The network for 'amyloid precursor protein biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

amyloid precursor protein biosynthetic process

The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease.

NameDescriptionProbabilityFunc Analog Organism
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.386
Npc1Niemann Pick type C10.301
Apoeapolipoprotein E0.242
Lrp1low density lipoprotein receptor-related protein 10.131
Appamyloid beta (A4) precursor protein0.102
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.096
Serinc3serine incorporator 30.088
Rdh8retinol dehydrogenase 80.073
Rnase4ribonuclease, RNase A family 40.058
Ptenphosphatase and tensin homolog0.056
Prnpprion protein0.038
Lamp2lysosomal-associated membrane protein 20.036
Ndfip1Nedd4 family interacting protein 10.034
Pcyt1aphosphate cytidylyltransferase 1, choline, alpha isoform0.033
B2mbeta-2 microglobulin0.029
Clstn1calsyntenin 10.026
Nfe2l2nuclear factor, erythroid derived 2, like 20.020
Cst3cystatin C0.020
Nfibnuclear factor I/B0.020
Tpp1tripeptidyl peptidase I0.019
Pttg1ippituitary tumor-transforming 1 interacting protein0.019
Aplp2amyloid beta (A4) precursor-like protein 20.018
Pgrmc1progesterone receptor membrane component 10.017
Laptm4alysosomal-associated protein transmembrane 4A0.017
Cyp4v3cytochrome P450, family 4, subfamily v, polypeptide 30.016
Ctsbcathepsin B0.015
Pros1protein S (alpha)0.014
Ctslcathepsin L0.014
Klf5Kruppel-like factor 50.013
Hsd17b11hydroxysteroid (17-beta) dehydrogenase 110.013
Utp20UTP20, small subunit (SSU) processome component, homolog (yeast)0.013
0610007C21RikRIKEN cDNA 0610007C21 gene0.012
Cfhcomplement component factor h0.012
Ahraryl-hydrocarbon receptor0.012
Nop14NOP14 nucleolar protein homolog (yeast)0.011
Tmbim6transmembrane BAX inhibitor motif containing 60.011
Nr3c1nuclear receptor subfamily 3, group C, member 10.011
Foxo1forkhead box O10.011
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.011
Cd47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
POLR2Jpolymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa0.113
LAMP2lysosomal-associated membrane protein 20.040
LAPTM4Alysosomal protein transmembrane 4 alpha0.021
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.019
TMEM59transmembrane protein 590.016
SH3BGRLSH3 domain binding glutamic acid-rich protein like0.016
APPamyloid beta (A4) precursor protein0.016
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 20.016
SP1Sp1 transcription factor0.013
CHEK2CHK2 checkpoint homolog (S. pombe)0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism