The network for 'integrin mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

integrin mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
Itgb1integrin beta 1 (fibronectin receptor beta)0.967
Rag1recombination activating gene 10.939
Ptprcprotein tyrosine phosphatase, receptor type, C0.930
Ilkintegrin linked kinase0.888
Ptk2PTK2 protein tyrosine kinase 20.876
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.840
Cd247CD247 antigen0.836
Ikzf1IKAROS family zinc finger 10.750
Vav1vav 1 oncogene0.723
Itga3integrin alpha 30.710
Pxnpaxillin0.616
FynFyn proto-oncogene0.586
Rag2recombination activating gene 20.556
CblCasitas B-lineage lymphoma0.553
Csf1rcolony stimulating factor 1 receptor0.533
Grb2growth factor receptor bound protein 20.490
SrcRous sarcoma oncogene0.473
Parvaparvin, alpha0.408
Vclvinculin0.403
Nos2nitric oxide synthase 2, inducible0.398
Hcsthematopoietic cell signal transducer0.393
Il2rginterleukin 2 receptor, gamma chain0.361
Ncf1neutrophil cytosolic factor 10.351
Ctnnb1catenin (cadherin associated protein), beta 10.306
Csf1colony stimulating factor 1 (macrophage)0.279
Cd19CD19 antigen0.265
Cd151CD151 antigen0.252
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.247
Lyz2lysozyme 20.230
Lcklymphocyte protein tyrosine kinase0.216
Bcar1breast cancer anti-estrogen resistance 10.202
Inpp5dinositol polyphosphate-5-phosphatase D0.193
Amotl2angiomotin-like 20.188
Hcls1hematopoietic cell specific Lyn substrate 10.179
Lcp2lymphocyte cytosolic protein 20.175
Ptpn11protein tyrosine phosphatase, non-receptor type 110.175
Cyr61cysteine rich protein 610.160
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.158
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.155
Col1a1collagen, type I, alpha 10.152
FasFas (TNF receptor superfamily member 6)0.145
TcraT-cell receptor alpha chain0.144
Rhocras homolog gene family, member C0.143
WasWiskott-Aldrich syndrome homolog (human)0.139
Vegfavascular endothelial growth factor A0.135
Grap2GRB2-related adaptor protein 20.132
FybFYN binding protein0.131
Taglntransgelin0.130
Laptm5lysosomal-associated protein transmembrane 50.129
Tln1talin 10.129
Wwtr1WW domain containing transcription regulator 10.128
AxlAXL receptor tyrosine kinase0.117
Leprleptin receptor0.114
Egr2early growth response 20.104
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.103
Tgfb1transforming growth factor, beta 10.101
Platplasminogen activator, tissue0.095
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.094
Nf1neurofibromatosis 10.094
Latlinker for activation of T cells0.094
Fkbp9FK506 binding protein 90.093
ItkIL2-inducible T-cell kinase0.091
Phldb2pleckstrin homology-like domain, family B, member 20.090
Clec4nC-type lectin domain family 4, member n0.083
Bgnbiglycan0.078
Bmpr1abone morphogenetic protein receptor, type 1A0.074
Fn1fibronectin 10.073
Flnafilamin, alpha0.073
Plcg2phospholipase C, gamma 20.072
Ifngr1interferon gamma receptor 10.071
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.069
Cd3eCD3 antigen, epsilon polypeptide0.068
Alox5aparachidonate 5-lipoxygenase activating protein0.067
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.065
Ptplad2protein tyrosine phosphatase-like A domain containing 20.064
Mrc1mannose receptor, C type 10.063
Chst14carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 140.063
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.063
Vav2vav 2 oncogene0.061
Col4a5collagen, type IV, alpha 50.061
Cd68CD68 antigen0.060
Fcgr2bFc receptor, IgG, low affinity IIb0.060
Apoeapolipoprotein E0.060
Enahenabled homolog (Drosophila)0.060
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.059
Vimvimentin0.059
Zap70zeta-chain (TCR) associated protein kinase0.059
Gab1growth factor receptor bound protein 2-associated protein 10.059
Wipf1WAS/WASL interacting protein family, member 10.057
Fermt2fermitin family homolog 2 (Drosophila)0.057
Cd22CD22 antigen0.057
Plcg1phospholipase C, gamma 10.054
Lama5laminin, alpha 50.053
Igf1insulin-like growth factor 10.052
Metmet proto-oncogene0.050
Hif1ahypoxia inducible factor 1, alpha subunit0.049
Ptgs2prostaglandin-endoperoxide synthase 20.049
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.049
Nab2Ngfi-A binding protein 20.048
Ctgfconnective tissue growth factor0.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-112Protein UNC-1120.572
C44C1.1Protein C44C1.10.284
unc-68Protein UNC-680.184
pat-4Protein PAT-40.130
unc-97Protein UNC-970.128
pat-6Protein PAT-60.125
unc-120Protein UNC-1200.108
sup-12Protein SUP-120.060
K03B8.6Protein K03B8.60.054
unc-95Protein UNC-950.053
pat-2Protein PAT-20.046
lgc-34Protein LGC-340.039
ttr-6Protein TTR-60.030
B0303.2Protein B0303.20.028
nos-3Protein NOS-30.027
lam-2Protein LAM-20.024
somi-1Protein SOMI-10.022
ina-1Protein INA-10.020
CELE_M04F3.5Protein M04F3.50.020
meg-2Protein MEG-20.020
pat-3Protein PAT-30.020
twk-18Protein TWK-180.019
wrk-1Protein WRK-10.018
hsf-1Protein HSF-10.018
F36A2.3Protein F36A2.30.018
gpb-2Protein GPB-20.017
CELE_B0238.10Protein B0238.100.017
let-268Protein LET-2680.017
W03G11.3Protein W03G11.30.017
sur-2Protein SUR-20.016
klp-3Protein KLP-30.016
CELE_M05D6.5Protein M05D6.50.016
unc-18Protein UNC-180.015
C18A3.4Protein C18A3.40.015
unc-1Protein UNC-10.014
let-60Protein LET-600.014
klp-7Protein KLP-70.014
pssy-1Protein PSSY-10.014
stn-2Protein STN-20.013
B0395.3Protein B0395.30.013
car-1Protein CAR-10.013
pqe-1Protein PQE-10.012
T05G5.1Protein T05G5.10.012
fzr-1Protein FZR-10.012
ost-1Protein OST-10.012
C46C11.3Protein C46C11.30.012
bath-40Protein BATH-400.011
ZK899.2Protein ZK899.20.011
T22D1.11Protein T22D1.110.011
lip-1Protein LIP-10.011
ptp-3Protein PTP-30.011
tsp-11Protein TSP-110.011
tag-163Protein TAG-1630.011
rsu-1Protein RSU-10.010
CELE_T04H1.2Protein T04H1.20.010
Y45G5AM.6Protein Y45G5AM.60.010
lbp-3Protein LBP-30.010
fln-2Protein FLN-20.010
cas-1Protein CAS-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
stcksteamer duck0.803
ifinflated0.595
wunwunen0.193
porporcupine0.118
LamCLamin C0.105
sglsugarless0.090
ShcSHC-adaptor protein0.085
Arp66BActin-related protein 66B0.080
mysmyospheroid0.065
lqfliquid facets0.062
zfh1Zn finger homeodomain 10.060
htlheartless0.055
inscinscuteable0.054
bazbazooka0.050
molmoladietz0.050
pcxpecanex0.048
diadiaphanous0.038
Mo25CG4083 gene product from transcript CG4083-RA0.035
IlkIntegrin linked kinase0.034
betaInt-nubeta[nu] integrin0.033
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.033
Vrp1Verprolin 10.032
pgant3polypeptide GalNAc transferase 30.031
NT1Neurotrophin 10.029
CG11299CG11299 gene product from transcript CG11299-RA0.026
Hip14Huntingtin-interacting protein 140.025
cnkconnector enhancer of ksr0.024
PaxPaxillin0.023
drkdownstream of receptor kinase0.022
HemHEM-protein0.022
RhoGAP15BCG4937 gene product from transcript CG4937-RC0.022
pfkpiefke0.021
CG32528CG32528 gene product from transcript CG32528-RA0.021
MicalMolecule interacting with CasL0.021
Sema-1aCG18405 gene product from transcript CG18405-RD0.021
dosdaughter of sevenless0.020
Rac2CG8556 gene product from transcript CG8556-RA0.019
SH3PX1CG6757 gene product from transcript CG6757-RA0.018
c11.1CG12132 gene product from transcript CG12132-RA0.018
CG14782CG14782 gene product from transcript CG14782-RA0.018
CG1572CG1572 gene product from transcript CG1572-RA0.018
cdicenter divider0.018
vps2CG14542 gene product from transcript CG14542-RA0.018
fufused0.017
CG8709CG8709 gene product from transcript CG8709-RK0.017
cgcombgap0.017
DabDisabled0.016
RhoLrho-like0.016
PgkPhosphoglycerate kinase0.016
cnocanoe0.016
SmoxSmad on X0.015
Flo-2flotillin 20.015
Mmp1Matrix metalloproteinase 10.015
icsicarus0.015
SaraSmad anchor for receptor activation0.015
CG30159CG30159 gene product from transcript CG30159-RC0.015
eveeven skipped0.014
CG10103CG10103 gene product from transcript CG10103-RA0.014
shnschnurri0.014
CG10627CG10627 gene product from transcript CG10627-RA0.014
srasarah0.013
MarfMitochondrial assembly regulatory factor0.013
VincVinculin0.013
bunbunched0.013
bynbrachyenteron0.012
CG6194CG6194 gene product from transcript CG6194-RA0.012
AnnIXAnnexin IX0.012
comtcomatose0.012
blowblown fuse0.012
par-1CG8201 gene product from transcript CG8201-RA0.012
Gap1GTPase-activating protein 10.012
spzspatzle0.012
rostrolling stone0.012
kstkarst0.012
eglegalitarian0.012
drongoCG3365 gene product from transcript CG3365-RH0.012
Rab7Rab-protein 70.011
Dap160Dynamin associated protein 1600.011
PyKPyruvate kinase0.011
spictspichthyin0.011
frcfringe connection0.011
Myo31DFMyosin 31DF0.011
ImpL3Ecdysone-inducible gene L30.011
flrflare0.011
Fak56DFocal Adhesion Kinase0.010
ptipCG32133 gene product from transcript CG32133-RA0.010
mthmethuselah0.010
gekgenghis khan0.010
slowslowdown0.010
CG6191CG6191 gene product from transcript CG6191-RA0.010
Hr46Hormone receptor-like in 460.010
fngfringe0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FN1fibronectin 11.000
FLNAfilamin A, alpha0.998
FYNFYN oncogene related to SRC, FGR, YES0.996
FHL2four and a half LIM domains 20.985
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.980
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.978
NME2non-metastatic cells 2, protein (NM23B) expressed in0.976
LCKlymphocyte-specific protein tyrosine kinase0.964
HCKhemopoietic cell kinase0.875
TLN1talin 10.870
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.857
CD63CD63 molecule0.817
VCLvinculin0.809
PXNpaxillin0.801
COL1A1collagen, type I, alpha 10.776
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.742
COL4A1collagen, type IV, alpha 10.715
LGALS1lectin, galactoside-binding, soluble, 10.709
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.700
COL1A2collagen, type I, alpha 20.676
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.657
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.653
PTK2PTK2 protein tyrosine kinase 20.649
THBS1thrombospondin 10.614
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.571
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.539
FLNBfilamin B, beta0.533
ILKintegrin-linked kinase0.528
PDIA3protein disulfide isomerase family A, member 30.519
COL3A1collagen, type III, alpha 10.491
MMP14matrix metallopeptidase 14 (membrane-inserted)0.476
SYKspleen tyrosine kinase0.417
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.409
GRB2growth factor receptor-bound protein 20.407
BCAR1breast cancer anti-estrogen resistance 10.403
IGFBP3insulin-like growth factor binding protein 30.372
BLNKB-cell linker0.361
COL5A2collagen, type V, alpha 20.351
SHC1SHC (Src homology 2 domain containing) transforming protein 10.351
EGFRepidermal growth factor receptor0.323
SPRR2Asmall proline-rich protein 2A0.320
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.317
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.303
ITGB4integrin, beta 40.299
DDR2discoidin domain receptor tyrosine kinase 20.290
ABI2abl-interactor 20.262
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.256
ACTN1actinin, alpha 10.248
TIMP1TIMP metallopeptidase inhibitor 10.237
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.233
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.227
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.222
PLECplectin0.205
DLG1discs, large homolog 1 (Drosophila)0.200
COL4A2collagen, type IV, alpha 20.194
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.193
LAMC1laminin, gamma 1 (formerly LAMB2)0.181
VAV1vav 1 guanine nucleotide exchange factor0.179
GAB1GRB2-associated binding protein 10.176
PTPRCprotein tyrosine phosphatase, receptor type, C0.173
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.172
PTPN1protein tyrosine phosphatase, non-receptor type 10.163
SNX33sorting nexin 330.156
ZNF746zinc finger protein 7460.154
VCAM1vascular cell adhesion molecule 10.141
SNX9sorting nexin 90.136
HPhaptoglobin0.135
FYBFYN binding protein0.131
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.125
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.123
HSPG2heparan sulfate proteoglycan 20.122
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.122
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.112
FBN1fibrillin 10.112
PARVAparvin, alpha0.103
COL6A1collagen, type VI, alpha 10.101
NME1non-metastatic cells 1, protein (NM23A) expressed in0.101
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.097
ANXA5annexin A50.092
COL6A2collagen, type VI, alpha 20.091
PLCG1phospholipase C, gamma 10.091
ALBalbumin0.090
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.088
PDLIM5PDZ and LIM domain 50.088
TCF4transcription factor 40.085
TGFBItransforming growth factor, beta-induced, 68kDa0.082
ENGendoglin0.082
ITGA6integrin, alpha 60.082
ITGB5integrin, beta 50.079
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.072
LAMB1laminin, beta 10.072
APOC1apolipoprotein C-I0.069
MED28mediator complex subunit 280.068
UBASH3Bubiquitin associated and SH3 domain containing B0.064
PTNpleiotrophin0.064
PTPN6protein tyrosine phosphatase, non-receptor type 60.063
TNS3tensin 30.061
CALD1caldesmon 10.060
FERMT2fermitin family member 20.060
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Bgnbiglycan0.148
Vimvimentin0.091
Fn1fibronectin 10.054
Col1a2collagen, type I, alpha 20.052
Nme1non-metastatic cells 1, protein (NM23A) expressed in0.035
Col5a2collagen, type V, alpha 20.034
Capn2calpain 20.031
Mgpmatrix Gla protein0.025
Loxlysyl oxidase0.023
Ptafrplatelet-activating factor receptor0.022
Anxa5annexin A50.020
Platplasminogen activator, tissue0.020
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.018
Calucalumenin0.018
Lrrc33leucine rich repeat containing 330.014
Vaspvasodilator-stimulated phosphoprotein0.010
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism