The network for 'negative regulation of t cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of t cell mediated cytotoxicity

Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.

NameDescriptionProbabilityFunc Analog Organism
FynFyn proto-oncogene0.980
Cd247CD247 antigen0.956
Il2rginterleukin 2 receptor, gamma chain0.952
Latlinker for activation of T cells0.938
Ikzf1IKAROS family zinc finger 10.918
Lcklymphocyte protein tyrosine kinase0.905
TcraT-cell receptor alpha chain0.551
Foxn1forkhead box N10.449
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.442
Wipf1WAS/WASL interacting protein family, member 10.317
Rag2recombination activating gene 20.291
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.227
Ptprcprotein tyrosine phosphatase, receptor type, C0.193
FasFas (TNF receptor superfamily member 6)0.164
Klf1Kruppel-like factor 1 (erythroid)0.132
Tnftumor necrosis factor0.117
Cul3cullin 30.112
Cd19CD19 antigen0.102
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.084
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.082
Oxr1oxidation resistance 10.074
Il2interleukin 20.073
Jak2Janus kinase 20.065
Ank1ankyrin 1, erythroid0.062
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.056
Hbb-b1hemoglobin, beta adult major chain0.050
Rasa3RAS p21 protein activator 30.048
Atp2c1ATPase, Ca++-sequestering0.048
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.048
Mef2amyocyte enhancer factor 2A0.048
Fcgr2bFc receptor, IgG, low affinity IIb0.045
Rag1recombination activating gene 10.044
B2mbeta-2 microglobulin0.042
Itgb2integrin beta 20.038
Epas1endothelial PAS domain protein 10.036
Laptm5lysosomal-associated protein transmembrane 50.035
Zfp260zinc finger protein 2600.034
Cd4CD4 antigen0.033
Gata1GATA binding protein 10.031
Oxtoxytocin0.030
Cd47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)0.029
Foxp3forkhead box P30.029
Spna1spectrin alpha 10.026
Zap70zeta-chain (TCR) associated protein kinase0.026
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.025
Lcp2lymphocyte cytosolic protein 20.025
Inpp5dinositol polyphosphate-5-phosphatase D0.024
Grb2growth factor receptor bound protein 20.023
Slc4a1solute carrier family 4 (anion exchanger), member 10.023
Ulk2Unc-51 like kinase 2 (C. elegans)0.023
Add2adducin 2 (beta)0.023
Vamp4vesicle-associated membrane protein 40.022
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.022
Jak1Janus kinase 10.021
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.021
Map3k14mitogen-activated protein kinase kinase kinase 140.020
ItkIL2-inducible T-cell kinase0.019
Vav1vav 1 oncogene0.019
Cd53CD53 antigen0.019
Ccr6chemokine (C-C motif) receptor 60.018
Lyz2lysozyme 20.018
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.017
Dlg1discs, large homolog 1 (Drosophila)0.017
Rap1bRAS related protein 1b0.016
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.015
FcrlaFc receptor-like A0.015
Pitx3paired-like homeodomain transcription factor 30.015
Il15interleukin 150.015
Nckap1lNCK associated protein 1 like0.015
Cd8aCD8 antigen, alpha chain0.014
Ptprnprotein tyrosine phosphatase, receptor type, N0.014
Tspo2translocator protein 20.014
Serinc1serine incorporator 10.013
Gp5glycoprotein 5 (platelet)0.013
FybFYN binding protein0.013
Snx13sorting nexin 130.013
Gfi1bgrowth factor independent 1B0.013
Gpr132G protein-coupled receptor 1320.013
Ptpreprotein tyrosine phosphatase, receptor type, E0.012
Mpomyeloperoxidase0.012
Cd28CD28 antigen0.012
Oprm1opioid receptor, mu 10.012
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.012
Plcg1phospholipase C, gamma 10.012
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.012
Ubl3ubiquitin-like 30.012
BtkBruton agammaglobulinemia tyrosine kinase0.012
Map3k5mitogen-activated protein kinase kinase kinase 50.012
Dync1i2dynein cytoplasmic 1 intermediate chain 20.012
Ifngr1interferon gamma receptor 10.011
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.011
Kctd12potassium channel tetramerisation domain containing 120.011
Ctsscathepsin S0.011
Rasa1RAS p21 protein activator 10.011
Mtmr6myotubularin related protein 60.011
Tmem30atransmembrane protein 30A0.011
Ccr1chemokine (C-C motif) receptor 10.010
Gypaglycophorin A0.010
Pklrpyruvate kinase liver and red blood cell0.010
Plcg2phospholipase C, gamma 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.948
PTPN6protein tyrosine phosphatase, non-receptor type 60.930
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.916
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.857
PILRApaired immunoglobin-like type 2 receptor alpha0.696
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.673
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.357
CD22CD22 molecule0.148
HK3hexokinase 3 (white cell)0.130
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.119
PTAFRplatelet-activating factor receptor0.107
SIGLEC7sialic acid binding Ig-like lectin 70.079
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.058
CD33CD33 molecule0.046
NOD2nucleotide-binding oligomerization domain containing 20.024
NLRP3NLR family, pyrin domain containing 30.024
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.023
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.023
SIRPB1signal-regulatory protein beta 10.019
TREM1triggering receptor expressed on myeloid cells 10.019
CCR1chemokine (C-C motif) receptor 10.019
AOAHacyloxyacyl hydrolase (neutrophil)0.018
CD86CD86 molecule0.017
CSKc-src tyrosine kinase0.017
CYTH4cytohesin 40.016
BIN2bridging integrator 20.016
IRF2interferon regulatory factor 20.016
CYBBcytochrome b-245, beta polypeptide0.015
TYMPthymidine phosphorylase0.015
FPR2formyl peptide receptor 20.014
TLR8toll-like receptor 80.013
FCARFc fragment of IgA, receptor for0.012
HCKhemopoietic cell kinase0.011
CD163CD163 molecule0.011
FPR1formyl peptide receptor 10.011
CEACAM3carcinoembryonic antigen-related cell adhesion molecule 30.010
SIGLEC9sialic acid binding Ig-like lectin 90.010
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism