The network for 'positive regulation of hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.

NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.825
Bglapbone gamma carboxyglutamate protein0.813
Cdkn1bcyclin-dependent kinase inhibitor 1B0.737
C1qacomplement component 1, q subcomponent, alpha polypeptide0.719
Nf1neurofibromatosis 10.637
Nr3c1nuclear receptor subfamily 3, group C, member 10.622
Sox11SRY-box containing gene 110.595
Edaectodysplasin-A0.565
Aldoaaldolase A, fructose-bisphosphate0.555
Retret proto-oncogene0.532
Bglap2bone gamma-carboxyglutamate protein 20.523
Lef1lymphoid enhancer binding factor 10.479
Lhcgrluteinizing hormone/choriogonadotropin receptor0.460
Tnftumor necrosis factor0.443
Zeb1zinc finger E-box binding homeobox 10.422
Fshrfollicle stimulating hormone receptor0.419
Bmp4bone morphogenetic protein 40.369
Map3k14mitogen-activated protein kinase kinase kinase 140.367
Arrb1arrestin, beta 10.328
Irs2insulin receptor substrate 20.322
Ldb3LIM domain binding 30.316
Ltalymphotoxin A0.312
Ptpn11protein tyrosine phosphatase, non-receptor type 110.308
Ikzf1IKAROS family zinc finger 10.306
Ltblymphotoxin B0.295
Ascl1achaete-scute complex homolog 1 (Drosophila)0.290
Esr1estrogen receptor 1 (alpha)0.286
Prlrprolactin receptor0.277
Leprleptin receptor0.272
Socs1suppressor of cytokine signaling 10.270
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.259
Ednrbendothelin receptor type B0.251
Gckglucokinase0.250
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.248
Pkm2pyruvate kinase, muscle0.246
Cd40CD40 antigen0.242
Lepleptin0.239
Eporerythropoietin receptor0.236
Hand1heart and neural crest derivatives expressed transcript 10.234
Cxcl13chemokine (C-X-C motif) ligand 130.224
Pdx1pancreatic and duodenal homeobox 10.224
Barx2BarH-like homeobox 20.221
Traf6TNF receptor-associated factor 60.221
Gprc6aG protein-coupled receptor, family C, group 6, member A0.218
Ppypancreatic polypeptide0.217
SrcRous sarcoma oncogene0.215
WwoxWW domain-containing oxidoreductase0.210
Tcf7transcription factor 7, T-cell specific0.209
Arrb2arrestin, beta 20.204
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.203
Pthlhparathyroid hormone-like peptide0.202
Coro1bcoronin, actin binding protein 1B0.197
Bsgbasigin0.194
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.191
Gpi1glucose phosphate isomerase 10.190
Hprthypoxanthine guanine phosphoribosyl transferase0.187
Ghrgrowth hormone receptor0.181
Klklotho0.180
Azgp1alpha-2-glycoprotein 1, zinc0.177
Lmx1bLIM homeobox transcription factor 1 beta0.176
Ighimmunoglobulin heavy chain complex0.176
Itgb1integrin beta 1 (fibronectin receptor beta)0.175
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.163
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.160
Adra2aadrenergic receptor, alpha 2a0.159
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.157
Olfr71olfactory receptor 710.153
Toxthymocyte selection-associated high mobility group box0.152
Lhx3LIM homeobox protein 30.150
Adra2badrenergic receptor, alpha 2b0.149
Cxcr5chemokine (C-X-C motif) receptor 50.148
Wnt4wingless-related MMTV integration site 40.146
Meox2mesenchyme homeobox 20.145
Ntf3neurotrophin 30.144
Pigrpolymeric immunoglobulin receptor0.144
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.143
Atoh7atonal homolog 7 (Drosophila)0.140
Krt72-pskeratin 72, pseudogene0.135
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.134
Fgf23fibroblast growth factor 230.134
Nkx6-1NK6 homeobox 10.133
Sox4SRY-box containing gene 40.132
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.129
Akr1c6aldo-keto reductase family 1, member C60.129
Sox2SRY-box containing gene 20.129
Fgf8fibroblast growth factor 80.129
Ifnginterferon gamma0.129
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.129
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.127
Otporthopedia homolog (Drosophila)0.125
Gata4GATA binding protein 40.125
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.124
Hrghistidine-rich glycoprotein0.121
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.119
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.117
Ins2insulin II0.117
Isl1ISL1 transcription factor, LIM/homeodomain0.116
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.116
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.114
Amhanti-Mullerian hormone0.114
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cyp-35A2Protein CYP-35A20.416
cyp-35C1Protein CYP-35C10.103
cyp-35A4Protein CYP-35A40.085
CELE_C08E8.4Protein C08E8.40.029
oac-46Protein OAC-460.027
CELE_C29F7.2Protein C29F7.20.027
cyp-35A3Protein CYP-35A30.026
cyp-33C9Protein CYP-33C90.023
unc-43Protein UNC-430.022
cyp-35A5Protein CYP-35A50.022
F08G5.6Protein F08G5.60.021
ugt-22Protein UGT-220.020
gpd-3Protein GPD-30.019
T16G1.6Protein T16G1.60.019
unc-32Protein UNC-320.019
W01A11.1Protein W01A11.10.017
ugt-16Protein UGT-160.017
pkg-1Protein PKG-10.016
ist-1Protein IST-10.015
lit-1Protein LIT-10.015
rrc-1Protein RRC-10.015
got-2.2Protein GOT-2.20.015
C27B7.7Protein C27B7.70.014
CELE_F27D4.6Protein F27D4.60.014
dyf-11Protein DYF-110.013
nhr-220Protein NHR-2200.013
acs-1Protein ACS-10.013
C34D10.1Protein C34D10.10.013
cdr-1Protein CDR-10.013
cyp-33E1Protein CYP-33E10.013
inx-19Protein INX-190.013
F35G2.5Protein F35G2.50.013
F13H6.3Protein F13H6.30.013
CELE_B0238.1Protein B0238.10.013
act-3Protein ACT-30.013
D2013.6Protein D2013.60.013
CELE_Y57G11C.15Protein Y57G11C.150.012
pyc-1Protein PYC-10.012
F58B4.5Protein F58B4.50.012
gei-18Protein GEI-180.012
C29F3.7Protein C29F3.70.012
CELE_C08F11.3Protein C08F11.30.012
unc-80Protein UNC-800.012
asm-3Protein ASM-30.012
pxd-1Protein PXD-10.012
grd-12Protein GRD-120.011
unc-9Protein UNC-90.011
T02B5.3Protein T02B5.30.011
lin-11Protein LIN-110.011
F21A3.2Protein F21A3.20.011
cyp-33C4Protein CYP-33C40.011
pcca-1Protein PCCA-10.011
nhr-206Protein NHR-2060.011
F47B8.4Protein F47B8.40.011
arrd-17Protein ARRD-170.011
anc-1Protein ANC-10.011
F46F3.3Protein F46F3.30.011
coq-1Protein COQ-10.011
cyp-35B1Protein CYP-35B10.011
K05B2.4Protein K05B2.40.011
CELE_Y47G6A.18Protein Y47G6A.180.011
F57B10.3Protein F57B10.30.011
unc-47Protein UNC-470.010
F43C11.7Protein F43C11.70.010
ugt-1Protein UGT-10.010
CELE_T19C9.8Protein T19C9.80.010
gst-4Protein GST-40.010
glr-4Protein GLR-40.010
CELE_H25K10.1Protein H25K10.10.010
skr-5Protein SKR-50.010
ugt-9Protein UGT-90.010
eya-1Protein EYA-10.010
glr-1Protein GLR-10.010
nhr-132Protein NHR-1320.010
gsp-1Protein GSP-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
exexpanded0.014
nejnejire0.013
CG34139CG34139 gene product from transcript CG34139-RD0.012
svpseven up0.012
CG42672CG42672 gene product from transcript CG42672-RD0.012
mttmangetout0.012
IppInositol polyphosphate 1-phosphatase0.012
grpgrapes0.011
hthhomothorax0.011
Mekk1CG7717 gene product from transcript CG7717-RB0.011
kaykayak0.011
cadcaudal0.011
Octbeta2RCG33976 gene product from transcript CG33976-RA0.011
NPFR1neuropeptide F receptor0.011
Gr43aGustatory receptor 43a0.010
HDAC6CG6170 gene product from transcript CG6170-RA0.010
toytwin of eyeless0.010
rtGEFrho-type guanine exchange factor0.010
GluRIIAGlutamate receptor IIA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.970
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.946
C1QAcomplement component 1, q subcomponent, A chain0.932
TEKTEK tyrosine kinase, endothelial0.829
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.723
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.681
HLA-DRB5major histocompatibility complex, class II, DR beta 50.577
INSRinsulin receptor0.575
FGAfibrinogen alpha chain0.558
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.494
SNAP23synaptosomal-associated protein, 23kDa0.494
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.470
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.412
HCKhemopoietic cell kinase0.384
FGBfibrinogen beta chain0.383
IGF1Rinsulin-like growth factor 1 receptor0.333
HLA-DMBmajor histocompatibility complex, class II, DM beta0.312
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.273
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.200
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.194
HNF4Ahepatocyte nuclear factor 4, alpha0.170
GRB10growth factor receptor-bound protein 100.160
GRB2growth factor receptor-bound protein 20.160
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.146
CAPNS1calpain, small subunit 10.146
BLNKB-cell linker0.145
GRB7growth factor receptor-bound protein 70.140
FGGfibrinogen gamma chain0.140
PSEN2presenilin 2 (Alzheimer disease 4)0.131
MAP3K5mitogen-activated protein kinase kinase kinase 50.129
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.127
C1QCcomplement component 1, q subcomponent, C chain0.125
CLASP1cytoplasmic linker associated protein 10.122
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.119
SNAP25synaptosomal-associated protein, 25kDa0.117
SYKspleen tyrosine kinase0.099
GOLGA2golgin A20.092
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.085
C1QBcomplement component 1, q subcomponent, B chain0.081
TTRtransthyretin0.070
CRHR1corticotropin releasing hormone receptor 10.065
SHC1SHC (Src homology 2 domain containing) transforming protein 10.065
HLA-DPB1major histocompatibility complex, class II, DP beta 10.064
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.062
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.060
WIPF1WAS/WASL interacting protein family, member 10.058
ADORA2Aadenosine A2a receptor0.057
HLA-DRB4major histocompatibility complex, class II, DR beta 40.054
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.054
IRS1insulin receptor substrate 10.043
SH2B1SH2B adaptor protein 10.041
SPDEFSAM pointed domain containing ets transcription factor0.036
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.036
SMURF2SMAD specific E3 ubiquitin protein ligase 20.034
SMAD2SMAD family member 20.033
APOA1apolipoprotein A-I0.033
MARCOmacrophage receptor with collagenous structure0.031
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.031
NCK1NCK adaptor protein 10.029
ESRRGestrogen-related receptor gamma0.029
IRF2interferon regulatory factor 20.028
SSTR3somatostatin receptor 30.028
YY1YY1 transcription factor0.026
RUSC2RUN and SH3 domain containing 20.026
NSFN-ethylmaleimide-sensitive factor0.025
GLIS2GLIS family zinc finger 20.024
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.024
HIPK2homeodomain interacting protein kinase 20.024
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.023
MYO6myosin VI0.023
CREBBPCREB binding protein0.022
HIC1hypermethylated in cancer 10.021
JAK1Janus kinase 10.020
SSTR2somatostatin receptor 20.020
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.020
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.020
BCRbreakpoint cluster region0.020
PLCG1phospholipase C, gamma 10.019
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.019
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.019
GNMTglycine N-methyltransferase0.018
MAPK10mitogen-activated protein kinase 100.018
RASA1RAS p21 protein activator (GTPase activating protein) 10.018
OCRLoculocerebrorenal syndrome of Lowe0.018
GAS7growth arrest-specific 70.018
LATlinker for activation of T cells0.018
FYNFYN oncogene related to SRC, FGR, YES0.018
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.017
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.017
STAT5Bsignal transducer and activator of transcription 5B0.017
DRD2dopamine receptor D20.017
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.017
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.017
EGFRepidermal growth factor receptor0.016
ITKIL2-inducible T-cell kinase0.016
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.016
GCKRglucokinase (hexokinase 4) regulator0.016
SVOPSV2 related protein homolog (rat)0.016
CCKcholecystokinin0.016
STAT5Asignal transducer and activator of transcription 5A0.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Glp1rglucagon-like peptide 1 receptor0.315
Prss3protease, serine, 30.301
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.254
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.234
G6pcglucose-6-phosphatase, catalytic subunit0.223
Robo1roundabout homolog 1 (Drosophila)0.213
Scn10asodium channel, voltage-gated, type X, alpha subunit0.191
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.154
Acrv1acrosomal vesicle protein 10.152
Phkg1phosphorylase kinase, gamma 10.140
Il4interleukin 40.137
Ush1cUsher syndrome 1C homolog (human)0.133
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.129
Plinperilipin0.128
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.116
Thtyrosine hydroxylase0.110
Tff3trefoil factor 3, intestinal0.108
Prlhrprolactin releasing hormone receptor0.106
Mamdc4MAM domain containing 40.103
Gad2glutamate decarboxylase 20.102
MlxiplMLX interacting protein-like0.098
Crhbpcorticotropin releasing hormone binding protein0.097
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.094
Acsl4acyl-CoA synthetase long-chain family member 40.092
Btcbetacellulin0.090
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.088
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.088
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.086
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.084
Hcrtr1hypocretin (orexin) receptor 10.084
Casp3caspase 30.084
Clcnkachloride channel Ka0.083
Cnga1cyclic nucleotide gated channel alpha 10.079
Rbp3retinol binding protein 3, interstitial0.076
Insrinsulin receptor0.076
Tnp1transition protein 10.075
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.074
Bcanbrevican0.074
Il1r1interleukin 1 receptor, type I0.072
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.072
Itih4inter alpha-trypsin inhibitor, heavy chain 40.072
Aqp2aquaporin 2 (collecting duct)0.071
Chrna7cholinergic receptor, nicotinic, alpha 70.070
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.069
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.068
Apoa4apolipoprotein A-IV0.067
Rgs9regulator of G-protein signaling 90.067
Galgalanin prepropeptide0.067
Nrg1neuregulin 10.066
Hcrthypocretin0.066
Pparaperoxisome proliferator activated receptor alpha0.066
Iappislet amyloid polypeptide0.065
Prlrprolactin receptor0.064
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.064
Trhrthyrotropin releasing hormone receptor0.063
Olr1496olfactory receptor 14960.063
Il9rinterleukin 9 receptor0.063
Necab2N-terminal EF-hand calcium binding protein 20.062
Grk1G protein-coupled receptor kinase 10.060
Csf1colony stimulating factor 1 (macrophage)0.060
Hand2heart and neural crest derivatives expressed 20.060
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.060
Svs3aseminal vesicle secretory protein 3A0.060
Csn2casein beta0.059
Cgaglycoprotein hormones, alpha polypeptide0.059
Smgbneonatal submandibular gland protein B0.058
Phox2apaired-like homeobox 2a0.058
Hrh3histamine receptor H30.058
F2rl1coagulation factor II (thrombin) receptor-like 10.058
Pzppregnancy-zone protein0.058
Esr2estrogen receptor 2 (ER beta)0.058
Chrm2cholinergic receptor, muscarinic 20.058
Itgb7integrin, beta 70.057
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.057
Pcsk1proprotein convertase subtilisin/kexin type 10.056
Albalbumin0.056
Dll3delta-like 3 (Drosophila)0.056
Dnase1deoxyribonuclease I0.055
Capn9calpain 90.055
Hcrtr2hypocretin (orexin) receptor 20.055
Vom2r53vomeronasal 2 receptor, 530.054
Nfascneurofascin0.054
Actr2ARP2 actin-related protein 2 homolog (yeast)0.054
Kiss1rKISS1 receptor0.054
Fgf2fibroblast growth factor 20.053
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.053
Ins2insulin 20.053
Prph2peripherin 20.053
Smcpsperm mitochondria-associated cysteine-rich protein0.053
Hrhairless0.052
Ces1ccarboxylesterase 1C0.052
Sstsomatostatin0.051
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.051
Tshbthyroid stimulating hormone, beta0.050
FaslgFas ligand (TNF superfamily, member 6)0.050
Cryba2crystallin, beta A20.049
Ube2d4ubiquitin-conjugating enzyme E2D 40.049
Abhd4abhydrolase domain containing 40.049
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.048
Ncanneurocan0.048
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism