The network for 'positive regulation of tumor necrosis factor biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of tumor necrosis factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

NameDescriptionProbabilityFunc Analog Organism
Ccr2chemokine (C-C motif) receptor 20.981
Clec4dC-type lectin domain family 4, member d0.834
Lyz2lysozyme 20.828
Ccr1chemokine (C-C motif) receptor 10.741
Ccl2chemokine (C-C motif) ligand 20.654
C3ar1complement component 3a receptor 10.556
Cd44CD44 antigen0.467
Ccr5chemokine (C-C motif) receptor 50.327
Tlr4toll-like receptor 40.309
Tlr2toll-like receptor 20.293
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.273
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.261
Msr1macrophage scavenger receptor 10.229
Clec4eC-type lectin domain family 4, member e0.165
Clec4nC-type lectin domain family 4, member n0.161
Ccl3chemokine (C-C motif) ligand 30.156
Ccr6chemokine (C-C motif) receptor 60.151
Klra2killer cell lectin-like receptor, subfamily A, member 20.135
Selpselectin, platelet0.132
Ear2eosinophil-associated, ribonuclease A family, member 20.131
C5ar1complement component 5a receptor 10.116
Cd14CD14 antigen0.110
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.097
Folr2folate receptor 2 (fetal)0.092
Klrk1killer cell lectin-like receptor subfamily K, member 10.090
Cybbcytochrome b-245, beta polypeptide0.089
Tlr8toll-like receptor 80.086
Cxcr2chemokine (C-X-C motif) receptor 20.084
Mmp9matrix metallopeptidase 90.084
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.083
Ccl6chemokine (C-C motif) ligand 60.078
Fpr2formyl peptide receptor 20.076
FcrlaFc receptor-like A0.076
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.075
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.074
BlkB lymphoid kinase0.074
Ccr3chemokine (C-C motif) receptor 30.074
Mmp8matrix metallopeptidase 80.072
Cxcl13chemokine (C-X-C motif) ligand 130.072
Il6interleukin 60.069
AF251705cDNA sequence AF2517050.069
Cd180CD180 antigen0.064
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.062
Ccl9chemokine (C-C motif) ligand 90.062
Cd300ldCD300 molecule-like family member d0.059
Ifnginterferon gamma0.058
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.056
Il1binterleukin 1 beta0.053
Myd88myeloid differentiation primary response gene 880.051
Itgamintegrin alpha M0.048
Klra9killer cell lectin-like receptor subfamily A, member 90.042
Fpr1formyl peptide receptor 10.041
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.039
FaslFas ligand (TNF superfamily, member 6)0.038
Clec4a2C-type lectin domain family 4, member a20.038
Elaneelastase, neutrophil expressed0.038
Cd7CD7 antigen0.038
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.037
Lair1leukocyte-associated Ig-like receptor 10.036
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.036
Trem3triggering receptor expressed on myeloid cells 30.034
Tlr7toll-like receptor 70.034
Ccl24chemokine (C-C motif) ligand 240.034
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.033
Fgd3FYVE, RhoGEF and PH domain containing 30.032
Tbxas1thromboxane A synthase 1, platelet0.032
Klra5killer cell lectin-like receptor, subfamily A, member 50.031
Il10interleukin 100.031
Clec7aC-type lectin domain family 7, member a0.031
Cd209gCD209g antigen0.030
Pf4platelet factor 40.030
Ncr1natural cytotoxicity triggering receptor 10.029
Cd33CD33 antigen0.029
Il18rapinterleukin 18 receptor accessory protein0.028
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.028
Clec4b1C-type lectin domain family 4, member b10.027
Ptprcprotein tyrosine phosphatase, receptor type, C0.027
Spp1secreted phosphoprotein 10.027
Clec5aC-type lectin domain family 5, member a0.026
Cd209bCD209b antigen0.026
Ms4a6dmembrane-spanning 4-domains, subfamily A, member 6D0.026
Klrg1killer cell lectin-like receptor subfamily G, member 10.025
Sfpi1SFFV proviral integration 10.024
Prg3proteoglycan 30.024
Ifitm6interferon induced transmembrane protein 60.022
Cd5lCD5 antigen-like0.022
Cd209aCD209a antigen0.022
Nos2nitric oxide synthase 2, inducible0.022
F2rl2coagulation factor II (thrombin) receptor-like 20.021
Cryabcrystallin, alpha B0.020
Leprleptin receptor0.020
Slpisecretory leukocyte peptidase inhibitor0.019
Map3k14mitogen-activated protein kinase kinase kinase 140.019
Efna1ephrin A10.019
Fcnaficolin A0.019
Sellselectin, lymphocyte0.019
MefvMediterranean fever0.018
Casp4caspase 4, apoptosis-related cysteine peptidase0.018
Fpr3formyl peptide receptor 30.018
Il1f9interleukin 1 family, member 90.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSPB8heat shock 22kDa protein 80.319
TRAF5TNF receptor-associated factor 50.111
LY96lymphocyte antigen 960.096
SYKspleen tyrosine kinase0.085
TICAM2toll-like receptor adaptor molecule 20.079
BAG3BCL2-associated athanogene 30.072
CYBBcytochrome b-245, beta polypeptide0.048
CRYABcrystallin, alpha B0.045
MYD88myeloid differentiation primary response gene (88)0.033
TRAF2TNF receptor-associated factor 20.030
LY86lymphocyte antigen 860.027
TLR4toll-like receptor 40.024
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.023
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.023
CCR1chemokine (C-C motif) receptor 10.022
TLR1toll-like receptor 10.021
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.020
FGL2fibrinogen-like 20.019
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.018
RNASE6ribonuclease, RNase A family, k60.017
ITGAMintegrin, alpha M (complement component 3 receptor 3 subunit)0.016
IGSF6immunoglobulin superfamily, member 60.015
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.014
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.013
CD33CD33 molecule0.013
PLEKpleckstrin0.012
F13A1coagulation factor XIII, A1 polypeptide0.011
TLR2toll-like receptor 20.011
HSF1heat shock transcription factor 10.011
CLEC4AC-type lectin domain family 4, member A0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism