The network for 'translesion synthesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

translesion synthesis

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Timelesstimeless homolog (Drosophila)0.764
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.727
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.693
Brca1breast cancer 10.549
Nsfl1cNSFL1 (p97) cofactor (p47)0.444
Cdt1chromatin licensing and DNA replication factor 10.428
Ccna2cyclin A20.413
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.399
Polhpolymerase (DNA directed), eta (RAD 30 related)0.370
Brca2breast cancer 20.354
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.354
Cdk1cyclin-dependent kinase 10.345
Wdhd1WD repeat and HMG-box DNA binding protein 10.305
Lig1ligase I, DNA, ATP-dependent0.293
Ncaphnon-SMC condensin I complex, subunit H0.287
Polipolymerase (DNA directed), iota0.286
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.265
Cdca5cell division cycle associated 50.253
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.244
TtkTtk protein kinase0.218
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.218
Chek1checkpoint kinase 1 homolog (S. pombe)0.212
Ccnb1cyclin B10.199
Mki67antigen identified by monoclonal antibody Ki 670.178
Ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.178
Polkpolymerase (DNA directed), kappa0.174
Rad51RAD51 homolog (S. cerevisiae)0.162
Eif4a2eukaryotic translation initiation factor 4A20.146
Kif11kinesin family member 110.132
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.124
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.124
Rad51ap1RAD51 associated protein 10.121
Clk4CDC like kinase 40.118
Ufd1lubiquitin fusion degradation 1 like0.116
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.109
Aurkbaurora kinase B0.108
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.106
Paip2polyadenylate-binding protein-interacting protein 20.105
Trip13thyroid hormone receptor interactor 130.104
Prim1DNA primase, p49 subunit0.102
Hdac6histone deacetylase 60.098
Prc1protein regulator of cytokinesis 10.097
Birc5baculoviral IAP repeat-containing 50.097
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.095
Tk1thymidine kinase 10.095
Dna2DNA replication helicase 2 homolog (yeast)0.093
Rrm2ribonucleotide reductase M20.092
Smc2structural maintenance of chromosomes 20.087
Ptmaprothymosin alpha0.084
Hprthypoxanthine guanine phosphoribosyl transferase0.083
Tacc3transforming, acidic coiled-coil containing protein 30.083
Ranbp1RAN binding protein 10.077
Ckap2cytoskeleton associated protein 20.073
Top2atopoisomerase (DNA) II alpha0.070
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.068
Cdc7cell division cycle 7 (S. cerevisiae)0.068
Ect2ect2 oncogene0.067
Kif4kinesin family member 40.066
Ercc6lexcision repair cross-complementing rodent repair deficiency complementation group 6 - like0.065
Parp2poly (ADP-ribose) polymerase family, member 20.064
Hellshelicase, lymphoid specific0.064
Rfc3replication factor C (activator 1) 30.064
Cdca8cell division cycle associated 80.063
E2f8E2F transcription factor 80.063
Orc1origin recognition complex, subunit 10.063
Cenpkcentromere protein K0.061
Tia1cytotoxic granule-associated RNA binding protein 10.059
Rev1REV1 homolog (S. cerevisiae)0.059
Cdca7lcell division cycle associated 7 like0.058
Plk4polo-like kinase 4 (Drosophila)0.058
Kif23kinesin family member 230.056
StilScl/Tal1 interrupting locus0.056
Rrm1ribonucleotide reductase M10.054
Ncapd2non-SMC condensin I complex, subunit D20.052
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.050
Fam103a1family with sequence similarity 103, member A10.050
Wee1WEE 1 homolog 1 (S. pombe)0.049
Cenphcentromere protein H0.049
Mms22lMMS22-like, DNA repair protein0.048
Plk1polo-like kinase 1 (Drosophila)0.048
Racgap1Rac GTPase-activating protein 10.047
Ube2tubiquitin-conjugating enzyme E2T (putative)0.047
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.045
Hmmrhyaluronan mediated motility receptor (RHAMM)0.044
Fbxo5F-box protein 50.044
Melkmaternal embryonic leucine zipper kinase0.042
BlmBloom syndrome, RecQ helicase-like0.042
Cdk2cyclin-dependent kinase 20.041
Psma4proteasome (prosome, macropain) subunit, alpha type 40.040
Slbpstem-loop binding protein0.040
Kntc1kinetochore associated 10.039
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.039
Clk1CDC-like kinase 10.037
Hat1histone aminotransferase 10.037
H2afzH2A histone family, member Z0.037
Tipintimeless interacting protein0.036
Zfand6zinc finger, AN1-type domain 60.036
Cdca7cell division cycle associated 70.034
Mis18bp1MIS18 binding protein 10.034
Ccnb2cyclin B20.034
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus101mutagen-sensitive 1010.819
rad50CG6339 gene product from transcript CG6339-RD0.658
mus205mutagen-sensitive 2050.645
mus308mutagen-sensitive 3080.606
RecQ5homolog of RecQ0.555
CG5524CG5524 gene product from transcript CG5524-RA0.494
DNApol-etaCG7143 gene product from transcript CG7143-RA0.484
lokloki0.411
Mcm3Minichromosome maintenance 30.374
nbsCG6754 gene product from transcript CG6754-RC0.220
Brca2Breast cancer 2, early onset homolog0.162
mus209mutagen-sensitive 2090.117
miminus0.100
hayhaywire0.094
mus210mutagen-sensitive 2100.093
mus201mutagen-sensitive 2010.078
mus309mutagen-sensitive 3090.072
spn-Aspindle A0.068
Smc5CG32438 gene product from transcript CG32438-RE0.061
Spc105RSpc105-related0.056
RecQ4CG7487 gene product from transcript CG7487-RA0.055
RnrLRibonucleoside diphosphate reductase large subunit0.050
mei-9meiotic 90.049
dmtdalmatian0.040
CG5290CG5290 gene product from transcript CG5290-RA0.036
dpadisc proliferation abnormal0.031
mre11meiotic recombination 110.029
mus304mutagen-sensitive 3040.028
ncdnon-claret disjunctional0.027
CDC45LCG3658 gene product from transcript CG3658-RA0.026
IrbpInverted repeat-binding protein0.024
CG5931CG5931 gene product from transcript CG5931-RA0.020
wdswill die slowly0.020
Chrac-14CG13399 gene product from transcript CG13399-RA0.019
Lig4Ligase40.016
Ercc1CG10215 gene product from transcript CG10215-RA0.015
l(1)G0095lethal (1) G00950.015
CG3065CG3065 gene product from transcript CG3065-RA0.015
lidlittle imaginal discs0.015
Rev1CG12189 gene product from transcript CG12189-RA0.014
Orc2Origin recognition complex subunit 20.014
CG9576CG9576 gene product from transcript CG9576-RA0.014
Cap-GCG34438 gene product from transcript CG34438-RF0.014
okrokra0.013
spn-Bspindle B0.013
stwlstonewall0.013
su(Hw)suppressor of Hairy wing0.013
CG12155CG12155 gene product from transcript CG12155-RA0.012
Mes2CG11100 gene product from transcript CG11100-RB0.012
Orc5Origin recognition complex subunit 50.012
CG10809CG10809 gene product from transcript CG10809-RA0.012
phrphotorepair0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAD18RAD18 homolog (S. cerevisiae)0.996
PCNAproliferating cell nuclear antigen0.992
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.895
POLHpolymerase (DNA directed), eta0.888
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.689
MSH6mutS homolog 6 (E. coli)0.575
RFC2replication factor C (activator 1) 2, 40kDa0.545
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.335
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.296
RFC3replication factor C (activator 1) 3, 38kDa0.272
FANCD2Fanconi anemia, complementation group D20.224
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.155
REV3LREV3-like, catalytic subunit of DNA polymerase zeta (yeast)0.153
ING2inhibitor of growth family, member 20.145
REV1REV1 homolog (S. cerevisiae)0.136
DTLdenticleless homolog (Drosophila)0.112
RPA2replication protein A2, 32kDa0.110
POLIpolymerase (DNA directed) iota0.108
ALDOAaldolase A, fructose-bisphosphate0.106
RFC1replication factor C (activator 1) 1, 145kDa0.103
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.100
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.099
POLEpolymerase (DNA directed), epsilon0.085
RPA3replication protein A3, 14kDa0.077
RPA1replication protein A1, 70kDa0.053
PGK1phosphoglycerate kinase 10.052
CHRAC1chromatin accessibility complex 10.048
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)0.044
POLKpolymerase (DNA directed) kappa0.043
CDT1chromatin licensing and DNA replication factor 10.040
DZIP3DAZ interacting protein 3, zinc finger0.037
PGAM1phosphoglycerate mutase 1 (brain)0.036
EXO1exonuclease 10.036
UBR1ubiquitin protein ligase E3 component n-recognin 10.034
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.032
CTDP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 10.031
UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.029
SUPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)0.028
PPIApeptidylprolyl isomerase A (cyclophilin A)0.028
BRCA1breast cancer 1, early onset0.027
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.027
FEN1flap structure-specific endonuclease 10.026
GMNNgeminin, DNA replication inhibitor0.018
FANCLFanconi anemia, complementation group L0.017
SIVA1SIVA1, apoptosis-inducing factor0.016
ZNF302zinc finger protein 3020.016
MSH3mutS homolog 3 (E. coli)0.014
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.013
MCM3minichromosome maintenance complex component 30.013
RBBP8retinoblastoma binding protein 80.012
FANCIFanconi anemia, complementation group I0.012
LIG1ligase I, DNA, ATP-dependent0.011
POLE4polymerase (DNA-directed), epsilon 4 (p12 subunit)0.011
RFC4replication factor C (activator 1) 4, 37kDa0.011
PRPS1phosphoribosyl pyrophosphate synthetase 10.011
CHEK1CHK1 checkpoint homolog (S. pombe)0.011
RAD1RAD1 homolog (S. pombe)0.011
FANCAFanconi anemia, complementation group A0.010
ENO1enolase 1, (alpha)0.010
BLMBloom syndrome, RecQ helicase-like0.010
RFC5replication factor C (activator 1) 5, 36.5kDa0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
REV1Rev1p0.862
RAD5Rad5p0.757
REV7Rev7p0.744
REV3Rev3p0.262
RAD9Rad9p0.171
POL2Pol2p0.167
POL32Pol32p0.159
DPB2Dpb2p0.103
RFC2Rfc2p0.102
RAD24Rad24p0.101
RAD30Rad30p0.096
POL3Pol3p0.083
PIF1Pif1p0.074
MGS1Mgs1p0.068
PSF1Psf1p0.059
POL12Pol12p0.057
POL30Pol30p0.057
RAD17Rad17p0.055
RNH201Rnh201p0.053
SHU1Shu1p0.051
PMS1Pms1p0.045
RNH203Rnh203p0.043
RAD57Rad57p0.043
SRD1Srd1p0.037
UBC13Ubc13p0.036
DLS1Dls1p0.036
RFC4Rfc4p0.035
SMC6Smc6p0.032
YLR264C-Ahypothetical protein0.032
MSH3Msh3p0.032
LEU2Leu2p0.030
CUP1-1Cup1-1p0.030
APN1Apn1p0.030
CRP1Crp1p0.030
URA3Ura3p0.029
MER1Mer1p0.029
YOL038C-Ahypothetical protein0.028
CDC9Cdc9p0.028
HXT3Hxt3p0.028
MSH6Msh6p0.028
YLR162Whypothetical protein0.028
YNL155Whypothetical protein0.026
ARG8Arg8p0.024
EST2Est2p0.024
RAD18Rad18p0.024
ARP10Arp10p0.023
YLR126Chypothetical protein0.023
WSS1Wss1p0.023
TIP1Tip1p0.023
RLF2Rlf2p0.023
MPT5Mpt5p0.023
HOHop0.023
YLR042Chypothetical protein0.022
ATP6Atp6p0.022
RAD55Rad55p0.022
YPR157Whypothetical protein0.022
YAR068Whypothetical protein0.022
YPL168Whypothetical protein0.022
PRS2Prs2p0.022
SWC7Swc7p0.021
ZPS1Zps1p0.021
PTI1Pti1p0.021
OPT2Opt2p0.021
AUA1Aua1p0.020
IRC5Irc5p0.020
HLR1Hlr1p0.020
YBR013Chypothetical protein0.020
POP6Pop6p0.020
PEX15Pex15p0.020
YIL151Chypothetical protein0.020
SPL2Spl2p0.020
HPF1Hpf1p0.020
NTG2Ntg2p0.019
APT2Apt2p0.019
XRS2Xrs2p0.019
CSM2Csm2p0.019
MF(ALPHA)2Mf(alpha)2p0.019
MET8Met8p0.019
PRI2Pri2p0.019
IZH4Izh4p0.019
FMT1Fmt1p0.018
YDR222Whypothetical protein0.018
YER137Chypothetical protein0.018
INM1Inm1p0.018
TYE7Tye7p0.018
BSC1Bsc1p0.018
TAF4Taf4p0.018
YOL013W-Ahypothetical protein0.018
RAD1Rad1p0.018
CPD1Cpd1p0.018
RAD23Rad23p0.017
DUN1Dun1p0.017
YAR066Whypothetical protein0.017
RPB3Rpb3p0.017
CUP1-2Cup1-2p0.017
UPS3Ups3p0.017
YLR040Chypothetical protein0.017
YGR126Whypothetical protein0.017
YAR029Whypothetical protein0.016
CHZ1Chz1p0.016