The network for 'transforming growth factor beta secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transforming growth factor beta secretion

The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs).

NameDescriptionProbabilityFunc Analog Organism
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.995
Col11a2collagen, type XI, alpha 20.993
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.983
Psg19pregnancy specific glycoprotein 190.974
Hbb-yhemoglobin Y, beta-like embryonic chain0.970
Psg21pregnancy-specific glycoprotein 210.960
Psg28pregnancy-specific glycoprotein 280.935
Slc26a4solute carrier family 26, member 40.911
Prl6a1prolactin family 6, subfamily a, member 10.882
Prl3b1prolactin family 3, subfamily b, member 10.878
Prl2b1prolactin family 2, subfamily b, member 10.835
Prl7a2prolactin family 7, subfamily a, member 20.784
Prl8a2prolactin family 8, subfamily a, member 20.753
Mmp1amatrix metallopeptidase 1a (interstitial collagenase)0.748
Prl7d1prolactin family 7, subfamily d, member 10.737
Gzmdgranzyme D0.709
Rhox9reproductive homeobox 90.700
Hbb-bh1hemoglobin Z, beta-like embryonic chain0.608
Tpbpatrophoblast specific protein alpha0.603
Pcdh12protocadherin 120.594
Ctsrcathepsin R0.580
Ptk6PTK6 protein tyrosine kinase 60.529
Sel1l2sel-1 suppressor of lin-12-like 2 (C. elegans)0.528
Zfp42zinc finger protein 420.503
Ceacam12carcinoembryonic antigen-related cell adhesion molecule 120.498
Rfpl4ret finger protein-like 40.469
Ctsmcathepsin M0.457
Prl7a1prolactin family 7, subfamily a, member 10.440
Serpinb9gserine (or cysteine) peptidase inhibitor, clade B, member 9g0.393
Vmn1r172vomeronasal 1 receptor 1720.367
Psg18pregnancy specific glycoprotein 180.351
Vmn1r45vomeronasal 1 receptor 450.328
Erv3endogenous retroviral sequence 30.320
Sox15SRY-box containing gene 150.301
DaoD-amino acid oxidase0.299
Psg17pregnancy specific glycoprotein 170.289
Ceacam13carcinoembryonic antigen-related cell adhesion molecule 130.275
Spam1sperm adhesion molecule 10.275
Tex19.1testis expressed gene 19.10.275
Prl7b1prolactin family 7, subfamily b, member 10.264
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.225
Prl3c1prolactin family 3, subfamily c, member 10.212
Psg23pregnancy-specific glycoprotein 230.204
Prl8a8prolactin family 8, subfamily a, member 810.188
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.179
Agrpagouti related protein0.175
Ctsjcathepsin J0.174
Prl8a6prolactin family 8, subfamily a, member 60.162
Tpbpbtrophoblast specific protein beta0.160
Prl7c1prolactin family 7, subfamily c, member 10.158
Svs6seminal vesicle secretory protein 60.154
Olfr1507olfactory receptor 15070.149
Cts6cathepsin 60.149
Prl3a1prolactin family 3, subfamily a, member 10.140
Gzmggranzyme G0.138
Trim61tripartite motif-containing 610.132
Gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.131
Mmp1bmatrix metallopeptidase 1b (interstitial collagenase)0.126
Ang3angiogenin, ribonuclease A family, member 30.102
Serpinb9cserine (or cysteine) peptidase inhibitor, clade B, member 9c0.101
Ccr1l1chemokine (C-C motif) receptor 1-like 10.096
Ceacam14carcinoembryonic antigen-related cell adhesion molecule 140.086
Olfr701olfactory receptor 7010.083
Psg26pregnancy-specific glycoprotein 260.083
Gcm1glial cells missing homolog 1 (Drosophila)0.082
Krt25keratin 250.078
Cts7cathepsin 70.074
Tpsb2tryptase beta 20.071
Serpinb9dserine (or cysteine) peptidase inhibitor, clade B, member 9d0.070
Ctsqcathepsin Q0.068
Vmn1r49vomeronasal 1, receptor 490.066
Mmp20matrix metallopeptidase 20 (enamelysin)0.059
Clca3chloride channel calcium activated 30.059
Slc34a1solute carrier family 34 (sodium phosphate), member 10.058
Gabra6gamma-aminobutyric acid (GABA) A receptor, subunit alpha 60.058
Rhox4dreproductive homeobox 4D0.058
Apoa4apolipoprotein A-IV0.057
Psg27pregnancy-specific glycoprotein 270.057
Gm3402predicted gene 34020.056
Pipprolactin induced protein0.055
Gsdma2gasdermin A20.053
Tdo2tryptophan 2,3-dioxygenase0.053
Ceacam9carcinoembryonic antigen-related cell adhesion molecule 90.050
Cer1cerberus 1 homolog (Xenopus laevis)0.049
Cct6bchaperonin containing Tcp1, subunit 6b (zeta)0.049
Hnf4ghepatocyte nuclear factor 4, gamma0.049
Starsteroidogenic acute regulatory protein0.049
Gzmcgranzyme C0.048
Tead4TEA domain family member 40.048
NanogNanog homeobox0.048
Robo3roundabout homolog 3 (Drosophila)0.047
1600015I10RikRIKEN cDNA 1600015I10 gene0.045
Pla2g4dphospholipase A2, group IVD0.044
1700031F05RikRIKEN cDNA 1700031F05 gene0.044
Prl3d1prolactin family 3, subfamily d, member 10.044
Ceacam15carcinoembryonic antigen-related cell adhesion molecule 150.043
Csn3casein kappa0.043
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.998
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.998
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.925
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.891
PILRApaired immunoglobin-like type 2 receptor alpha0.819
SIGLEC7sialic acid binding Ig-like lectin 70.781
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.374
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.275
PTAFRplatelet-activating factor receptor0.186
HK3hexokinase 3 (white cell)0.179
CSKc-src tyrosine kinase0.067
TREM1triggering receptor expressed on myeloid cells 10.066
SIGLEC9sialic acid binding Ig-like lectin 90.051
FCN1ficolin (collagen/fibrinogen domain containing) 10.033
CCR1chemokine (C-C motif) receptor 10.029
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.028
TYMPthymidine phosphorylase0.028
NLRP3NLR family, pyrin domain containing 30.028
AOAHacyloxyacyl hydrolase (neutrophil)0.026
MARCOmacrophage receptor with collagenous structure0.026
MS4A4Amembrane-spanning 4-domains, subfamily A, member 40.025
SIRPB1signal-regulatory protein beta 10.022
AIF1allograft inflammatory factor 10.021
VSIG4V-set and immunoglobulin domain containing 40.019
FPR1formyl peptide receptor 10.019
CD300ACD300a molecule0.018
LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 50.018
BIN2bridging integrator 20.018
CD86CD86 molecule0.018
CD163CD163 molecule0.018
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.018
CD300CCD300c molecule0.017
NOD2nucleotide-binding oligomerization domain containing 20.017
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.016
FPR2formyl peptide receptor 20.016
PTPN6protein tyrosine phosphatase, non-receptor type 60.015
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.014
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.014
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.014
AQP9aquaporin 90.012
CFPcomplement factor properdin0.012
TLR8toll-like receptor 80.012
HLA-Gmajor histocompatibility complex, class I, G0.011
CR1complement component (3b/4b) receptor 1 (Knops blood group)0.011
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.011
S100A12S100 calcium binding protein A120.011
CASP5caspase 5, apoptosis-related cysteine peptidase0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism