The network for 'skeletal system morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Foxc1forkhead box C11.000
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Fgfr3fibroblast growth factor receptor 31.000
Runx2runt related transcription factor 21.000
Pax3paired box gene 31.000
Fgf8fibroblast growth factor 81.000
Rargretinoic acid receptor, gamma1.000
Hoxa1homeobox A11.000
Pitx2paired-like homeodomain transcription factor 21.000
Msx2homeobox, msh-like 21.000
Fgfr1fibroblast growth factor receptor 10.999
Tcfap2atranscription factor AP-2, alpha0.999
Hand1heart and neural crest derivatives expressed transcript 10.999
Tbx1T-box 10.999
Pax2paired box gene 20.999
Prrx1paired related homeobox 10.999
Col2a1collagen, type II, alpha 10.999
Gli2GLI-Kruppel family member GLI20.998
Eya1eyes absent 1 homolog (Drosophila)0.998
Col1a1collagen, type I, alpha 10.998
Bmp4bone morphogenetic protein 40.998
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.998
Meox2mesenchyme homeobox 20.998
Ror2receptor tyrosine kinase-like orphan receptor 20.997
Foxc2forkhead box C20.997
Dlx5distal-less homeobox 50.997
Prrx2paired related homeobox 20.997
Lhx1LIM homeobox protein 10.996
Sox9SRY-box containing gene 90.996
Otx2orthodenticle homolog 2 (Drosophila)0.996
Hoxa3homeobox A30.995
Bmp7bone morphogenetic protein 70.995
Hoxd11homeobox D110.995
Msx1homeobox, msh-like 10.993
Pkd1polycystic kidney disease 1 homolog0.993
Twist2twist homolog 2 (Drosophila)0.992
Pitx1paired-like homeodomain transcription factor 10.991
Hoxa2homeobox A20.991
Pbx1pre B-cell leukemia transcription factor 10.989
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.989
Pax9paired box gene 90.989
Fgf3fibroblast growth factor 30.989
En1engrailed 10.989
Hoxb3homeobox B30.988
Pax6paired box gene 60.988
Hoxa9homeobox A90.987
Pthlhparathyroid hormone-like peptide0.986
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.986
Ptenphosphatase and tensin homolog0.986
Hoxd13homeobox D130.985
Tgfbr2transforming growth factor, beta receptor II0.984
Tgfb2transforming growth factor, beta 20.983
Smad6MAD homolog 6 (Drosophila)0.982
Hoxb6homeobox B60.982
Pax8paired box gene 80.981
Tbx3T-box 30.979
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.979
Rarbretinoic acid receptor, beta0.978
Fbn1fibrillin 10.974
Acvr1activin A receptor, type 10.974
Alx3aristaless-like homeobox 30.972
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.972
Wt1Wilms tumor 1 homolog0.970
Fgf18fibroblast growth factor 180.969
Zic3zinc finger protein of the cerebellum 30.965
Gdf5growth differentiation factor 50.965
Gscgoosecoid homeobox0.962
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.962
Hoxd3homeobox D30.961
Twist1twist homolog 1 (Drosophila)0.960
Foxa2forkhead box A20.959
Snai1snail homolog 1 (Drosophila)0.958
RybpRING1 and YY1 binding protein0.956
Lhx3LIM homeobox protein 30.956
Ascl1achaete-scute complex homolog 1 (Drosophila)0.955
Alx4aristaless-like homeobox 40.955
Gdnfglial cell line derived neurotrophic factor0.954
Loxlysyl oxidase0.949
Rnf2ring finger protein 20.949
Wnt6wingless-related MMTV integration site 60.948
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.945
Rspo2R-spondin 2 homolog (Xenopus laevis)0.942
Isl1ISL1 transcription factor, LIM/homeodomain0.941
Foxg1forkhead box G10.937
Gata4GATA binding protein 40.935
Hoxa11homeobox A110.935
Tbx15T-box 150.931
Hoxa13homeobox A130.928
Tcf21transcription factor 210.923
Nr5a1nuclear receptor subfamily 5, group A, member 10.922
Hoxb1homeobox B10.922
Bdnfbrain derived neurotrophic factor0.910
Bnc1basonuclin 10.906
Tbx2T-box 20.906
Hoxb4homeobox B40.903
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox9aSRY-box containing gene 9a0.997
barx1BarH-like homeobox 10.986
myod1myogenic differentiation 10.968
hoxb3ahomeo box B3a0.951
foxd3forkhead box D30.946
foxi1forkhead box I10.936
jag1bjagged 1b0.932
bmp2bbone morphogenetic protein 2b0.898
gata3GATA-binding protein 30.883
bmp2abone morphogenetic protein 2a0.853
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.853
raraaretinoic acid receptor, alpha a0.837
pax8paired box gene 80.832
brpf1bromodomain and PHD finger containing, 10.828
tp63tumor protein p630.807
prdm1aPR domain containing 1a, with ZNF domain0.801
wnt5bwingless-type MMTV integration site family, member 5b0.790
bmp4bone morphogenetic protein 40.781
dlx3bdistal-less homeobox gene 3b0.773
ptch2patched 20.760
fras1Fraser syndrome 10.747
pitx3paired-like homeodomain transcription factor 30.743
foxa2forkhead box A20.724
bocbrother of CDO0.723
col2a1acollagen type II, alpha-1a0.706
col5a1procollagen, type V, alpha 10.700
ptch1patched 10.700
hoxd4ahomeo box D4a0.660
shhasonic hedgehog a0.653
pax2apaired box gene 2a0.631
hoxb5bhomeo box B5b0.618
hoxa2bhomeo box A2b0.615
mab21l2mab-21-like 20.613
dlx5adistal-less homeobox gene 5a0.607
pax6apaired box gene 6a0.582
egr2bearly growth response 2b0.581
hoxa4ahomeo box A4a0.580
myf5myogenic factor 50.564
pthlhparathyroid hormone-like hormone0.552
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.550
wnt11rwingless-type MMTV integration site family, member 11, related0.536
dlx2adistal-less homeobox gene 2a0.531
cmybtranscription factor cmyb0.529
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.517
hapln1ahyaluronan and proteoglycan link protein 1a0.511
sulf1sulfatase 10.511
gria3bglutamate receptor, ionotrophic, AMPA 3b0.499
snai1asnail homolog 1a (Drosophila)0.499
hoxd10ahomeo box D10a0.499
gli2aGLI-Kruppel family member GLI2a0.495
tnfrsfatumor necrosis factor receptor superfamily, member a0.493
dlx4adistal-less homeobox gene 4a0.491
brd4bromodomain containing 40.491
sox32SRY-box containing gene 320.482
tbx1T-box 10.479
rarabretinoic acid receptor, alpha b0.476
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.468
frem2aFras1 related extracellular matrix protein 2a0.464
grem2gremlin 2, cysteine knot superfamily0.464
runx3runt-related transcription factor 30.463
disp1dispatched homolog 1 (Drosophila)0.456
msxcmuscle segment homeobox C0.454
hoxb4ahomeo box B4a0.447
dag1dystroglycan 10.440
acvr1lactivin A receptor, type I like0.429
efnb2aephrin B2a0.413
wnt11wingless-type MMTV integration site family, member 110.409
gpr126G protein-coupled receptor 1260.405
lhx5LIM homeobox 50.389
prrx1apaired related homeobox 1a0.383
rargbretinoic acid receptor, gamma b0.382
gata4GATA-binding protein 40.375
fbn2bfibrillin 2b0.373
foxn4forkhead box N40.373
kdrlkinase insert domain receptor like0.371
six4bsine oculis homeobox homolog 4b0.371
hoxa9bhomeo box A9b0.368
smad1MAD homolog 1 (Drosophila)0.367
hoxa3ahomeo box A3a0.365
fgfr2fibroblast growth factor receptor 20.364
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.357
eya1eyes absent homolog 10.356
prdm5PR domain containing 50.355
gata2aGATA-binding protein 2a0.352
msxdmuscle segment homeobox D0.350
fgf20bfibroblast growth factor 20b0.348
lect1leukocyte cell derived chemotaxin 10.336
tbx5aT-box 5a0.334
pax9paired box gene 90.334
crabp2acellular retinoic acid binding protein 2, a0.333
runx2brunt-related transcription factor 2b0.333
gria4aglutamate receptor, ionotropic, AMPA 4a0.332
edn1endothelin 10.330
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
COL1A1collagen, type I, alpha 10.961
HOXB5homeobox B50.951
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.934
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.911
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.882
PAX3paired box 30.797
TGFB1transforming growth factor, beta 10.787
NCOR1nuclear receptor corepressor 10.592
EP300E1A binding protein p3000.568
HOXA5homeobox A50.511
COL2A1collagen, type II, alpha 10.511
CREBBPCREB binding protein0.465
DDR2discoidin domain receptor tyrosine kinase 20.463
MMS22LMMS22-like, DNA repair protein0.461
HOXA10homeobox A100.457
FGF1fibroblast growth factor 1 (acidic)0.451
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.438
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.407
SMAD4SMAD family member 40.381
POU3F2POU class 3 homeobox 20.356
FGFR2fibroblast growth factor receptor 20.335
HOXB6homeobox B60.316
PBX1pre-B-cell leukemia homeobox 10.250
USP11ubiquitin specific peptidase 110.248
NOTCH3notch 30.243
MMP14matrix metallopeptidase 14 (membrane-inserted)0.232
FOXF2forkhead box F20.231
MSX1msh homeobox 10.218
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.216
LOXlysyl oxidase0.215
RUNX1runt-related transcription factor 10.213
NOTCH1notch 10.213
COL6A1collagen, type VI, alpha 10.203
HOXA4homeobox A40.193
HOXD9homeobox D90.189
COL1A2collagen, type I, alpha 20.186
BMP7bone morphogenetic protein 70.185
HOXC8homeobox C80.178
MEF2Amyocyte enhancer factor 2A0.175
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.166
SHC1SHC (Src homology 2 domain containing) transforming protein 10.165
SMAD3SMAD family member 30.158
TBX2T-box 20.154
SH3BP4SH3-domain binding protein 40.153
WWP2WW domain containing E3 ubiquitin protein ligase 20.151
POU5F1POU class 5 homeobox 10.150
HOXB3homeobox B30.150
HOXB13homeobox B130.149
HOXB9homeobox B90.148
MDFIMyoD family inhibitor0.141
IGFBP5insulin-like growth factor binding protein 50.140
SMAD7SMAD family member 70.133
TP53tumor protein p530.133
FBLN2fibulin 20.126
COL3A1collagen, type III, alpha 10.126
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.125
COL5A1collagen, type V, alpha 10.119
SOX2SRY (sex determining region Y)-box 20.119
RARAretinoic acid receptor, alpha0.117
PRRX2paired related homeobox 20.117
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.116
FOXC1forkhead box C10.115
TWIST1twist homolog 1 (Drosophila)0.112
PTHLHparathyroid hormone-like hormone0.112
NTRK1neurotrophic tyrosine kinase, receptor, type 10.111
FGF3fibroblast growth factor 30.111
LBX1ladybird homeobox 10.110
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.110
GATA4GATA binding protein 40.109
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.109
HOXA3homeobox A30.109
BMP4bone morphogenetic protein 40.106
HOXC11homeobox C110.104
WISP1WNT1 inducible signaling pathway protein 10.103
HMGA2high mobility group AT-hook 20.103
ADAM12ADAM metallopeptidase domain 120.102
EGR2early growth response 20.100
TAL1T-cell acute lymphocytic leukemia 10.099
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.097
JAG1jagged 10.095
ANGPT1angiopoietin 10.092
COL11A1collagen, type XI, alpha 10.091
MEOX2mesenchyme homeobox 20.091
FGF7fibroblast growth factor 70.090
FOXF1forkhead box F10.089
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.088
FSTL1follistatin-like 10.087
RNF31ring finger protein 310.086
FBLN1fibulin 10.086
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.083
GATA2GATA binding protein 20.083
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.081
HOXD11homeobox D110.081
WNT2wingless-type MMTV integration site family member 20.080
FGF18fibroblast growth factor 180.079
PTENphosphatase and tensin homolog0.078
SOX11SRY (sex determining region Y)-box 110.078
OTPorthopedia homeobox0.078
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.934
Col3a1collagen, type III, alpha 10.919
Col12a1collagen, type XII, alpha 10.808
Loxlysyl oxidase0.474
Lamc1laminin, gamma 10.286
Col1a2collagen, type I, alpha 20.282
Pcolceprocollagen C-endopeptidase enhancer0.261
Col5a1collagen, type V, alpha 10.229
Ptpn14protein tyrosine phosphatase, non-receptor type 140.187
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.144
Aebp1AE binding protein 10.115
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.107
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.104
Col5a2collagen, type V, alpha 20.087
Loxl1lysyl oxidase-like 10.079
Fn1fibronectin 10.071
Postnperiostin, osteoblast specific factor0.062
Fgfr2fibroblast growth factor receptor 20.052
Prrx1paired related homeobox 10.045
Lef1lymphoid enhancer binding factor 10.042
Col15a1collagen, type XV, alpha 10.041
Shox2short stature homeobox 20.041
Slit3slit homolog 3 (Drosophila)0.039
Tcfe2atranscription factor E2a0.038
TekTEK tyrosine kinase, endothelial0.036
Col4a1collagen, type IV, alpha 10.036
Tgfbr2transforming growth factor, beta receptor II0.030
Igfbp5insulin-like growth factor binding protein 50.030
Tnctenascin C0.029
Hoxa1homeo box A10.029
Myh9myosin, heavy chain 9, non-muscle0.028
Mmp2matrix metallopeptidase 20.028
Lect1leukocyte cell derived chemotaxin 10.028
Enpepglutamyl aminopeptidase0.028
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.025
Dab2disabled homolog 2 (Drosophila)0.024
Scarf2scavenger receptor class F, member 20.024
Fbn1fibrillin 10.023
Socs3suppressor of cytokine signaling 30.023
Fstl1follistatin-like 10.023
Ece1endothelin converting enzyme 10.023
Col6a2collagen, type VI, alpha 20.023
Efna5ephrin A50.023
Angpt2angiopoietin 20.023
Fkbp10FK506 binding protein 100.022
Col11a2collagen, type XI, alpha 20.021
Ptbp1polypyrimidine tract binding protein 10.019
Prrx2paired related homeobox 20.019
Sod3superoxide dismutase 3, extracellular0.019
Bmp6bone morphogenetic protein 60.018
Col14a1collagen, type XIV, alpha 10.017
Galr1galanin receptor 10.017
Mybpc2myosin binding protein C, fast-type0.017
Gprc5cG protein-coupled receptor, family C, group 5, member C0.017
Pecam1platelet/endothelial cell adhesion molecule 10.016
Hoxc4homeo box C40.016
Znf503zinc finger protein 5030.016
Msx2msh homeobox 20.015
Psen1presenilin 10.015
S1pr2sphingosine-1-phosphate receptor 20.015
Cercamcerebral endothelial cell adhesion molecule0.015
Col4a2collagen, type IV, alpha 20.015
Srpxsushi-repeat-containing protein, X-linked0.015
Tgfb2transforming growth factor, beta 20.015
Nfyanuclear transcription factor-Y alpha0.014
Hoxd9homeo box D90.014
Hoxb7homeo box B70.014
Nr5a1nuclear receptor subfamily 5, group A, member 10.014
Ltbp4latent transforming growth factor beta binding protein 40.014
Egr2early growth response 20.014
Flt1FMS-related tyrosine kinase 10.014
Baiap2BAI1-associated protein 20.014
Agtr1aangiotensin II receptor, type 1a0.014
Hapln1hyaluronan and proteoglycan link protein 10.013
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.013
Pcsk1proprotein convertase subtilisin/kexin type 10.013
Cyyr1cysteine/tyrosine-rich 10.013
Hoxa5homeo box A50.012
Nup153nucleoporin 1530.012
Ageradvanced glycosylation end product-specific receptor0.012
Pear1platelet endothelial aggregation receptor 10.012
Dnah8dynein, axonemal, heavy chain 80.012
Trhrthyrotropin releasing hormone receptor0.012
Notch1Notch homolog 1, translocation-associated (Drosophila)0.011
RestRE1-silencing transcription factor0.011
Foxd3forkhead box D30.011
Gdf11growth differentiation factor 110.011
Prl8a2prolactin family 8, subfamily a, member 20.011
Grip1glutamate receptor interacting protein 10.011
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.011
Notch3Notch homolog 3 (Drosophila)0.011
Snai2snail homolog 2 (Drosophila)0.011
Bmp1bone morphogenetic protein 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism