The network for 'negative regulation of b cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of b cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.

NameDescriptionProbabilityFunc Analog Organism
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.999
Ighimmunoglobulin heavy chain complex0.988
Cd19CD19 antigen0.987
Rc3h1RING CCCH (C3H) domains 10.915
Ikzf1IKAROS family zinc finger 10.909
Ptenphosphatase and tensin homolog0.812
Pou2af1POU domain, class 2, associating factor 10.764
FynFyn proto-oncogene0.755
Trp53transformation related protein 530.643
Kdrkinase insert domain protein receptor0.640
Ptprcprotein tyrosine phosphatase, receptor type, C0.639
Map3k7mitogen-activated protein kinase kinase kinase 70.622
Myd88myeloid differentiation primary response gene 880.618
CblCasitas B-lineage lymphoma0.617
Csf1colony stimulating factor 1 (macrophage)0.518
Ikbkginhibitor of kappaB kinase gamma0.423
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.405
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.394
Nlrp3NLR family, pyrin domain containing 30.385
Traf6TNF receptor-associated factor 60.385
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.350
Prf1perforin 1 (pore forming protein)0.344
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.338
Tnftumor necrosis factor0.303
Il18interleukin 180.278
S1pr2sphingosine-1-phosphate receptor 20.272
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.240
Inpp5dinositol polyphosphate-5-phosphatase D0.232
Cd4CD4 antigen0.231
Lyz2lysozyme 20.231
Cd28CD28 antigen0.230
Map3k14mitogen-activated protein kinase kinase kinase 140.230
Tcf4transcription factor 40.224
Sfrp2secreted frizzled-related protein 20.222
Cd40CD40 antigen0.219
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.219
Tgfbr2transforming growth factor, beta receptor II0.218
WasWiskott-Aldrich syndrome homolog (human)0.205
Ltalymphotoxin A0.205
Tcf3transcription factor 30.195
Cdh5cadherin 50.192
Tlr4toll-like receptor 40.187
Tnip1TNFAIP3 interacting protein 10.179
Dok1docking protein 10.155
Socs1suppressor of cytokine signaling 10.152
Mdm2transformed mouse 3T3 cell double minute 20.152
Latlinker for activation of T cells0.147
BlnkB-cell linker0.146
Itsn1intersectin 1 (SH3 domain protein 1A)0.145
Hif1ahypoxia inducible factor 1, alpha subunit0.141
Il2rginterleukin 2 receptor, gamma chain0.138
Ccr7chemokine (C-C motif) receptor 70.133
Il4rainterleukin 4 receptor, alpha0.130
Ifnginterferon gamma0.126
Card11caspase recruitment domain family, member 110.125
Birc3baculoviral IAP repeat-containing 30.123
Foxp3forkhead box P30.121
Icosinducible T-cell co-stimulator0.116
Gli2GLI-Kruppel family member GLI20.115
Casp8caspase 80.114
Il10interleukin 100.113
Hhexhematopoietically expressed homeobox0.112
Hckhemopoietic cell kinase0.110
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.105
Cxcr4chemokine (C-X-C motif) receptor 40.103
Traf2TNF receptor-associated factor 20.102
Cd22CD22 antigen0.101
Il27rainterleukin 27 receptor, alpha0.101
Prdm1PR domain containing 1, with ZNF domain0.098
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.097
Ptgs2prostaglandin-endoperoxide synthase 20.093
PycardPYD and CARD domain containing0.092
FasFas (TNF receptor superfamily member 6)0.092
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.091
Plcg2phospholipase C, gamma 20.090
Pgrmc1progesterone receptor membrane component 10.087
Rb1retinoblastoma 10.085
C3ar1complement component 3a receptor 10.085
Sfrp1secreted frizzled-related protein 10.084
Vegfavascular endothelial growth factor A0.084
FaddFas (TNFRSF6)-associated via death domain0.084
Cd180CD180 antigen0.081
Grb2growth factor receptor bound protein 20.081
Irf8interferon regulatory factor 80.079
Il2rbinterleukin 2 receptor, beta chain0.079
BC013712cDNA sequence BC0137120.078
Ltblymphotoxin B0.078
Foxn1forkhead box N10.076
Il6interleukin 60.073
Ccr6chemokine (C-C motif) receptor 60.072
Ptmaprothymosin alpha0.071
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.070
Id2inhibitor of DNA binding 20.069
Itgb1integrin beta 1 (fibronectin receptor beta)0.069
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.069
Ptk2PTK2 protein tyrosine kinase 20.069
Stat3signal transducer and activator of transcription 30.068
Ldlrlow density lipoprotein receptor0.068
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.067
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CD80CD80 molecule0.353
THOC2THO complex 20.175
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.160
THOC5THO complex 50.129
CD86CD86 molecule0.079
TNIP2TNFAIP3 interacting protein 20.079
TFF1trefoil factor 10.070
TNIP1TNFAIP3 interacting protein 10.067
SLAMF1signaling lymphocytic activation molecule family member 10.064
GRAP2GRB2-related adaptor protein 20.061
IL10RAinterleukin 10 receptor, alpha0.060
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.060
CASP9caspase 9, apoptosis-related cysteine peptidase0.056
TP53BP1tumor protein p53 binding protein 10.052
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.045
NCOR2nuclear receptor corepressor 20.044
HDAC9histone deacetylase 90.042
CASP10caspase 10, apoptosis-related cysteine peptidase0.037
IL22RA2interleukin 22 receptor, alpha 20.034
FASLGFas ligand (TNF superfamily, member 6)0.033
IL22RA1interleukin 22 receptor, alpha 10.031
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.028
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.027
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.027
XIAPX-linked inhibitor of apoptosis0.027
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.025
CASP7caspase 7, apoptosis-related cysteine peptidase0.019
FRA10AC1fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 10.018
THOC4THO complex 40.018
PMLpromyelocytic leukemia0.017
MAPK12mitogen-activated protein kinase 120.016
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.015
SH2D1ASH2 domain containing 1A0.015
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.014
IL4Rinterleukin 4 receptor0.014
TNFtumor necrosis factor0.014
ATMINATM interactor0.013
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.012
TERF1telomeric repeat binding factor (NIMA-interacting) 10.011
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.011
MDM2Mdm2 p53 binding protein homolog (mouse)0.011
FANCD2Fanconi anemia, complementation group D20.011
CTLA4cytotoxic T-lymphocyte-associated protein 40.011
DCLRE1CDNA cross-link repair 1C0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ddr2discoidin domain receptor tyrosine kinase 20.014
Cd53Cd53 molecule0.012
Ptprcprotein tyrosine phosphatase, receptor type, C0.011
Il1r1interleukin 1 receptor, type I0.011
MGC112715hypothetical protein LOC6908990.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism