adaptor protein 20.610
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.594
CCR5chemokine (C-C motif) receptor 50.513
LATlinker for activation of T cells0.511
PTPN6protein tyrosine phosphatase, non-receptor type 60.510
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.457
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.427
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.421
CCL4chemokine (C-C motif) ligand 40.385
ICAM1intercellular adhesion molecule 10.358
APLFaprataxin and PNKP like factor0.351
CD80CD80 molecule0.346
CCR1chemokine (C-C motif) receptor 10.345
BLNKB-cell linker0.334
TICAM2toll-like receptor adaptor molecule 20.331
H2AFXH2A histone family, member X0.324
MDC1mediator of DNA-damage checkpoint 10.322
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.305
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.304
CCR2chemokine (C-C motif) receptor 20.295
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.268
CAV1caveolin 1, caveolae protein, 22kDa0.265
SNAP23synaptosomal-associated protein, 23kDa0.261
NR0B1nuclear receptor subfamily 0, group B, member 10.258
VCAM1vascular cell adhesion molecule 10.244
FN1fibronectin 10.226
CCL5chemokine (C-C motif) ligand 50.223
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.207
IL2RGinterleukin 2 receptor, gamma0.202
TRAF1TNF receptor-associated factor 10.196
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.194
PILRApaired immunoglobin-like type 2 receptor alpha0.189
CXCL9chemokine (C-X-C motif) ligand 90.185
CREBBPCREB binding protein0.184
FLNAfilamin A, alpha0.183
PSEN2presenilin 2 (Alzheimer disease 4)0.178
MSH6mutS homolog 6 (E. coli)0.175
TGFB1transforming growth factor, beta 10.174
TGIF1TGFB-induced factor homeobox 10.169
BIRC3baculoviral IAP repeat containing 30.162
PTPRCprotein tyrosine phosphatase, receptor type, C0.157
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.155
HCKhemopoietic cell kinase0.153
CCR7chemokine (C-C motif) receptor 70.150
IL4Rinterleukin 4 receptor0.144
CD63CD63 molecule0.129
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.129
LIN9lin-9 homolog (C. elegans)0.127
CCL22chemokine (C-C motif) ligand 220.127
RAD50RAD50 homolog (S. cerevisiae)0.126
SOCS3suppressor of cytokine signaling 30.121
HK3hexokinase 3 (white cell)0.120
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.117
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.117
C19orf50chromosome 19 open reading frame 500.115
CCL8chemokine (C-C motif) ligand 80.115
NLRC4NLR family, CARD domain containing 40.114
ARandrogen receptor0.113
IL23Ainterleukin 23, alpha subunit p190.112
TRAF3TNF receptor-associated factor 30.110
LST1leukocyte specific transcript 10.109
IL4interleukin 40.106
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.104
TLR2toll-like receptor 20.104
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.103
TNFRSF9tumor necrosis factor receptor superfamily, member 90.099
SHC1SHC (Src homology 2 domain containing) transforming protein 10.098
IGSF6immunoglobulin superfamily, member 60.098
CFPcomplement factor properdin0.095
CD48CD48 molecule0.095
NRP1neuropilin 10.095
TP53BP1tumor protein p53 binding protein 10.094
NCOR2nuclear receptor corepressor 20.093
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.093
IL10RAinterleukin 10 receptor, alpha0.091
IL2RBinterleukin 2 receptor, beta0.091
SIGLEC7sialic acid binding Ig-like lectin 70.090
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.090
LAPTM5lysosomal protein transmembrane 50.089
PSEN1presenilin 10.089
CXCL10chemokine (C-X-C motif) ligand 100.088
GBAglucosidase, beta, acid0.085
SIRPB1signal-regulatory protein beta 10.084
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.082
PECAM1platelet/endothelial cell adhesion molecule0.082
IRF4interferon regulatory factor 40.082
IL7Rinterleukin 7 receptor0.080
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.079
IL10interleukin 100.078
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.076
IFNGinterferon, gamma0.075
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.075
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hckhemopoietic cell kinase0.344
Cd53Cd53 molecule0.279
Il2rbinterleukin 2 receptor, beta0.212
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.209
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.209
Cd4Cd4 molecule0.180
Cd38CD38 molecule0.168
Sirpasignal-regulatory protein alpha0.163
Ptprcprotein tyrosine phosphatase, receptor type, C0.147
Cybbcytochrome b-245, beta polypeptide0.145
Ptafrplatelet-activating factor receptor0.133
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.110
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.109
Csf1colony stimulating factor 1 (macrophage)0.108
Actr3ARP3 actin-related protein 3 homolog (yeast)0.096
Ripk3receptor-interacting serine-threonine kinase 30.091
Tgfbr2transforming growth factor, beta receptor II0.083
Itpr2inositol 1,4,5-triphosphate receptor, type 20.082
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.079
Dock8dedicator of cytokinesis 80.078
Il2rginterleukin 2 receptor, gamma0.077
Vav1vav 1 guanine nucleotide exchange factor0.076
Plauplasminogen activator, urokinase0.076
Bin2bridging integrator 20.075
Ptpn18protein tyrosine phosphatase, non-receptor type 180.073
Casp1caspase 10.069
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.069
Inpp5dinositol polyphosphate-5-phosphatase D0.064
Arl11ADP-ribosylation factor-like 110.064
Ctsecathepsin E0.062
Cd247Cd247 molecule0.062
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.054
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.053
Prf1perforin 1 (pore forming protein)0.053
Ccr5chemokine (C-C motif) receptor 50.049
Morf4l2mortality factor 4 like 20.049
Ciitaclass II, major histocompatibility complex, transactivator0.048
Myo1fmyosin IF0.047
Arhgap4Rho GTPase activating protein 40.047
Rassf5Ras association (RalGDS/AF-6) domain family member 50.046
Clec4a3C-type lectin domain family 4, member a30.046
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.045
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.045
Wdr1WD repeat domain 10.045
Cmklr1chemokine-like receptor 10.042
Lcp2lymphocyte cytosolic protein 20.041
Plcg2phospholipase C, gamma 20.041
Psd4pleckstrin and Sec7 domain containing 40.037
Soat1sterol O-acyltransferase 10.036
Igsf6immunoglobulin superfamily, member 60.036
Icam1intercellular adhesion molecule 10.035
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.035
Itgb2integrin, beta 20.035
Cd86CD86 molecule0.035
Icosinducible T-cell co-stimulator0.034
Sellselectin L0.033
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.032
Pitpnaphosphatidylinositol transfer protein, alpha0.032
Rhohras homolog gene family, member H0.031
Arrdc1arrestin domain containing 10.031
Calm1calmodulin 10.031
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.031
Irf5interferon regulatory factor 50.030
Gzmkgranzyme K0.030
Cd8bCD8b molecule0.030
Il17rainterleukin 17 receptor A0.029
Arhgap9Rho GTPase activating protein 90.029
FaslgFas ligand (TNF superfamily, member 6)0.028
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.027
Tlr4toll-like receptor 40.027
Ptger2prostaglandin E receptor 2 (subtype EP2)0.026
Arhgap25Rho GTPase activating protein 250.026
Cd3gCD3 molecule, gamma0.026
Klhl6kelch-like 6 (Drosophila)0.026
Tbxas1thromboxane A synthase 1, platelet0.025
Mov10Moloney leukemia virus 100.025
Lypd3Ly6/Plaur domain containing 30.025
Laptm5lysosomal protein transmembrane 50.025
Eporerythropoietin receptor0.024
Cd37CD37 molecule0.024
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.024
Cyp2s1cytochrome P450, family 2, subfamily s, polypeptide 10.023
Cxcr3chemokine (C-X-C motif) receptor 30.023
Acrv1acrosomal vesicle protein 10.023
Ctsccathepsin C0.023
Mpeg1macrophage expressed 10.023
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.023
Havcr1hepatitis A virus cellular receptor 10.023
MutyhmutY homolog (E. coli)0.023
Hrh2histamine receptor H 20.022
Dok2docking protein 20.022
Tgfbr3transforming growth factor, beta receptor III0.022
Phox2apaired-like homeobox 2a0.021
Klrc1killer cell lectin-like receptor subfamily C, member 10.021
Dchs1dachsous 1 (Drosophila)0.021
C5ar1complement component 5a receptor 10.021
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.021
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.021
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.020
Bdkrb2bradykinin receptor B20.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism