The network for 'mesoderm formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesoderm formation

The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Hand1heart and neural crest derivatives expressed transcript 10.997
Pax2paired box gene 20.997
Bmp4bone morphogenetic protein 40.995
Lef1lymphoid enhancer binding factor 10.991
Isl1ISL1 transcription factor, LIM/homeodomain0.986
Hoxa1homeobox A10.985
Pitx2paired-like homeodomain transcription factor 20.984
Gli3GLI-Kruppel family member GLI30.983
Pbx1pre B-cell leukemia transcription factor 10.980
Sox2SRY-box containing gene 20.978
Zic3zinc finger protein of the cerebellum 30.975
Fgfr1fibroblast growth factor receptor 10.975
Gata4GATA binding protein 40.970
Eya1eyes absent 1 homolog (Drosophila)0.963
Otx2orthodenticle homolog 2 (Drosophila)0.958
Fgf8fibroblast growth factor 80.955
Efnb2ephrin B20.955
Tbx3T-box 30.954
Hoxa13homeobox A130.948
Atoh7atonal homolog 7 (Drosophila)0.947
Foxc1forkhead box C10.942
Hoxd11homeobox D110.941
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.937
Prrx1paired related homeobox 10.926
Pax6paired box gene 60.922
Foxa2forkhead box A20.919
Ntf3neurotrophin 30.905
Alx4aristaless-like homeobox 40.894
Hand2heart and neural crest derivatives expressed transcript 20.881
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.868
Ascl1achaete-scute complex homolog 1 (Drosophila)0.863
Dlx5distal-less homeobox 50.858
Lhx1LIM homeobox protein 10.849
Foxf1aforkhead box F1a0.836
Tgfb2transforming growth factor, beta 20.833
Jag1jagged 10.827
Pax3paired box gene 30.815
Pax8paired box gene 80.814
Msx1homeobox, msh-like 10.813
Tbx1T-box 10.807
Tbx2T-box 20.806
Pitx1paired-like homeodomain transcription factor 10.804
Hoxd13homeobox D130.799
Smad4MAD homolog 4 (Drosophila)0.783
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.783
Gdnfglial cell line derived neurotrophic factor0.780
Msx2homeobox, msh-like 20.776
Sfrp2secreted frizzled-related protein 20.769
Bdnfbrain derived neurotrophic factor0.766
Pou3f3POU domain, class 3, transcription factor 30.750
Crb2crumbs homolog 2 (Drosophila)0.731
Smad6MAD homolog 6 (Drosophila)0.719
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.705
Neurod1neurogenic differentiation 10.702
Hoxa11homeobox A110.679
Wt1Wilms tumor 1 homolog0.678
Fgf15fibroblast growth factor 150.676
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.675
Bmpr1abone morphogenetic protein receptor, type 1A0.671
Foxd2forkhead box D20.663
Sall4sal-like 4 (Drosophila)0.648
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.637
Hmx3H6 homeobox 30.623
Wnt4wingless-related MMTV integration site 40.623
Vangl2vang-like 2 (van gogh, Drosophila)0.617
Dkk1dickkopf homolog 1 (Xenopus laevis)0.607
Retret proto-oncogene0.602
Lmx1bLIM homeobox transcription factor 1 beta0.601
Gbx2gastrulation brain homeobox 20.600
Pou5f1POU domain, class 5, transcription factor 10.596
Apcadenomatosis polyposis coli0.589
Tlx3T-cell leukemia, homeobox 30.587
Onecut1one cut domain, family member 10.575
Fgf10fibroblast growth factor 100.574
Gata6GATA binding protein 60.571
Tcf21transcription factor 210.570
Wnt3awingless-related MMTV integration site 3A0.563
Sox9SRY-box containing gene 90.559
Neurog1neurogenin 10.558
Rargretinoic acid receptor, gamma0.555
Acvr1activin A receptor, type 10.546
Wnt6wingless-related MMTV integration site 60.536
Bcl2B-cell leukemia/lymphoma 20.521
Efna4ephrin A40.499
Meis2Meis homeobox 20.492
Efna2ephrin A20.449
Runx2runt related transcription factor 20.442
Foxd3forkhead box D30.436
Nkx2-1NK2 homeobox 10.434
Lmx1aLIM homeobox transcription factor 1 alpha0.434
Ror2receptor tyrosine kinase-like orphan receptor 20.431
Vax1ventral anterior homeobox containing gene 10.429
Tcfap2ctranscription factor AP-2, gamma0.426
Nos3nitric oxide synthase 3, endothelial cell0.424
Gata3GATA binding protein 30.417
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx2bT-box 2b0.989
fgf3fibroblast growth factor 30.956
flhfloating head0.939
tbx16T-box gene 160.938
tbx1T-box 10.929
tbx5aT-box 5a0.925
hnf1baHNF1 homeobox Ba0.909
oepone-eyed pinhead0.896
lef1lymphocyte enhancer binding factor 10.891
atoh1batonal homolog 1b0.850
fgfr1afibroblast growth factor receptor 1a0.847
tll1tolloid-like 10.822
ndr2nodal-related 20.821
voxventral homeobox0.797
gbx2gastrulation brain homeo box 20.790
ephb4beph receptor B4b0.790
klf4Kruppel-like factor 40.789
spry4sprouty (Drosophila) homolog 40.785
tbx20T-box 200.760
atoh1aatonal homolog 1a0.758
ventventral expressed homeobox0.743
ntlano tail a0.729
eomesaeomesodermin homolog a0.723
vsx1visual system homeobox 1 homolog, chx10-like0.702
wnt5bwingless-type MMTV integration site family, member 5b0.659
tbx6T-box gene 60.600
nkd1naked cuticle homolog 1 (Drosophila)0.592
bmp4bone morphogenetic protein 40.554
bmp2bbone morphogenetic protein 2b0.534
shhasonic hedgehog a0.531
evx1even-skipped homeobox 10.520
fli1afriend leukemia integration 1a0.516
sox32SRY-box containing gene 320.495
hoxa13bhomeo box A13b0.472
admpanti-dorsalizing morphogenic protein0.435
fzd10frizzled homolog 100.434
hmx3homeo box (H6 family) 30.428
plcg1phospholipase C, gamma 10.412
mibmind bomb0.401
snai1bsnail homolog 1b (Drosophila)0.398
gata1aGATA binding protein 1a0.396
notch3notch homolog 30.395
six4bsine oculis homeobox homolog 4b0.378
wnt4awingless-type MMTV integration site family, member 4a0.363
dkk1bdickkopf 1b0.361
wnt10awingless-type MMTV integration site family, member 10a0.348
runx2brunt-related transcription factor 2b0.348
fgf8afibroblast growth factor 8 a0.331
gli1GLI-Kruppel family member 10.323
gro2groucho 20.320
tbx2aT-box gene 2a0.313
hmx4H6 family homeobox 40.312
per3period homolog 3 (Drosophila)0.309
hoxc8ahomeo box C8a0.303
hoxa2bhomeo box A2b0.302
cdx4caudal type homeo box transcription factor 40.298
pax2apaired box gene 2a0.287
gro1groucho 10.284
msxcmuscle segment homeobox C0.279
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.278
hoxd4ahomeo box D4a0.277
hoxb5bhomeo box B5b0.276
wnt8bwingless-type MMTV integration site family, member 8b0.272
cdh2cadherin 2, neuronal0.270
alas2aminolevulinate, delta-, synthetase 20.262
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.254
fgfr4fibroblast growth factor receptor 40.238
wnt3wingless-type MMTV integration site family, member 30.235
her5hairy-related 50.232
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.230
pea3ETS-domain transcription factor pea30.224
fgf10afibroblast growth factor 10a0.219
gata4GATA-binding protein 40.218
epb4.1l4erythrocyte protein band 4.1-like 40.215
sp5lSp5 transcription factor-like0.207
dbx1adeveloping brain homeobox 1a0.200
eya1eyes absent homolog 10.198
tal1T-cell acute lymphocytic leukemia 10.197
lama5laminin, alpha 50.186
gpc4glypican 40.185
frem1aFras1 related extracellular matrix 1a0.185
lhx1bLIM homeobox 1b0.183
klf2aKruppel-like factor 2a0.177
tead3aTEA domain family member 3 a0.176
hhiphedgehog interacting protein0.176
lhx2bLIM homeobox 2b0.173
prrx1apaired related homeobox 1a0.172
dusp6dual specificity phosphatase 60.167
bmp2abone morphogenetic protein 2a0.163
mespbmesoderm posterior b0.159
eng1aengrailed 1a0.154
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.153
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
gbbglass bottom boat0.737
stumpsCG31317 gene product from transcript CG31317-RC0.681
cicubitus interruptus0.489
EgfrEpidermal growth factor receptor0.452
eyaeyes absent0.424
slp1sloppy paired 10.345
fkhfork head0.265
LanB1CG7123 gene product from transcript CG7123-RA0.253
CG4168CG4168 gene product from transcript CG4168-RA0.222
wbwing blister0.203
DadDaughters against dpp0.202
frcfringe connection0.193
Mef2Myocyte enhancer factor 20.161
botvbrother of tout-velu0.138
mewmultiple edematous wings0.138
HLH54FCG5005 gene product from transcript CG5005-RA0.101
E(spl)Enhancer of split0.097
nkdnaked cuticle0.087
sogshort gastrulation0.082
CG14869CG14869 gene product from transcript CG14869-RB0.070
eveeven skipped0.069
Nrx-IVNeurexin IV0.063
LanALaminin A0.054
Rho1CG8416 gene product from transcript CG8416-RB0.050
VAChTCG32848 gene product from transcript CG32848-RA0.048
HmgcrHMG Coenzyme A reductase0.047
fasfaint sausage0.045
jebjelly belly0.045
MadMothers against dpp0.043
LanB2Laminin B20.043
TrhTryptophan hydroxylase0.039
thrthree rows0.038
Rac1CG2248 gene product from transcript CG2248-RA0.037
ptrproximal to raf0.036
rtGEFrho-type guanine exchange factor0.035
Rac2CG8556 gene product from transcript CG8556-RA0.034
Ras85DRas oncogene at 85D0.034
Mes2CG11100 gene product from transcript CG11100-RB0.030
rapretina aberrant in pattern0.029
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FHL2four and a half LIM domains 20.965
PBX1pre-B-cell leukemia homeobox 10.910
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.823
SMAD2SMAD family member 20.797
SMAD3SMAD family member 30.695
BMPR1Abone morphogenetic protein receptor, type IA0.595
BMP2bone morphogenetic protein 20.588
FGF1fibroblast growth factor 1 (acidic)0.567
NR4A1nuclear receptor subfamily 4, group A, member 10.377
FN1fibronectin 10.342
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.241
LRP6low density lipoprotein receptor-related protein 60.237
TLN1talin 10.184
MEIS1Meis homeobox 10.180
JAG1jagged 10.174
RUNX1runt-related transcription factor 10.164
SETD8SET domain containing (lysine methyltransferase) 80.163
MEIS2Meis homeobox 20.107
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.104
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.097
FOXD3forkhead box D30.095
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.090
SMAD4SMAD family member 40.089
SCHIP1schwannomin interacting protein 10.087
FLNAfilamin A, alpha0.071
PDIA3protein disulfide isomerase family A, member 30.068
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.062
SMURF1SMAD specific E3 ubiquitin protein ligase 10.061
GATA2GATA binding protein 20.054
FGFR1fibroblast growth factor receptor 10.044
SP1Sp1 transcription factor0.037
SOX2SRY (sex determining region Y)-box 20.037
SMAD7SMAD family member 70.036
NOTCH3notch 30.033
ITGA6integrin, alpha 60.032
ITGB4integrin, beta 40.031
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.030
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.029
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.027
APCadenomatous polyposis coli0.027
FZD1frizzled homolog 1 (Drosophila)0.026
PTPRCprotein tyrosine phosphatase, receptor type, C0.026
FLNBfilamin B, beta0.025
FBLN1fibulin 10.025
ZFXzinc finger protein, X-linked0.025
THBS1thrombospondin 10.025
ARandrogen receptor0.024
MYOD1myogenic differentiation 10.024
ATF7IPactivating transcription factor 7 interacting protein0.022
BMP1bone morphogenetic protein 10.021
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.020
EGR1early growth response 10.019
FGFR2fibroblast growth factor receptor 20.019
FGFR3fibroblast growth factor receptor 30.018
RANBP9RAN binding protein 90.018
CYTH1cytohesin 10.017
FGF10fibroblast growth factor 100.017
ATN1atrophin 10.016
MYO10myosin X0.015
EPS8epidermal growth factor receptor pathway substrate 80.014
GSK3Bglycogen synthase kinase 3 beta0.014
ALDOAaldolase A, fructose-bisphosphate0.014
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.014
CREBBPCREB binding protein0.014
PSEN1presenilin 10.012
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.012
AKIP1A kinase (PRKA) interacting protein 10.012
SETD7SET domain containing (lysine methyltransferase) 70.011
HOXA10homeobox A100.011
FOXF2forkhead box F20.011
HMGA1high mobility group AT-hook 10.010
CD9CD9 molecule0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a2nuclear receptor subfamily 4, group A, member 20.218
Ptpn12protein tyrosine phosphatase, non-receptor type 120.180
Fgfr2fibroblast growth factor receptor 20.110
Nr4a1nuclear receptor subfamily 4, group A, member 10.109
Smad7SMAD family member 70.076
Strnstriatin, calmodulin binding protein0.053
Unc5bunc-5 homolog B (C. elegans)0.052
RT1-DOaRT1 class II, locus DOa0.050
Ptgs2prostaglandin-endoperoxide synthase 20.048
Nfianuclear factor I/A0.045
Nek9NIMA (never in mitosis gene a)- related kinase 90.044
Emp1epithelial membrane protein 10.042
Pcdhgc3protocadherin gamma subfamily C, 30.041
Grm5glutamate receptor, metabotropic 50.037
Arl5aADP-ribosylation factor-like 5A0.036
Sox13SRY (sex determining region Y)-box 130.036
Lamc1laminin, gamma 10.036
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.035
Lnpepleucyl/cystinyl aminopeptidase0.034
Itpr2inositol 1,4,5-triphosphate receptor, type 20.032
Gclcglutamate-cysteine ligase, catalytic subunit0.032
Mcammelanoma cell adhesion molecule0.031
Jag2jagged 20.031
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.030
Sox17SRY (sex determining region Y)-box 170.028
Notch2Notch homolog 2 (Drosophila)0.028
Pacs1phosphofurin acidic cluster sorting protein 10.027
Nkd1naked cuticle homolog 1 (Drosophila)0.026
Irs1insulin receptor substrate 10.026
Nfibnuclear factor I/B0.026
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.026
Dlgap2discs, large (Drosophila) homolog-associated protein 20.025
Gdf11growth differentiation factor 110.025
Olfml2bolfactomedin-like 2B0.025
Ehfets homologous factor0.024
Mc3rmelanocortin 3 receptor0.024
Abp10annexin V-binding protein ABP-100.024
Tcfe2atranscription factor E2a0.023
Nppcnatriuretic peptide precursor C0.023
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.023
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.023
Efnb1ephrin B10.023
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.023
Nr2f2nuclear receptor subfamily 2, group F, member 20.023
Rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.023
Sardhsarcosine dehydrogenase0.022
Gfi1growth factor independent 1 transcription repressor0.022
Acvr1activin A receptor, type I0.022
Gpr20G protein-coupled receptor 200.021
Garnl1GTPase activating Rap/RanGAP domain-like 10.021
Foxc2forkhead box C20.021
Creb1cAMP responsive element binding protein 10.020
Tceb3transcription elongation factor B (SIII), polypeptide 30.020
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.020
Amhanti-Mullerian hormone0.019
Ubtfupstream binding transcription factor, RNA polymerase I0.019
Arf6ADP-ribosylation factor 60.019
FanceFanconi anemia, complementation group E0.019
Vegfavascular endothelial growth factor A0.019
Chl1cell adhesion molecule with homology to L1CAM0.019
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.019
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.018
Hdac1lhistone deacetylase 1-like0.018
Cercamcerebral endothelial cell adhesion molecule0.018
Mapk6mitogen-activated protein kinase 60.018
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.018
Adra2badrenergic, alpha-2B-, receptor0.018
Ppp1r10protein phosphatase 1, regulatory subunit 100.018
Klhl22kelch-like 22 (Drosophila)0.018
Bmp3bone morphogenetic protein 30.018
Bcl2B-cell CLL/lymphoma 20.017
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.017
Ctnna1catenin (cadherin associated protein), alpha 10.017
Col12a1collagen, type XII, alpha 10.017
Slc30a1solute carrier family 30 (zinc transporter), member 10.017
Atxn1ataxin 10.017
Prr5lproline rich 5 like0.017
Dact1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)0.017
Megf6multiple EGF-like-domains 60.017
Fosl2fos-like antigen 20.017
Egr2early growth response 20.017
Madcam1mucosal vascular addressin cell adhesion molecule 10.017
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.016
SnrkSNF related kinase0.016
Abcc9ATP-binding cassette, subfamily C (CFTR/MRP), member 90.016
Fgfr1Fibroblast growth factor receptor 10.016
Ageradvanced glycosylation end product-specific receptor0.016
Dock6dedicator of cytokinesis 60.016
Tcf4transcription factor 40.016
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.016
Ncam1neural cell adhesion molecule 10.016
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.016
Krt19keratin 190.016
Ube3aubiquitin protein ligase E3A0.015
Ppp2r2aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform0.015
Nfe2l2nuclear factor, erythroid derived 2, like 20.015
Krt14lkeratin 14-like0.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism