The network for 'cartilage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cartilage development

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Fgfr1fibroblast growth factor receptor 11.000
Gli2GLI-Kruppel family member GLI21.000
Fgf8fibroblast growth factor 81.000
Prrx1paired related homeobox 10.999
Fgfr3fibroblast growth factor receptor 30.999
Gli3GLI-Kruppel family member GLI30.998
Rargretinoic acid receptor, gamma0.997
Col2a1collagen, type II, alpha 10.997
Pax3paired box gene 30.994
Tgfb2transforming growth factor, beta 20.993
Ror2receptor tyrosine kinase-like orphan receptor 20.992
Hand2heart and neural crest derivatives expressed transcript 20.990
Hoxa2homeobox A20.990
Eya1eyes absent 1 homolog (Drosophila)0.989
Dlx5distal-less homeobox 50.989
Pax2paired box gene 20.988
Col1a1collagen, type I, alpha 10.986
Ednraendothelin receptor type A0.985
Tbx1T-box 10.985
Bmp4bone morphogenetic protein 40.985
Prrx2paired related homeobox 20.985
Hoxa11homeobox A110.984
Hoxd13homeobox D130.982
Hoxa1homeobox A10.978
En1engrailed 10.975
Hoxd3homeobox D30.974
Hoxa13homeobox A130.972
Sfrp2secreted frizzled-related protein 20.971
Acvr1activin A receptor, type 10.968
Smad3MAD homolog 3 (Drosophila)0.968
Ascl1achaete-scute complex homolog 1 (Drosophila)0.967
Twist1twist homolog 1 (Drosophila)0.964
Fgf10fibroblast growth factor 100.962
Sox9SRY-box containing gene 90.961
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.961
Gbx2gastrulation brain homeobox 20.958
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.956
Fzd8frizzled homolog 8 (Drosophila)0.953
Gpc3glypican 30.953
Foxc1forkhead box C10.949
Twist2twist homolog 2 (Drosophila)0.948
Gas1growth arrest specific 10.945
Pax9paired box gene 90.944
Hoxa5homeobox A50.941
Vegfavascular endothelial growth factor A0.941
Lhx3LIM homeobox protein 30.940
Pthlhparathyroid hormone-like peptide0.937
Hoxa10homeobox A100.936
Isl1ISL1 transcription factor, LIM/homeodomain0.936
Lmx1aLIM homeobox transcription factor 1 alpha0.934
Snai1snail homolog 1 (Drosophila)0.931
Tgfbr2transforming growth factor, beta receptor II0.931
Mrc2mannose receptor, C type 20.918
Gscgoosecoid homeobox0.918
Tgfb1transforming growth factor, beta 10.915
Nos3nitric oxide synthase 3, endothelial cell0.915
Sox2SRY-box containing gene 20.893
Hoxa3homeobox A30.890
Gdf5growth differentiation factor 50.886
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.879
Hoxd9homeobox D90.879
Pitx2paired-like homeodomain transcription factor 20.878
Fgf15fibroblast growth factor 150.878
Fbn1fibrillin 10.871
Vangl2vang-like 2 (van gogh, Drosophila)0.869
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.864
Fgf18fibroblast growth factor 180.862
Wnt3awingless-related MMTV integration site 3A0.861
Wnt5awingless-related MMTV integration site 5A0.856
Foxc2forkhead box C20.851
Bmp5bone morphogenetic protein 50.840
Gdnfglial cell line derived neurotrophic factor0.839
Tbx15T-box 150.837
Hes1hairy and enhancer of split 1 (Drosophila)0.836
Pbx1pre B-cell leukemia transcription factor 10.833
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.827
Ece1endothelin converting enzyme 10.823
Pkd1polycystic kidney disease 1 homolog0.817
Pitx1paired-like homeodomain transcription factor 10.816
Meox2mesenchyme homeobox 20.809
Pou3f3POU domain, class 3, transcription factor 30.797
Tbx3T-box 30.788
Col11a1collagen, type XI, alpha 10.783
Rararetinoic acid receptor, alpha0.783
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.768
Bmpr1abone morphogenetic protein receptor, type 1A0.765
Mapk14mitogen-activated protein kinase 140.764
Loxlysyl oxidase0.763
Tcfap2atranscription factor AP-2, alpha0.753
Bmp7bone morphogenetic protein 70.751
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.749
Zfp503zinc finger protein 5030.748
Hoxd11homeobox D110.740
Hspg2perlecan (heparan sulfate proteoglycan 2)0.738
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.996
jag1bjagged 1b0.995
sox9aSRY-box containing gene 9a0.995
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.989
col1a1acollagen, type I, alpha 1a0.971
fgf3fibroblast growth factor 30.958
prdm1aPR domain containing 1a, with ZNF domain0.927
foxi1forkhead box I10.922
uxs1UDP-glucuronic acid decarboxylase 10.897
col5a1procollagen, type V, alpha 10.894
edn1endothelin 10.855
barx1BarH-like homeobox 10.853
fn1fibronectin 10.821
gli2aGLI-Kruppel family member GLI2a0.819
ndr2nodal-related 20.819
snai1asnail homolog 1a (Drosophila)0.809
eya1eyes absent homolog 10.787
bmp2abone morphogenetic protein 2a0.783
gdf6agrowth differentiation factor 6a0.778
osr1odd-skipped related 1 (Drosophila)0.771
mef2camyocyte enhancer factor 2ca0.768
tp63tumor protein p630.754
csnk1a1casein kinase 1, alpha 10.744
fli1afriend leukemia integration 1a0.738
brpf1bromodomain and PHD finger containing, 10.709
col1a2collagen, type I, alpha 20.705
myod1myogenic differentiation 10.686
matn4matrilin 40.684
dlx3bdistal-less homeobox gene 3b0.681
fgf17fibroblast growth factor 170.664
wnt9bwingless-type MMTV integration site family, member 9B0.655
spry4sprouty (Drosophila) homolog 40.654
lmx1b.1LIM homeobox transcription factor 1, beta 10.638
ctgfconnective tissue growth factor0.634
hand2heart and neural crest derivatives expressed transcript 20.632
rargaretinoic acid receptor gamma a0.630
bocbrother of CDO0.617
col5a2lcollagen, type V, alpha 2-like0.610
pax9paired box gene 90.606
vcanbversican b0.592
disp1dispatched homolog 1 (Drosophila)0.589
hoxa13bhomeo box A13b0.583
nkx3.2NK3 homeobox 20.581
efnb2aephrin B2a0.573
furinafurin (paired basic amino acid cleaving enzyme) a0.550
flhfloating head0.528
thbs1thrombospondin 10.522
runx3runt-related transcription factor 30.521
xylt1xylosyltransferase 10.518
hapln1ahyaluronan and proteoglycan link protein 1a0.505
pcsk5bproprotein convertase subtilisin/kexin type 5b0.501
dlx5adistal-less homeobox gene 5a0.496
tgfb2transforming growth factor, beta 20.496
dlx6adistal-less homeobox gene 6a0.494
spns2spinster homolog 2 (Drosophila)0.492
dlx4adistal-less homeobox gene 4a0.488
fras1Fraser syndrome 10.487
fgfr1afibroblast growth factor receptor 1a0.476
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.472
tbx2aT-box gene 2a0.463
ptch1patched 10.440
loxl2blysyl oxidase-like 2b0.437
hoxa3ahomeo box A3a0.433
shhasonic hedgehog a0.430
dmrt2adoublesex and mab-3 related transcription factor 2a0.428
foxa3forkhead box A30.424
fgfr2fibroblast growth factor receptor 20.422
bmp4bone morphogenetic protein 40.413
hey1hairy/enhancer-of-split related with YRPW motif 10.404
fgf4fibroblast growth factor 40.400
lef1lymphocyte enhancer binding factor 10.398
ptpraprotein tyrosine phosphatase, receptor type, A0.398
cdx4caudal type homeo box transcription factor 40.398
tgfbitransforming growth factor, beta-induced0.397
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.396
dlx2adistal-less homeobox gene 2a0.392
notch2notch homolog 20.386
gli1GLI-Kruppel family member 10.378
tfectranscription factor EC0.378
acvr1lactivin A receptor, type I like0.376
foxa2forkhead box A20.374
hoxb4ahomeo box B4a0.372
sulf1sulfatase 10.371
prrx1apaired related homeobox 1a0.370
fgfr3fibroblast growth factor receptor 30.368
mecomMDS1 and EVI1 complex locus0.366
tcf7transcription factor 7 (T-cell specific, HMG-box)0.365
gbx2gastrulation brain homeo box 20.361
jag2jagged 20.355
col9a2procollagen, type IX, alpha 20.353
nrp1aneuropilin 1a0.349
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.348
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.997
FBN1fibrillin 10.908
SMAD7SMAD family member 70.904
PAX3paired box 30.782
FN1fibronectin 10.745
LOXlysyl oxidase0.705
LTBP2latent transforming growth factor beta binding protein 20.685
COL1A1collagen, type I, alpha 10.671
MMP14matrix metallopeptidase 14 (membrane-inserted)0.653
COL3A1collagen, type III, alpha 10.638
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.637
COL1A2collagen, type I, alpha 20.583
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.458
BMP2bone morphogenetic protein 20.420
COL6A1collagen, type VI, alpha 10.408
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.365
BMPR1Abone morphogenetic protein receptor, type IA0.362
FSTL1follistatin-like 10.347
SMAD3SMAD family member 30.347
COL5A2collagen, type V, alpha 20.343
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.326
FGF1fibroblast growth factor 1 (acidic)0.326
SMAD4SMAD family member 40.325
COL6A2collagen, type VI, alpha 20.324
CTGFconnective tissue growth factor0.312
NOTCH3notch 30.309
TGFB1transforming growth factor, beta 10.306
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.297
COL5A1collagen, type V, alpha 10.296
FGFR1fibroblast growth factor receptor 10.292
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.233
MAPK1mitogen-activated protein kinase 10.216
TNCtenascin C0.205
BMP7bone morphogenetic protein 70.201
EP300E1A binding protein p3000.198
HOXD9homeobox D90.198
THBS1thrombospondin 10.192
RB1retinoblastoma 10.186
SEC31ASEC31 homolog A (S. cerevisiae)0.180
POSTNperiostin, osteoblast specific factor0.174
COL2A1collagen, type II, alpha 10.172
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.172
HIPK2homeodomain interacting protein kinase 20.166
FGF2fibroblast growth factor 2 (basic)0.165
CALD1caldesmon 10.160
MSX1msh homeobox 10.156
DDR2discoidin domain receptor tyrosine kinase 20.154
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.148
BMP1bone morphogenetic protein 10.145
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.131
BBS10Bardet-Biedl syndrome 100.128
FOXD3forkhead box D30.127
LAMC1laminin, gamma 1 (formerly LAMB2)0.126
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.121
HOXA10homeobox A100.120
IGFBP5insulin-like growth factor binding protein 50.115
BMI1BMI1 polycomb ring finger oncogene0.115
TWIST1twist homolog 1 (Drosophila)0.114
WNT1wingless-type MMTV integration site family, member 10.113
FZD1frizzled homolog 1 (Drosophila)0.113
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.112
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.112
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.110
BMPR1Bbone morphogenetic protein receptor, type IB0.110
MFAP5microfibrillar associated protein 50.108
PCOLCEprocollagen C-endopeptidase enhancer0.107
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.106
PKD2polycystic kidney disease 2 (autosomal dominant)0.105
RARAretinoic acid receptor, alpha0.101
TGFBR1transforming growth factor, beta receptor 10.097
EDNRAendothelin receptor type A0.097
LOXL1lysyl oxidase-like 10.097
NRP1neuropilin 10.092
ACVR1activin A receptor, type I0.092
TGFB3transforming growth factor, beta 30.090
GDF5growth differentiation factor 50.090
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.089
FAPfibroblast activation protein, alpha0.089
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.087
MXRA5matrix-remodelling associated 50.083
TGFB2transforming growth factor, beta 20.081
PTCH1patched 10.079
COL6A3collagen, type VI, alpha 30.076
WNT3Awingless-type MMTV integration site family, member 3A0.074
FBLN2fibulin 20.073
RUNX1runt-related transcription factor 10.072
TP53tumor protein p530.070
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.069
HMGA2high mobility group AT-hook 20.068
SULF1sulfatase 10.068
HDAC6histone deacetylase 60.068
IGFBP3insulin-like growth factor binding protein 30.068
NR4A1nuclear receptor subfamily 4, group A, member 10.067
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.924
Col3a1collagen, type III, alpha 10.905
Col1a2collagen, type I, alpha 20.811
Col5a2collagen, type V, alpha 20.557
Col12a1collagen, type XII, alpha 10.317
Col5a1collagen, type V, alpha 10.246
Fn1fibronectin 10.234
Dab2disabled homolog 2 (Drosophila)0.131
Loxl1lysyl oxidase-like 10.093
Shox2short stature homeobox 20.080
Loxlysyl oxidase0.078
Tgfbr2transforming growth factor, beta receptor II0.073
Anxa1annexin A10.070
Mfap4microfibrillar-associated protein 40.064
Col4a5collagen, type IV, alpha 50.055
Fgfr2fibroblast growth factor receptor 20.051
Lamc1laminin, gamma 10.049
Nr1d2nuclear receptor subfamily 1, group D, member 20.045
Hapln1hyaluronan and proteoglycan link protein 10.043
Pcolceprocollagen C-endopeptidase enhancer0.042
Col15a1collagen, type XV, alpha 10.041
Tgfb3transforming growth factor, beta 30.041
Nup153nucleoporin 1530.041
Srpxsushi-repeat-containing protein, X-linked0.039
DbpD site of albumin promoter (albumin D-box) binding protein0.038
Sod3superoxide dismutase 3, extracellular0.038
Aldh6a1aldehyde dehydrogenase 6 family, member A10.037
Irs1insulin receptor substrate 10.037
Col9a1collagen, type IX, alpha 10.037
Fbn1fibrillin 10.036
Ece1endothelin converting enzyme 10.036
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.036
Gpr176G protein-coupled receptor 1760.036
Igfbp5insulin-like growth factor binding protein 50.035
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.034
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.034
Postnperiostin, osteoblast specific factor0.033
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.033
Hoxc4homeo box C40.033
Angptl2angiopoietin-like 20.031
Rararetinoic acid receptor, alpha0.030
Smad6SMAD family member 60.030
Ralgdsral guanine nucleotide dissociation stimulator0.029
Col6a2collagen, type VI, alpha 20.029
Gja1gap junction protein, alpha 10.029
Map3k3mitogen activated protein kinase kinase kinase 30.028
Aebp1AE binding protein 10.028
Ctskcathepsin K0.028
S1pr2sphingosine-1-phosphate receptor 20.028
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.027
Lrpap1low density lipoprotein receptor-related protein associated protein 10.027
RGD1305645similar to RIKEN cDNA 1500015O100.027
Col2a1collagen, type II, alpha 10.027
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.026
C1qtnf6C1q and tumor necrosis factor related protein 60.026
Cpzcarboxypeptidase Z0.025
Sox17SRY (sex determining region Y)-box 170.025
Mgpmatrix Gla protein0.024
Sox10SRY (sex determining region Y)-box 100.023
Sdc2syndecan 20.023
Ccnd3cyclin D30.022
Nbl1neuroblastoma, suppression of tumorigenicity 10.022
Esr1estrogen receptor 10.022
Col8a1collagen, type VIII, alpha 10.022
Sdc3syndecan 30.021
Lect1leukocyte cell derived chemotaxin 10.021
Foxd4forkhead box D40.021
Bmp6bone morphogenetic protein 60.021
Scarf2scavenger receptor class F, member 20.021
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.021
Glt25d1glycosyltransferase 25 domain containing 10.020
Syn3synapsin III0.020
Cyb5r1cytochrome b5 reductase 10.019
Arandrogen receptor0.019
Fzd2frizzled homolog 2 (Drosophila)0.019
Ptpn14protein tyrosine phosphatase, non-receptor type 140.019
Fgfr1Fibroblast growth factor receptor 10.019
Tgfbr3transforming growth factor, beta receptor III0.019
Psen1presenilin 10.019
Tpothyroid peroxidase0.019
Unc5bunc-5 homolog B (C. elegans)0.019
Tgfb1transforming growth factor, beta 10.018
Gpx3glutathione peroxidase 30.018
Foxe3forkhead box E30.018
Hapln4hyaluronan and proteoglycan link protein 40.018
Grin2cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.018
Magmyelin-associated glycoprotein0.018
Ptbp1polypyrimidine tract binding protein 10.018
Ccdc80coiled-coil domain containing 800.017
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism