The network for 'histone lysine demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone lysine demethylation

The modification of a histone by the removal of a methyl group from a lysine residue.

NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.999
Kdm1alysine (K)-specific demethylase 1A0.715
Kdm2blysine (K)-specific demethylase 2B0.701
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.548
BcorBCL6 interacting corepressor0.508
Clk1CDC-like kinase 10.390
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.349
Sin3atranscriptional regulator, SIN3A (yeast)0.289
March7membrane-associated ring finger (C3HC4) 70.269
Cbx8chromobox homolog 8 (Drosophila Pc class)0.267
Zfp292zinc finger protein 2920.233
Skp1aS-phase kinase-associated protein 1A0.179
Clk4CDC like kinase 40.154
Ctbp1C-terminal binding protein 10.098
Men1multiple endocrine neoplasia 10.093
Eif2s3yeukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked0.093
Ints3integrator complex subunit 30.090
Ring1ring finger protein 10.078
Ccng2cyclin G20.077
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.077
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.068
Arid1aAT rich interactive domain 1A (SWI-like)0.065
Zfp654zinc finger protein 6540.064
Rbm22RNA binding motif protein 220.063
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.060
Arid1bAT rich interactive domain 1B (SWI-like)0.055
Klhl24kelch-like 24 (Drosophila)0.051
A930001N09RikRIKEN cDNA A930001N09 gene0.049
Cul9cullin 90.048
Csnk2a2casein kinase 2, alpha prime polypeptide0.045
Pcgf2polycomb group ring finger 20.043
Sp1trans-acting transcription factor 10.042
Utyubiquitously transcribed tetratricopeptide repeat gene, Y chromosome0.042
Fbxl3F-box and leucine-rich repeat protein 30.038
Sp4trans-acting transcription factor 40.035
Kdm5dlysine (K)-specific demethylase 5D0.035
Jarid2jumonji, AT rich interactive domain 20.032
Lin28alin-28 homolog A (C. elegans)0.030
Phrf1PHD and ring finger domains 10.030
Morf4l1mortality factor 4 like 10.029
Zfand6zinc finger, AN1-type domain 60.028
RybpRING1 and YY1 binding protein0.025
Paip2polyadenylate-binding protein-interacting protein 20.023
Ccnl1cyclin L10.023
4833420G17RikRIKEN cDNA 4833420G17 gene0.022
Kdm4clysine (K)-specific demethylase 4C0.022
Clk3CDC-like kinase 30.022
Epc1enhancer of polycomb homolog 1 (Drosophila)0.020
Eif4a2eukaryotic translation initiation factor 4A20.020
Ctdp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 10.019
Fbxo38F-box protein 380.019
Fiz1Flt3 interacting zinc finger protein 10.019
MgaMAX gene associated0.018
Kdm3bKDM3B lysine (K)-specific demethylase 3B0.018
Maml1mastermind like 1 (Drosophila)0.017
Dbx1developing brain homeobox 10.017
Tcf3transcription factor 30.017
Csnk2a1casein kinase 2, alpha 1 polypeptide0.016
Bnip3lBCL2/adenovirus E1B interacting protein 3-like0.016
Zfand5zinc finger, AN1-type domain 50.016
Sesn1sestrin 10.015
Rlfrearranged L-myc fusion sequence0.015
Xrn15'-3' exoribonuclease 10.015
Avl9AVL9 homolog (S. cerevisiase)0.015
Mbtd1mbt domain containing 10.015
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.015
Arid4bAT rich interactive domain 4B (RBP1-like)0.015
Mat2bmethionine adenosyltransferase II, beta0.014
AW549877expressed sequence AW5498770.013
Zfp68zinc finger protein 680.013
Edc4enhancer of mRNA decapping 40.013
Usp21ubiquitin specific peptidase 210.013
Sf3b1splicing factor 3b, subunit 10.013
Xrcc1X-ray repair complementing defective repair in Chinese hamster cells 10.013
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.013
Atf7ipactivating transcription factor 7 interacting protein0.013
Chfrcheckpoint with forkhead and ring finger domains0.012
Rxrbretinoid X receptor beta0.012
Bap1Brca1 associated protein 10.012
Prmt5protein arginine N-methyltransferase 50.012
Dnmt1DNA methyltransferase (cytosine-5) 10.012
Tab3TGF-beta activated kinase 1/MAP3K7 binding protein 30.012
Tcof1Treacher Collins Franceschetti syndrome 1, homolog0.012
Med13mediator complex subunit 130.012
Chd4chromodomain helicase DNA binding protein 40.012
Upf2UPF2 regulator of nonsense transcripts homolog (yeast)0.012
Tex10testis expressed gene 100.011
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.011
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.011
Thap11THAP domain containing 110.011
Rnf38ring finger protein 380.011
Ubap2ubiquitin-associated protein 20.011
Aff4AF4/FMR2 family, member 40.010
Criptcysteine-rich PDZ-binding protein0.010
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.010
Trpm7transient receptor potential cation channel, subfamily M, member 70.010
Pcf11cleavage and polyadenylation factor subunit homolog (S. cerevisiae)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ankrd12ankyrin repeat domain 120.333
phf2PHD finger protein 20.223
tcf12transcription factor 120.181
wu:fi04c06wu:fi04c060.157
kdm4blysine (K)-specific demethylase 4B0.132
fbxl5F-box and leucine-rich repeat protein 50.118
ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.100
si:dkey-175m17.8si:dkey-175m17.80.098
wu:fj55b04wu:fj55b040.092
si:dkey-21n12.1si:dkey-21n12.10.084
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.076
npeppsaminopeptidase puromycin sensitive0.067
tecpr2tectonin beta-propeller repeat containing 20.066
supt6hsuppressor of Ty 6 homolog0.058
phrf1PHD and ring finger domains 10.054
im:7163548im:71635480.052
strn3striatin, calmodulin binding protein 30.051
brapBRCA1 associated protein0.050
nvlnuclear VCP-like0.049
fxr2fragile X mental retardation, autosomal homolog 20.048
zgc:113421zgc:1134210.044
gpatch8G patch domain containing 80.044
btg1B-cell translocation gene 10.043
si:ch211-57k11.10si:ch211-57k11.100.040
rnf146ring finger protein 1460.039
kdm1alysine (K)-specific demethylase 1a0.039
spna2spectrin alpha 20.039
brd3bbromodomain containing 3b0.034
sall1asal-like 1a (Drosophila)0.032
auts2autism susceptibility candidate 20.031
ralgapa1Ral GTPase activating protein, alpha subunit 1 (catalytic)0.031
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.031
LOC100536021spectrin beta chain, brain 1-like0.031
zgc:162740zgc:1627400.029
mbnl2muscleblind-like 2 (Drosophila)0.028
zgc:101761zgc:1017610.028
myef2myelin expression factor 20.028
peli1bpellino homolog 1b (Drosophila)0.026
kidins220bkinase D-interacting substrate of 220b0.025
ptenaphosphatase and tensin homolog A0.024
atp2b4ATPase, Ca++ transporting, plasma membrane 40.024
si:ch211-81a5.7si:ch211-81a5.70.023
nfianuclear factor I/A0.023
ncdnneurochondrin0.023
wwp2WW domain containing E3 ubiquitin protein ligase 20.021
celf2cugbp, Elav-like family member 20.021
ep300bE1A binding protein p300 b0.020
wu:fa07b03wu:fa07b030.020
noc3lnucleolar complex associated 3 homolog (S. cerevisiae)0.020
pcmtd1protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 10.020
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.020
tsc22d2TSC22 domain family 2 and TSC22 domain family, member 20.019
rnf41ring finger protein 410.019
arid4aAT rich interactive domain 4A (RBP1-like)0.019
brd8bromodomain containing 80.019
caskcalcium/calmodulin-dependent serine protein kinase0.018
ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.018
arrb2aarrestin, beta 2a0.018
taf1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.017
exoc7exocyst complex component 70.017
zgc:114097zgc:1140970.017
clasp2cytoplasmic linker associated protein 20.017
sb:cb134sb:cb1340.016
midnmidnolin0.016
faf1Fas associated factor 10.016
ppp3ccaprotein phosphatase 3, catalytic subunit, gamma isozyme, a0.016
senp6aSUMO1/sentrin specific peptidase 6a0.016
serinc1serine incorporator 10.015
st6gal2ST6 beta-galactosamide alpha-2,6-sialyltranferase 20.015
abca5ATP-binding cassette, sub-family A (ABC1), member 50.015
fbln4fibulin 40.015
ints1integrator complex subunit 10.015
zgc:101130zgc:1011300.015
pcdh10bprotocadherin 10b0.014
c1orf109c1orf109 homolog (H. sapiens)0.014
si:ch73-60e21.1si:ch73-60e21.10.014
mpped2metallophosphoesterase domain containing 20.014
zgc:152984zgc:1529840.014
si:ch211-173p18.3si:ch211-173p18.30.014
gtf3c3general transcription factor IIIC, polypeptide 30.014
kdm5clysine (K)-specific demethylase 5C0.014
zgc:77407zgc:774070.014
lhx6LIM homeobox 60.014
macf1microtubule-actin crosslinking factor 10.013
zgc:92510zgc:925100.013
kpnb1karyopherin (importin) beta 10.013
kif5bbkinesin family member 5B, b0.013
ppp3r1bprotein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b0.013
notch3notch homolog 30.013
rc3rabconnectin 30.013
LOC562592endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like0.013
siah1seven in absentia homolog 1 (Drosophila)0.013
smurf2SMAD specific E3 ubiquitin protein ligase 20.013
nt5dc25'-nucleotidase domain containing 20.012
zdhhc8bzinc finger, DHHC-type containing 8b0.012
zgc:136773zgc:1367730.012
si:ch211-260p9.1si:ch211-260p9.10.012
tnrc6btrinucleotide repeat containing 6B0.012
smn1survival motor neuron 10.012
ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.012
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.163
dupdouble parked0.117
CG8924CG8924 gene product from transcript CG8924-RB0.103
CG5098CG5098 gene product from transcript CG5098-RA0.078
hephhephaestus0.077
CG2926CG2926 gene product from transcript CG2926-RA0.077
pr-set7CG3307 gene product from transcript CG3307-RC0.065
CG9795CG9795 gene product from transcript CG9795-RD0.054
dntdoughnut on 20.053
MED15Mediator complex subunit 150.043
UtxCG5640 gene product from transcript CG5640-RD0.038
pitaCG3941 gene product from transcript CG3941-RA0.036
Sin3ACG8815 gene product from transcript CG8815-RC0.035
CG11092CG11092 gene product from transcript CG11092-RA0.034
cgcombgap0.034
RgaRegena0.032
d4CG2682 gene product from transcript CG2682-RB0.031
Bre1CG10542 gene product from transcript CG10542-RA0.030
Cap-GCG34438 gene product from transcript CG34438-RF0.029
msl-3male-specific lethal 30.029
Cpsf160Cleavage and polyadenylation specificity factor 1600.029
SRm160CG11274 gene product from transcript CG11274-RA0.027
ash1absent, small, or homeotic discs 10.024
traltrailer hitch0.024
Ulp1CG12359 gene product from transcript CG12359-RA0.021
stwlstonewall0.021
rad50CG6339 gene product from transcript CG6339-RD0.020
Su(var)2-10Suppressor of variegation 2-100.020
CG7372CG7372 gene product from transcript CG7372-RA0.020
cavcaravaggio0.019
nonA-lnonA-like0.018
Rrp6CG7292 gene product from transcript CG7292-RB0.018
DekCG5935 gene product from transcript CG5935-RA0.018
mus101mutagen-sensitive 1010.017
RhoGAP54DCG6477 gene product from transcript CG6477-RA0.017
unc-119CG1659 gene product from transcript CG1659-RA0.016
CG6945CG6945 gene product from transcript CG6945-RA0.016
Top2Topoisomerase 20.015
BRWD3CG31132 gene product from transcript CG31132-RA0.015
Patr-1Protein associated with topo II related - 10.014
astasteroid0.014
Ge-1CG6181 gene product from transcript CG6181-RA0.014
CG7332CG7332 gene product from transcript CG7332-RA0.014
Nup358Nucleoporin 3580.014
Kdm4AHistone demethylase 4A0.013
CG11399CG11399 gene product from transcript CG11399-RB0.013
CG5146CG5146 gene product from transcript CG5146-RA0.013
SsdpSequence-specific single-stranded DNA-binding protein0.013
SfmbtScm-related gene containing four mbt domains0.013
Hr39Hormone receptor-like in 390.012
fendforked end0.012
CG31365CG31365 gene product from transcript CG31365-RA0.012
AmunCG2446 gene product from transcript CG2446-RB0.011
CG7139CG7139 gene product from transcript CG7139-RB0.011
DNApol-iotaCG7602 gene product from transcript CG7602-RB0.011
MEP-1CG1244 gene product from transcript CG1244-RG0.011
Taf2TBP-associated factor 20.011
MAN1CG3167 gene product from transcript CG3167-RA0.011
CG7379CG7379 gene product from transcript CG7379-RA0.011
chmchameau0.011
Nup214Nucleoporin 2140.010
CG3735CG3735 gene product from transcript CG3735-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCORBCL6 corepressor0.813
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.264
UBXN7UBX domain protein 70.106
ZFYzinc finger protein, Y-linked0.098
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.094
RIOK3RIO kinase 3 (yeast)0.090
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.088
ZFXzinc finger protein, X-linked0.082
DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.080
USP9Yubiquitin specific peptidase 9, Y-linked0.074
NCOA6nuclear receptor coactivator 60.069
PUM1pumilio homolog 1 (Drosophila)0.049
ZNF512Bzinc finger protein 512B0.046
RLFrearranged L-myc fusion0.036
SAMD3sterile alpha motif domain containing 30.035
RPS4Y1ribosomal protein S4, Y-linked 10.034
PRMT6protein arginine methyltransferase 60.030
UBR1ubiquitin protein ligase E3 component n-recognin 10.030
JUNDjun D proto-oncogene0.026
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.025
RCOR1REST corepressor 10.024
CHD4chromodomain helicase DNA binding protein 40.023
ZNF148zinc finger protein 1480.023
PCGF1polycomb group ring finger 10.022
MTA2metastasis associated 1 family, member 20.022
ZNF292zinc finger protein 2920.022
RXRAretinoid X receptor, alpha0.021
MTA3metastasis associated 1 family, member 30.020
HIST1H3Bhistone cluster 1, H3b0.020
BRD2bromodomain containing 20.018
BRD1bromodomain containing 10.018
KDM5Dlysine (K)-specific demethylase 5D0.017
UTYubiquitously transcribed tetratricopeptide repeat gene, Y-linked0.016
SNAI1snail homolog 1 (Drosophila)0.016
HIST1H4Fhistone cluster 1, H4f0.016
FEM1Cfem-1 homolog c (C. elegans)0.016
ANKZF1ankyrin repeat and zinc finger domain containing 10.016
JARID2jumonji, AT rich interactive domain 20.016
KLHL24kelch-like 24 (Drosophila)0.015
PHF21APHD finger protein 21A0.015
KIAA0182KIAA01820.015
USP9Xubiquitin specific peptidase 9, X-linked0.015
ATAD2BATPase family, AAA domain containing 2B0.015
KDM5Blysine (K)-specific demethylase 5B0.014
CCNG2cyclin G20.013
OFCC1orofacial cleft 1 candidate 10.013
RCOR3REST corepressor 30.013
BAZ2Abromodomain adjacent to zinc finger domain, 2A0.013
MLL3myeloid/lymphoid or mixed-lineage leukemia 30.012
PHF1PHD finger protein 10.012
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.012
CYorf15Achromosome Y open reading frame 15A0.012
ANKHD1-EIF4EBP3ANKHD1-EIF4EBP3 readthrough0.012
HBP1HMG-box transcription factor 10.011
MTA1metastasis associated 10.011
MXI1MAX interactor 10.011
RBBP5retinoblastoma binding protein 50.011
PELI1pellino homolog 1 (Drosophila)0.011
SMAD7SMAD family member 70.010
MED13Lmediator complex subunit 13-like0.010
CHD8chromodomain helicase DNA binding protein 80.010
PELP1proline, glutamate and leucine rich protein 10.010
CUX1cut-like homeobox 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Arid4aAT rich interactive domain 4A (Rbp1 like)0.024
RGD1564560similar to RCK0.012
Phf12PHD finger protein 120.012
LOC682469similar to jumonji domain containing 1B0.012
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism