The network for 'protein stabilization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.960
Mdm2transformed mouse 3T3 cell double minute 20.793
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.454
Shhsonic hedgehog0.368
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.327
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.195
Pbx1pre B-cell leukemia transcription factor 10.193
Gli3GLI-Kruppel family member GLI30.179
Tsc2tuberous sclerosis 20.146
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.144
Msx1homeobox, msh-like 10.128
Lrrk2leucine-rich repeat kinase 20.122
Bmp4bone morphogenetic protein 40.111
Rpgrip1lRpgrip1-like0.110
Hbb-b1hemoglobin, beta adult major chain0.105
Prnpprion protein0.100
Cops6COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)0.094
Prrx1paired related homeobox 10.091
Spna1spectrin alpha 10.087
Tcf4transcription factor 40.081
Fgfr1fibroblast growth factor receptor 10.077
Hand2heart and neural crest derivatives expressed transcript 20.075
Ctnnb1catenin (cadherin associated protein), beta 10.061
Fgf8fibroblast growth factor 80.061
Tcfap2atranscription factor AP-2, alpha0.060
Hbb-b2hemoglobin, beta adult minor chain0.060
Sox4SRY-box containing gene 40.059
Isl1ISL1 transcription factor, LIM/homeodomain0.058
Pax3paired box gene 30.057
Id3inhibitor of DNA binding 30.056
Fgfr2fibroblast growth factor receptor 20.056
Ank1ankyrin 1, erythroid0.055
Nf1neurofibromatosis 10.053
Otx2orthodenticle homolog 2 (Drosophila)0.050
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.048
SkilSKI-like0.047
Hand1heart and neural crest derivatives expressed transcript 10.046
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.046
Pim1proviral integration site 10.043
Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.042
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.041
DaxxFas death domain-associated protein0.041
Id1inhibitor of DNA binding 10.040
Gps1G protein pathway suppressor 10.039
Hspa9heat shock protein 90.038
Axin1axin 10.038
Acvr1activin A receptor, type 10.037
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.037
Smad6MAD homolog 6 (Drosophila)0.036
Rab11aRAB11a, member RAS oncogene family0.035
Sox9SRY-box containing gene 90.035
Slc4a1solute carrier family 4 (anion exchanger), member 10.033
Pax6paired box gene 60.033
Ptch1patched homolog 10.032
Stat5asignal transducer and activator of transcription 5A0.032
Cops5COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)0.031
Epas1endothelial PAS domain protein 10.030
Apcadenomatosis polyposis coli0.030
Creb1cAMP responsive element binding protein 10.030
Ttc7tetratricopeptide repeat domain 70.029
Cops3COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)0.029
Ednraendothelin receptor type A0.029
Spnb1spectrin beta 10.029
Eedembryonic ectoderm development0.029
Rspo2R-spondin 2 homolog (Xenopus laevis)0.028
Jarid2jumonji, AT rich interactive domain 20.028
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.028
Ctsbcathepsin B0.028
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.027
Appamyloid beta (A4) precursor protein0.027
Gata4GATA binding protein 40.027
Tal1T-cell acute lymphocytic leukemia 10.027
P4hbprolyl 4-hydroxylase, beta polypeptide0.027
Lef1lymphoid enhancer binding factor 10.026
Pou5f1POU domain, class 5, transcription factor 10.026
Bmp7bone morphogenetic protein 70.025
Per1period homolog 1 (Drosophila)0.025
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.025
Stk4serine/threonine kinase 40.024
Pklrpyruvate kinase liver and red blood cell0.024
ND6NADH dehydrogenase subunit 60.023
Rint1RAD50 interactor 10.022
Bmpr1abone morphogenetic protein receptor, type 1A0.022
Hes1hairy and enhancer of split 1 (Drosophila)0.022
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.021
Alx1ALX homeobox 10.021
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.021
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.021
Dync1i2dynein cytoplasmic 1 intermediate chain 20.020
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.020
Tgfb2transforming growth factor, beta 20.020
Smad4MAD homolog 4 (Drosophila)0.020
Eya1eyes absent 1 homolog (Drosophila)0.020
Actg1actin, gamma, cytoplasmic 10.020
Trp63transformation related protein 630.020
Hsp90b1heat shock protein 90, beta (Grp94), member 10.020
Pim3proviral integration site 30.019
Zzz3zinc finger, ZZ domain containing 30.019
Gli2GLI-Kruppel family member GLI20.019
Cops8COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)0.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.652
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.649
tnni1altroponin I, skeletal, slow like0.528
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.365
smyhc2slow myosin heavy chain 20.346
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.330
myhz2myosin, heavy polypeptide 2, fast muscle specific0.283
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.276
cct5chaperonin containing TCP1, subunit 5 (epsilon)0.247
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.205
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.203
smyhc1slow myosin heavy chain 10.174
hsp90a.2heat shock protein 90-alpha 20.153
cand1cullin-associated and neddylation-dissociated 10.149
actn3aactinin alpha 3a0.145
fzd7bfrizzled homolog 7b0.138
npc2Niemann-Pick disease, type C20.135
dpysl5adihydropyrimidinase-like 5a0.131
LOC100151531zinc finger protein Gfi-1b-like0.128
ephb4beph receptor B4b0.120
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.115
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.113
ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.113
rtn3reticulon 30.113
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.112
hoxb6bhomeo box B6b0.108
mef2dmyocyte enhancer factor 2d0.107
caprin1acell cycle associated protein 1a0.104
actr1ARP1 actin-related protein 1, centractin (yeast)0.104
sox11aSRY-box containing gene 11a0.103
tnnc1btroponin C type 1b (slow)0.103
actn3bactinin alpha 3b0.098
smyhc3slow myosin heavy chain 30.098
ptpraprotein tyrosine phosphatase, receptor type, A0.097
arpp19acAMP-regulated phosphoprotein 19a0.096
LOC100149834cdc2-related kinase, arginine/serine-rich-like0.095
hoxd4ahomeo box D4a0.091
mxi1max interacting protein0.091
nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.091
tnni1btroponin I, skeletal, slow b0.089
tpm1tropomyosin 1 (alpha)0.087
ftr82finTRIM family, member 820.087
srsf1aserine/arginine-rich splicing factor 1a0.084
mta2metastasis associated 1 family, member 20.084
jkampjnk1/mapk8-associated membrane protein0.081
immtinner membrane protein, mitochondrial (mitofilin)0.080
sod2superoxide dismutase 2, mitochondrial0.079
cct8chaperonin containing TCP1, subunit 8 (theta)0.078
gmfbglia maturation factor, beta0.078
naa50N(alpha)-acetyltransferase 50, NatE catalytic subunit0.078
rbm4.1RNA binding motif protein 4.10.077
rtn1areticulon 1a0.077
zgc:152900zgc:1529000.076
hat1histone acetyltransferase 10.074
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.074
si:ch211-51m24.3si:ch211-51m24.30.074
slc48a1bsolute carrier family 48 (heme transporter), member 1b0.074
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.074
tnnt3btroponin T3b, skeletal, fast0.074
actr6ARP6 actin-related protein 6 homolog (yeast)0.070
e2f4E2F transcription factor 40.070
ptmaaprothymosin, alpha a0.070
zgc:123178zgc:1231780.069
zgc:65827zgc:658270.069
myhc4myosin heavy chain 40.069
stmn2bstathmin-like 2b0.068
mibmind bomb0.068
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.068
tgfb1atransforming growth factor, beta 1a0.068
spry2sprouty homolog 20.067
ckbbcreatine kinase, brain b0.067
nr2f1anuclear receptor subfamily 2, group F, member 1a0.066
rargaretinoic acid receptor gamma a0.066
zgc:56304zgc:563040.066
junjun proto-oncogene0.065
ube2i2ubiquitin-conjugating enzyme E2I20.064
zgc:101724zgc:1017240.062
stau1staufen, RNA binding protein, homolog 1 (Drosophila)0.061
aldh7a1aldehyde dehydrogenase 7 family, member A10.060
znf703zinc finger protein 7030.059
tfdp1atranscription factor Dp-1, a0.059
slc25a22solute carrier family 25 (mitochondrial carrier: glutamate), member 220.058
slc38a3solute carrier family 38, member 30.058
myogmyogenin0.058
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.056
tcp1t-complex polypeptide 10.056
wu:fb76c12wu:fb76c120.055
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.054
mcm6MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)0.054
lrpprcleucine-rich PPR-motif containing0.054
eef2beukaryotic translation elongation factor 2b0.054
prdx2peroxiredoxin 20.054
hoxc6bhomeo box C6b0.054
spry4sprouty (Drosophila) homolog 40.054
fb06f03high-mobility group nucleosome binding domain 1-like0.052
eif3deukaryotic translation initiation factor 3, subunit D0.052
aif1lallograft inflammatory factor 1-like0.051
acss2acyl-CoA synthetase short-chain family member 20.051
chst10carbohydrate sulfotransferase 100.051
puf60apoly-U binding splicing factor a0.050
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.993
RASSF5Ras association (RalGDS/AF-6) domain family member 50.991
STK3serine/threonine kinase 30.946
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.917
STK4serine/threonine kinase 40.889
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.805
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.768
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.745
MDM2Mdm2 p53 binding protein homolog (mouse)0.738
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.579
SMAD7SMAD family member 70.533
CCT8chaperonin containing TCP1, subunit 8 (theta)0.525
P4HBprolyl 4-hydroxylase, beta polypeptide0.487
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.453
FLOT2flotillin 20.448
PSEN1presenilin 10.430
WDR5WD repeat domain 50.421
C19orf39chromosome 19 open reading frame 390.411
RNF11ring finger protein 110.356
SMAD3SMAD family member 30.355
FLOT1flotillin 10.317
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.316
RASSF3Ras association (RalGDS/AF-6) domain family member 30.295
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.290
TSC2tuberous sclerosis 20.257
SMURF2SMAD specific E3 ubiquitin protein ligase 20.246
GBAglucosidase, beta, acid0.211
A2Malpha-2-macroglobulin0.207
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.206
ZSWIM7zinc finger, SWIM-type containing 70.205
DAXXdeath-domain associated protein0.192
ARRB1arrestin, beta 10.183
RB1retinoblastoma 10.182
UBQLN1ubiquilin 10.165
MDM4Mdm4 p53 binding protein homolog (mouse)0.165
PDIA3protein disulfide isomerase family A, member 30.163
POU3F2POU class 3 homeobox 20.162
ABI1abl-interactor 10.158
AKT1v-akt murine thymoma viral oncogene homolog 10.152
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.148
RAD51L1RAD51-like 1 (S. cerevisiae)0.146
PDIA4protein disulfide isomerase family A, member 40.140
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.136
LAPTM5lysosomal protein transmembrane 50.133
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.132
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.131
SMAD1SMAD family member 10.130
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.127
CSNK1A1casein kinase 1, alpha 10.126
DSC2desmocollin 20.125
RASSF1Ras association (RalGDS/AF-6) domain family member 10.125
PAX3paired box 30.123
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.117
HSPB1heat shock 27kDa protein 10.115
RASSF2Ras association (RalGDS/AF-6) domain family member 20.111
HYOU1hypoxia up-regulated 10.106
COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.106
SMAD4SMAD family member 40.104
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.101
NBR1neighbor of BRCA1 gene 10.101
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.101
GFERgrowth factor, augmenter of liver regeneration0.100
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.100
RYBPRING1 and YY1 binding protein0.099
APOC1apolipoprotein C-I0.092
DSG2desmoglein 20.092
XIAPX-linked inhibitor of apoptosis0.089
TADA3transcriptional adaptor 30.088
CCT4chaperonin containing TCP1, subunit 4 (delta)0.086
BTRCbeta-transducin repeat containing0.086
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.085
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.085
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.084
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.084
CTNND1catenin (cadherin-associated protein), delta 10.083
HNRNPKheterogeneous nuclear ribonucleoprotein K0.082
MAP1Smicrotubule-associated protein 1S0.081
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.081
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.081
TCP1t-complex 10.081
ARID1AAT rich interactive domain 1A (SWI-like)0.080
COG4component of oligomeric golgi complex 40.079
SMAD5SMAD family member 50.078
C19orf10chromosome 19 open reading frame 100.078
HSPA1Bheat shock 70kDa protein 1B0.077
FUNDC2FUN14 domain containing 20.074
NCLnucleolin0.072
CCDC6coiled-coil domain containing 60.070
FOXD3forkhead box D30.067
ARRB2arrestin, beta 20.067
PSEN2presenilin 2 (Alzheimer disease 4)0.067
MEN1multiple endocrine neoplasia I0.066
HSPH1heat shock 105kDa/110kDa protein 10.065
PBRM1polybromo 10.065
APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 20.064
PUM1pumilio homolog 1 (Drosophila)0.064
TCF12transcription factor 120.063
LIMD1LIM domains containing 10.063
PBX1pre-B-cell leukemia homeobox 10.063
TTRtransthyretin0.062
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PRK1Prk1p0.011