The network for 'protein tetramerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein tetramerization

The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.

NameDescriptionProbabilityFunc Analog Organism
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.886
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.496
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.290
Etfaelectron transferring flavoprotein, alpha polypeptide0.261
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.239
Dlg4discs, large homolog 4 (Drosophila)0.222
Pgls6-phosphogluconolactonase0.176
Hint2histidine triad nucleotide binding protein 20.154
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.137
Acaa2acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)0.133
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.119
Mceemethylmalonyl CoA epimerase0.106
Eci1enoyl-Coenzyme A delta isomerase 10.097
Nudt1nudix (nucleoside diphosphate linked moiety X)-type motif 10.094
Ldb3LIM domain binding 30.089
Etfbelectron transferring flavoprotein, beta polypeptide0.086
Nos1nitric oxide synthase 1, neuronal0.083
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.073
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.067
S100a10S100 calcium binding protein A10 (calpactin)0.062
Insrinsulin receptor0.061
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.061
Mbmyoglobin0.058
Ptpn11protein tyrosine phosphatase, non-receptor type 110.056
Gltscr2glioma tumor suppressor candidate region gene 20.055
Emx1empty spiracles homolog 1 (Drosophila)0.053
Anxa2annexin A20.052
Akr7a5aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)0.052
Tmem205transmembrane protein 2050.051
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.051
Igf2rinsulin-like growth factor 2 receptor0.051
Fgfr1fibroblast growth factor receptor 10.049
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.048
Il16interleukin 160.048
Gstk1glutathione S-transferase kappa 10.045
Pnmtphenylethanolamine-N-methyltransferase0.044
Phyhphytanoyl-CoA hydroxylase0.038
Lage3L antigen family, member 30.037
Nudt14nudix (nucleoside diphosphate linked moiety X)-type motif 140.036
Eci2enoyl-Coenzyme A delta isomerase 20.036
Umpsuridine monophosphate synthetase0.035
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.035
Scp2sterol carrier protein 2, liver0.035
Cmblcarboxymethylenebutenolidase-like (Pseudomonas)0.033
Prkceprotein kinase C, epsilon0.033
Prox1prospero-related homeobox 10.032
Ppdpfpancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)RIKEN cDNA 2700038C09 gene0.031
Hrhairless0.031
S100a6S100 calcium binding protein A6 (calcyclin)0.031
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.029
Tmem48transmembrane protein 480.028
0610011F06RikRIKEN cDNA 0610011F06 gene0.028
Gstt2glutathione S-transferase, theta 20.028
1110001A16RikRIKEN cDNA 1110001A16 gene0.028
Cbr1carbonyl reductase 10.028
Hif1ahypoxia inducible factor 1, alpha subunit0.028
Chpt1choline phosphotransferase 10.027
Glod4glyoxalase domain containing 40.027
Pcbd2pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 20.027
Hsdl2hydroxysteroid dehydrogenase like 20.026
Bsnbassoon0.026
Cldn16claudin 160.026
Nr2f1nuclear receptor subfamily 2, group F, member 10.026
Aco1aconitase 10.025
Selenbp1selenium binding protein 10.025
MpndMPN domain containing0.025
Mrps24mitochondrial ribosomal protein S240.024
Slc25a10solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 100.024
Tmem79transmembrane protein 790.024
Ghrgrowth hormone receptor0.024
Nr2f2nuclear receptor subfamily 2, group F, member 20.024
Acad11acyl-Coenzyme A dehydrogenase family, member 110.024
Cyb5cytochrome b-50.023
Cpt2carnitine palmitoyltransferase 20.023
Cbscystathionine beta-synthase0.023
Grb10growth factor receptor bound protein 100.023
Pparaperoxisome proliferator activated receptor alpha0.022
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.022
S100a11S100 calcium binding protein A11 (calgizzarin)0.022
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.022
Clyblcitrate lyase beta like0.022
Pacsin1protein kinase C and casein kinase substrate in neurons 10.021
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.021
Gpd1glycerol-3-phosphate dehydrogenase 1 (soluble)0.021
Prkccprotein kinase C, gamma0.021
Nr1h4nuclear receptor subfamily 1, group H, member 40.021
Foxn1forkhead box N10.021
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.020
Egfrepidermal growth factor receptor0.020
Grip1glutamate receptor interacting protein 10.020
Dnm1dynamin 10.020
NsfN-ethylmaleimide sensitive fusion protein0.020
Nr1i3nuclear receptor subfamily 1, group I, member 30.020
Mutmethylmalonyl-Coenzyme A mutase0.020
Dlg2discs, large homolog 2 (Drosophila)0.020
Aldh1a7aldehyde dehydrogenase family 1, subfamily A70.020
Thrbthyroid hormone receptor beta0.020
Etfdhelectron transferring flavoprotein, dehydrogenase0.020
Tk1thymidine kinase 10.019
Nr1i2nuclear receptor subfamily 1, group I, member 20.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ace-2Protein ACE-20.026
ace-4Protein ACE-40.025
ace-1Protein ACE-10.021
ace-3Protein ACE-30.019
brp-1Protein BRP-10.016
K07E3.4Protein K07E3.40.012
F37C4.5Protein F37C4.50.011
F33H2.3Protein F33H2.30.011
maa-1Protein MAA-10.011
ctl-3Protein CTL-30.011
CELE_B0238.10Protein B0238.100.011
iftb-1Protein IFTB-10.010
ttr-15Protein TTR-150.010
sago-1Protein SAGO-10.010
pqn-39Protein PQN-390.010
ttr-35Protein TTR-350.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.882
S100A6S100 calcium binding protein A60.866
S100A10S100 calcium binding protein A100.692
SMN1survival of motor neuron 1, telomeric0.677
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.676
DLG4discs, large homolog 4 (Drosophila)0.654
CCR5chemokine (C-C motif) receptor 50.597
S100A11S100 calcium binding protein A110.499
MDM2Mdm2 p53 binding protein homolog (mouse)0.482
CXCL2chemokine (C-X-C motif) ligand 20.469
CCL3chemokine (C-C motif) ligand 30.455
SCP2sterol carrier protein 20.402
ANXA2annexin A20.361
LGALS1lectin, galactoside-binding, soluble, 10.337
LIN7Blin-7 homolog B (C. elegans)0.308
WWOXWW domain containing oxidoreductase0.294
S100A4S100 calcium binding protein A40.289
NME1non-metastatic cells 1, protein (NM23A) expressed in0.279
HLCSholocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)0.274
IDEinsulin-degrading enzyme0.207
ARRB1arrestin, beta 10.205
MED25mediator complex subunit 250.198
PEX5peroxisomal biogenesis factor 50.196
NME2non-metastatic cells 2, protein (NM23B) expressed in0.192
IL8interleukin 80.181
EGFRepidermal growth factor receptor0.163
RARAretinoic acid receptor, alpha0.141
HADHhydroxyacyl-CoA dehydrogenase0.140
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.125
TRIP13thyroid hormone receptor interactor 130.109
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.103
S100A9S100 calcium binding protein A90.096
SPOPspeckle-type POZ protein0.093
S100A8S100 calcium binding protein A80.093
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.088
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.087
NUDT21nudix (nucleoside diphosphate linked moiety X)-type motif 210.086
ANXA1annexin A10.085
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.084
WDYHV1WDYHV motif containing 10.084
RCC1regulator of chromosome condensation 10.078
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.074
FAF1Fas (TNFRSF6) associated factor 10.074
HLA-DRB4major histocompatibility complex, class II, DR beta 40.072
AHCYadenosylhomocysteinase0.072
GSTZ1glutathione transferase zeta 10.072
HIBCH3-hydroxyisobutyryl-CoA hydrolase0.072
ECH1enoyl CoA hydratase 1, peroxisomal0.071
IRS1insulin receptor substrate 10.069
DLGAP1discs, large (Drosophila) homolog-associated protein 10.068
AREGamphiregulin0.068
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.066
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.066
S100A1S100 calcium binding protein A10.066
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.065
CALB1calbindin 1, 28kDa0.065
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.064
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.062
IL1Binterleukin 1, beta0.062
ECI1enoyl-CoA delta isomerase 10.061
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.061
NR0B2nuclear receptor subfamily 0, group B, member 20.060
ZYXzyxin0.057
TK1thymidine kinase 1, soluble0.056
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.056
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.053
CCR1chemokine (C-C motif) receptor 10.053
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.053
INSRinsulin receptor0.051
HLA-DMBmajor histocompatibility complex, class II, DM beta0.051
HLA-DRB5major histocompatibility complex, class II, DR beta 50.049
S100PS100 calcium binding protein P0.049
PAICSphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.049
ECI2enoyl-CoA delta isomerase 20.048
PEX19peroxisomal biogenesis factor 190.047
IL1RNinterleukin 1 receptor antagonist0.047
CAV1caveolin 1, caveolae protein, 22kDa0.046
ETFDHelectron-transferring-flavoprotein dehydrogenase0.045
MYOZ1myozenin 10.044
S100BS100 calcium binding protein B0.043
PDLIM1PDZ and LIM domain 10.042
FKBP4FK506 binding protein 4, 59kDa0.042
PEX14peroxisomal biogenesis factor 140.041
IGF1Rinsulin-like growth factor 1 receptor0.041
PI3peptidase inhibitor 3, skin-derived0.041
BIRC3baculoviral IAP repeat containing 30.041
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.041
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.040
ANXA4annexin A40.040
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.039
GHRgrowth hormone receptor0.039
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.038
LMNAlamin A/C0.038
CCL2chemokine (C-C motif) ligand 20.038
LGALS3lectin, galactoside-binding, soluble, 30.036
CCL4chemokine (C-C motif) ligand 40.036
LNX1ligand of numb-protein X 10.035
EPT1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)0.035
ESR1estrogen receptor 10.034
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.034
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.509
Pkm2pyruvate kinase, muscle0.475
Acadvlacyl-Coenzyme A dehydrogenase, very long chain0.249
Dlg4discs, large homolog 4 (Drosophila)0.218
Pgm1phosphoglucomutase 10.170
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.160
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.157
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.157
Lrrc7leucine rich repeat containing 70.137
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.122
Pygmphosphorylase, glycogen, muscle0.118
Gcdhglutaryl-Coenzyme A dehydrogenase0.115
Gria1glutamate receptor, ionotropic, AMPA 10.114
Etfdhelectron-transferring-flavoprotein dehydrogenase0.100
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.084
Cpt2carnitine palmitoyltransferase 20.079
Nlgn2neuroligin 20.071
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.068
Acat1acetyl-coenzyme A acetyltransferase 10.067
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.066
Eef1a2eukaryotic translation elongation factor 1 alpha 20.066
Fn3kfructosamine 3 kinase0.061
Etfaelectron-transfer-flavoprotein, alpha polypeptide0.060
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.058
Impg2interphotoreceptor matrix proteoglycan 20.057
Nolc1nucleolar and coiled-body phosphoprotein 10.057
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.056
Dlgap3discs, large (Drosophila) homolog-associated protein 30.056
Map1amicrotubule-associated protein 1A0.054
Acaa2acetyl-Coenzyme A acyltransferase 20.048
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.048
Aldh9a1aldehyde dehydrogenase 9 family, member A10.047
Tfrctransferrin receptor0.044
Ces1ecarboxylesterase 1E0.043
Grip1glutamate receptor interacting protein 10.043
Rxrgretinoid X receptor gamma0.042
Camk4calcium/calmodulin-dependent protein kinase IV0.041
RGD1309501hypothetical LOC3055520.040
Chrm3cholinergic receptor, muscarinic 30.040
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.038
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.038
Mosc1MOCO sulphurase C-terminal domain containing 10.038
Eci2enoyl-Coenzyme A delta isomerase 20.037
Etfbelectron-transfer-flavoprotein, beta polypeptide0.037
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.037
Cdx1caudal type homeo box 10.036
Ldhdlactate dehydrogenase D0.036
Slc22a1solute carrier family 22 (organic cation transporter), member 10.035
Xcl1chemokine (C motif) ligand 10.035
Slc25a20solute carrier family 25 (carnitine/acylcarnitine translocase), member 200.035
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.034
Prkcbprotein kinase C, beta0.034
Stxbp1syntaxin binding protein 10.034
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.033
Map2microtubule-associated protein 20.033
Rpl36aribosomal protein L36a0.033
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.033
Gria3glutamate receptor, ionotrophic, AMPA 30.032
Anxa5annexin A50.032
Pdk2pyruvate dehydrogenase kinase, isozyme 20.032
Trim23tripartite motif-containing 230.031
Grik3glutamate receptor, ionotropic, kainate 30.031
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.031
Naglt1Na+ dependent glucose transporter 10.031
RGD1308165similar to hypothetical protein MGC173370.031
Olfm1olfactomedin 10.030
Hpcal4hippocalcin-like 40.030
Tmod2tropomodulin 20.030
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.030
Ppp1r9aprotein phosphatase 1, regulatory (inhibitor) subunit 9A0.030
Fgf14fibroblast growth factor 140.030
Fkbp4FK506 binding protein 40.030
Cntn2contactin 2 (axonal)0.029
Arandrogen receptor0.029
Trdntriadin0.029
Anxa2annexin A20.029
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.029
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.029
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.029
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.029
St18suppression of tumorigenicity 180.028
Uoxurate oxidase0.028
Gfra2GDNF family receptor alpha 20.028
Ddcdopa decarboxylase (aromatic L-amino acid decarboxylase)0.028
Oplah5-oxoprolinase (ATP-hydrolysing)0.028
Robo2roundabout homolog 2 (Drosophila)0.028
Hes5hairy and enhancer of split 5 (Drosophila)0.028
Lrit1leucine-rich repeat, immunoglobulin-like and transmembrane domains 10.027
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.027
Dmddystrophin0.026
Slc14a2solute carrier family 14 (urea transporter), member 20.026
Garnl1GTPase activating Rap/RanGAP domain-like 10.026
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.026
Gpiglucose phosphate isomerase0.026
Sorbs3sorbin and SH3 domain containing 30.025
LOC688549hypothetical protein LOC6885490.025
Bin1bridging integrator 10.025
Spata9spermatogenesis associated 90.025
Slc38a3solute carrier family 38, member 30.025
Gad2glutamate decarboxylase 20.025
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RNR2Rnr2p0.018
RNR3Rnr3p0.011
WTM2Wtm2p0.010